Fred H Linthicum

Summary

Affiliation: House Ear Institute
Country: USA

Publications

  1. ncbi Tuberculous otitis media
    Fred H Linthicum Jr
    House Ear Institute, Los Angeles, California, USA
    Otol Neurotol 23:235-6. 2002
  2. ncbi Spiral ganglion cell loss is unrelated to segmental cochlear sensory system degeneration in humans
    Fred H Linthicum
    House Ear Institute, Los Angeles, California, USA
    Otol Neurotol 30:418-422. 2009
  3. ncbi Temporal bone histopathology case of the month: acute hearing loss due to cryptococcal meningitis in a patient with acquired immunodeficiency syndrome
    Fred H Linthicum
    Temporal Bone Laboratory, House Ear Institute, Los Angeles, CA, USA
    Otol Neurotol 28:723-4. 2007
  4. ncbi The fate of mastoid obliteration tissue: a histopathological study
    Fred H Linthicum
    Temporal Bone Laboratory, the House Ear Institute, Los Angeles, California, USA
    Laryngoscope 112:1777-81. 2002
  5. ncbi Growth of postoperative remnants of unilateral vestibular nerve schwannoma: role of the vestibular ganglion
    Fred H Linthicum
    House Ear Institute, Los Angeles, Calif 9057, USA
    ORL J Otorhinolaryngol Relat Spec 64:138-42. 2002
  6. ncbi Symptomatic postsurgical traumatic neuromas
    Jose N Fayad
    House Clinic and House Ear Institute, Keck School of Medicine of the University of Southern California, Los Angeles, California 90057, USA
    Otol Neurotol 30:981-4. 2009
  7. ncbi Petrous apex cholesterol granuloma: maintenance of drainage pathway, the histopathology of surgical management and histopathologic evidence for the exposed marrow theory
    Michael Hoa
    House Clinic, Los Angeles, California, USA
    Otol Neurotol 33:1059-65. 2012
  8. ncbi Distribution of low-frequency nerve fibers in the auditory nerve: Temporal bone findings and clinical implications
    Jose N Fayad
    Department of Histopathology, Temporal Bone Laboratory, House Ear Institute, Los Angeles, California 90057, USA
    Otol Neurotol 27:1074-7. 2006
  9. ncbi Endolymphatic pseudohydrops of the cochlear apex
    Andres Makarem
    House Ear Institute, Los Angeles, CA 90057, USA
    Otolaryngol Head Neck Surg 143:269-73. 2010
  10. ncbi Cavitating otosclerosis: clinical, radiologic, and histopathologic correlations
    Andre O Makarem
    Department of Histopathology, House Ear Institute, UCLA Medical Center, Los Angeles, California, U S A
    Otol Neurotol 31:381-4. 2010

