Rick Friedman

Summary

Affiliation: House Ear Institute
Country: USA

Publications

  1. ncbi request reprint Correction of progressive hearing loss in superior canal dehiscence syndrome
    Eric P Wilkinson
    House Ear Clinic, 2100 West Third Street, Los Angeles, CA 90057, USA
    Laryngoscope 118:10-3. 2008
  2. doi request reprint Hearing preservation with the middle cranial fossa approach for neurofibromatosis type 2
    Rick A Friedman
    House Clinic and House Research Institute, Los Angeles, California, USA
    Otol Neurotol 32:1530-7. 2011
  3. doi request reprint A paradigm shift in salvage surgery for radiated vestibular schwannoma
    Rick A Friedman
    House Clinic and House Research Institute, Los Angeles, California 90057, USA
    Otol Neurotol 32:1322-8. 2011
  4. pmc GRM7 variants confer susceptibility to age-related hearing impairment
    Rick A Friedman
    House Ear Institute, Gonda Research Center for Cell and Molecular Biology, Los Angeles, CA, USA
    Hum Mol Genet 18:785-96. 2009
  5. ncbi request reprint Management of cerebrospinal fluid leaks after acoustic tumor removal
    Rick A Friedman
    House Clinic and House Ear Institute, Los Angeles, California 90057, USA
    Neurosurgery 61:35-9; discussion 39-40. 2007
  6. ncbi request reprint Maternally inherited nonsyndromic hearing loss
    R A Friedman
    House Ear Clinic and House Ear Institute, Los Angeles, California 90057, USA
    Am J Med Genet 84:369-72. 1999
  7. ncbi request reprint Surgical salvage after failed irradiation for vestibular schwannoma
    Rick A Friedman
    House Clinic and House Ear Institute, Los Angeles, CA 90057, USA
    Laryngoscope 115:1827-32. 2005
  8. ncbi request reprint Eya1 acts upstream of Tbx1, Neurogenin 1, NeuroD and the neurotrophins BDNF and NT-3 during inner ear development
    Rick A Friedman
    Gonda Department of Cell and Molecular Biology, House Ear Institute, 2100 W Third Street, Los Angeles, CA 90057, USA
    Mech Dev 122:625-34. 2005
  9. ncbi request reprint Hearing preservation in patients with vestibular schwannomas with sudden sensorineural hearing loss
    R A Friedman
    House Ear Clinic and House Ear Institute, the Piedmont Ear, Nose and Throat Associates, Los Angeles, CA 90057, USA
    Otolaryngol Head Neck Surg 125:544-51. 2001
  10. ncbi request reprint Long-term hearing preservation after middle fossa removal of vestibular schwannoma
    Rick A Friedman
    House Ear Institute, Los Angeles, CA 90057, USA
    Otolaryngol Head Neck Surg 129:660-5. 2003

