K A Kirou

Summary

Affiliation: Hospital for Special Surgery
Country: USA

Publications

  1. doi Anti-interferon alpha treatment in SLE
    Kyriakos A Kirou
    Mary Kirkland Center for Lupus Research, Hospital for Special Surgery, Weill Cornell Medical College, 535 East 70th Street, New York, NY 10021, USA
    Clin Immunol 148:303-12. 2013
  2. ncbi Activation of the interferon-alpha pathway identifies a subgroup of systemic lupus erythematosus patients with distinct serologic features and active disease
    Kyriakos A Kirou
    Mary Kirkland Center for Lupus Research, Hospital for Special Surgery and Weill Medical College of Cornell University, New York, New York, USA
    Arthritis Rheum 52:1491-503. 2005
  3. ncbi Activation of type I interferon in systemic lupus erythematosus
    Kyriakos A Kirou
    Assistant Professor of Clinical Medicine and Assistant Scientist, Mary Kirkland Center for Lupus Research, Department of Medicine, Hospital for Special Surgery and Weill Medical College of Cornell University, 535 East 70th Street, New York, NY 10021, USA
    Expert Rev Clin Immunol 3:579-88. 2007
  4. ncbi Sarcoidosis presenting with large vessel vasculitis and osteosclerosis-related bone and joint pain
    K A Kirou
    Division of Rheumatology, Hospital for Special Surger, New York, NY 10021, USA
    Clin Exp Rheumatol 18:401-3. 2000
  5. ncbi Regulation of CD40 ligand expression in systemic lupus erythematosus
    M K Crow
    Department of Medicine, Hospital for Special Surgery and Weill Medical College of Cornell University, New York City, New York, USA
    Curr Opin Rheumatol 13:361-9. 2001
  6. ncbi Microarray analysis of interferon-regulated genes in SLE
    Mary K Crow
    Mary Kirkland Center for Lupus Research, Hospital for Special Surgery, 535 East 70th Street, New York, NY, USA
    Autoimmunity 36:481-90. 2003
  7. ncbi Interferon-alpha in systemic lupus erythematosus
    Mary K Crow
    Mary Kirkland Center for Lupus Research, Hospital for Special Surgery, Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA
    Curr Opin Rheumatol 16:541-7. 2004
  8. ncbi Coordinate overexpression of interferon-alpha-induced genes in systemic lupus erythematosus
    Kyriakos A Kirou
    Hospital for Special Surgery, and Weill Medical College of Cornell University, New York, New York 10021, USA
    Arthritis Rheum 50:3958-67. 2004
  9. ncbi Measurement of cytokines in autoimmune disease
    Kyriakos A Kirou
    Mary Kirkland Center for Lupus Research, Hospital for Special Surgery, New York, NY, USA
    Methods Mol Med 102:129-54. 2004
  10. ncbi Remission of juvenile rheumatoid arthritis after infection with parvovirus B19
    H E Bateman
    Division of Rheumatology, Hospital for Special Surgery and Cornell University Weil Medical College, New York, New York 10021, USA
    J Rheumatol 26:2482-4. 1999

