V R Gordeuk

Summary

Affiliation: Howard University
Country: USA

Publications

  1. pmc Angiogenic and inflammatory markers of cardiopulmonary changes in children and adolescents with sickle cell disease
    Xiaomei Niu
    Center for Sickle Cell Disease, Howard University, Washington, DC, United States of America
    PLoS ONE 4:e7956. 2009
  2. pmc Chuvash polycythemia VHLR200W mutation is associated with down-regulation of hepcidin expression
    Victor R Gordeuk
    Center for Sickle Cell Disease, Department of Medicine, Howard University, Washington, DC 20060, USA
    Blood 118:5278-82. 2011
  3. pmc Hepcidin induces HIV-1 transcription inhibited by ferroportin
    Min Xu
    Center for Sickle Cell Disease, Department of Medicine, Howard University, Washington, DC 20060, USA
    Retrovirology 7:104. 2010
  4. ncbi Vascular complications in Chuvash polycythemia
    Victor R Gordeuk
    Department of Medicine and Center for Sickle Cell Disease, Howard University, Washington, District of Columbia, USA
    Semin Thromb Hemost 32:289-94. 2006
  5. pmc Ferroportin Q248h, dietary iron, and serum ferritin in community African-Americans with low to high alcohol consumption
    Victor R Gordeuk
    College of Medicine, Howard University, Washington, DC 20060, USA
    Alcohol Clin Exp Res 32:1947-53. 2008
  6. ncbi Circulating cytokines in pulmonary tuberculosis according to HIV status and dietary iron content
    V R Gordeuk
    Center for Sickle Cell Disease and Department of Medicine, Howard University, Washington, DC 20060, USA
    Int J Tuberc Lung Dis 13:1267-73. 2009
  7. pmc Relationship of erythropoietin, fetal hemoglobin, and hydroxyurea treatment to tricuspid regurgitation velocity in children with sickle cell disease
    Victor R Gordeuk
    Howard University, Washington, DC 20060, USA
    Blood 114:4639-44. 2009
  8. pmc Serum ferritin concentrations and body iron stores in a multicenter, multiethnic primary-care population
    Victor R Gordeuk
    Department of Medicine and Center for Sickle Cell Disease, Howard University, Washington, District of Columbia 20060, USA
    Am J Hematol 83:618-26. 2008
  9. ncbi Congenital disorder of oxygen sensing: association of the homozygous Chuvash polycythemia VHL mutation with thrombosis and vascular abnormalities but not tumors
    Victor R Gordeuk
    Center for Sickle Cell Disease, Department of Medicine, Howard University, Washington, DC 20059, USA
    Blood 103:3924-32. 2004
  10. pmc Relative systemic hypertension in patients with sickle cell disease is associated with risk of pulmonary hypertension and renal insufficiency
    Victor R Gordeuk
    Center for Sickle Cell Disease, Howard University, Washington, District of Columbia 20060, USA
    Am J Hematol 83:15-8. 2008

Research Grants

Detail Information

Publications80

  1. pmc Angiogenic and inflammatory markers of cardiopulmonary changes in children and adolescents with sickle cell disease
    Xiaomei Niu
    Center for Sickle Cell Disease, Howard University, Washington, DC, United States of America
    PLoS ONE 4:e7956. 2009
    ..Pulmonary hypertension is associated with hemolysis and hypoxia, but other unidentified factors are likely involved in pathogenesis as well...
  2. pmc Chuvash polycythemia VHLR200W mutation is associated with down-regulation of hepcidin expression
    Victor R Gordeuk
    Center for Sickle Cell Disease, Department of Medicine, Howard University, Washington, DC 20060, USA
    Blood 118:5278-82. 2011
    ..In conclusion, up-regulation of the hypoxic response leads to decreased expression of hepcidin that may be independent of increased erythropoietin levels and increased RBC counts...
  3. pmc Hepcidin induces HIV-1 transcription inhibited by ferroportin
    Min Xu
    Center for Sickle Cell Disease, Department of Medicine, Howard University, Washington, DC 20060, USA
    Retrovirology 7:104. 2010
    ..Here, we analyzed the effect of ferroportin and hepcidin on HIV-1 transcription...
  4. ncbi Vascular complications in Chuvash polycythemia
    Victor R Gordeuk
    Department of Medicine and Center for Sickle Cell Disease, Howard University, Washington, District of Columbia, USA
    Semin Thromb Hemost 32:289-94. 2006
    ..Further investigation of the vascular complications of Chuvash polycythemia may increase our fundamental knowledge of thrombophilia, bleeding diatheses, and protection from cancer...
  5. pmc Ferroportin Q248h, dietary iron, and serum ferritin in community African-Americans with low to high alcohol consumption
    Victor R Gordeuk
    College of Medicine, Howard University, Washington, DC 20060, USA
    Alcohol Clin Exp Res 32:1947-53. 2008
    ..We examined the associations of ferroportin Q248H, alcohol and dietary iron with serum ferritin, aspartate aminotransaminase (AST) and alanine aminotransaminase (ALT) concentrations in African-Americans...
