Research Topics
Genomes and GenesSpecies | Ping ChenSummaryAffiliation: House Ear Institute Country: USA Publications
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Detail Information
Publications
Overriding imatinib resistance with a novel ABL kinase inhibitorNeil P Shah
Division of Hematology and Oncology, Department of Medicine, The David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA
Science 305:399-401. 2004..These data illustrate how molecular insight into kinase inhibitor resistance can guide the design of second-generation targeted therapies...- Three circadian clock genes Per2, Arntl, and Npas2 contribute to winter depressionTimo Partonen
Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland
Ann Med 39:229-38. 2007..We hypothesized that sequence variations in three genes, including Per2, Arntl, and Npas2, which form a functional unit at the core of the circadian clock, predispose to winter depression... - The role of Math1 in inner ear development: Uncoupling the establishment of the sensory primordium from hair cell fate determinationPing Chen
Gonda Department of Cell and Molecular Biology, House Ear Institute, Los Angeles, CA 90057, USA
Development 129:2495-505. 2002.... - Progressive hearing loss in mice lacking the cyclin-dependent kinase inhibitor Ink4dPing Chen
Gonda Department of Cell and Molecular Biology, House Ear Institute, 2100 W 3rd St, Fifth Floor, Los Angeles, CA 90057, USA
Nat Cell Biol 5:422-6. 2003..Our results identify a novel mechanism underlying a non-syndromic form of progressive hearing loss in mice... - Cochlear gap junctions coassembled from Cx26 and 30 show faster intercellular Ca2+ signaling than homomeric counterpartsJianjun Sun
Section on Neurobiology, Leslie and Susan Gonda Department of Cell and Molecular Biology, House Ear Institute, Los Angeles, California, USA
Am J Physiol Cell Physiol 288:C613-23. 2005.... - Acid-sensing ion channel 2 contributes a major component to acid-evoked excitatory responses in spiral ganglion neurons and plays a role in noise susceptibility of miceBen gang Peng
Section on Neurobiology, Gonda Department of Cell and Molecular Biology, House Ear Institute, Los Angeles, California 90057, USA
J Neurosci 24:10167-75. 2004..g., ischemia or inflammation of the inner ear) to excitotoxicity... 
Hey2 functions in parallel with Hes1 and Hes5 for mammalian auditory sensory organ developmentShuangding Li
Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
BMC Dev Biol 8:20. 2008..This study explores the expression and function of a putative Notch target gene...- Expression of Islet1 marks the sensory and neuronal lineages in the mammalian inner earKristen Radde-Gallwitz
Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
J Comp Neurol 477:412-21. 2004.... - Math1-driven GFP expression in the developing nervous system of transgenic miceEllen A Lumpkin
Department of Physiology, University of California, San Francisco, 600 16th Street, San Francisco, CA 94143-2280, USA
Gene Expr Patterns 3:389-95. 2003.... - [Influence of peroxisome proliferator-activated receptor gamma on airway inflammation of guinea pigs with asthma]Zhi-jian Bao
Department of Respiratory Medicine, Xiangya Second Hospital, Central South University, Changsha 410011, China
Zhonghua Jie He He Hu Xi Za Zhi 27:169-73. 2004..The anti-inflammatory effect of PPAR-gamma may be associated with the use of ligand agonist and(or) glucocorticoids... - Ciliary proteins link basal body polarization to planar cell polarity regulationChonnettia Jones
Department of Cell Biology, Emory University School of Medicine, 615 Michael St, Atlanta, Georgia 30322, USA
Nat Genet 40:69-77. 2008..Thus, our data uncover a distinct requirement for ciliary genes in basal body positioning and morphological polarization during PCP regulation... - Shaping the mammalian auditory sensory organ by the planar cell polarity pathwayMichael Kelly
Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
Int J Dev Biol 51:535-47. 2007..The PCP of the sensory organs in the vestibule of the inner ear will also be described briefly... - Analysis of connexin subunits required for the survival of vestibular hair cellsYan Qu
Department of Otolaryngology, Emory University School of Medicine, Atlanta, Georgia 30322 3030, USA
