Sung Kyun Moon

Summary

Affiliation: House Ear Institute
Country: USA

Publications

  1. ncbi request reprint Activation of a Src-dependent Raf-MEK1/2-ERK signaling pathway is required for IL-1alpha-induced upregulation of beta-defensin 2 in human middle ear epithelial cells
    Sung Kyun Moon
    Gonda Department of Cell and Molecular Biology, House Ear Institute, 2100 West 3rd Street, Los Angeles, CA 90057, USA
    Biochim Biophys Acta 1590:41-51. 2002
  2. pmc Spiral ligament fibrocyte-derived MCP-1/CCL2 contributes to inner ear inflammation secondary to nontypeable H. influenzae-induced otitis media
    Jeong Im Woo
    Division of Cell Biology and Genetics, House Ear Institute, 2100 West 3rd Street, Los Angeles, CA, USA
    BMC Infect Dis 10:314. 2010
  3. pmc Lysozyme M deficiency leads to an increased susceptibility to Streptococcus pneumoniae-induced otitis media
    Jun Shimada
    Gonda Department of Cell and Molecular Biology, House Ear Institute, Los Angeles, CA, USA
    BMC Infect Dis 8:134. 2008
  4. pmc Induction of beta defensin 2 by NTHi requires TLR2 mediated MyD88 and IRAK-TRAF6-p38MAPK signaling pathway in human middle ear epithelial cells
    Haa Yung Lee
    The Gonda Department of Cell and Molecular Biology, House Ear Institute, Los Angeles, CA, USA
    BMC Infect Dis 8:87. 2008
  5. doi request reprint The Korean hearing in noise test
    Sung K Moon
    Department of Otolaryngology, Ajou University School of Medicine, Suwon, Korea
    Int J Audiol 47:375-6. 2008
  6. pmc Activities of matrix metalloproteinases and tissue inhibitor of metalloproteinase-2 in idiopathic hemotympanum and otitis media with effusion
    Sung K Moon
    Gonda Department of Cell and Molecular Biology, House Ear Institute, Los Angeles, CA, USA
    Acta Otolaryngol 128:144-50. 2008
  7. pmc Synergistic effect of interleukin 1 alpha on nontypeable Haemophilus influenzae-induced up-regulation of human beta-defensin 2 in middle ear epithelial cells
    Sung Kyun Moon
    The Gonda Department of Cell and Molecular Biology, House Ear Institute, Los Angeles, CA, USA
    BMC Infect Dis 6:12. 2006
  8. ncbi request reprint Spiral ligament fibrocytes release chemokines in response to otitis media pathogens
    Sung Kyun Moon
    Department of Gonda Cell and Molecular Biology, House Ear Institute, Los Angeles, CA 90057, USA
    Acta Otolaryngol 126:564-9. 2006
  9. ncbi request reprint Immortalization of normal adult human middle ear epithelial cells using a retrovirus containing the E6/E7 genes of human papillomavirus type 16
    Young Myoung Chun
    Gonda Department of Cell and Molecular Biology, Los Angeles, California, USA
    Ann Otol Rhinol Laryngol 111:507-17. 2002
  10. pmc Antimicrobial activity of innate immune molecules against Streptococcus pneumoniae, Moraxella catarrhalis and nontypeable Haemophilus influenzae
    Haa Yung Lee
    The Gonda Department of Cell and Molecular Biology, House Ear Institute, Los Angeles, California 90057, USA
    BMC Infect Dis 4:12. 2004