  6. ncbi Circulating cytokines in pulmonary tuberculosis according to HIV status and dietary iron content
    V R Gordeuk
    Center for Sickle Cell Disease and Department of Medicine, Howard University, Washington, DC 20060, USA
    Int J Tuberc Lung Dis 13:1267-73. 2009
    ..To evaluate human immunodeficiency virus (HIV) serology, dietary iron and serum concentrations of markers of T-helper type (Th) 1 and Th-2 immune pathways in the setting of tuberculosis (TB)...
  7. pmc Relationship of erythropoietin, fetal hemoglobin, and hydroxyurea treatment to tricuspid regurgitation velocity in children with sickle cell disease
    Victor R Gordeuk
    Howard University, Washington, DC 20060, USA
    Blood 114:4639-44. 2009
    ..The hemolysis-lowering and hemoglobin F-augmenting effects of hydroxyurea may exert countervailing influences on pulmonary blood pressure in sickle cell disease...
  8. pmc Serum ferritin concentrations and body iron stores in a multicenter, multiethnic primary-care population
    Victor R Gordeuk
    Department of Medicine and Center for Sickle Cell Disease, Howard University, Washington, District of Columbia 20060, USA
    Am J Hematol 83:618-26. 2008
    ..Serum ferritin >900 microg/L in male C282Y homozygotes is predictive of moderately increased iron stores...
  9. ncbi Congenital disorder of oxygen sensing: association of the homozygous Chuvash polycythemia VHL mutation with thrombosis and vascular abnormalities but not tumors
    Victor R Gordeuk
    Center for Sickle Cell Disease, Department of Medicine, Howard University, Washington, DC 20059, USA
    Blood 103:3924-32. 2004
    ..Thus, Chuvash polycythemia is a distinct VHL syndrome manifested by thrombosis, vascular abnormalities, and intact hypoxic regulation despite increased basal expression of hypoxia-regulated genes...
  10. pmc Relative systemic hypertension in patients with sickle cell disease is associated with risk of pulmonary hypertension and renal insufficiency
    Victor R Gordeuk
    Center for Sickle Cell Disease, Howard University, Washington, District of Columbia 20060, USA
    Am J Hematol 83:15-8. 2008
    ..Whether antihypertensive and/or nitric oxide donor therapy in sickle cell disease patients with relative hypertension prevents these and other complications should be determined by clinical trials...
  11. ncbi Efficacy and safety of sildenafil in the treatment of severe pulmonary hypertension in patients with hemoglobinopathies
    Victor R Gordeuk
    Center for Sickle Cell Disease, Howard University 2121 Georgia Ave NW, Washington, DC, 20059 USA
    Haematologica 90:433-4. 2005
  12. pmc Elevated tricuspid regurgitation velocity and decline in exercise capacity over 22 months of follow up in children and adolescents with sickle cell anemia
    Victor R Gordeuk
    Center for Sickle Cell Disease, Howard University, Washington, DC 20060, USA
    Haematologica 96:33-40. 2011
    ..The role of intravascular hemolysis in the development of this complication is controversial...
  13. ncbi The association of serum ferritin and transferrin receptor concentrations with mortality in women with human immunodeficiency virus infection
    Victor R Gordeuk
    Center for Sickle Cell Disease and Dept of Medicine, Howard University, Washington, DC 20059, USA
    Haematologica 91:739-43. 2006
    ..We studied the relationship of indirect measures of iron stores with mortality in highly active antiretroviral therapy (HAART)-naive participants from the Women's Interagency HIV Study...
  14. ncbi Plasmodium falciparum and Plasmodium yoelii: effect of the iron chelation prodrug dexrazoxane on in vitro cultures
    M Loyevsky
    George Washington University Medical Center, Washington, DC 20037, USA
    Exp Parasitol 91:105-14. 1999
    ....
  15. ncbi Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia
    Sonny O Ang
    Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    Nat Genet 32:614-21. 2002
    ....
  16. ncbi An IRP-like protein from Plasmodium falciparum binds to a mammalian iron-responsive element
    M Loyevsky
    Howard University, Washington, DC, USA
    Blood 98:2555-62. 2001
    ....
  17. ncbi Chelation of iron within the erythrocytic Plasmodium falciparum parasite by iron chelators
    M Loyevsky
    Department of Medicine, The George Washington University Medical Center, Washington, DC 20037, USA
    Mol Biochem Parasitol 101:43-59. 1999
    ....
  18. pmc Complete blood count, measures of iron status and inflammatory markers in inner-city African Americans with undiagnosed hepatitis C seropositivity
    Hilary Ufearo
    Department of Medicine, Howard University College of Medicine, Washington, DC, USA
    Clin Chim Acta 411:653-6. 2010
    ..We aimed to determine how often changes in hematologic, iron metabolic and inflammatory markers occur in individuals with undiagnosed HCV in the community...
