H Ashktorab


Affiliation: Howard University
Country: USA


  1. request reprint
    Ashktorab H, Begum R, Akhgar A, Smoot D, Elbedawi M, Daremipouran M, et al. Folate status and risk of colorectal polyps in African Americans. Dig Dis Sci. 2007;52:1462-70 pubmed
    ..Smoking and alcohol consumption were found to be risk factors for colon polyps. APC gene-promoter sequence methylation found in peripheral blood may be an indicator of risk for polyp formation and an important screening tool. ..
  2. Ashktorab H, Rahi H, Nouraie M, Shokrani B, Lee E, Haydari T, et al. GPNMB methylation: a new marker of potentially carcinogenic colon lesions. BMC Cancer. 2018;18:1068 pubmed publisher
    ..The functional analysis established GPNMB as a potential tumor suppressor gene. As such, GPNMB might be useful as a biomarker of adenomas with high carcinogenic potential. ..
  3. Ashktorab H, Schäffer A, Daremipouran M, Smoot D, Lee E, Brim H. Distinct genetic alterations in colorectal cancer. PLoS ONE. 2010;5:e8879 pubmed publisher
    ..The observed CIN may play a distinctive role in CRC in AAs. ..
  4. Ashktorab H, Entezari O, Nouraie M, Dowlati E, Frederick W, Woods A, et al. Helicobacter pylori protection against reflux esophagitis. Dig Dis Sci. 2012;57:2924-8 pubmed publisher
    ..pylori has a significant negative association with esophagitis in AAs which may point to a protective role of H. pylori in the pathogenesis of esophagitis. In addition, H. pylori may be the reason for the low GERD complications in AAs. ..
  5. Ashktorab H, Nouri Z, Nouraie M, Razjouyan H, Lee E, Dowlati E, et al. Esophageal carcinoma in African Americans: a five-decade experience. Dig Dis Sci. 2011;56:3577-82 pubmed publisher
  6. Brim H, Zahaf M, Laiyemo A, Nouraie M, Perez Perez G, Smoot D, et al. Gastric Helicobacter pylori infection associates with an increased risk of colorectal polyps in African Americans. BMC Cancer. 2014;14:296 pubmed publisher
    ..pylori infection is associated with an increased risk of colorectal polyps in African Americans. Patients with H. pylori induced gastritis may benefit from early screening colonoscopy as a preventative measure for colorectal cancer. ..
  7. Ashktorab H, Ogundipe T, Brim H, Shahnazi A, Laiyemo A, Lee E, et al. Lymph nodes' evaluation in relation to colorectal cancer staging among African Americans. BMC Cancer. 2015;15:976 pubmed publisher
    ..However this increase does not seem to affect the stage or percentage of metastatic lymph nodes' detection in CRC patients. ..
  8. Ashktorab H, Hermann P, Nouraie M, Shokrani B, Lee E, Haidary T, et al. Increased MACC1 levels in tissues and blood identify colon adenoma patients at high risk. J Transl Med. 2016;14:215 pubmed publisher
    ..The plasma transcripts can be used to stratify African American patients at risk for potential malignant colonic lesions. ..
  9. Ashktorab H, Brim H, Al Riyami M, Date A, Al Mawaly K, Kashoub M, et al. Sporadic colon cancer: mismatch repair immunohistochemistry and microsatellite instability in Omani subjects. Dig Dis Sci. 2008;53:2723-31 pubmed publisher
    ..In conclusion, although the overall rate of CRC is unknown in this region, the frequency of MSI in CRC in this region appears to be the same as in Caucasians in the USA. ..

More Information


  1. Brim H, Mokarram P, Naghibalhossaini F, Saberi Firoozi M, Al Mandhari M, Al Mawaly K, et al. Impact of BRAF, MLH1 on the incidence of microsatellite instability high colorectal cancer in populations based study. Mol Cancer. 2008;7:68 pubmed publisher
    ..The high occurrence of MSI-H tumors in African Americans may have significant implications for treatment, since patients with MSI-H lesions display a different response to chemotherapeutic agents such as 5-fluorouracil. ..
  2. Ashktorab H, Dashwood R, Dashwood M, Zaidi S, Hewitt S, Green W, et al. H. pylori-induced apoptosis in human gastric cancer cells mediated via the release of apoptosis-inducing factor from mitochondria. Helicobacter. 2008;13:506-17 pubmed publisher
    ..pylori. Hence, the balance between apoptosis and proliferation in these cells may be altered in response to injury caused by H. pylori infection, leading to an increased risk of cancer. ..
  3. Ashktorab H, Green W, Finzi G, Sessa F, Nouraie M, Lee E, et al. SEL1L, an UPR response protein, a potential marker of colonic cell transformation. Dig Dis Sci. 2012;57:905-12 pubmed publisher
    ..Since SEL1L's major function lies within ER stress and active ERAD response, it may identify CRCs with differentiated secretory phenotype and acute cellular stress. ..
  4. Afsari A, Lee E, Shokrani B, Boortalary T, Sherif Z, Nouraie M, et al. Clinical and Pathological Risk Factors Associated with Liver Fibrosis and Steatosis in African-Americans with Chronic Hepatitis C. Dig Dis Sci. 2017;62:2159-2165 pubmed publisher
    ..5, P = 0.034) and inflammation grade (P = 0.001). This study shows that steatosis is independently associated with fibrosis in African-American patients with HCV infection. Female patients were at higher risk of steatosis. ..
  5. Ashktorab H, Nguza B, Fatemi M, Nouraie M, Smoot D, Schäffer A, et al. Case-control study of vitamin D, dickkopf homolog 1 (DKK1) gene methylation, VDR gene polymorphism and the risk of colon adenoma in African Americans. PLoS ONE. 2011;6:e25314 pubmed publisher
    ..We found an inverse association between serum 25(OH)D(3) and colon polyp in AAs. VDR SNPs and DKK1 methylation were not associated with colon polyp. Vitamin D levels may in part explain the higher incidence of polyp in AAs. ..
  6. Ashktorab H, Vilmenay K, Brim H, Laiyemo A, Kibreab A, Nouraie M. Colorectal Cancer in Young African Americans: Is It Time to Revisit Guidelines and Prevention?. Dig Dis Sci. 2016;61:3026-3030 pubmed publisher
  7. Brim H, Yooseph S, Lee E, Sherif Z, Abbas M, Laiyemo A, et al. A Microbiomic Analysis in African Americans with Colonic Lesions Reveals Streptococcus sp.VT162 as a Marker of Neoplastic Transformation. Genes (Basel). 2017;8: pubmed publisher
    ..matched normal and adenomas vs. healthy subjects' stools. Streptococcus sp. VT_162 specific 16S rDNA was validated in an independent cohort. These findings might facilitate non-invasive screening for colorectal cancer. ..