Ping Chen

Summary

Affiliation: House Ear Institute
Country: USA

Publications

  1. ncbi request reprint Overriding imatinib resistance with a novel ABL kinase inhibitor
    Neil P Shah
    Division of Hematology and Oncology, Department of Medicine, The David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA
    Science 305:399-401. 2004
  2. ncbi request reprint Three circadian clock genes Per2, Arntl, and Npas2 contribute to winter depression
    Timo Partonen
    Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland
    Ann Med 39:229-38. 2007
  3. ncbi request reprint The role of Math1 in inner ear development: Uncoupling the establishment of the sensory primordium from hair cell fate determination
    Ping Chen
    Gonda Department of Cell and Molecular Biology, House Ear Institute, Los Angeles, CA 90057, USA
    Development 129:2495-505. 2002
  4. ncbi request reprint Progressive hearing loss in mice lacking the cyclin-dependent kinase inhibitor Ink4d
    Ping Chen
    Gonda Department of Cell and Molecular Biology, House Ear Institute, 2100 W 3rd St, Fifth Floor, Los Angeles, CA 90057, USA
    Nat Cell Biol 5:422-6. 2003
  5. ncbi request reprint Cochlear gap junctions coassembled from Cx26 and 30 show faster intercellular Ca2+ signaling than homomeric counterparts
    Jianjun Sun
    Section on Neurobiology, Leslie and Susan Gonda Department of Cell and Molecular Biology, House Ear Institute, Los Angeles, California, USA
    Am J Physiol Cell Physiol 288:C613-23. 2005
  6. ncbi request reprint Acid-sensing ion channel 2 contributes a major component to acid-evoked excitatory responses in spiral ganglion neurons and plays a role in noise susceptibility of mice
    Ben gang Peng
    Section on Neurobiology, Gonda Department of Cell and Molecular Biology, House Ear Institute, Los Angeles, California 90057, USA
    J Neurosci 24:10167-75. 2004
  7. pmc Hey2 functions in parallel with Hes1 and Hes5 for mammalian auditory sensory organ development
    Shuangding Li
    Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
    BMC Dev Biol 8:20. 2008
  8. ncbi request reprint Expression of Islet1 marks the sensory and neuronal lineages in the mammalian inner ear
    Kristen Radde-Gallwitz
    Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Comp Neurol 477:412-21. 2004
  9. ncbi request reprint Math1-driven GFP expression in the developing nervous system of transgenic mice
    Ellen A Lumpkin
    Department of Physiology, University of California, San Francisco, 600 16th Street, San Francisco, CA 94143 2280, USA
    Gene Expr Patterns 3:389-95. 2003
  10. ncbi request reprint [Influence of peroxisome proliferator-activated receptor gamma on airway inflammation of guinea pigs with asthma]
    Zhi jian Bao
    Department of Respiratory Medicine, Xiangya Second Hospital, Central South University, Changsha 410011, China
    Zhonghua Jie He He Hu Xi Za Zhi 27:169-73. 2004

Collaborators

  • N Segil
  • Jianjun Sun
  • Neil P Shah
  • Feng Liu
  • Yanping Zhang
  • C Abdala
  • Mary E Dickinson
  • Shuangding Li
  • Jagabandhu Das
  • Chonnettia Jones
  • Xi Lin
  • Dong Qian
  • Jianbo Wang
  • Yan Qu
  • Sharayne Mark
  • Kristen Radde-Gallwitz
  • Wenxue Tang
  • Goran Sohl
  • Klaus Willecke
  • Timo Partonen
  • Michael Kelly
  • Shoeb Ahmad
  • Tao Li
  • Xiaohui Zhang
  • Anthony Wynshaw-Boris
  • Jun Xing Huang
  • Zhi jian Bao
  • Ben gang Peng
  • Ellen A Lumpkin
  • Yong Wu
  • Scott H Watterson
  • Isabelle Foucher
  • Boglarka Banizs
  • Bradley K Yoder
  • Venus C Roper
  • Christine Petit
  • Martin Schalling
  • Pia Soronen
  • Qing Chang
  • Stefan Wellek
  • Jens Treutlein
  • Tiina Paunio
  • Maj Liz Persson
  • Asude Alpman
  • Josef Frank
  • Dalian Ding
  • Siegfried Kasper
  • Marcella Rietschel
  • Carolina Johansson
  • Xing Dai
  • Gunter Schumann
  • Zhu Qing Jia
  • Karen P Steel
  • Andreas Koch
  • Ian Dahlke
  • Liviu Aron
  • Jill Hibshman
  • Agnieszka Rzadzinska
  • Richard Salvi
  • Kang tao Ma
  • Leena Peltonen
  • Martin Depner
  • Yan Ming Li
  • Chun yan Zhou
  • Rolf Adolfsson
  • Mark Lathrop
  • Yuhua Li
  • Scott E Fraser
  • Natasha S Hamblet
  • John B Wallingford
  • Brendan C Brinkman
  • Jorma Toppari
  • Andres Collazo
  • Wei Yan
  • Seung Jong Yoo
  • Eeva Salminen
  • Rong Yu Qian
  • Zheng Xiang Song
  • Shu Zhen Yan
  • Ling Pan
  • Shoab Ahmad
  • Jun wei Deng
  • Shanping Chen
  • Margaret P Price
  • Lin Gan
  • Xu dong Xiang
  • Daniel Cheney
  • Angelika Doetzlhofer
  • Adil Omer-Abdalla
  • Yuan zhong Chen

