N Segil

Summary

Affiliation: House Ear Institute
Country: USA

Publications

  1. ncbi p27(Kip1) links cell proliferation to morphogenesis in the developing organ of Corti
    P Chen
    Department of Cell and Molecular Biology, House Ear Institute, Los Angeles, CA 90057, USA
    Development 126:1581-90. 1999
  2. ncbi Progressive hearing loss in mice lacking the cyclin-dependent kinase inhibitor Ink4d
    Ping Chen
    Gonda Department of Cell and Molecular Biology, House Ear Institute, 2100 W 3rd St, Fifth Floor, Los Angeles, CA 90057, USA
    Nat Cell Biol 5:422-6. 2003
  3. ncbi A morphogenetic wave of p27Kip1 transcription directs cell cycle exit during organ of Corti development
    Yun Shain Lee
    Gonda Department of Cell and Molecular Biology, House Ear Institute, 2100 West 3rd Street, Los Angeles, CA 90057, USA
    Development 133:2817-26. 2006
  4. ncbi BMP signaling is necessary for patterning the sensory and nonsensory regions of the developing mammalian cochlea
    Takahiro Ohyama
    Division of Cell Biology and Genetics, House Ear Institute, Los Angeles, California 90057, USA
    J Neurosci 30:15044-51. 2010
  5. ncbi The role of Math1 in inner ear development: Uncoupling the establishment of the sensory primordium from hair cell fate determination
    Ping Chen
    Gonda Department of Cell and Molecular Biology, House Ear Institute, Los Angeles, CA 90057, USA
    Development 129:2495-505. 2002
  6. ncbi In vitro growth and differentiation of mammalian sensory hair cell progenitors: a requirement for EGF and periotic mesenchyme
    Angelika Doetzlhofer
    Gonda Department of Cell and Molecular Biology, House Ear Institute, Los Angeles, CA 90057, USA
    Dev Biol 272:432-47. 2004
  7. ncbi Notch signaling augments the canonical Wnt pathway to specify the size of the otic placode
    Chathurani S Jayasena
    Gonda Department of Cell and Molecular Biology, House Ear Institute, 2100 West 3rd Street, Los Angeles, CA 90057, USA
    Development 135:2251-61. 2008
  8. ncbi Cross-regulation of Ngn1 and Math1 coordinates the production of neurons and sensory hair cells during inner ear development
    Steven Raft
    Gonda Department of Cell and Molecular Biology, House Ear Institute, 2100 West 3rd Street, Los Angeles CA 90057, USA
    Development 134:4405-15. 2007
  9. ncbi Prospective identification and purification of hair cell and supporting cell progenitors from the embryonic cochlea
    Angelika Doetzlhofer
    Gonda Department of Cell and Molecular Biology, House Ear Institute, 2100 West Third Street, Los Angeles, CA 90057, USA
    Brain Res 1091:282-8. 2006
  10. ncbi Hey2 regulation by FGF provides a Notch-independent mechanism for maintaining pillar cell fate in the organ of Corti
    Angelika Doetzlhofer
    Gonda Department of Cell and Molecular Biology, House Ear Institute, Los Angeles, CA 90057, USA
    Dev Cell 16:58-69. 2009

Research Grants

  1. The cell cycle in ototoxin induced hair cell death.
    Neil Segil; Fiscal Year: 2007
  2. Cell cycle in development and regeneration of the inner ear
    Neil Segil; Fiscal Year: 2007
  3. CELL CYCLE IN DEVELOPMENT / REGENERATION OF THE INNER EA
    Neil Segil; Fiscal Year: 2003
  4. Marking hair cell progenitors with BAC transgenics
    Neil Segil; Fiscal Year: 2004
  5. Cell cycle in development and regeneration of the inner ear
    Neil Segil; Fiscal Year: 2011

