Sisir K Dutta

Summary

Affiliation: Howard University
Country: USA

Publications

  1. pmc Differential gene expression and a functional analysis of PCB-exposed children: understanding disease and disorder development
    Sisir K Dutta
    Molecular Genetics Laboratory, Howard University, Washington, DC 20059, USA
    Environ Int 40:143-54. 2012
  2. pmc Analysis of the toxicogenomic effects of exposure to persistent organic pollutants (POPs) in Slovakian girls: correlations between gene expression and disease risk
    Partha Sarathi Mitra
    Howard University, Washington, DC 20059, USA
    Environ Int 39:188-99. 2012
  3. pmc Polychlorinated biphenyls (PCB-153) and (PCB-77) absorption in human liver (HepG2) and kidney (HK2) cells in vitro: PCB levels and cell death
    Somiranjan Ghosh
    Department of Biology, Howard University, Washington DC 20059, USA
    Environ Int 36:893-900. 2010
  4. pmc Global gene expression and Ingenuity biological functions analysis on PCBs 153 and 138 induced human PBMC in vitro reveals differential mode(s) of action in developing toxicities
    Somiranjan Ghosh
    Molecular Genetics Laboratory, Department of Biology, Howard University, Washington, DC 20059, USA
    Environ Int 37:838-57. 2011
  5. pmc PCB congener specific oxidative stress response by microarray analysis using human liver cell line
    Supriyo De
    Department of Biology, Howard University, Washington, DC 20059, United States
    Environ Int 36:907-17. 2010
  6. ncbi request reprint CYP1A1 and MT1K are congener specific biomarker genes for liver diseases induced by PCBs
    Sisir K Dutta
    Molecular Genetics Laboratory, Department of Biology, Howard University, 415 College Street, NW, Washington DC 20059, USA
    Environ Toxicol Pharmacol 25:218-21. 2008
  7. ncbi request reprint Altered protein expressions in chronic PCB-153-induced human liver (HepG2) cells
    Somiranjan Ghosh
    Department of Biology, Howard University, Washington, DC, USA
    Int J Toxicol 26:203-12. 2007

Research Grants

Collaborators

  • Irva Hertz-Picciotto
  • Shizhu Zang
  • Tomas Trnovec
  • Somiranjan Ghosh
  • Supriyo De
  • Eric P Hoffman
  • Partha Sarathi Mitra
  • Svetlana Ghimbovschi
  • Eva Sovcikova
  • Lubica Palkovicova
  • Dean Sonneborn
  • Partha S Mitra
  • Akanchha Kesari
  • Linda Moses
  • Raghunath Chatterjee
  • Folahan O Ayorinde
  • Y Q Chen
  • Darryl C Sutton
  • Yongqing Chen

Detail Information

Publications7

  1. pmc Differential gene expression and a functional analysis of PCB-exposed children: understanding disease and disorder development
    Sisir K Dutta
    Molecular Genetics Laboratory, Howard University, Washington, DC 20059, USA
    Environ Int 40:143-54. 2012
    ..Future endeavors of supervised genotyping of pathway-specific molecular epidemiological studies and population biomarker validations are already underway to reveal individual risk factors in these PCB-exposed populations...
  2. pmc Analysis of the toxicogenomic effects of exposure to persistent organic pollutants (POPs) in Slovakian girls: correlations between gene expression and disease risk
    Partha Sarathi Mitra
    Howard University, Washington, DC 20059, USA
    Environ Int 39:188-99. 2012
    ..This report underscores the importance of further study to validate the results in a random population and to evaluate the use of the identified genes as biomarkers for POP exposure...
  3. pmc Polychlorinated biphenyls (PCB-153) and (PCB-77) absorption in human liver (HepG2) and kidney (HK2) cells in vitro: PCB levels and cell death
    Somiranjan Ghosh
    Department of Biology, Howard University, Washington DC 20059, USA
    Environ Int 36:893-900. 2010
    ....
  4. pmc Global gene expression and Ingenuity biological functions analysis on PCBs 153 and 138 induced human PBMC in vitro reveals differential mode(s) of action in developing toxicities
    Somiranjan Ghosh
    Molecular Genetics Laboratory, Department of Biology, Howard University, Washington, DC 20059, USA
    Environ Int 37:838-57. 2011
    ....
  5. pmc PCB congener specific oxidative stress response by microarray analysis using human liver cell line
    Supriyo De
    Department of Biology, Howard University, Washington, DC 20059, United States
    Environ Int 36:907-17. 2010
    ..In contrast, PCB-77 acted through the aryl hydrocarbon receptor. It induced oxidative stress through the involvement of cytochrome P450 (CYP1A1) leading to apoptosis through AHR/ARNT pathway...
  6. ncbi request reprint CYP1A1 and MT1K are congener specific biomarker genes for liver diseases induced by PCBs
    Sisir K Dutta
    Molecular Genetics Laboratory, Department of Biology, Howard University, 415 College Street, NW, Washington DC 20059, USA
    Environ Toxicol Pharmacol 25:218-21. 2008
    ..Affymetrix oligonucleotide microarrays (mRNA) were used to screen the entire genome of human liver cells in a time-dependent exposure and were further validated by quantitative real-time RT-PCR...
  7. ncbi request reprint Altered protein expressions in chronic PCB-153-induced human liver (HepG2) cells
    Somiranjan Ghosh
    Department of Biology, Howard University, Washington, DC, USA
    Int J Toxicol 26:203-12. 2007
    ..g., p21, p53, and c-myc) proteins in the cellular model. These results suggest that chronic exposure to PCB-153 can induce cell survival by altering several apoptotic and tumor suppressor proteins...

Research Grants2