  19. ncbi Endemic polycythemia in Russia: mutation in the VHL gene
    Sonny O Ang
    Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    Blood Cells Mol Dis 28:57-62. 2002
    ..These findings strongly suggest that CP is a congenital disorder of oxygen homeostasis...
  20. pmc Altered cytokine profiles in patients with Chuvash polycythemia
    Xiaomei Niu
    Center for Sickle Cell Disease and Department of Medicine, Howard University, Washington, District of Columbia 20060, USA
    Am J Hematol 84:74-8. 2009
    ..In conclusion, the up-regulated hypoxic response in Chuvash polycythemia is associated with increased plasma products of both the Th1 and Th2 pathways, but the balance between the two pathways seems to be preserved...
  21. ncbi African Americans at risk for increased iron stores or liver disease
    Fitzroy W Dawkins
    Division of Hematology Oncology, Department of Medicine, Howard University, Washington, DC, USA
    Am J Med 120:734.e1-9. 2007
    ....
  22. ncbi Mixture distribution analysis of phenotypic markers reflecting HFE gene mutations
    Christine E McLaren
    Department of Medicine, Epidemiology Division, University of California, 224 Irvine Hall, Irvine, CA 92697 7550, USA
    Blood 102:4563-6. 2003
    ..These results suggest that statistical modeling of population clinical laboratory test data can reveal the influence of a major locus gene defect and perhaps can be applied to other aspects of body metabolism than iron...
  23. ncbi Mixture models of serum iron measures in population screening for hemochromatosis and iron overload
    Christine E McLaren
    Epidemiology Division, Department of Medicine, University of California, Irvine, CA 92697, USA
    Transl Res 148:196-206. 2006
    ..It was concluded that mixture modeling of phenotypic data may provide a clinical guide for screening with gender-specific thresholds to identify potential samples for genetic testing...
  24. ncbi The impact of body mass index on pulse pressure in obesity
    John Kwagyan
    General Clinical Research Center, Howard University College of Medicine, NW, Washington, DC 20060, USA
    J Hypertens 23:619-24. 2005
    ..Pulse pressure, a marker of arterial vascular properties, has been linked to cardiovascular diseases and complications. This study examined the impact of excess body mass and cardiovascular disease risk factors on pulse pressure (PP)...
  25. pmc Effects of root extracts of Fagara zanthoxyloides on the in vitro growth and stage distribution of Plasmodium falciparum
    Olakunle O Kassim
    Department of Microbiology, Howard University College of Medicine, 520 W St, NW, Washington, DC 20059, USA
    Antimicrob Agents Chemother 49:264-8. 2005
    ..Additional experiments showed that fagaronine also inhibited P. falciparum growth, with an IC(50) of 0.018 microg/ml. The results of this study suggest that the antimalarial activity of fagaronine deserves further investigation...
  26. pmc Association of G6PD with lower haemoglobin concentration but not increased haemolysis in patients with sickle cell anaemia
    Mehdi Nouraie
    Center for Sickle Cell Disease, Howard University, Washington, DC 20060, USA
    Br J Haematol 150:218-25. 2010
    ..007), and increased severe pain episodes (P < 0.001). In conclusion, G6PD(202A,376G) may be associated with lower haemoglobin concentration in sickle cell anaemia by a mechanism other than increased haemolysis...
  27. ncbi Obese African Americans: the prevalence of dyslipidemia, hypertension, and diabetes mellitus
    Otelio S Randall
    Department of Medicine, Howard University, Washington, DC 20060, USA
    Ethn Dis 14:384-8. 2004
    ..The prevalence of the cardiovascular disease risk factors, dyslipidemia, hypertension, and diabetes mellitus, is increased in the setting of obesity...
  28. ncbi Novel aroylhydrazone and thiosemicarbazone iron chelators with anti-malarial activity against chloroquine-resistant and -sensitive parasites
    Asikiya Walcourt
    Center for Sickle Cell Disease, Howard University, 2121 Georgia Avenue, Washington, DC 20060, USA
    Int J Biochem Cell Biol 36:401-7. 2004
    ..Our studies suggest that this class of lipophilic chelators may have potential as useful agents for the treatment of malaria...
  29. ncbi Iron overload in Africans and African-Americans and a common mutation in the SCL40A1 (ferroportin 1) gene
    Victor R Gordeuk
    Howard University College of Medicine, Washington, DC 20059, USA
    Blood Cells Mol Dis 31:299-304. 2003
    ..We conclude that the Q248H mutation is a common polymorphism in the ferroportin 1 gene in African populations that may be associated with mild anemia and a tendency to iron loading...
