Research Topics
Genomes and Genes | Eric MeffreSummaryAffiliation: Hospital for Special Surgery Country: USA Publications
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Publications
Defective B cell tolerance checkpoints in systemic lupus erythematosusSergey Yurasov
Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA
J Exp Med 201:703-11. 2005..We conclude that SLE is associated with abnormal early B cell tolerance...- Autoantibody selection and production in early human lifeEric Meffre
Hospital for Special Surgery, Weill Medical College of Cornell University, New York, NY 10021, USA
J Clin Invest 117:598-601. 2007..We present a molecular basis for the limited and common repertoire of antibodies produced by fetal B cells, which may be distinct from the abnormalities in B cell development described in patients with autoimmune diseases... - Efficient generation of monoclonal antibodies from single human B cells by single cell RT-PCR and expression vector cloningThomas Tiller
Max Planck Institute for Infection Biology, D 10117 Berlin, Germany
J Immunol Methods 329:112-24. 2008.... 
B-cell tolerance checkpoints in health and autoimmunityEric Meffre
Hospital for Special Surgery, Weill Medical College of Cornell University, New York, NY 10021, USA
Curr Opin Immunol 20:632-8. 2008..Under normal circumstances, several mechanisms regulate the removal of autoreactive B cells and defects in central and peripheral B cell tolerance checkpoints are associated with the development of autoimmunity in humans...- Surrogate light chain expressing human peripheral B cells produce self-reactive antibodiesEric Meffre
Laboratory of Molecular Immunology, The Rockefeller University, 1230 York Ave, New York, NY 10021, USA
J Exp Med 199:145-50. 2004..We conclude that V-preB+L+ B cells are a unique subset of normal circulating human B cells that escape central tolerance mechanisms and express self-reactive antibodies including potentially harmful ANAs... - CD40 ligand and MHC class II expression are essential for human peripheral B cell toleranceMaxime Hervé
Laboratory of Biochemistry and Molecular Immunology, Hospital for Special Surgery, New York, NY 10021, USA
J Exp Med 204:1583-93. 2007..The decreased frequency of MHC class II-restricted CD4(+) regulatory T cells in CD40L-deficient patients suggests that these T cells may mediate peripheral B cell tolerance through CD40L-CD40 and MHC class II-TCR interactions... - Complement receptor 2/CD21- human naive B cells contain mostly autoreactive unresponsive clonesIsabelle Isnardi
Laboratory of Molecular Immunology, Hospital for Special Surgery, New York, NY, USA
Blood 115:5026-36. 2010..Thus, CD21(-/lo) B cells contain mostly autoreactive unresponsive clones, which express a specific set of molecules that may represent new biomarkers to identify anergic B cells in humans... - Impaired early B cell tolerance in patients with rheumatoid arthritisJonathan Samuels
Laboratory of Biochemistry and Molecular Immunology, Hospital for Special Surgery, Cornell University, New York, NY 10021, USA
J Exp Med 201:1659-67. 2005..Thus, RA patients exhibit defective B cell tolerance checkpoints that may favor the development of autoimmunity... - Inflammation-independent defective early B cell tolerance checkpoints in rheumatoid arthritisLaurence Menard
Hospital for Special Surgery, New York, New York
Arthritis Rheum 63:1237-45. 2011..The aim of this study was to assess the impact of standard immunosuppressive treatments, methotrexate and anti-tumor necrosis factor α (anti-TNFα) agents, on early B cell tolerance checkpoints in RA patients... 
Human B cell tolerance and its failure in rheumatoid arthritisJonathan Samuels
Laboratory of Biochemistry and Molecular Immunology, Hospital for Special Surgery, Research Department, 535 E. 70th St, New York, NY 10021, USA
Ann N Y Acad Sci 1062:116-26. 2005....- Predominant autoantibody production by early human B cell precursorsHedda Wardemann
Laboratory of Molecular Immunology, Rockefeller University, New York, NY 10021, USA
Science 301:1374-7. 2003..Most of these autoantibodies were removed from the population at two discrete checkpoints during B cell development. Inefficient checkpoint regulation would lead to substantial increases in circulating autoantibodies... - Unmutated and mutated chronic lymphocytic leukemias derive from self-reactive B cell precursors despite expressing different antibody reactivityMaxime Hervé
Laboratory of Biochemistry and Molecular Immunology, Hospital for Special Surgery, New York, New York 10021, USA
J Clin Invest 115:1636-43. 2005..We concluded that both UM-CLLs and M-CLLs originate from self-reactive B cell precursors and that SHM plays an important role in the development of the disease by altering original BCR autoreactivity... - IRAK-4- and MyD88-dependent pathways are essential for the removal of developing autoreactive B cells in humansIsabelle Isnardi
Laboratory of Biochemistry and Molecular Immunology, Hospital for Special Surgery, New York, NY 10021, USA
Immunity 29:746-57. 2008.... - Bruton's tyrosine kinase is essential for human B cell toleranceYen Shing Ng
Laboratory of Biochemistry and Molecular Immunology, The Hospital for Special Surgery, New York, NY 10021, USA
J Exp Med 200:927-34. 2004..Nevertheless, XLA B cells are enriched in autoreactive clones. Our results demonstrate that Btk is essential in regulating thresholds for human B cell tolerance... - The transmembrane activator TACI triggers immunoglobulin class switching by activating B cells through the adaptor MyD88Bing He
Department of Medicine, Mount Sinai School of Medicine, New York, NY, USA
Nat Immunol 11:836-45. 2010..TACI-induced CSR was impaired in mice and humans lacking MyD88 or the kinase IRAK4, which indicates that MyD88 controls a B cell-intrinsic, TIR-independent, TACI-dependent pathway for immunoglobulin diversification... - Role of BCR affinity in T cell dependent antibody responses in vivoTien-An Yang Shih
Laboratory of Molecular Immunology, The Rockefeller University New York, NY 10021, USA
Nat Immunol 3:570-5. 2002..We conclude that in addition to the selection that occurs in GCs, stringent selection for high-affinity clones is also imposed in the early stages of the T cell dependent immune response in vivo... - Deletion of immunoglobulin beta in developing B cells leads to cell deathEric Meffre
Laboratory of Molecular Immunology, The Rockefeller University and Howard Hughes Medical Institute, 1230 York Avenue, New York, NY 10021 6399, USA
Proc Natl Acad Sci U S A 99:11334-9. 2002..In addition, complementation of null mutations with cDNAs under the control of heterologous bacterial artificial chromosomes is a useful method for cell-type-specific and developmentally regulated gene ablation in vivo... - Genomic instability in mice lacking histone H2AXArkady Celeste
Experimental Immunology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Science 296:922-7. 2002..Thus, H2AX is critical for facilitating the assembly of specific DNA-repair complexes on damaged DNA...
Research Grants
- Loss of B cell tolerance in rheumatoid arthritisEric Meffre; Fiscal Year: 2007..These studies have significant implications for understanding how people with autoimmune diseases produce antibodies that attack their body and may provide clues for development of new medications. ..