Research Grants

  1. Cell and Molecular Analysis of Human Temporal Bones
    Fred Linthicum; Fiscal Year: 2007

Collaborators

Detail Information

Publications47

  1. ncbi Tuberculous otitis media
    Fred H Linthicum Jr
    House Ear Institute, Los Angeles, California, USA
    Otol Neurotol 23:235-6. 2002
  2. ncbi Spiral ganglion cell loss is unrelated to segmental cochlear sensory system degeneration in humans
    Fred H Linthicum
    House Ear Institute, Los Angeles, California, USA
    Otol Neurotol 30:418-422. 2009
    ..To demonstrate that contrary to what occurs in animals, neuron loss in the human spiral ganglion is not in proportion to organ of Corti hair or supporting cell loss...
  3. ncbi Temporal bone histopathology case of the month: acute hearing loss due to cryptococcal meningitis in a patient with acquired immunodeficiency syndrome
    Fred H Linthicum
    Temporal Bone Laboratory, House Ear Institute, Los Angeles, CA, USA
    Otol Neurotol 28:723-4. 2007
  4. ncbi The fate of mastoid obliteration tissue: a histopathological study
    Fred H Linthicum
    Temporal Bone Laboratory, the House Ear Institute, Los Angeles, California, USA
    Laryngoscope 112:1777-81. 2002
    ..To demonstrate the histopathological fate of tissues used for mastoid obliteration over a period of 30 years...
  5. ncbi Growth of postoperative remnants of unilateral vestibular nerve schwannoma: role of the vestibular ganglion
    Fred H Linthicum
    House Ear Institute, Los Angeles, Calif 9057, USA
    ORL J Otorhinolaryngol Relat Spec 64:138-42. 2002
    ..3%). Immunohistochemical labeling of dividing cells demonstrated that segments of tumor adjacent to the vestibular nerve and ganglion contained more dividing cells than were present in areas of the tumor at a distance from them...
  6. ncbi Symptomatic postsurgical traumatic neuromas
    Jose N Fayad
    House Clinic and House Ear Institute, Keck School of Medicine of the University of Southern California, Los Angeles, California 90057, USA
    Otol Neurotol 30:981-4. 2009
    ....
  7. ncbi Petrous apex cholesterol granuloma: maintenance of drainage pathway, the histopathology of surgical management and histopathologic evidence for the exposed marrow theory
    Michael Hoa
    House Clinic, Los Angeles, California, USA
    Otol Neurotol 33:1059-65. 2012
    ....
  8. ncbi Distribution of low-frequency nerve fibers in the auditory nerve: Temporal bone findings and clinical implications
    Jose N Fayad
    Department of Histopathology, Temporal Bone Laboratory, House Ear Institute, Los Angeles, California 90057, USA
    Otol Neurotol 27:1074-7. 2006
    ..Low-frequency cochlear fibers are on the outer surface of the auditory nerve adjacent to the vestibular nerve in the distal part of the internal auditory canal...
  9. ncbi Endolymphatic pseudohydrops of the cochlear apex
    Andres Makarem
    House Ear Institute, Los Angeles, CA 90057, USA
    Otolaryngol Head Neck Surg 143:269-73. 2010
    ..To demonstrate that what appears to be endolymphatic hydrops of the apical scala media is normal anatomy...
  10. ncbi Cavitating otosclerosis: clinical, radiologic, and histopathologic correlations
    Andre O Makarem
    Department of Histopathology, House Ear Institute, UCLA Medical Center, Los Angeles, California, U S A
    Otol Neurotol 31:381-4. 2010
    ..Here, we describe and introduce into the literature the unusual histologic and radiologic findings of cavitation and its possible clinical relevance in patients with advanced cochlear otosclerosis...
  11. ncbi Cochlear otosclerosis and endolymphatic hydrops
    Andres Makarem
    Department of Histopathology, House Ear Institute, Los Angeles, California, USA
    Otol Neurotol 29:571-2. 2008
  12. ncbi Temporal bone involvement in multiple myeloma
    Boris G Naraev
    Histopathology Department, House Ear Institute, Los Angeles, California 90057, USA
    Otol Neurotol 27:580-1. 2006
  13. ncbi The effect of organ of corti loss on ganglion cell survival in humans
    Karen Borne Teufert
    Histopathology Department, House Ear Institute, Los Angeles, California 90057, USA
    Otol Neurotol 27:1146-51. 2006
    ..Severe spiral ganglion cell loss does not necessarily follow loss of hair cells or supporting cells in humans...
  14. ncbi Round window versus cochleostomy technique in cochlear implantation: histologic findings
    Celine Richard
    House Research Institute, Los Angeles, California, USA
    Otol Neurotol 33:1181-7. 2012