  30. doi Inhibition of in-vitro growth of Plasmodium falciparum by Pseudocedrela kotschyi extract alone and in combination with Fagara zanthoxyloides extract
    Olakunle O Kassim
    Department of Microbiology, Howard University College of Medicine, Washington, DC 20059, USA
    Trans R Soc Trop Med Hyg 103:698-702. 2009
    ..Isobologram analysis of the results indicated a synergistic interaction between the two extracts at low concentrations, while interactions at higher concentrations showed antagonistic effects...
  31. ncbi Hemochromatosis and Iron Overload Screening (HEIRS) study design for an evaluation of 100,000 primary care-based adults
    Christine E McLaren
    Epidemiology Division, College of Medicine, University of California, Irvine 92697, USA
    Am J Med Sci 325:53-62. 2003
    ..Participants are recruited from 5 Field Centers. Laboratory testing and data management and analysis are performed in a Central Laboratory and Coordinating Center, respectively...
  32. ncbi Expression of a recombinant IRP-like Plasmodium falciparum protein that specifically binds putative plasmodial IREs
    Mark Loyevsky
    Center for Sickle Cell Disease, Howard University, 2121 Georgia Avenue, NW, Washington, DC 20059, USA
    Mol Biochem Parasitol 126:231-8. 2003
    ..Endogenous PfIRPa retained all three putative 32P-IREs at the same position on the gel as the recombinant PfIRPa...
  33. pmc Cobalamin status in sickle cell disease
    O I Ajayi
    Department of Internal Medicine, Division of Hematology Oncology, Howard University Hospital, 2041 Georgia Avenue N W, Washington, DC 20060, USA
    Int J Lab Hematol 35:31-7. 2013
    ..Our aim was to prospectively compare cobalamin status in African-Americans with and without SCD...
  34. ncbi The eosinophilic response and haematological recovery after treatment for Plasmodium falciparum malaria
    L H Camacho
    Department of Medicine, George Washington University Medical Center, Washington DC, USA
    Trop Med Int Health 4:471-5. 1999
    ..006) and in 54 patients with stool parasites (r = 0.32; P = 0.0019). These results suggest that a robust eosinophilic response shortly after completing antimalarial therapy predicts a good recovery from malaria-associated anaemia...
  35. doi Ferritin and increased vs upper reference interval tibc saturation to identify increased iron stores in African Americans
    O C Onyekwere
    Center for Sickle Cell Disease, Department of Pediatrics and Child Health, Howard University, Washington, DC 20060, USA
    Clin Chim Acta 405:71-5. 2009
    ..Increased serum ferritin (SF) in combination with increased total iron binding capacity saturation (TS) in the upper reference internal was evaluated to identify African Americans with increased iron stores...
  36. ncbi An iron regulatory-like protein expressed in Plasmodium falciparum displays aconitase activity
    Marcus Hodges
    The Center for Sickle Cell Disease, Howard University, Washington, DC 20059, USA
    Mol Biochem Parasitol 143:29-38. 2005
    ..Further understanding of the role of PfIRPa/aconitase in the regulation of P. falciparum homeostasis may contribute towards the development of novel antimalarial strategies against plasmodial species...
  37. ncbi Maintaining iron balance in women blood donors of childbearing age: summary of a workshop
    Celso Bianco
    America s Blood Centers, Washington, DC, USA
    Transfusion 42:798-805. 2002
  38. pmc Elevated tricuspid regurgitant jet velocity in children and adolescents with sickle cell disease: association with hemolysis and hemoglobin oxygen desaturation
    Caterina P Minniti
    Children s National Medical Center, Washington, DC, USA
    Haematologica 94:340-7. 2009
    ....
  39. ncbi Antimalarial effect of iron chelators
    Victor R Gordeuk
    George Washington University Medical Center, 2150 Pennsylvania Ave NW, Washington, DC 20037, USA
    Adv Exp Med Biol 509:251-72. 2002
  40. ncbi Relationship between transferrin saturation and iron stores in the African American and US Caucasian populations: analysis of data from the third National Health and Nutrition Examination Survey
    C E McLaren
    Division of Epidemiology, University of California, Irvine, College of Medicine, Irvine, CA 92697 7550, USA
    Blood 98:2345-51. 2001
    ..002 for all). These results are consistent with the concept that population transferrin saturation subpopulations reflect different levels of storage iron...
  41. ncbi Iron status and the outcome of HIV infection: an overview
    V R Gordeuk
    Center for Sickle Cell Disease and Department of Medicine, Howard University College of Medicine, Washington, DC 20059, USA
    J Clin Virol 20:111-5. 2001
    ..CONCLUSION: These four observations raise the possibility that high iron status may adversely influence the outcome of HIV-1 infection...
  42. ncbi Assessment of antimalarial effect of ICL670A on in vitro cultures of Plasmodium falciparum
    C Goudeau
    Department of Microbiology, Howard University College of Medicine, 2121 Georgia Avenue NW, Washington, DC 20059, USA
    Br J Haematol 115:918-23. 2001
    ..Further studies to address the question of the antimalarial potential of ICL670A in combination with classic antimalarials would be of interest...