Detail Information

Publications25

  1. ncbi request reprint Overriding imatinib resistance with a novel ABL kinase inhibitor
    Neil P Shah
    Division of Hematology and Oncology, Department of Medicine, The David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA
    Science 305:399-401. 2004
    ..These data illustrate how molecular insight into kinase inhibitor resistance can guide the design of second-generation targeted therapies...
  2. ncbi request reprint Three circadian clock genes Per2, Arntl, and Npas2 contribute to winter depression
    Timo Partonen
    Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland
    Ann Med 39:229-38. 2007
    ..We hypothesized that sequence variations in three genes, including Per2, Arntl, and Npas2, which form a functional unit at the core of the circadian clock, predispose to winter depression...
  3. ncbi request reprint The role of Math1 in inner ear development: Uncoupling the establishment of the sensory primordium from hair cell fate determination
    Ping Chen
    Gonda Department of Cell and Molecular Biology, House Ear Institute, Los Angeles, CA 90057, USA
    Development 129:2495-505. 2002
    ....
  4. ncbi request reprint Progressive hearing loss in mice lacking the cyclin-dependent kinase inhibitor Ink4d
    Ping Chen
    Gonda Department of Cell and Molecular Biology, House Ear Institute, 2100 W 3rd St, Fifth Floor, Los Angeles, CA 90057, USA
    Nat Cell Biol 5:422-6. 2003
    ..Our results identify a novel mechanism underlying a non-syndromic form of progressive hearing loss in mice...
  5. ncbi request reprint Cochlear gap junctions coassembled from Cx26 and 30 show faster intercellular Ca2+ signaling than homomeric counterparts
    Jianjun Sun
    Section on Neurobiology, Leslie and Susan Gonda Department of Cell and Molecular Biology, House Ear Institute, Los Angeles, California, USA
    Am J Physiol Cell Physiol 288:C613-23. 2005
    ....
  6. ncbi request reprint Acid-sensing ion channel 2 contributes a major component to acid-evoked excitatory responses in spiral ganglion neurons and plays a role in noise susceptibility of mice
    Ben gang Peng
    Section on Neurobiology, Gonda Department of Cell and Molecular Biology, House Ear Institute, Los Angeles, California 90057, USA
    J Neurosci 24:10167-75. 2004
    ..g., ischemia or inflammation of the inner ear) to excitotoxicity...
  7. pmc Hey2 functions in parallel with Hes1 and Hes5 for mammalian auditory sensory organ development
    Shuangding Li
    Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
    BMC Dev Biol 8:20. 2008
    ..This study explores the expression and function of a putative Notch target gene...
  8. ncbi request reprint Expression of Islet1 marks the sensory and neuronal lineages in the mammalian inner ear
    Kristen Radde-Gallwitz
    Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Comp Neurol 477:412-21. 2004
    ....
  9. ncbi request reprint Math1-driven GFP expression in the developing nervous system of transgenic mice
    Ellen A Lumpkin
    Department of Physiology, University of California, San Francisco, 600 16th Street, San Francisco, CA 94143 2280, USA
    Gene Expr Patterns 3:389-95. 2003
    ....
  10. ncbi request reprint [Influence of peroxisome proliferator-activated receptor gamma on airway inflammation of guinea pigs with asthma]
    Zhi jian Bao
    Department of Respiratory Medicine, Xiangya Second Hospital, Central South University, Changsha 410011, China
    Zhonghua Jie He He Hu Xi Za Zhi 27:169-73. 2004
    ..To investigate the influence and mechanism of peroxisome proliferator-activated receptor gamma (PPAR-gamma) and its ligand agonist rosiglitazone on airway inflammation of guinea pigs with asthma...
  11. ncbi request reprint Ciliary proteins link basal body polarization to planar cell polarity regulation
    Chonnettia Jones
    Department of Cell Biology, Emory University School of Medicine, 615 Michael St, Atlanta, Georgia 30322, USA
    Nat Genet 40:69-77. 2008
    ..Thus, our data uncover a distinct requirement for ciliary genes in basal body positioning and morphological polarization during PCP regulation...
  12. ncbi request reprint Shaping the mammalian auditory sensory organ by the planar cell polarity pathway
    Michael Kelly
    Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Int J Dev Biol 51:535-47. 2007
    ..The PCP of the sensory organs in the vestibule of the inner ear will also be described briefly...
  13. pmc Analysis of connexin subunits required for the survival of vestibular hair cells
    Yan Qu
    Department of Otolaryngology, Emory University School of Medicine, Atlanta, Georgia 30322 3030, USA