    ....
  15. ncbi Multichannel cochlear implants: relation of histopathology to performance
    Jose N Fayad
    House Clinic and Department of Histopathology, House Ear Institute, 2122 W 3rd Street, Los Angeles, CA 90057, USA
    Laryngoscope 116:1310-20. 2006
    ..To determine the relationship of surviving neural elements to auditory function in multichannel cochlear implant temporal bones...
  16. ncbi Rapid hearing loss in chronic lymphocytic leukemia
    Boris G Naraev
    Histopathology Department, House Ear Institute, Los Angeles, California 90057, USA
    Otol Neurotol 27:445-6. 2006
  17. ncbi Traumatic neuroma of the tympanic (Jacobson's) nerve as a possible cause of otalgia
    Boris G Naraev
    House Ear Institute, Los Angeles, CA 90057, USA
    Otolaryngol Head Neck Surg 138:735-7. 2008
    ..To show that traumatic neuroma of the tympanic (Jacobson's) nerve may be a cause of recurrent intractable otalgia in patients following radical mastoidectomies...
  18. ncbi Histopathologic assessment of fibrosis and new bone formation in implanted human temporal bones using 3D reconstruction
    Jose N Fayad
    Department of Histopathology, House Ear Institute, Los Angeles, CA 90057, USA
    Otolaryngol Head Neck Surg 141:247-52. 2009
    ..To evaluate new bone formation and fibrosis in implanted human temporal bones and relate that to neurosensory elements preservation...
  19. ncbi Histopathologic markers of hearing loss in intralabyrinthine schwannomas: implications for management
    Felipe Santos
    House Clinic, House Ear Institute, Los Angeles, California 90057, USA
    Otol Neurotol 32:1542-7. 2011
    ..This study aimed to review the clinical history and management of patients with intralabyrinthine schwannomas and evaluate the histopathologic features of these tumors...
  20. ncbi Hearing loss in chronic lymphocytic leukemia
    Matthew Taljebini
    House Ear Institute, Los Angeles, California 90057, USA
    Otol Neurotol 28:282-3. 2007
  21. ncbi Exostoses of the external auditory canal
    Fred H Linthicum
    House Ear Institute, Los Angeles, California, USA
    Otol Neurotol 26:1243-4. 2005
  22. ncbi Activities of matrix metalloproteinases and tissue inhibitor of metalloproteinase-2 in idiopathic hemotympanum and otitis media with effusion
    Sung K Moon
    Gonda Department of Cell and Molecular Biology, House Ear Institute, Los Angeles, CA, USA
    Acta Otolaryngol 128:144-50. 2008
    ..Further studies are necessary for elucidating its correlation with the sequelae of otitis media with effusion (OME) and idiopathic hemotympanum...
  23. ncbi Mondini dysplasia of the bony and membranous labyrinth
    Paul K Holden
    Keck School of Medicine, Los Angeles, California 90057, USA
    Otol Neurotol 26:133. 2005
  24. ncbi Glomus jugulare tumor
    Paul K Holden
    Keck School of Medicine, Los Angeles, California, USA
    Otol Neurotol 26:312-3. 2005
  25. ncbi Histopathologic changes in the vestibule after cochlear implantation
    Hui-Chi Tien
    House Ear Institute, Los Angeles, CA 90057, USA
    Otolaryngol Head Neck Surg 127:260-4. 2002
    ..Keeping the electrode array in the scala tympani will minimize vestibular damage...
  26. ncbi The human auditory system: a timeline of development
    Jean K Moore
    Department of Histopathology, House Ear Institute, Los Angeles, USA
    Int J Audiol 46:460-78. 2007
    ..Some consideration is given to the potential negative effects of deafness-induced sound deprivation during the perinatal period and childhood...
  27. ncbi Cochlear endosteal erosion with focal osteomyelitis induced by cochlear implantation
    Joni K Doherty
    Department of Otolaryngology--Head and Neck Surgery, University of Southern California, Los Angeles, California, USA
    Otol Neurotol 25:1029-30. 2004
  28. ncbi Spiral ligament and stria vascularis changes in cochlear otosclerosis: effect on hearing level
    Joni K Doherty
    Department of Otolaryngology Head and Neck Surgery, University of Southern California, Los Angeles, USA
    Otol Neurotol 25:457-64. 2004
    ....
  29. ncbi Presbycusic neuritic degeneration within the osseous spiral lamina
    Margaret A Chen
    Division of Head and Neck Surgery, Department of Surgery, University of California, San Diego, and Department of Electron Microscopy, House Ear Institute, Los Angeles, California 90057, USA
    Otol Neurotol 27:316-22. 2006