  43. ncbi Congenital polycythemias/erythrocytoses
    Victor R Gordeuk
    Center for Sickle Cell Disease and Department of Medicine, Howard University, Washington, DC, USA
    Haematologica 90:109-16. 2005
    ..Whether phlebotomy therapy reduces complications and prolongs survival in congenital polycythemia is not known...
  44. doi Plasmodium falciparum: Activity of artemisinin against Plasmodium falciparum cultured in sickle trait hemoglobin AS and normal hemoglobin AA red blood cells
    A Walcourt
    Department of Physiology and Biophysics, Howard University College of Medicine, 520 W Street, Seely G Mudd Building, NW, Washington, DC 20059, USA
    Exp Parasitol 120:381-4. 2008
    ..4). IC(50) values for chloroquine were also similar in AA (22+/-8nM) and AS (20+/-11nM) erythrocytes. These results show no evidence of elevated artemisinin activity on P. falciparum in AS erythrocytes in vitro...
  45. pmc Iron chelators ICL670 and 311 inhibit HIV-1 transcription
    Zufan Debebe
    Center for Sickle Cell Disease, Howard University College of Medicine, Washington, DC 20060, USA
    Virology 367:324-33. 2007
    ..Further consideration should be given to the development of iron chelators for future anti-retroviral therapeutics...
  46. ncbi Severe vaso-occlusive episodes associated with use of systemic corticosteroids in patients with sickle cell disease
    Deepika S Darbari
    Center for Cancer and Blood Disorders, Children s National Medical Center, Washington, DC, USA
    J Natl Med Assoc 100:948-51. 2008
    ..We conclude that corticosteroids should be used with caution in patients with SCD...
  47. ncbi African iron overload
    Victor R Gordeuk
    Department of Medicine, Center for Sickle Cell Disease, Howard University, Washington, DC, USA
    Semin Hematol 39:263-9. 2002
    ..Recent studies also indicate that non-HFE iron overload occurs in African-Americans, but the prevalence and possible genetic basis is yet to be determined...
  48. pmc Phosphorylation of HIV-1 Tat by CDK2 in HIV-1 transcription
    Tatyana Ammosova
    Center for Sickle Cell Disease, Howard University College of Medicine, Washington, DC 20059, USA
    Retrovirology 3:78. 2006
    ..In the present study, we analyzed whether Tat is phosphorylated in cultured cells by CDK2 and whether Tat phosphorylation has a regulatory effect on HIV-1 transcription...
  49. pmc Increased size of solid organs in patients with Chuvash polycythemia and in mice with altered expression of HIF-1alpha and HIF-2alpha
    Donghoon Yoon
    Department of Medicine, University of Utah, Salt Lake, UT 84132, USA
    J Mol Med (Berl) 88:523-30. 2010
    ..At least in the liver, this phenotype may result from increased HIF-2alpha and decreased p21(Cip1) levels leading to increased hepatocyte proliferation...
  50. pmc A critical role for the host mediator macrophage migration inhibitory factor in the pathogenesis of malarial anemia
    Michael A McDevitt
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Exp Med 203:1185-96. 2006
    ..These data suggest that polymorphisms at the MIF locus may influence the levels of MIF produced in the innate response to malaria infection and the likelihood of anemic complications...
  51. pmc The heterozygote advantage of the Chuvash polycythemia VHLR200W mutation may be protection against anemia
    Galina Y Miasnikova
    Chuvash Republic Clinical Hospital No 1, Cheboksary, Russia
    Haematologica 96:1371-4. 2011
    ..4-22.7; P=0.017). In conclusion, heterozygosity for VHL(R200W) may provide protection from anemia; such protection could explain the persistence of this mutation...
  52. ncbi Circumstances of death in adult sickle cell disease patients
    Deepika S Darbari
    Center for Sickle Cell Disease, Howard University, Washington, DC, USA
    Am J Hematol 81:858-63. 2006
    ..In this proportional mortality study of adults with SCD, PHT was the leading finding at the time of death. Thromboembolism was associated with PHT, and iron overload was associated with cirrhosis...
  53. ncbi Nuclear targeting of protein phosphatase-1 by HIV-1 Tat protein
    Tatyana Ammosova
    Center for Sickle Cell Disease, Howard University, Washington, DC 20059, USA
    J Biol Chem 280:36364-71. 2005
    ..Our results suggest that Tat might function as a nuclear regulator of PP1 and that interaction of Tat with PP1 is critical for activation of HIV-1 transcription by Tat...
