Weng C, Gupta S, Geraghty P, Foronjy R, Pernis A. Cigarette smoke inhibits ROCK2 activation in T cells and modulates IL-22 production. Mol Immunol. 2016;71:115-122 pubmed publisher
..Using a GEF pull-down assay we furthermore identify ARHGEF1 as a key upstream regulator of ROCK2 whose activity in T cells is inhibited by CS. Thus CS can inhibit the ROCK2-IRF4 axis and modulate T cell production of IL-22. ..