    ..These cases can be identified by a gradual down-sloping audiogram in contrast to sensory (hair cell) presbycusis, which is characterized by a precipitous high tone loss...
  30. ncbi Activation of a Src-dependent Raf-MEK1/2-ERK signaling pathway is required for IL-1alpha-induced upregulation of beta-defensin 2 in human middle ear epithelial cells
    Sung Kyun Moon
    Gonda Department of Cell and Molecular Biology, House Ear Institute, 2100 West 3rd Street, Los Angeles, CA 90057, USA
    Biochim Biophys Acta 1590:41-51. 2002
    ..Moreover, we demonstrate that the transcriptional activation of hBD-2 gene by IL-1 alpha is mediated through an Src-dependent Raf-MEK1/2-ERK signaling pathway...
  31. ncbi Aberrant carotid artery
    Jason A Biller
    University of Southern California School of Medicine, Los Angeles, California, U.S.A
    Otol Neurotol 23:407-8. 2002
  32. ncbi Wegener's granuloma
    Hamza El Shafaai Ahmed
    Assiut University, Assiut, Egypt
    Otol Neurotol 26:548-9. 2005
  33. ncbi Intralabyrinthine schwannoma
    Alaa Hamed
    Department of Otolaryngology, Ophthalmology Research Institute, Cairo, Egypt
    Otol Neurotol 26:1085-6. 2005
  34. ncbi Temporal bone fracture and latent meningitis: temporal bone histopathology study of the month
    Holger Sudhoff
    Department of Otorhinolaryngology, Head and Neck Surgery, St Elisabeth Hospital, University of Bochum, Germany
    Otol Neurotol 24:521-2. 2003
  35. ncbi Malignant external otitis: temporal bone histopathology case of the month
    Holger Sudhoff
    Department of Otorhinolaryngology, Head and Neck Surgery, St. Elisabeth Hospital, University of Bochum, Germany
    Otol Neurotol 24:346-7. 2003
  36. ncbi On the myth of the glial/schwann junction (Obersteiner-Redlich zone): origin of vestibular nerve schwannomas
    John E Xenellis
    Otol Neurotol 24:1. 2003
  37. ncbi Treacher Collins syndrome (mandibulofacial dysostosis)
    Miquel A Crovetto
    Hospital de Basurto, Vizcaya, Spain
    Otol Neurotol 23:1005. 2002
  38. ncbi Expression of neuregulin and activation of erbB receptors in vestibular schwannomas: possible autocrine loop stimulation
    Marlan R Hansen
    Department of Otolaryngology Head and Neck Surgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA
    Otol Neurotol 25:155-9. 2004
    ..We sought to determine whether vestibular schwannomas are capable of producing and responding to the glial growth factor neuregulin...
  39. ncbi External auditory canal cholesteatoma
    Ramin Naim
    Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, Mannheim, Germany
    Otol Neurotol 25:412-3. 2004
  40. ncbi Temporal bone osteopetrosis
    Alla A Wahab Hamed
    Ophthalmology Research Institute, Cairo, Egypt
    Otol Neurotol 25:635. 2004
  41. ncbi Endolymphatic hydrops without Ménière's syndrome
    H Cengiz Alpay
    Otorhinolaryngology-Head and Neck Surgery Department, Medical Faculty, Firat University, Elazig, Turkey
    Otol Neurotol 28:871-2. 2007
  42. ncbi Schwannoma invading the cochlea in a neurofibromatosis type 2 patient
    Yogen R Abelak
    Regional Specialistic Hospital, Wroclaw, Poland
    Otol Neurotol 28:284-5. 2007
  43. ncbi Multiple otosclerotic foci without hearing loss
    Fred H Linthicum
    Area of Otolaryngology, Campus Bio-Medico University of Rome, Rome, Italy
    Otol Neurotol 28:572-3. 2007
  44. ncbi Metastatic melanoma
    Eric Yang
    University of Utah, Health Sciences Center, Division of Otolaryngology, Salt Lake City Utah, USA
    Otol Neurotol 26:821-2. 2005
  45. ncbi Human cochleae with three turns: an unreported malformation
    Qing Tian
    HealthCare Partners, Torrance, California 90057, USA
    Laryngoscope 116:800-3. 2006
    ..6 mm compared with a mean of 33.8 mm in the normal bones. CONCLUSIONS: Human cochleae with three turns exist as an unreported anomaly. This is a new category of anomaly, not likely based on interruption of development...
  46. ncbi Stria vascularis hearing loss
    Antonella Castaldo
    Institute of Orl of II, University of Naples, Naples, Italy
    Otol Neurotol 27:285-6. 2006
  47. ncbi Human temporal bone consortium for research resource enhancement
    Saumil N Merchant
    Otol Neurotol 29:271-4. 2008

Research Grants3

  1. Cell and Molecular Analysis of Human Temporal Bones
    Fred Linthicum; Fiscal Year: 2007
    ..Specific Aim 6: To encourage collaborations with investigators who have little experience using human temporal bones. Specific Aim 7: To encourage participation of young scientists in temporal bone research. ..