  54. ncbi Genetics, diagnosis and treatment of hemochromatosis
    Victor R Gordeuk
    Center for Sickle Cell Disease, Department of Medicine, Howard University, Washington, DC, USA
    Clin Adv Hematol Oncol 1:216-7. 2003
  55. pmc Hepatic macrophage iron aggravates experimental alcoholic steatohepatitis
    Shigang Xiong
    Department of Pathology, Keck School of Medicine, University of Southern California, 1333 San Pablo St, MMR 402, Los Angeles, CA 90033 9141, USA
    Am J Physiol Gastrointest Liver Physiol 295:G512-21. 2008
    ..Our results suggest enhanced iron uptake as a mechanism of KC iron loading in ALD and demonstrate the ILI response as a function acquired by differentiated macrophages in humans and as a priming mechanism for ALD...
  56. pmc Elevated homocysteine, glutathione and cysteinylglycine concentrations in patients homozygous for the Chuvash polycythemia VHL mutation
    Adelina I Sergueeva
    Cheboksary Children s Hospital, Cheboksary, Russia
    Haematologica 93:279-82. 2008
    ..We conclude that up-regulated hypoxia-sensing may influence multiple steps in thiol metabolism. The effects of the resultant elevated levels of homocysteine and glutathione on systemic blood pressure may largely balance each other out...
  57. pmc Bivariate mixture modeling of transferrin saturation and serum ferritin concentration in Asians, African Americans, Hispanics, and whites in the Hemochromatosis and Iron Overload Screening (HEIRS) Study
    Christine E McLaren
    Department of Epidemiology, University of California, Irvine, California, USA
    Transl Res 151:97-109. 2008
    ..This approach can identify populations in which hereditary or acquired factors influence metabolism measurement...
  58. pmc Biological variability of transferrin saturation and unsaturated iron-binding capacity
    Paul C Adams
    Department of Medicine, University Hospital, London, Ontario, Canada
    Am J Med 120:999.e1-7. 2007
    ..Unsaturated iron-binding capacity has similar performance at lower cost. However, the within-person biological variability of both these tests may limit their ability at commonly used cut points to detect HFE C282Y homozygous patients...
  59. ncbi Effect of ferroportin Q248H polymorphism on iron status in African children
    Ishmael Kasvosve
    Department of Chemical Pathology, University of Zimbabwe College of Health Sciences, Harare, Zimbabwe
    Am J Clin Nutr 82:1102-6. 2005
    ..The Q248H mutation in ferroportin, a cellular iron exporter regulated by iron status and inflammation, may be associated with high iron stores in African adults...
  60. ncbi Hemochromatosis and iron-overload screening in a racially diverse population
    Paul C Adams
    Department of Medicine, London Health Sciences Centre, London, Ont, Canada
    N Engl J Med 352:1769-78. 2005
    ..Iron overload and hemochromatosis are common, treatable conditions. HFE genotypes, levels of serum ferritin, transferrin saturation values, and self-reported medical history were studied in a multiethnic primary care population...
  61. ncbi Initial screening transferrin saturation values, serum ferritin concentrations, and HFE genotypes in whites and blacks in the Hemochromatosis and Iron Overload Screening Study
    James C Barton
    Southern Iron Disorders Center, Birmingham, Alabama 35209, USA
    Genet Test 9:231-41. 2005
    ..Possible explanations for differences in TfSat and SF in whites and blacks and pertinence to the detection of hemochromatosis, iron overload, and other disorders with similar phenotypes are discussed...
  62. ncbi Reference intervals of serum transferrin receptors in pre-school children in Zimbabwe
    Ishmael Kasvosve
    Department of Chemical Pathology, University of Zimbabwe College of Health Sciences, Harare, Zimbabwe
    Clin Chim Acta 382:138-41. 2007
    ..This study provides an estimate of the serum transferrin receptor reference intervals in African children using the Ramco Laboratories, Stafford, TX assay kit...
  63. ncbi Determinants and characteristics of mean corpuscular volume and hemoglobin concentration in white HFE C282Y homozygotes in the hemochromatosis and iron overload screening study
    Christine E McLaren
    Department of Epidemiology, University of California, Irvine, California 92697, USA
    Am J Hematol 82:898-905. 2007
    ..2 g/dL higher in women with C282Y/C282Y than in controls. Greater mean MCV in C282Y homozygosity reflects increased mean TfSat and mean SF in men and women; an additional effect of genotype on MCV and Hb was detected in women...
  64. ncbi Endothelin-1, vascular endothelial growth factor and systolic pulmonary artery pressure in patients with Chuvash polycythemia
    Vladimir I Bushuev
    Chuvash Republic Cardiac Center, Cheboksary, Chuvashia, Russia
    Haematologica 91:744-9. 2006
    ..We postulated that endothelin-1 and pulmonary artery pressure may be elevated in Chuvash polycythemia...
