Timothy A Brown

Summary

Affiliation: Howard Hughes Medical Institute
Country: USA

Publications

  1. pmc Approaches toward super-resolution fluorescence imaging of mitochondrial proteins using PALM
    Timothy A Brown
    Howard Hughes Medical Institute, Janelia Farm Research Campus, 19700 Helix Drive, Ashburn, VA 20147 2408, USA
    Methods 51:458-63. 2010
  2. pmc Superresolution fluorescence imaging of mitochondrial nucleoids reveals their spatial range, limits, and membrane interaction
    Timothy A Brown
    Howard Hughes Medical Institute, Janelia Farm Research Campus, Ashburn, VA 20147, USA
    Mol Cell Biol 31:4994-5010. 2011
  3. pmc Native R-loops persist throughout the mouse mitochondrial DNA genome
    Timothy A Brown
    Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia 20147 2408, USA
    J Biol Chem 283:36743-51. 2008
  4. pmc Replication of mitochondrial DNA occurs by strand displacement with alternative light-strand origins, not via a strand-coupled mechanism
    Timothy A Brown
    Howard Hughes Medical Institute, Chevy Chase, Maryland 20815, USA
    Genes Dev 19:2466-76. 2005
  5. ncbi request reprint Genesis and wanderings: origins and migrations in asymmetrically replicating mitochondrial DNA
    Timothy A Brown
    Howard Hughes Medical Institute, Janelia Farm Research Campus, Ashburn, Virginia, USA
    Cell Cycle 5:917-21. 2006
  6. pmc Release of replication termination controls mitochondrial DNA copy number after depletion with 2',3'-dideoxycytidine
    Timothy A Brown
    Howard Hughes Medical Institute, Beckman Center for Molecular and Genetic Medicine, Stanford University School of Medicine, Stanford, CA 94305 5323, USA
    Nucleic Acids Res 30:2004-10. 2002

Detail Information

Publications6

  1. pmc Approaches toward super-resolution fluorescence imaging of mitochondrial proteins using PALM
    Timothy A Brown
    Howard Hughes Medical Institute, Janelia Farm Research Campus, 19700 Helix Drive, Ashburn, VA 20147 2408, USA
    Methods 51:458-63. 2010
    ..PALM and similar methods have the capacity to dramatically increase our ability to image proteins within mitochondria, and to expand our knowledge of the location of macromolecules beyond the current limits of immunoEM...
  2. pmc Superresolution fluorescence imaging of mitochondrial nucleoids reveals their spatial range, limits, and membrane interaction
    Timothy A Brown
    Howard Hughes Medical Institute, Janelia Farm Research Campus, Ashburn, VA 20147, USA
    Mol Cell Biol 31:4994-5010. 2011
    ..Determinations revealing high packing density, separation from the matrix, and tight association with the inner membrane underscore the role of mechanisms that regulate access to mtDNA and that remain largely unknown...
  3. pmc Native R-loops persist throughout the mouse mitochondrial DNA genome
    Timothy A Brown
    Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia 20147 2408, USA
    J Biol Chem 283:36743-51. 2008
    ..These results demonstrate that variously processed and targeted mtRNAs within mammalian mitochondria likely have multiple functions in addition to their conventional roles...
  4. pmc Replication of mitochondrial DNA occurs by strand displacement with alternative light-strand origins, not via a strand-coupled mechanism
    Timothy A Brown
    Howard Hughes Medical Institute, Chevy Chase, Maryland 20815, USA
    Genes Dev 19:2466-76. 2005
    ..These data reconcile the original displacement mode of replication with the data obtained from 2D gel analyses...
  5. ncbi request reprint Genesis and wanderings: origins and migrations in asymmetrically replicating mitochondrial DNA
    Timothy A Brown
    Howard Hughes Medical Institute, Janelia Farm Research Campus, Ashburn, Virginia, USA
    Cell Cycle 5:917-21. 2006
    ..The assortment and assignment of these forms is relevant to the interpretation of experimental data and may also yield insight into the molecular basis of replication errors...
  6. pmc Release of replication termination controls mitochondrial DNA copy number after depletion with 2',3'-dideoxycytidine
    Timothy A Brown
    Howard Hughes Medical Institute, Beckman Center for Molecular and Genetic Medicine, Stanford University School of Medicine, Stanford, CA 94305 5323, USA
    Nucleic Acids Res 30:2004-10. 2002
    ..However, termination of D-loop strand synthesis is persistent, indicating formation of the D-loop structure has a purpose that is required under conditions of rapid recovery of depleted mtDNA...