N Segil

Summary

Affiliation: House Ear Institute
Country: USA

Publications

  1. ncbi request reprint p27(Kip1) links cell proliferation to morphogenesis in the developing organ of Corti
    P Chen
    Department of Cell and Molecular Biology, House Ear Institute, Los Angeles, CA 90057, USA
    Development 126:1581-90. 1999
  2. ncbi request reprint Progressive hearing loss in mice lacking the cyclin-dependent kinase inhibitor Ink4d
    Ping Chen
    Gonda Department of Cell and Molecular Biology, House Ear Institute, 2100 W 3rd St, Fifth Floor, Los Angeles, CA 90057, USA
    Nat Cell Biol 5:422-6. 2003
  3. ncbi request reprint A morphogenetic wave of p27Kip1 transcription directs cell cycle exit during organ of Corti development
    Yun Shain Lee
    Gonda Department of Cell and Molecular Biology, House Ear Institute, 2100 West 3rd Street, Los Angeles, CA 90057, USA
    Development 133:2817-26. 2006
  4. pmc BMP signaling is necessary for patterning the sensory and nonsensory regions of the developing mammalian cochlea
    Takahiro Ohyama
    Division of Cell Biology and Genetics, House Ear Institute, Los Angeles, California 90057, USA
    J Neurosci 30:15044-51. 2010
  5. ncbi request reprint The role of Math1 in inner ear development: Uncoupling the establishment of the sensory primordium from hair cell fate determination
    Ping Chen
    Gonda Department of Cell and Molecular Biology, House Ear Institute, Los Angeles, CA 90057, USA
    Development 129:2495-505. 2002
  6. ncbi request reprint In vitro growth and differentiation of mammalian sensory hair cell progenitors: a requirement for EGF and periotic mesenchyme
    Angelika Doetzlhofer
    Gonda Department of Cell and Molecular Biology, House Ear Institute, Los Angeles, CA 90057, USA
    Dev Biol 272:432-47. 2004
  7. pmc Notch signaling augments the canonical Wnt pathway to specify the size of the otic placode
    Chathurani S Jayasena
    Gonda Department of Cell and Molecular Biology, House Ear Institute, 2100 West 3rd Street, Los Angeles, CA 90057, USA
    Development 135:2251-61. 2008
  8. ncbi request reprint Cross-regulation of Ngn1 and Math1 coordinates the production of neurons and sensory hair cells during inner ear development
    Steven Raft
    Gonda Department of Cell and Molecular Biology, House Ear Institute, 2100 West 3rd Street, Los Angeles CA 90057, USA
    Development 134:4405-15. 2007
  9. ncbi request reprint Prospective identification and purification of hair cell and supporting cell progenitors from the embryonic cochlea
    Angelika Doetzlhofer
    Gonda Department of Cell and Molecular Biology, House Ear Institute, 2100 West Third Street, Los Angeles, CA 90057, USA
    Brain Res 1091:282-8. 2006
  10. pmc Hey2 regulation by FGF provides a Notch-independent mechanism for maintaining pillar cell fate in the organ of Corti
    Angelika Doetzlhofer
    Gonda Department of Cell and Molecular Biology, House Ear Institute, Los Angeles, CA 90057, USA
    Dev Cell 16:58-69. 2009

Collaborators

  • Ping Chen
  • Yuji Mishina
  • Jane Johnson
  • Mary E Dickinson
  • Ulla Pirvola
  • Takahiro Ohyama
  • C Abdala
  • Feng Liu
  • Angelika Doetzlhofer
  • Andrew K Groves
  • Yun Shain Lee
  • Chathurani S Jayasena
  • Patricia M White
  • Steven Raft
  • Heidi Laine
  • Jianbo Wang
  • Andrew Groves
  • Patricia White
  • Kristen Radde-Gallwitz
  • Ellen A Lumpkin
  • Martin L Basch
  • Manfred Gessler
  • Herson Quinones
  • Martine F Roussel
  • Johanna Mantela
  • Jukka Ylikoski
  • Lisa V Goodrich
  • Edmund J Koundakjian
  • Marikki Laiho
  • Sharayne Mark
  • Brendan C Brinkman
  • Anthony Wynshaw-Boris
  • Natasha S Hamblet
  • Scott E Fraser
  • John B Wallingford
  • Xi Lin
  • Lin Gan
  • Ling Pan
  • Henry Haeberle
  • Preeti Parab
  • Adil Omer-Abdalla
  • Tandi Collisson