  65. pmc Thyroid-stimulating hormone and free thyroxine levels in persons with HFE C282Y homozygosity, a common hemochromatosis genotype: the HEIRS study
    James C Barton
    Southern Iron Disorders Center, 2022 Brookwood Medical Center Drive, Birmingham, AL 35209, USA
    Thyroid 18:831-8. 2008
    ..We evaluated thyroid-stimulating hormone (TSH) and free thyroxine (T4) in white participants of the primary care-based Hemochromatosis and Iron Overload Screening (HEIRS) Study...
  66. pmc Characteristics of participants with self-reported hemochromatosis or iron overload at HEIRS study initial screening
    James C Barton
    Southern Iron Disorders Center, Birmingham, Alabama, USA
    Am J Hematol 83:126-32. 2008
    ..Previous H/IO reports in some participants could be explained by treatment that induced iron depletion before initial screening, misdiagnosis, or participant misunderstanding of their physician or the initial screening questionnaire...
  67. ncbi HFE C282Y homozygotes aged 25-29 years at HEIRS Study initial screening
    James C Barton
    Southern Iron Disorders Center, Birmingham, Alabama, USA
    Genet Test 11:269-75. 2007
    ..Screening using an elevated TfSat criterion would fail to detect some C282Y homozygotes aged 25-29 years...
  68. ncbi Basal endocrine status in African dietary iron overload
    Lynette McNamara
    Division of Haematology Oncology, Department of Medicine, University of the Witwatersrand Medical School, Johannesburg, South Africa
    Endocrine 21:241-4. 2003
    ..We conclude therefore that there appears to be no major impairment of endocrine function in the basal state in African iron overload subjects with moderate to severe degrees of iron loading...
  69. ncbi Ferroportin (Q248H) mutations in African families with dietary iron overload
    Lynne McNamara
    Division of Hematology Oncology, Department of Medicine, University of the Witwatersrand, Johannesburg, South Africa
    J Gastroenterol Hepatol 20:1855-8. 2005
    ..The prevalence of the ferroportin Q248H mutation, unique to African people, and its association with dietary iron overload, mean cell volume (MCV) and C-reactive protein (CRP) were examined in 19 southern African families...
  70. ncbi Association of serum transferrin receptor concentration with markers of inflammation in Zimbabwean children
    Ishmael Kasvosve
    Department of Chemical Pathology, University of Zimbabwe College of Health Sciences, Harare, Zimbabwe
    Clin Chim Acta 371:130-6. 2006
    ....
  71. ncbi Smoking, iron, and tuberculosis
    Johan R Boelaert
    Lancet 362:1243-4. 2003
  72. ncbi Effect of transferrin polymorphism on the metabolism of vitamin C in Zimbabwean adults
    Ishmael Kasvosve
    Department of Chemical Pathology, Medical School, University of Zimbabwe, Harare, Zimbabwe
    Am J Clin Nutr 75:321-5. 2002
    ..Transferrin is the major iron binding protein in human plasma. In black persons, the transferrin CD phenotype has been associated with alterations in certain markers of iron status...
  73. ncbi Liver diseases in the hemochromatosis and iron overload screening study
    Paul C Adams
    Department of Medicine, University Hospital, 339 Windermere Road, London, Ontario, Canada N6A 5A5
    Clin Gastroenterol Hepatol 4:918-23; quiz 807. 2006
    ..The Hemochromatosis and Iron Overload Screening (HEIRS) Study screened 101,168 primary care participants for iron overload with serum transferrin saturation (TS), ferritin, and C282Y and H63D mutations of the HFE gene...
  74. ncbi Sickle cell disease and pulmonary hypertension in Africa: a global perspective and review of epidemiology, pathophysiology, and management
    Zakari Y Aliyu
    Vascular Medicine Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 1662, USA
    Am J Hematol 83:63-70. 2008
    ..There is clearly a need to include Africa and other parts of the world with high SCD prevalence in future comprehensive studies on the epidemiology and treatment of end organ complications of an aging SCD population world-wide...
  75. pmc Association of ferroportin Q248H polymorphism with elevated levels of serum ferritin in African Americans in the Hemochromatosis and Iron Overload Screening (HEIRS) Study
    Charles A Rivers
    Departments of Microbiology, Medicine, and Epidemiology and International Health, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Blood Cells Mol Dis 38:247-52. 2007
    ..012). There were no significant differences in Q248H frequencies in men and women control participants. We conclude that the frequency of the FPN1 Q248H polymorphism is greater in AA men with elevated SF than in those with normal SF...
  76. ncbi Protein energy malnutrition and risk of tuberculosis infection
    Johan R Boelaert
    Lancet 360:1102. 2002
  77. ncbi The effect of the host's iron status on tuberculosis
    Johan R Boelaert
    Internal Medicine, Unit of Renal and Infectious Diseases, Algemeen Ziekenhuis St Jan, Brugge, B 8000, Belgium
    J Infect Dis 195:1745-53. 2007
    ..Thus, the host's iron status may be an important yet underevaluated factor in TB prevention and therapy and in TB vaccine design...
