Steven R Goldring

Summary

Affiliation: Hospital for Special Surgery
Country: USA

Publications

  1. doi request reprint The role of bone in osteoarthritis pathogenesis
    Steven R Goldring
    The Hospital for Special Surgery, Weill Medical College of Cornell University, 535 East 70th Street, New York, NY 10021, USA
    Rheum Dis Clin North Am 34:561-71. 2008
  2. pmc Osteoimmunology and bone homeostasis: relevance to spondyloarthritis
    Steven R Goldring
    The Hospital for Special Surgery, Weill Cornell Medical College, 535 East 70th Street, New York, NY 10128, USA
    Curr Rheumatol Rep 15:342. 2013
  3. doi request reprint Bone remodelling in inflammatory arthritis
    Steven R Goldring
    Research Division, Department of Medicine, Hospital for Special Surgery, Weill Cornell Medical College, 535 East 70th Street, New York, NY 10128, USA
    Ann Rheum Dis 72:ii52-5. 2013
  4. pmc Plasma proteins take their toll on the joint in osteoarthritis
    Steven R Goldring
    Hospital for Special Surgery, Weill Cornell Medical Center, New York, NY, USA
    Arthritis Res Ther 14:111. 2012
  5. pmc Novel dexamethasone-HPMA copolymer conjugate and its potential application in treatment of rheumatoid arthritis
    Dong Wang
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE 68198 6025, USA
    Arthritis Res Ther 9:R2. 2007
  6. pmc Development of a macromolecular prodrug for the treatment of inflammatory arthritis: mechanisms involved in arthrotropism and sustained therapeutic efficacy
    Ling Dong Quan
    Department of Pharmaceutical Sciences, University of Nebraska Medical Center, 986025 Nebraska Medical Center, Omaha, NE 68198 6025, USA
    Arthritis Res Ther 12:R170. 2010
  7. doi request reprint Role of bone in osteoarthritis pathogenesis
    Steven R Goldring
    The Hospital for Special Surgery, Weill College of Medicine of Cornell University, 535 East 70th Street, New York, NY 10021, USA
    Med Clin North Am 93:25-35, xv. 2009
  8. doi request reprint Needs and opportunities in the assessment and treatment of osteoarthritis of the knee and hip: the view of the rheumatologist
    Steven R Goldring
    The Hospital for Special Surgery, Weill College of Medicine of Cornell University, 535 East 70th Street, New York, NY 10021, USA
    J Bone Joint Surg Am 91:4-6. 2009
  9. ncbi request reprint Clinical aspects, pathology and pathophysiology of osteoarthritis
    S R Goldring
    Hospital for Special Surgery, Weill Medical College of Cornell University, New York, NY 10021, USA
    J Musculoskelet Neuronal Interact 6:376-8. 2006
  10. pmc The relative timing of exposure to phagocytosable particulates and to osteoclastogenic cytokines is critically important in the determination of myeloid cell fate
    Douglas E James
    Hospital for Special Surgery, New York, NY 10021, USA
    J Immunol 185:1265-73. 2010