J Comp Neurol 504:499-507. 2007..Hybrid GJs co-assembled from Cx26 and Cx30 were not essential for the survival of saccular hair cells... - Carboxyl terminus of Nkx2.5 impairs its interaction with p300Tao Li
Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing 100083, China
J Mol Biol 370:976-92. 2007..5 to histone deacetylase inhibitor. These results establish that p300 acts as an Nkx2.5 cofactor and facilitates increased Nkx2.5 activity by relieving the conformational impediment of its inhibitory C-terminal domain... - Wnt5a functions in planar cell polarity regulation in miceDong Qian
Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
Dev Biol 306:121-33. 2007..Together, these findings demonstrate that Wnt5a functions in PCP regulation in mice... - Restoration of connexin26 protein level in the cochlea completely rescues hearing in a mouse model of human connexin30-linked deafnessShoeb Ahmad
Department of Otolaryngology, Yerkes Microarray Core, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322 3030, USA
Proc Natl Acad Sci U S A 104:1337-41. 2007.... - Planar cell polarity signaling in vertebratesChonnettia Jones
Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
Bioessays 29:120-32. 2007..This review summarizes the morphogenesis of this model system to assist the interpretation of the emerging data and proposes molecular mechanisms underlying PCP signaling in vertebrates... - Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulationJianbo Wang
Department of Pediatrics and Medicine, University of California, San Diego, 9500 Gilman Drive, MC 0627, La Jolla, CA 92093 0627, USA
Development 133:1767-78. 2006..These results are discussed in light of recent models on PCP and convergent extension... - Gap junction-mediated intercellular biochemical coupling in cochlear supporting cells is required for normal cochlear functionsYanping Zhang
Department of Otolaryngology, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322 3030, USA
Proc Natl Acad Sci U S A 102:15201-6. 2005..Therefore, GJ-mediated intercellular exchange of biochemically important molecules is required for normal cochlear functions... - Regulation of polarized extension and planar cell polarity in the cochlea by the vertebrate PCP pathwayJianbo Wang
Department of Pediatrics and Medicine, University of California San Diego School of Medicine, La Jolla, California 92093, USA
Nat Genet 37:980-5. 2005.... - Synthesis and SAR of novel imidazoquinoxaline-based Lck inhibitors: improvement of cell potencyPing Chen
Discovery Chemistry, Bristol Myers Squibb Pharmaceutical Research Institute, PO Box 4000, Princeton, NJ 08543, USA
Bioorg Med Chem Lett 12:3153-6. 2002..Significant improvement of the cellular activity was achieved over the initial lead, compound 2... - Novel inhibitors of IMPDH: a highly potent and selective quinolone-based seriesScott H Watterson
Bristol Myers Squibb PRI, PO Box 400, Princeton, NJ 08543 4000, USA
Bioorg Med Chem Lett 13:543-6. 2003..A series of novel quinolone-based small molecule inhibitors of inosine monophosphate dehydrogenase (IMPDH) was explored. The synthesis and the structure-activity relationships (SARs) derived from in vitro studies are described... - [The effect of anti-bcr-abl hammerhead ribozyme on bone marrow purging]Yong Wu
Fujian Institute of Hematology, Union Hospital, Fujian Medical University, Fuzhou 350001, China
Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 35:859-63. 2003..The results suggest that anti-bcr-abl ribozyme might be used for bone marrow puring of CML cells... - Suppression of malignant growth of human breast cancer cells by ectopic expression of integrin-linked kinasePing Chen
Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Int J Cancer 111:881-91. 2004..These findings directly demonstrate that ILK deficiency facilitates neoplastic growth and invasion and suggest a novel role for the ILK gene in the suppression of tumor metastasis... - Relationship between proliferative activity of cancer cells and clinicopathological factors in patients with esophageal squamous cell carcinomaJun Xing Huang
Department of Oncology and Pathology, The People s Hospital of Taizhou, Taizhou 225300, Jiangsu Province, China
World J Gastroenterol 11:2956-9. 2005....