Research Topics
Genomes and Genes | Felix FriedbergSummaryAffiliation: Howard University Country: USA Publications
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Publications
Sequence homology of the 3'-untranslated region of calmodulin III in mammalsF Friedberg
Howard University College of Medicine, Department of Biochemistry and Molecular Biology, Washington, DC 20059, USA
Mol Biol Rep 28:27-30. 2001..This high sequence conservation suggests an important function in the localization or regulation of CaM mRNA...
Calmodulin genes in zebrafish (revisited)Felix Friedberg
Howard University College of Medicine, 520 W St, NW, Washington, DC 20059, USA
Mol Biol Rep 32:55-60. 2005....
Parvalbumin isoforms in zebrafishFelix Friedberg
Department of Biochemistry and Molecular Biology, Howard University, Washington, DC, NW, USA
Mol Biol Rep 32:167-75. 2005..A bifurcation of isoforms into 1 and 4; 2 and 3; 6 and 7; 8 and 9 appears to have occurred simultaneously in more recent time, i.e. perhaps approximately 60 mys ago when primates and rodents branched...
Evolutionary aspects of calmodulinF Friedberg
Department of Biochemistry and Molecular Biology, Howard University, College of Medicine, Washington, DC 20059, USA
IUBMB Life 51:215-21. 2001..These distinct untranslated regions may permit regulation of CaM levels at discrete cellular sites during differentiation and in highly specialized cell types such as neurons...
Duplex (or quadruplet) CH domain containing human multidomain proteins: an inventoryFelix Friedberg
Howard University Medical School, Washington, DC, USA
Mol Biol Rep 37:1707-16. 2010..Gene duplication with subsequent modification and small domain gene recombination which formed multidomain proteins are important forces driving evolution...
Singlet CH domain containing human multidomain proteins: an inventoryFelix Friedberg
Howard University Medical School, Washington, DC, USA
Mol Biol Rep 37:1531-9. 2010..The varying modular nature within multidomain proteins should have accelerated evolutionary changes to a degree not feasible to achieve by means of mere post-duplication mutational changes...
Alternative splicing for members of human mosaic domain superfamilies. I. The CH and LIM domains containing group of proteinsFelix Friedberg
Howard University Medical School, Washington, USA
Mol Biol Rep 36:1059-81. 2009..In the splicings, described in this paper, multiple isoforms rather than a single isoform appear as products during the gene expression...
Centrin isoforms in mammals. Relation to calmodulinFelix Friedberg
Department of Biochemistry and Molecular Biology, Howard University Medical School, Washington, DC, USA
Mol Biol Rep 33:243-52. 2006..carriers (each molecule possessing four EF hands which possibly interact with different association constants)-if they are both present within a cell-randomly chosen for their service to the specific proteins with which they interact?..
Single and multiple CH (calponin homology) domain containing multidomain proteins in Arabidopsis and Saccharomyces: an inventoryFelix Friedberg
Howard University Medical School, Washington, DC, USA
Mol Biol Rep 38:213-8. 2011..e. domains such as spectrin or IG-FLMN) were available in Arabidopsis. Possibly transposons create new chimeric multidomain genes by mixing and matching genes or gene fragments...
Age and detection of retroprocessed pseudogenes in murine rodentsFelix Friedberg
Department of Biochemistry and Molecular Biology, Howard University, College of Medicine, Washington, DC 20059, USA
J Mol Evol 54:102-6. 2002..The existence of psi3 CALMII and psi alpha-tubulin pseudogenes of Rattus norvegicus among species belonging to Rattus sensu stricto is evidence for the common ancestry of this group...
Multiple calmodulin genes in fishFelix Friedberg
Howard University College of Medicine, 520 W St, N W, Washington, DC 20059, USA
Mol Biol Rep 29:377-82. 2002..These short regions of identity are shared primarily between the mammalian CaM II and CaM I and the alpha gene and beta gene of fish, respectively. Thus, the multi-gene one protein system occurs among fish as well as among mammals...
Single and multiple CH (calponin homology) domain containing multidomain proteins in Dictyostelium discoideum: an inventoryFelix Friedberg
Howard University Medical School, Washington, DC, USA
Mol Biol Rep 37:2853-62. 2010..Although extensive data exist for a few of the D. discoideum CH proteins, most remain to be characterized and our analysis may help predicting some of their properties...
Conservation of the 3'-untranslated regions of calmodulin mRNAs in cetaceansF Friedberg
Department of Biochemistry and Molecular Biology, College of Medicine, Howard University, Washington, DC, USA
Mol Biol Rep 30:193-8. 2003..The three CaM genes from all species showed a close phylogenetic relationship based on these 3'UTR sequences. Such high conservation of the 3'UTRs suggests a specialized and significant function for this region in mammals...