Detail Information

Publications15

  1. ncbi request reprint p27(Kip1) links cell proliferation to morphogenesis in the developing organ of Corti
    P Chen
    Department of Cell and Molecular Biology, House Ear Institute, Los Angeles, CA 90057, USA
    Development 126:1581-90. 1999
    ..Homozygous mutant mice are severely hearing impaired. Thus, p27(Kip1) provides a link between developmental control of cell proliferation and the morphological development of the inner ear...
  2. ncbi request reprint Progressive hearing loss in mice lacking the cyclin-dependent kinase inhibitor Ink4d
    Ping Chen
    Gonda Department of Cell and Molecular Biology, House Ear Institute, 2100 W 3rd St, Fifth Floor, Los Angeles, CA 90057, USA
    Nat Cell Biol 5:422-6. 2003
    ..Our results identify a novel mechanism underlying a non-syndromic form of progressive hearing loss in mice...
  3. ncbi request reprint A morphogenetic wave of p27Kip1 transcription directs cell cycle exit during organ of Corti development
    Yun Shain Lee
    Gonda Department of Cell and Molecular Biology, House Ear Institute, 2100 West 3rd Street, Los Angeles, CA 90057, USA
    Development 133:2817-26. 2006
    ..This report establishes a link between the spatial and temporal pattern of p27(Kip1) transcription and the control of cell number during sensory organ morphogenesis...
  4. pmc BMP signaling is necessary for patterning the sensory and nonsensory regions of the developing mammalian cochlea
    Takahiro Ohyama
    Division of Cell Biology and Genetics, House Ear Institute, Los Angeles, California 90057, USA
    J Neurosci 30:15044-51. 2010
    ..Our results suggest BMP signaling is required for patterning sensory and nonsensory tissue in the mammalian cochlea...
  5. ncbi request reprint The role of Math1 in inner ear development: Uncoupling the establishment of the sensory primordium from hair cell fate determination
    Ping Chen
    Gonda Department of Cell and Molecular Biology, House Ear Institute, Los Angeles, CA 90057, USA
    Development 129:2495-505. 2002
    ....
  6. ncbi request reprint In vitro growth and differentiation of mammalian sensory hair cell progenitors: a requirement for EGF and periotic mesenchyme
    Angelika Doetzlhofer
    Gonda Department of Cell and Molecular Biology, House Ear Institute, Los Angeles, CA 90057, USA
    Dev Biol 272:432-47. 2004
    ..Lastly, we show that early postnatal cochlear tissue also contains cells that can divide and generate new sensory hair cells in vitro...
  7. pmc Notch signaling augments the canonical Wnt pathway to specify the size of the otic placode
    Chathurani S Jayasena
    Gonda Department of Cell and Molecular Biology, House Ear Institute, 2100 West 3rd Street, Los Angeles, CA 90057, USA
    Development 135:2251-61. 2008
    ....
  8. ncbi request reprint Cross-regulation of Ngn1 and Math1 coordinates the production of neurons and sensory hair cells during inner ear development
    Steven Raft
    Gonda Department of Cell and Molecular Biology, House Ear Institute, 2100 West 3rd Street, Los Angeles CA 90057, USA
    Development 134:4405-15. 2007
    ..We propose that Ngn1, as well as promoting neurogenesis, maintains an uncommitted progenitor cell population through Notch-mediated lateral inhibition, and Math1 irreversibly commits these progenitors to a hair-cell fate...
  9. ncbi request reprint Prospective identification and purification of hair cell and supporting cell progenitors from the embryonic cochlea
    Angelika Doetzlhofer
    Gonda Department of Cell and Molecular Biology, House Ear Institute, 2100 West Third Street, Los Angeles, CA 90057, USA
    Brain Res 1091:282-8. 2006
    ....
  10. pmc Hey2 regulation by FGF provides a Notch-independent mechanism for maintaining pillar cell fate in the organ of Corti
    Angelika Doetzlhofer
    Gonda Department of Cell and Molecular Biology, House Ear Institute, Los Angeles, CA 90057, USA
    Dev Cell 16:58-69. 2009
    ....
  11. ncbi request reprint Mammalian cochlear supporting cells can divide and trans-differentiate into hair cells
    Patricia M White
    Gonda Department of Cell and Molecular Biology, House Ear Institute, 2100 W Third Street, Los Angeles, California 90057, USA
    Nature 441:984-7. 2006
    ..These results indicate that postnatal mammalian supporting cells are potential targets for therapeutic manipulation...
  12. ncbi request reprint Math1-driven GFP expression in the developing nervous system of transgenic mice
    Ellen A Lumpkin
    Department of Physiology, University of California, San Francisco, 600 16th Street, San Francisco, CA 94143 2280, USA
    Gene Expr Patterns 3:389-95. 2003
    ....
  13. ncbi request reprint p19(Ink4d) and p21(Cip1) collaborate to maintain the postmitotic state of auditory hair cells, their codeletion leading to DNA damage and p53-mediated apoptosis
    Heidi Laine
    Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland
    J Neurosci 27:1434-44. 2007
    ....
  14. pmc Expression of Islet1 marks the sensory and neuronal lineages in the mammalian inner ear
    Kristen Radde-Gallwitz
    Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Comp Neurol 477:412-21. 2004
    ....
  15. pmc Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation
    Jianbo Wang
    Department of Pediatrics and Medicine, University of California, San Diego, 9500 Gilman Drive, MC 0627, La Jolla, CA 92093 0627, USA
    Development 133:1767-78. 2006
    ..These results are discussed in light of recent models on PCP and convergent extension...