Collaborators

Detail Information

Publications31

  1. doi request reprint The role of bone in osteoarthritis pathogenesis
    Steven R Goldring
    The Hospital for Special Surgery, Weill Medical College of Cornell University, 535 East 70th Street, New York, NY 10021, USA
    Rheum Dis Clin North Am 34:561-71. 2008
    ..In addition, the relationship of these changes to the alterations in articular cartilage and the other tissues comprising the diarthrodial joint are reviewed...
  2. pmc Osteoimmunology and bone homeostasis: relevance to spondyloarthritis
    Steven R Goldring
    The Hospital for Special Surgery, Weill Cornell Medical College, 535 East 70th Street, New York, NY 10128, USA
    Curr Rheumatol Rep 15:342. 2013
    ....
  3. doi request reprint Bone remodelling in inflammatory arthritis
    Steven R Goldring
    Research Division, Department of Medicine, Hospital for Special Surgery, Weill Cornell Medical College, 535 East 70th Street, New York, NY 10128, USA
    Ann Rheum Dis 72:ii52-5. 2013
    ..This review will focus on recent advances in the understanding of the cellular and molecular mechanisms that contribute to the differential pattern of articular bone remodelling in these prototypical inflammatory forms of arthritis...
  4. pmc Plasma proteins take their toll on the joint in osteoarthritis
    Steven R Goldring
    Hospital for Special Surgery, Weill Cornell Medical Center, New York, NY, USA
    Arthritis Res Ther 14:111. 2012
    ..These results demonstrate a novel mechanism by which synovial inflammation can be initiated in patients with OA and how this process may contribute to the pathogenesis of OA joint pathology...
  5. pmc Novel dexamethasone-HPMA copolymer conjugate and its potential application in treatment of rheumatoid arthritis
    Dong Wang
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE 68198 6025, USA
    Arthritis Res Ther 9:R2. 2007
    ..This newly developed drug delivery system provides a unique method for selective targeting of glucocorticoids to inflamed joints which may potentially reduce systemic side effects...
  6. pmc Development of a macromolecular prodrug for the treatment of inflammatory arthritis: mechanisms involved in arthrotropism and sustained therapeutic efficacy
    Ling Dong Quan
    Department of Pharmaceutical Sciences, University of Nebraska Medical Center, 986025 Nebraska Medical Center, Omaha, NE 68198 6025, USA
    Arthritis Res Ther 12:R170. 2010
    ....
  7. doi request reprint Role of bone in osteoarthritis pathogenesis
    Steven R Goldring
    The Hospital for Special Surgery, Weill College of Medicine of Cornell University, 535 East 70th Street, New York, NY 10021, USA
    Med Clin North Am 93:25-35, xv. 2009
    ..This article focuses on the specific skeletal features of OA and the putative mechanisms involved in their pathogenesis...
  8. doi request reprint Needs and opportunities in the assessment and treatment of osteoarthritis of the knee and hip: the view of the rheumatologist
    Steven R Goldring
    The Hospital for Special Surgery, Weill College of Medicine of Cornell University, 535 East 70th Street, New York, NY 10021, USA
    J Bone Joint Surg Am 91:4-6. 2009
    ....
  9. ncbi request reprint Clinical aspects, pathology and pathophysiology of osteoarthritis
    S R Goldring
    Hospital for Special Surgery, Weill Medical College of Cornell University, New York, NY 10021, USA
    J Musculoskelet Neuronal Interact 6:376-8. 2006
  10. pmc The relative timing of exposure to phagocytosable particulates and to osteoclastogenic cytokines is critically important in the determination of myeloid cell fate
    Douglas E James
    Hospital for Special Surgery, New York, NY 10021, USA
    J Immunol 185:1265-73. 2010
    ..Thus, the relative timing of exposure to phagocytosable particulates and to osteoclastogenic cytokines is critically important in the determination of myeloid cell fate...
  11. doi request reprint Orthopedic wear debris mediated inflammatory osteolysis is mediated in part by NALP3 inflammasome activation
    Lyndsey Burton
    Hospital for Special Surgery, 535 East 70th Street, New York, New York 10021, USA
    J Orthop Res 31:73-80. 2013
    ..Our findings identify the NALP3 inflammasome as a critical mediator of orthopedic wear-induced osteolysis and as a viable therapeutic target for the treatment of periprosthetic osteolysis...
  12. doi request reprint Articular cartilage and subchondral bone in the pathogenesis of osteoarthritis
    Mary B Goldring
    The Hospital for Special Surgery, Weill Cornell Medical College, New York, NY, USA
    Ann N Y Acad Sci 1192:230-7. 2010
    ..This review focuses on the specific articular cartilage and skeletal features of OA and the putative mechanisms involved in their pathogenesis...
  13. pmc Negative regulation of osteoclast precursor differentiation by CD11b and β2 integrin-B-cell lymphoma 6 signaling
    Kyung Hyun Park-Min
    Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, New York, NY, USA
    J Bone Miner Res 28:135-49. 2013
    ....
  14. pmc Inhibition of RANK expression and osteoclastogenesis by TLRs and IFN-gamma in human osteoclast precursors
    Jong Dae Ji
    Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, New York, NY 10021, USA
    J Immunol 183:7223-33. 2009
    ..Our findings identify a new mechanism of homeostatic regulation of osteoclastogenesis that targets RANK expression and limits bone resorption during infection and inflammation...
  15. ncbi request reprint Osteoarthritis
    Mary B Goldring
    Laboratory for Cartilage Biology, Research Division, The Hospital for Special Surgery, Weill College of Medicine of Cornell University, New York 10021, USA
    J Cell Physiol 213:626-34. 2007
    ....
  16. ncbi request reprint ESE-1 is a novel transcriptional mediator of angiopoietin-1 expression in the setting of inflammation