Research Grants

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Correction of progressive hearing loss in superior canal dehiscence syndrome
    Eric P Wilkinson
    House Ear Clinic, 2100 West Third Street, Los Angeles, CA 90057, USA
    Laryngoscope 118:10-3. 2008
    ..We also contrast the index case of progressive mixed loss with the more frequent conductive hearing loss seen in SSCDS...
  2. doi request reprint Hearing preservation with the middle cranial fossa approach for neurofibromatosis type 2
    Rick A Friedman
    House Clinic and House Research Institute, Los Angeles, California, USA
    Otol Neurotol 32:1530-7. 2011
    ..To examine hearing preservation rates, facial nerve outcomes, and tumor recurrence rates in patients with neurofibromatosis Type 2 undergoing a primary middle cranial fossa approach for vestibular schwannoma removal...
  3. doi request reprint A paradigm shift in salvage surgery for radiated vestibular schwannoma
    Rick A Friedman
    House Clinic and House Research Institute, Los Angeles, California 90057, USA
    Otol Neurotol 32:1322-8. 2011
    ..Determine whether more conservative management for surgical salvage after failed radiation leads to better facial nerve outcomes...
  4. pmc GRM7 variants confer susceptibility to age-related hearing impairment
    Rick A Friedman
    House Ear Institute, Gonda Research Center for Cell and Molecular Biology, Los Angeles, CA, USA
    Hum Mol Genet 18:785-96. 2009
    ..Together these data indicate that common alleles of GRM7 contribute to an individual's risk of developing ARHI, possibly through a mechanism of altered susceptibility to glutamate excitotoxicity...
  5. ncbi request reprint Management of cerebrospinal fluid leaks after acoustic tumor removal
    Rick A Friedman
    House Clinic and House Ear Institute, Los Angeles, California 90057, USA
    Neurosurgery 61:35-9; discussion 39-40. 2007
    ..To present a logical algorithm for management of postoperative cerebrospinal fluid (CSF) leak that occurs after acoustic tumor removal, and to describe a method for eustachian tube resection...
  6. ncbi request reprint Maternally inherited nonsyndromic hearing loss
    R A Friedman
    House Ear Clinic and House Ear Institute, Los Angeles, California 90057, USA
    Am J Med Genet 84:369-72. 1999
    ..The search for this novel molecular defect is underway...
  7. ncbi request reprint Surgical salvage after failed irradiation for vestibular schwannoma
    Rick A Friedman
    House Clinic and House Ear Institute, Los Angeles, CA 90057, USA
    Laryngoscope 115:1827-32. 2005
    ..Compare vestibular schwannoma (VS) surgical outcome between patients with prior irradiation and those not previously treated...
  8. ncbi request reprint Eya1 acts upstream of Tbx1, Neurogenin 1, NeuroD and the neurotrophins BDNF and NT-3 during inner ear development
    Rick A Friedman
    Gonda Department of Cell and Molecular Biology, House Ear Institute, 2100 W Third Street, Los Angeles, CA 90057, USA
    Mech Dev 122:625-34. 2005
    ..We discuss a potential mechanism for the absence of neural precursors in the Eya1-/- inner ears and the primary and secondary mechanisms for the loss of cochleovestibular ganglion cells in the Eya1bor/bor hypomorphic mutant...
  9. ncbi request reprint Hearing preservation in patients with vestibular schwannomas with sudden sensorineural hearing loss
    R A Friedman
    House Ear Clinic and House Ear Institute, the Piedmont Ear, Nose and Throat Associates, Los Angeles, CA 90057, USA
    Otolaryngol Head Neck Surg 125:544-51. 2001
    ....
  10. ncbi request reprint Long-term hearing preservation after middle fossa removal of vestibular schwannoma
    Rick A Friedman
    House Ear Institute, Los Angeles, CA 90057, USA
    Otolaryngol Head Neck Surg 129:660-5. 2003
    ..Pure-tone thresholds, before resection and at least 5 years after resection, and speech discrimination scores are reported...
  11. ncbi request reprint Early proactive management of vestibular schwannomas in neurofibromatosis type 2
    D E Brackmann
    House Ear Clinic and House Ear Institute, Los Angeles, California 90057, USA
    Neurosurgery 49:274-80; discussion 280-3. 2001
    ..CONCLUSION: Early surgical intervention to treat acoustic tumors among patients with neurofibromatosis Type 2 is a feasible treatment strategy, with high rates of hearing and facial nerve function preservation...
  12. ncbi request reprint Neurotologic skull base surgery in pediatric patients
    Calhoun D Cunningham
    House Ear Clinic and House Ear Institute, Los Angeles, California, USA
    Otol Neurotol 26:231-6. 2005
    ..The purpose of this study is to provide a clinical review of neurotologic skull base surgery in the pediatric population...
  13. ncbi request reprint Identification of two major loci that suppress hearing loss and cochlear dysmorphogenesis in Eya1bor/bor mice
    Haoru Niu
    Gonda Cell and Molecular Biology Research Laboratories, House Ear Institute, 2100 W Third Street, Los Angeles, CA 90057, USA