    J Comp Neurol 504:499-507. 2007
    ..Hybrid GJs co-assembled from Cx26 and Cx30 were not essential for the survival of saccular hair cells...
  14. ncbi request reprint Carboxyl terminus of Nkx2.5 impairs its interaction with p300
    Tao Li
    Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing 100083, China
    J Mol Biol 370:976-92. 2007
    ..5 to histone deacetylase inhibitor. These results establish that p300 acts as an Nkx2.5 cofactor and facilitates increased Nkx2.5 activity by relieving the conformational impediment of its inhibitory C-terminal domain...
  15. pmc Wnt5a functions in planar cell polarity regulation in mice
    Dong Qian
    Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Dev Biol 306:121-33. 2007
    ..Together, these findings demonstrate that Wnt5a functions in PCP regulation in mice...
  16. pmc Restoration of connexin26 protein level in the cochlea completely rescues hearing in a mouse model of human connexin30-linked deafness
    Shoeb Ahmad
    Department of Otolaryngology, Yerkes Microarray Core, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322 3030, USA
    Proc Natl Acad Sci U S A 104:1337-41. 2007
    ....
  17. ncbi request reprint Planar cell polarity signaling in vertebrates
    Chonnettia Jones
    Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Bioessays 29:120-32. 2007
    ..This review summarizes the morphogenesis of this model system to assist the interpretation of the emerging data and proposes molecular mechanisms underlying PCP signaling in vertebrates...
  18. ncbi request reprint Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation
    Jianbo Wang
    Department of Pediatrics and Medicine, University of California, San Diego, 9500 Gilman Drive, MC 0627, La Jolla, CA 92093 0627, USA
    Development 133:1767-78. 2006
    ..These results are discussed in light of recent models on PCP and convergent extension...
  19. pmc Gap junction-mediated intercellular biochemical coupling in cochlear supporting cells is required for normal cochlear functions
    Yanping Zhang
    Department of Otolaryngology, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322 3030, USA
    Proc Natl Acad Sci U S A 102:15201-6. 2005
    ..Therefore, GJ-mediated intercellular exchange of biochemically important molecules is required for normal cochlear functions...
  20. pmc Regulation of polarized extension and planar cell polarity in the cochlea by the vertebrate PCP pathway
    Jianbo Wang
    Department of Pediatrics and Medicine, University of California San Diego School of Medicine, La Jolla, California 92093, USA
    Nat Genet 37:980-5. 2005
    ....
  21. ncbi request reprint Synthesis and SAR of novel imidazoquinoxaline-based Lck inhibitors: improvement of cell potency
    Ping Chen
    Discovery Chemistry, Bristol Myers Squibb Pharmaceutical Research Institute, PO Box 4000, Princeton, NJ 08543, USA
    Bioorg Med Chem Lett 12:3153-6. 2002
    ..Significant improvement of the cellular activity was achieved over the initial lead, compound 2...
  22. ncbi request reprint Novel inhibitors of IMPDH: a highly potent and selective quinolone-based series
    Scott H Watterson
    Bristol Myers Squibb PRI, PO Box 400, Princeton, NJ 08543 4000, USA
    Bioorg Med Chem Lett 13:543-6. 2003
    ..A series of novel quinolone-based small molecule inhibitors of inosine monophosphate dehydrogenase (IMPDH) was explored. The synthesis and the structure-activity relationships (SARs) derived from in vitro studies are described...
  23. ncbi request reprint [The effect of anti-bcr-abl hammerhead ribozyme on bone marrow purging]
    Yong Wu
    Fujian Institute of Hematology, Union Hospital, Fujian Medical University, Fuzhou 350001, China
    Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 35:859-63. 2003
    ..The results suggest that anti-bcr-abl ribozyme might be used for bone marrow puring of CML cells...
  24. ncbi request reprint Suppression of malignant growth of human breast cancer cells by ectopic expression of integrin-linked kinase
    Ping Chen
    Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Int J Cancer 111:881-91. 2004
    ..These findings directly demonstrate that ILK deficiency facilitates neoplastic growth and invasion and suggest a novel role for the ILK gene in the suppression of tumor metastasis...
  25. ncbi request reprint Relationship between proliferative activity of cancer cells and clinicopathological factors in patients with esophageal squamous cell carcinoma
    Jun Xing Huang
    Department of Oncology and Pathology, The People s Hospital of Taizhou, Taizhou 225300, Jiangsu Province, China
    World J Gastroenterol 11:2956-9. 2005
    ....