    Courtney Brown
    Beth Israel Deaconess Medical Center, Department of Medicine, New England Baptist Bone and Joint Institute, Harvard Institutes of Medicine, 4 Blackfan Circle, Boston, MA 02115, USA
    J Biol Chem 279:12794-803. 2004
    ..Our results support a novel paradigm for the ETS factor ESE-1 as a transcriptional mediator of angiogenesis in the setting of inflammation...
  17. ncbi request reprint Comparison of cathepsins K and S expression within the rheumatoid and osteoarthritic synovium
    Wu Shiun Hou
    Mount Sinai School of Medicine, New York, New York 10029, USA
    Arthritis Rheum 46:663-74. 2002
    ....
  18. pmc Amylin inhibits bone resorption while the calcitonin receptor controls bone formation in vivo
    Romain Dacquin
    Department of Molecular and Human Genetics and Bone Disease Program of Texas, Baylor College of Medicine, One Baylor Plaza, Room S921, Houston, TX 77030, USA
    J Cell Biol 164:509-14. 2004
    ..Thus, amylin is a physiological regulator of bone resorption that acts through an unidentified receptor...
  19. ncbi request reprint Responses to the proinflammatory cytokines interleukin-1 and tumor necrosis factor alpha in cells derived from rheumatoid synovium and other joint tissues involve nuclear factor kappaB-mediated induction of the Ets transcription factor ESE-1
    Franck Grall
    New England Baptist Bone and Joint Institute, Beth Israel Deaconess Medical Center and Harvard Medical School, and Beth Israel Deaconess Medical Center Genomics Center, Boston, Massachusetts 02115, USA
    Arthritis Rheum 48:1249-60. 2003
    ....
  20. ncbi request reprint Bone and joint destruction in rheumatoid arthritis: what is really happening?
    Steven R Goldring
    Harvard Medical School, New England Baptist Bone and Joint Institute, Boston, Massachusetts 02215, USA
    J Rheumatol Suppl 65:44-8. 2002
    ..These observations suggest that osteoclasts mediate focal bone erosions in RA and that targeting of osteoclasts and osteoclast mediated bone resorption represents a rational approach to preventing or reducing focal bone loss in RA...
  21. ncbi request reprint Rheumatic diseases: the effects of inflammation on bone
    Nicole C Walsh
    Beth Israel Deaconess Medical Center, New England Baptist Bone and Joint Institute, Harvard Institutes of Medicine, Boston, MA 02115, USA
    Immunol Rev 208:228-51. 2005
    ..In this review, we provide an overview of the cell types, inflammatory mediators, and mechanisms that are implicated in bone loss and new bone formation in inflammatory joint diseases...
  22. ncbi request reprint Relationship between cartilage stiffness and dGEMRIC index: correlation and prediction
    Marta Baldassarri
    New England Baptist Bone and Joint Institute, Boston, Massachusetts, USA
    J Orthop Res 25:904-12. 2007
    ..A generalized relationship was found to provide good correspondence across sources and regions. Use of the dGEMRIC index as a predictive measure of stiffness is possible, depending on the application's acceptable error...
  23. ncbi request reprint Eating bone or adding it: the Wnt pathway decides
    Steven R Goldring
    Nat Med 13:133-4. 2007
  24. pmc The role played by cell-substrate interactions in the pathogenesis of osteoclast-mediated peri-implant osteolysis
    Zhenxin Shen
    New England Baptist Bone and Joint Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Arthritis Res Ther 8:R70. 2006
    ..We speculate that, in addition to the role of cytokines and growth factors, the substrate with which these cells interact plays a critical role in their differential phenotypic and functional properties...
  25. ncbi request reprint Bisphosphonates: environmental protection for the joint?
    Steven R Goldring
    Arthritis Rheum 50:2044-7. 2004
  26. ncbi request reprint Nitric oxide promotes infectious bone resorption by enhancing cytokine-stimulated interstitial collagenase synthesis in osteoblasts
    Sze Kwan Lin
    Department of Dentistry, National Taiwan University Hospital, Taipei, Taiwan
    J Bone Miner Res 18:39-46. 2003
    ..These data suggest that NO derived from macrophages after LPS stimulation may enhance bone loss by augmenting the cytokine-induced MMP-1 production in osteoblasts...
  27. ncbi request reprint Increase in expression of receptor activator of nuclear factor kappaB at sites of bone erosion correlates with progression of inflammation in evolving collagen-induced arthritis
    Erik Lubberts
    University Medical Center Nijmegen, Nijmegen, The Netherlands
    Arthritis Rheum 46:3055-64. 2002
    ..This study was undertaken to identify in vivo the hitherto-unknown origin and localization of RANK-expressing osteoclast precursor cells at sites of bone erosion in arthritis...
  28. ncbi request reprint Pathogenesis of bone erosions in rheumatoid arthritis
    Steven R Goldring
    Beth Israel Deaconess Medical Center, Harvard Medical School, and New England Baptist Bone and Joint Institute, Harvard Institutes of Medicine, Boston, Massachusetts 02115, USA
    Curr Opin Rheumatol 14:406-10. 2002
    ..These findings provide a rational framework for developing targeted therapies that can specifically inhibit or slow the progressive focal bone destruction associated with the rheumatoid synovial lesion...
  29. ncbi request reprint Pathogenesis of bone lesions in rheumatoid arthritis
    Steven R Goldring
    Harvard Institutes of Medicine, Room 241, 4 Blackfan Circle, Boston, MA 02115, USA
    Curr Rheumatol Rep 4:226-31. 2002
    ....
  30. ncbi request reprint Microscopic metallic wear and tissue response in failed titanium hallux metatarsophalangeal implants: two cases
    Navid Ghalambor
    The Hand Care Center, Orange, California, USA
    Foot Ankle Int 23:158-62. 2002
    ....