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Activation of a Src-dependent Raf-MEK1/2-ERK signaling pathway is required for IL-1alpha-induced upregulation of beta-defensin 2 in human middle ear epithelial cells
    Sung Kyun Moon
    Gonda Department of Cell and Molecular Biology, House Ear Institute, 2100 West 3rd Street, Los Angeles, CA 90057, USA
    Biochim Biophys Acta 1590:41-51. 2002
    ..Moreover, we demonstrate that the transcriptional activation of hBD-2 gene by IL-1 alpha is mediated through an Src-dependent Raf-MEK1/2-ERK signaling pathway...
  2. pmc Spiral ligament fibrocyte-derived MCP-1/CCL2 contributes to inner ear inflammation secondary to nontypeable H. influenzae-induced otitis media
    Jeong Im Woo
    Division of Cell Biology and Genetics, House Ear Institute, 2100 West 3rd Street, Los Angeles, CA, USA
    BMC Infect Dis 10:314. 2010
    ..Previously, we showed that spiral ligament fibrocytes (SLFs) recognize OM pathogens and up-regulate chemokines. Here, we aim to determine a key molecule derived from SLFs, contributing to OM-induced inner ear inflammation...
  3. pmc Lysozyme M deficiency leads to an increased susceptibility to Streptococcus pneumoniae-induced otitis media
    Jun Shimada
    Gonda Department of Cell and Molecular Biology, House Ear Institute, Los Angeles, CA, USA
    BMC Infect Dis 8:134. 2008
    ..Lysozyme shows the ubiquitous expression in wide varieties of species and tissues including the tubotympanum of mammals. We aim to investigate the effects of lysozyme depletion on pneumococcal clearance from the middle ear cavity...
  4. pmc Induction of beta defensin 2 by NTHi requires TLR2 mediated MyD88 and IRAK-TRAF6-p38MAPK signaling pathway in human middle ear epithelial cells
    Haa Yung Lee
    The Gonda Department of Cell and Molecular Biology, House Ear Institute, Los Angeles, CA, USA
    BMC Infect Dis 8:87. 2008
    ..We believe that this report is the first attempt to elucidate NTHi induced beta-defensin expression in airway mucosa, which includes the middle ear...
  5. doi request reprint The Korean hearing in noise test
    Sung K Moon
    Department of Otolaryngology, Ajou University School of Medicine, Suwon, Korea
    Int J Audiol 47:375-6. 2008
  6. pmc Activities of matrix metalloproteinases and tissue inhibitor of metalloproteinase-2 in idiopathic hemotympanum and otitis media with effusion
    Sung K Moon
    Gonda Department of Cell and Molecular Biology, House Ear Institute, Los Angeles, CA, USA
    Acta Otolaryngol 128:144-50. 2008
    ..Further studies are necessary for elucidating its correlation with the sequelae of otitis media with effusion (OME) and idiopathic hemotympanum...
  7. pmc Synergistic effect of interleukin 1 alpha on nontypeable Haemophilus influenzae-induced up-regulation of human beta-defensin 2 in middle ear epithelial cells
    Sung Kyun Moon
    The Gonda Department of Cell and Molecular Biology, House Ear Institute, Los Angeles, CA, USA
    BMC Infect Dis 6:12. 2006
    ....
  8. ncbi request reprint Spiral ligament fibrocytes release chemokines in response to otitis media pathogens
    Sung Kyun Moon
    Department of Gonda Cell and Molecular Biology, House Ear Institute, Los Angeles, CA 90057, USA
    Acta Otolaryngol 126:564-9. 2006
    ..Spiral ligament fibrocytes (SLFs) may be involved in the innate immune response of the inner ear by producing chemoattractants for recruiting inflammatory cells such as neutrophils and monocytes...
  9. ncbi request reprint Immortalization of normal adult human middle ear epithelial cells using a retrovirus containing the E6/E7 genes of human papillomavirus type 16
    Young Myoung Chun
    Gonda Department of Cell and Molecular Biology, Los Angeles, California, USA
    Ann Otol Rhinol Laryngol 111:507-17. 2002
    ..HMEEC-1 will also be useful in the search for new drugs and biological agents for the treatment of otitis media...
  10. pmc Antimicrobial activity of innate immune molecules against Streptococcus pneumoniae, Moraxella catarrhalis and nontypeable Haemophilus influenzae
    Haa Yung Lee
    The Gonda Department of Cell and Molecular Biology, House Ear Institute, Los Angeles, California 90057, USA
    BMC Infect Dis 4:12. 2004
    ....
  11. ncbi request reprint Expression of beta-defensins in human middle ear cholesteatoma
    Keehyun Park
    Department of Otolaryngology, Ajou University School of Medicine, Suwon, South Korea
    Acta Otolaryngol 123:236-40. 2003
    ..To establish the eventual presence of human beta-defensins (hBD) in middle ea r cholesteatoma and paired retroauricular skin samples obtained during surgical treatment...
  12. ncbi request reprint Expression of water channel proteins (aquaporins) in the rat Eustachian tube and middle ear mucosa
    Sung Ho Kang
    Gonda Department of Cell and Molecular Biology, House Ear Institute, Los Angeles, CA 90057, USA
    Acta Otolaryngol 127:687-92. 2007
    ....
  13. ncbi request reprint Functional study of GJB2 in hereditary hearing loss
    Yun Hoon Choung
    Department of Otolaryngology, University School of Medicine, Suwon, Korea
    Laryngoscope 112:1667-71. 2002
    ..The objective of the study was to identify how 235delC and E114G changes found in the Korean population affected the function of using molecular biological techniques...
  14. ncbi request reprint Expression of hepatocyte growth factor and c-Met in hypopharyngeal squamous cell carcinoma
    Chul Ho Kim
    Department of Otolaryngology, Ajou University School of Medicine, Suwon, South Korea
    Acta Otolaryngol 126:88-94. 2006
    ..Our results suggest that hepatocyte growth factor (HGF) may play an important role in the progression of hypopharyngeal cancer...
  15. ncbi request reprint Various causes and clinical characteristics in vertigo in children with normal eardrums
    Yun Hoon Choung
    Department of Otolaryngology, Ajou University School of Medicine, 5 Woncheon dong, Paldal Gu, Suwon 442 721, South Korea
    Int J Pediatr Otorhinolaryngol 67:889-94. 2003
    ....
  16. ncbi request reprint Three cases of Waardenburg syndrome type 2 in a Korean family
    Joong Hyuk Choi
    Department of Ophthalmology, Ajou University, School of Medicine, Suwon, Korea
    Korean J Ophthalmol 18:185-9. 2004
    ..The genetic studies revealed no mutation in either PAX3 or MITF genes. The genetic basis, as yet unknown for most cases of WS type 2, might be found with further investigation...
  17. ncbi request reprint 3D micro-CT images of ossicles destroyed by middle ear cholesteatoma
    Keehyun Park
    Department of Otolaryngology, Ajou University School of Medicine, Suwon, South Korea
    Acta Otolaryngol 124:403-7. 2004
    ..To reconstruct the 3D structures of normal ossicles and ossicles destroyed by different cholesteatomas, and to compare the volume fractions of the two types of ossicles...
  18. ncbi request reprint Immortalization of rat eustachian tube epithelial cells by adenovirus 12-simian virus 40 hybrid virus
    Sunji Jin
    Laboratory of Immunology, National Institute on Deafness and Other Communication Disorders, Bethesda, Maryland, USA
    Ann Otol Rhinol Laryngol 111:919-25. 2002
    ..Together, our results suggest that the cell line originated from eustachian tube epithelial cells from a male rat and was successfully immortalized by the Ad12-SV40 virus...