    Genomics 88:302-8. 2006
    ..Quantitative PCR demonstrated that this modifying effect did not result from an increase in wild-type Eya1 mRNA, suggesting Mead1 and Mead2 are interacting directly or indirectly with Eya1 during inner ear development...
  14. ncbi request reprint Hearing preservation surgery for neurofibromatosis Type 2-related vestibular schwannoma in pediatric patients
    William H Slattery
    House Ear Clinic, House Ear Institute, Los Angeles, California 90057, USA
    J Neurosurg 106:255-60. 2007
    ..The authors reviewed the proportion of pediatric patients with neurofibromatosis Type 2 (NF2) in whom hearing was preserved after middle fossa resection of vestibular schwannoma (VS)...
  15. ncbi request reprint Controversies in building a management algorithm for vestibular schwannomas
    Joni K Doherty
    House Clinic and House Ear Institute, Los Angeles, California 90057, USA
    Curr Opin Otolaryngol Head Neck Surg 14:305-13. 2006
    ..The present review examines the various mainstream treatment options, benefits and risks, and controversies involved in developing a management algorithm for treatment of vestibular schwannoma...
  16. ncbi request reprint Intratympanic steroid injection for treatment of idiopathic sudden hearing loss
    William H Slattery
    House Ear Institute, House Ear Clinic, Los Angeles, California 90057, USA
    Otolaryngol Head Neck Surg 133:251-9. 2005
    ..To conduct a clinical trial of intratympanic steroid injection for idiopathic sudden sensorineural hearing loss in subjects who failed oral steroid therapy...
  17. pmc A comparative study of Eya1 and Eya4 protein function and its implication in branchio-oto-renal syndrome and DFNA10
    Yuzhou Zhang
    Molecular Otolaryngology Research Laboratories, University of Iowa, Iowa City, IA 52242, USA
    J Assoc Res Otolaryngol 5:295-304. 2004
    ..These results are consistent with clinical data and implicate haploinsufficiency as the cause of BOR syndrome and DFNA10...
  18. ncbi request reprint Genetics of hearing loss: Allelism and modifier genes produce a phenotypic continuum
    Richard K McHugh
    Section on Hereditary Disorders of the Ear, House Ear Institute, Los Angeles, California 90057, USA
    Anat Rec A Discov Mol Cell Evol Biol 288:370-81. 2006
    ..Characterizing modifier genes may result in better treatment options for patients with hearing loss and define new diagnostic and therapeutic targets...
  19. ncbi request reprint Effect of ciprodex on graft healing in tympanoplasty
    Ashley Starkweather
    University of Southern California, School of Medicine, Los Angeles, CA, USA
    Adv Ther 24:427-35. 2007
    ..Although this study is limited by its retrospective design, the data suggest that the use of Ciprodex during tympanoplasty has no detrimental effect on postoperative graft healing...
  20. pmc A natural allele of Nxf1 suppresses retrovirus insertional mutations
    Jennifer A Floyd
    Biomedical Sciences Graduate Program, UCSD School of Medicine, 9500 Gilman Drive, La Jolla, California 92093 0644, USA
    Nat Genet 35:221-8. 2003
    ..A congenic Mvb1(CAST) allele is a useful tool for modifying gene expression from existing mutations and could be used to manipulate engineered mutations containing retroviral elements...
  21. ncbi request reprint The evolution of surgical approaches for posterior fossa meningiomas
    Ted Shen
    House Ear Clinic, House Ear Institute, and University of Southern California Keck School of Medicine, Los Angeles, California, USA
    Otol Neurotol 25:394-7. 2004
    ..We review our current treatment algorithm and present our postoperative outcomes with attention to facial and auditory neural preservation...
  22. ncbi request reprint Congenital middle ear cholesteatoma
    J Walter Kutz
    House Ear Clinic, Los Angeles, USA
    Ear Nose Throat J 86:654. 2007
  23. ncbi request reprint Surgical management of skull base chondroblastoma
    J Walter Kutz
    House Ear Institute, Los Angeles, California, USA
    Laryngoscope 117:848-53. 2007
    ..We reviewed our experience with chondroblastoma of the skull base with an emphasis on current lateral skull base approaches and long-term tumor control...

Research Grants8

  1. Study of a genetic network involved in ear development
    Rick Friedman; Fiscal Year: 2005
    ..These and future experiments represent the natural progression from my Mentored Clinical Scientist Development Award (K08). ..
  2. Genetic Analysis of Age Related Hearing Impairment
    Rick Friedman; Fiscal Year: 2009
    ..This improved knowledge base can be anticipated to constitute fertile ground for developing new evidence-based preventive and therapeutic approaches to treating ARHI. ..
  3. Genetic Analysis of Age Related Hearing Impairment
    Rick A Friedman; Fiscal Year: 2010
    ..This improved knowledge base can be anticipated to constitute fertile ground for developing new evidence-based preventive and therapeutic approaches to treating ARHI. ..