  78. ncbi Targeting malaria with polyamines
    Andrew J Geall
    Vical Inc, 10390 Pacific Center Court, San Diego, California 92121, USA
    Bioconjug Chem 15:1161-5. 2004
    ..The fluorescent spermine mimic was the only probe to show measurable intracellular accumulation. This was observed in late stage development but not in the ring stages or in uninfected erythrocytes...
  79. ncbi Iron status in black persons is not influenced by haptoglobin polymorphism
    Ishmael Kasvosve
    Department of Chemical Pathology, Medical School, University of Zimbabwe, Harare
    Clin Chem Lab Med 40:810-3. 2002
    ..These results suggest that haptoglobin phenotypic variation may not be a factor which influences iron status in black persons...
  80. ncbi The HIF2A gene in familial erythrocytosis
    Josef T Prchal
    N Engl J Med 358:1966; author reply 1966-7. 2008

Research Grants18

  1. SEVERE MALARIAL ANEMIA AND ALTERED IMMUNE FUNCTION
    Victor Gordeuk; Fiscal Year: 2000
    ..The nutritional status, underlying parasitic infections, and genotypes and numbers of infecting P. falciparum strains will also be characterized. ..
  2. Pulmonary Hypertension and the Hypoxic Response in SCD
    Victor Gordeuk; Fiscal Year: 2007
    ..Aim 3. Using micro array analysis and high throughput genotyping, examine patterns of gene expression and candidate gene polymorphisms of the HIF-mediated hypoxic response in SCO and CP patients with and without PHTN. ..
  3. Howard-CNMC Sickle Cell Disease Clinical Center
    Victor Gordeuk; Fiscal Year: 2007
    ..A major feature of both sickle cell programs has always been continuity of care and participation in collaborative research. ..
  4. HOWARD UNIVERSITY RESEARCH SCIENTIST AWARD
    Victor Gordeuk; Fiscal Year: 2007
    ..4. Organize research seminars at Howard University- bring leading investigators from these collaborating institutions for seminars at Howard University. ..
  5. Pulmonary Hypertension and the Hypoxic Response in SCD
    Victor Gordeuk; Fiscal Year: 2007
    ..Aim 3. Using micro array analysis and high throughput genotyping, examine patterns of gene expression and candidate gene polymorphisms of the HIF-mediated hypoxic response in SCD and CP patients with and without PHTN. ..
  6. Howard-CNMC Sickle Cell Disease Clinical Center
    Victor Gordeuk; Fiscal Year: 2007
    ..A major feature of both sickle cell programs has always been continuity of care and participation in collaborative research. ..
  7. Pulmonary Hypertension and the Hypoxic Response in SCD
    Victor Gordeuk; Fiscal Year: 2006
    ..Aim 3. Using micro array analysis and high throughput genotyping, examine patterns of gene expression and candidate gene polymorphisms of the HIF-mediated hypoxic response in SCD and CP patients with and without PHTN. ..
  8. Howard-CNMC Sickle Cell Disease Clinical Center
    Victor Gordeuk; Fiscal Year: 2006
    ..A major feature of both sickle cell programs has always been continuity of care and participation in collaborative research. ..
  9. Pulmonary Hypertension and the Hypoxic Response in SCD
    Victor Gordeuk; Fiscal Year: 2005
    ..Aim 3. Using micro array analysis and high throughput genotyping, examine patterns of gene expression and candidate gene polymorphisms of the HIF-mediated hypoxic response in SCD and CP patients with and without PHTN. ..
  10. SEVERE MALARIAL ANEMIA AND ALTERED IMMUNE FUNCTION
    Victor Gordeuk; Fiscal Year: 2004
    ..The nutritional status, underlying parasitic infections, and genotypes and numbers of infecting P. falciparum strains will also be characterized. ..
  11. SEVERE MALARIAL ANEMIA AND ALTERED IMMUNE FUNCTION
    Victor Gordeuk; Fiscal Year: 2003
    ..The nutritional status, underlying parasitic infections, and genotypes and numbers of infecting P. falciparum strains will also be characterized. ..
  12. SEVERE MALARIAL ANEMIA AND ALTERED IMMUNE FUNCTION
    Victor Gordeuk; Fiscal Year: 2003
    ..The nutritional status, underlying parasitic infections, and genotypes and numbers of infecting P. falciparum strains will also be characterized. ..
  13. SEVERE MALARIAL ANEMIA AND ALTERED IMMUNE FUNCTION
    Victor Gordeuk; Fiscal Year: 2002
    ..The nutritional status, underlying parasitic infections, and genotypes and numbers of infecting P. falciparum strains will also be characterized. ..
  14. SEVERE MALARIAL ANEMIA AND ALTERED IMMUNE FUNCTION
    Victor Gordeuk; Fiscal Year: 2001
    ..The nutritional status, underlying parasitic infections, and genotypes and numbers of infecting P. falciparum strains will also be characterized. ..