Research Grants

  1. Post-transcriptional regulation of CD40L in SLE
    Kyriakos Kirou; Fiscal Year: 2007

Collaborators

Detail Information

Publications14

  1. doi Anti-interferon alpha treatment in SLE
    Kyriakos A Kirou
    Mary Kirkland Center for Lupus Research, Hospital for Special Surgery, Weill Cornell Medical College, 535 East 70th Street, New York, NY 10021, USA
    Clin Immunol 148:303-12. 2013
    ....
  2. ncbi Activation of the interferon-alpha pathway identifies a subgroup of systemic lupus erythematosus patients with distinct serologic features and active disease
    Kyriakos A Kirou
    Mary Kirkland Center for Lupus Research, Hospital for Special Surgery and Weill Medical College of Cornell University, New York, New York, USA
    Arthritis Rheum 52:1491-503. 2005
    ..This study examined the hypothesis that increased disease severity and activity, as well as distinct autoantibody specificities, characterize SLE patients with activation of the type I IFN pathway...
  3. ncbi Activation of type I interferon in systemic lupus erythematosus
    Kyriakos A Kirou
    Assistant Professor of Clinical Medicine and Assistant Scientist, Mary Kirkland Center for Lupus Research, Department of Medicine, Hospital for Special Surgery and Weill Medical College of Cornell University, 535 East 70th Street, New York, NY 10021, USA
    Expert Rev Clin Immunol 3:579-88. 2007
    ..First, IFN may be a useful biomarker of disease subtype and activity and, second, IFN is a rational target for therapeutic intervention. Cautious blockade of this pathway might eliminate an important contributor to autoimmunity...
  4. ncbi Sarcoidosis presenting with large vessel vasculitis and osteosclerosis-related bone and joint pain
    K A Kirou
    Division of Rheumatology, Hospital for Special Surger, New York, NY 10021, USA
    Clin Exp Rheumatol 18:401-3. 2000
    ..Biopsies from bone and lymph node revealed non-caseating granulomas and no evidence of malignancy or infection, confirming the clinical impression of sarcoidosis...
  5. ncbi Regulation of CD40 ligand expression in systemic lupus erythematosus
    M K Crow
    Department of Medicine, Hospital for Special Surgery and Weill Medical College of Cornell University, New York City, New York, USA
    Curr Opin Rheumatol 13:361-9. 2001
    ..More complete characterization of the mechanisms that regulate the magnitude and duration of CD40L expression should suggest new approaches to modulate this promising therapeutic target...
  6. ncbi Microarray analysis of interferon-regulated genes in SLE
    Mary K Crow
    Mary Kirkland Center for Lupus Research, Hospital for Special Surgery, 535 East 70th Street, New York, NY, USA
    Autoimmunity 36:481-90. 2003
    ..Definition of the nature of the major IFNs, or other factors, that drive the IFN-regulated gene expression signature noted in SLE is an important area for investigation that may lead to new approaches to targeted therapy of SLE...
  7. ncbi Interferon-alpha in systemic lupus erythematosus
    Mary K Crow
    Mary Kirkland Center for Lupus Research, Hospital for Special Surgery, Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA
    Curr Opin Rheumatol 16:541-7. 2004
    ....
  8. ncbi Coordinate overexpression of interferon-alpha-induced genes in systemic lupus erythematosus
    Kyriakos A Kirou
    Hospital for Special Surgery, and Weill Medical College of Cornell University, New York, New York 10021, USA
    Arthritis Rheum 50:3958-67. 2004
    ....
  9. ncbi Measurement of cytokines in autoimmune disease
    Kyriakos A Kirou
    Mary Kirkland Center for Lupus Research, Hospital for Special Surgery, New York, NY, USA
    Methods Mol Med 102:129-54. 2004
    ..Detailed methods are provided for these assays...
  10. ncbi Remission of juvenile rheumatoid arthritis after infection with parvovirus B19
    H E Bateman
    Division of Rheumatology, Hospital for Special Surgery and Cornell University Weil Medical College, New York, New York 10021, USA
    J Rheumatol 26:2482-4. 1999
    ..Subsequent investigation revealed acute infection with parvovirus B19. Following clinical improvement over 10-14 days solely with supportive care, her underlying disease remained in remission for about 7 months...
  11. ncbi Soluble mediators as therapeutic targets in systemic lupus erythematosus: cytokines, immunoglobulin receptors, and the complement system
    Kyriakos A Kirou
    Weill Medical College of Cornell University, New York, NY, USA
    Rheum Dis Clin North Am 32:103-19, ix. 2006
    ....
  12. ncbi Cytokine-mediated regulation of activating and inhibitory Fc gamma receptors in human monocytes
    Yi Liu
    Research Division, Hospital for Special Surgery, Department of Medicine and Graduate Program in Immunology, Weill Medical College of Cornell University, 535 East 70th Street, New York, NY 10021, USA
    J Leukoc Biol 77:767-76. 2005
    ..Our findings suggest that the cytokine milieu can induce changes in the relative expression of Fc gammaR with opposing function and thus, may regulate the amplitude of Fc gammaR-mediated uptake and inflammation...
  13. ncbi Elevated levels of soluble CD40 ligand (sCD40L) in serum of patients with systemic autoimmune diseases
    Andreas Goules
    Department of Pathophysiology, School of Medicine, National University of Athens, 75 M Asias Street, 11527 Athens, Greece
    J Autoimmun 26:165-71. 2006
    ..Soluble CD40L is elevated in sera of SS and SLE patients but further investigation is needed to determine its possible role in SLE nephritis and Sjögren's syndrome...

Research Grants1

  1. Post-transcriptional regulation of CD40L in SLE
    Kyriakos Kirou; Fiscal Year: 2007
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