Collaborators

Detail Information

Publications15

  1. ncbi p27(Kip1) links cell proliferation to morphogenesis in the developing organ of Corti
    P Chen
    Department of Cell and Molecular Biology, House Ear Institute, Los Angeles, CA 90057, USA
    Development 126:1581-90. 1999
    ..Homozygous mutant mice are severely hearing impaired. Thus, p27(Kip1) provides a link between developmental control of cell proliferation and the morphological development of the inner ear...
  2. ncbi Progressive hearing loss in mice lacking the cyclin-dependent kinase inhibitor Ink4d
    Ping Chen
    Gonda Department of Cell and Molecular Biology, House Ear Institute, 2100 W 3rd St, Fifth Floor, Los Angeles, CA 90057, USA
    Nat Cell Biol 5:422-6. 2003
    ..Our results identify a novel mechanism underlying a non-syndromic form of progressive hearing loss in mice...
  3. ncbi A morphogenetic wave of p27Kip1 transcription directs cell cycle exit during organ of Corti development
    Yun Shain Lee
    Gonda Department of Cell and Molecular Biology, House Ear Institute, 2100 West 3rd Street, Los Angeles, CA 90057, USA
    Development 133:2817-26. 2006
    ..This report establishes a link between the spatial and temporal pattern of p27(Kip1) transcription and the control of cell number during sensory organ morphogenesis...
  4. ncbi BMP signaling is necessary for patterning the sensory and nonsensory regions of the developing mammalian cochlea
    Takahiro Ohyama
    Division of Cell Biology and Genetics, House Ear Institute, Los Angeles, California 90057, USA
    J Neurosci 30:15044-51. 2010
    ..Our results suggest BMP signaling is required for patterning sensory and nonsensory tissue in the mammalian cochlea...
  5. ncbi The role of Math1 in inner ear development: Uncoupling the establishment of the sensory primordium from hair cell fate determination
    Ping Chen
    Gonda Department of Cell and Molecular Biology, House Ear Institute, Los Angeles, CA 90057, USA
    Development 129:2495-505. 2002
    ....
  6. ncbi In vitro growth and differentiation of mammalian sensory hair cell progenitors: a requirement for EGF and periotic mesenchyme
    Angelika Doetzlhofer
    Gonda Department of Cell and Molecular Biology, House Ear Institute, Los Angeles, CA 90057, USA
    Dev Biol 272:432-47. 2004
    ..Lastly, we show that early postnatal cochlear tissue also contains cells that can divide and generate new sensory hair cells in vitro...
  7. ncbi Notch signaling augments the canonical Wnt pathway to specify the size of the otic placode
    Chathurani S Jayasena
    Gonda Department of Cell and Molecular Biology, House Ear Institute, 2100 West 3rd Street, Los Angeles, CA 90057, USA
    Development 135:2251-61. 2008
    ....
  8. ncbi Cross-regulation of Ngn1 and Math1 coordinates the production of neurons and sensory hair cells during inner ear development
    Steven Raft
    Gonda Department of Cell and Molecular Biology, House Ear Institute, 2100 West 3rd Street, Los Angeles CA 90057, USA
    Development 134:4405-15. 2007
    ..We propose that Ngn1, as well as promoting neurogenesis, maintains an uncommitted progenitor cell population through Notch-mediated lateral inhibition, and Math1 irreversibly commits these progenitors to a hair-cell fate...
  9. ncbi Prospective identification and purification of hair cell and supporting cell progenitors from the embryonic cochlea
    Angelika Doetzlhofer
    Gonda Department of Cell and Molecular Biology, House Ear Institute, 2100 West Third Street, Los Angeles, CA 90057, USA
    Brain Res 1091:282-8. 2006
    ....
  10. ncbi Hey2 regulation by FGF provides a Notch-independent mechanism for maintaining pillar cell fate in the organ of Corti
    Angelika Doetzlhofer
    Gonda Department of Cell and Molecular Biology, House Ear Institute, Los Angeles, CA 90057, USA
    Dev Cell 16:58-69. 2009
    ....
  11. ncbi Mammalian cochlear supporting cells can divide and trans-differentiate into hair cells
    Patricia M White
    Gonda Department of Cell and Molecular Biology, House Ear Institute, 2100 W. Third Street, Los Angeles, California 90057, USA
    Nature 441:984-7. 2006
    ..These results indicate that postnatal mammalian supporting cells are potential targets for therapeutic manipulation...
  12. ncbi Math1-driven GFP expression in the developing nervous system of transgenic mice
    Ellen A Lumpkin
    Department of Physiology, University of California, San Francisco, 600 16th Street, San Francisco, CA 94143-2280, USA
    Gene Expr Patterns 3:389-95. 2003
    ....
  13. ncbi p19(Ink4d) and p21(Cip1) collaborate to maintain the postmitotic state of auditory hair cells, their codeletion leading to DNA damage and p53-mediated apoptosis
    Heidi Laine
    Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland
    J Neurosci 27:1434-44. 2007
    ....
  14. ncbi Expression of Islet1 marks the sensory and neuronal lineages in the mammalian inner ear
    Kristen Radde-Gallwitz
    Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Comp Neurol 477:412-21. 2004
    ....
  15. ncbi Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation
    Jianbo Wang
    Department of Pediatrics and Medicine, University of California, San Diego, 9500 Gilman Drive, MC 0627, La Jolla, CA 92093 0627, USA
    Development 133:1767-78. 2006
    ..These results are discussed in light of recent models on PCP and convergent extension...

Research Grants17

  1. The cell cycle in ototoxin induced hair cell death.
    Neil Segil; Fiscal Year: 2007
    ..Strategies to protect hair cells from ototoxin induced cell death would allow more aggressive use of chemotherapy agents and antibiotic treatment of infections that are now limited'by -their known ototoxic side effects. ..
  2. Cell cycle in development and regeneration of the inner ear
    Neil Segil; Fiscal Year: 2007
    ..This specific aim investigates the molecular basis for the age-dependent change in p27 regulation that we hypothesize underlies the lack of regeneration in the mammalian inner ear. ..
  3. CELL CYCLE IN DEVELOPMENT / REGENERATION OF THE INNER EA
    Neil Segil; Fiscal Year: 2003
    ..In addition, we will compare the regulation of p27kip1 expression in mice and in chickens, which are able to undergo proliferative proliferation in response to hair cell loss (Aim 3). ..
  4. Marking hair cell progenitors with BAC transgenics
    Neil Segil; Fiscal Year: 2004
    ..In the Specific Aim 3, the same purified otic epithelial sub-populations will be profiled using micro-arrays to provide initial information about gene expression networks in the developing inner ear. ..
  5. Cell cycle in development and regeneration of the inner ear
    Neil Segil; Fiscal Year: 2011
    ..This specific aim investigates the molecular basis for the age-dependent change in p27 regulation that we hypothesize underlies the lack of regeneration in the mammalian innerear. ..