Affiliation: Hospital for Special Surgery
- OsteoarthritisMary B Goldring
Laboratory for Cartilage Biology, Research Division, The Hospital for Special Surgery, Weill College of Medicine of Cornell University, New York 10021, USA
J Cell Physiol 213:626-34. 2007....
- Epigenomic and microRNA-mediated regulation in cartilage development, homeostasis, and osteoarthritisMary B Goldring
Research Division, The Hospital for Special Surgery, Weill Cornell Medical College, New York, NY 10021, USA
Trends Mol Med 18:109-18. 2012..Herein, we summarize epigenetic and miRNA-mediated mechanisms impacting on OA progression and in this context offer potential therapeutic strategies for OA treatment...
- Cells of the synovium in rheumatoid arthritis. ChondrocytesMiguel Otero
Research Division of the Hospital for Special Surgery, Weill College of Medicine of Cornell University, Caspary Research Building, 535 E 70th Street, New York, NY 10021, USA
Arthritis Res Ther 9:220. 2007..This review covers current knowledge about the specific cellular and biochemical mechanisms that account for the disruption of the integrity of the cartilage matrix in RA...
- Cartilage homeostasis in health and rheumatic diseasesMary B Goldring
Research Division, Hospital for Special Surgery, Affiliated with Weill College of Medicine of Cornell University, New York, NY 10021, USA
Arthritis Res Ther 11:224. 2009..This review will cover current knowledge about the specific cellular and biochemical mechanisms that regulate cartilage homeostasis and pathology...
- Defining the roles of inflammatory and anabolic cytokines in cartilage metabolismM B Goldring
Hospital for Special Surgery, New York, NY 10021, USA
Ann Rheum Dis 67:iii75-82. 2008..These genes have also been examined in mouse models of OA, in which discoidin domain receptor 2 is associated with MMP-13-mediated remodelling, in order to understand their roles in physiological cartilage homoeostasis and joint disease...
- Articular cartilage and subchondral bone in the pathogenesis of osteoarthritisMary B Goldring
The Hospital for Special Surgery, Weill Cornell Medical College, New York, NY, USA
Ann N Y Acad Sci 1192:230-7. 2010..This review focuses on the specific articular cartilage and skeletal features of OA and the putative mechanisms involved in their pathogenesis...
- Inflammation in osteoarthritisMary B Goldring
Research Division, The Hospital for Special Surgery, Weill Cornell Medical College, New York, New York 10021, USA
Curr Opin Rheumatol 23:471-8. 2011....
- Roles of inflammatory and anabolic cytokines in cartilage metabolism: signals and multiple effectors converge upon MMP-13 regulation in osteoarthritisMary B Goldring
Tissue Engineering, Regeneration, and Repair Program, Research Division, The Hospital for Special Surgery, Weill Cornell Medical College, New York, NY 10021, USA
Eur Cell Mater 21:202-20. 2011..Our work points to common mediators of these processes in human OA cartilage and in early through late stages of OA in surgical and genetic mouse models...
- Chondrogenesis, joint formation, and articular cartilage regenerationIkemefuna Onyekwelu
Tissue Engineering Regeneration and Repair Program, Hospital for Special Surgery, New York, New York, USA
J Cell Biochem 107:383-92. 2009....
- GADD45beta enhances Col10a1 transcription via the MTK1/MKK3/6/p38 axis and activation of C/EBPbeta-TAD4 in terminally differentiating chondrocytesKaneyuki Tsuchimochi
Laboratory for Cartilage Biology, Research Division, The Hospital for Special Surgery, Weill Cornell Medical College, New York, New York 10021, USA
J Biol Chem 285:8395-407. 2010..Collectively, we have uncovered a novel molecular mechanism linking GADD45beta via the MTK1/MKK3/6/p38 axis to C/EBPbeta-TAD4 activation of Col10a1 transcription in terminally differentiating chondrocytes...
- Cartilage oligomeric matrix protein/thrombospondin 5 supports chondrocyte attachment through interaction with integrinsFaye Hui Chen
Department of Orthopaedic Surgery, Columbia University, New York, New York 10032, USA
J Biol Chem 280:32655-61. 2005..Through these interactions, COMP/TSP5 may be able to regulate cellular activities and respond to environment in the surrounding cartilage matrix...
- Vascular endothelial growth factor (VEGF) induces matrix metalloproteinase expression in immortalized chondrocytesThomas Pufe
Department of Anatomy, University of Kiel, D-24098 Kiel, Germany
J Pathol 202:367-74. 2004..These findings indicate that VEGF is an autocrine stimulator of immortalized chondrocytes that mediates mainly destructive processes in osteoarthritis...
- Update on the biology of the chondrocyte and new approaches to treating cartilage diseasesMary B Goldring
Department of Medicine, Division of Rheumatology, Beth Israel Deaconess Medical Center, New England Baptist Bone and Joint Institute and Harvard Medical School, Boston, MA 02115, USA
Best Pract Res Clin Rheumatol 20:1003-25. 2006....
- Reactive oxygen species induce expression of vascular endothelial growth factor in chondrocytes and human articular cartilage explantsJakob Fay
Department of Trauma Surgery, University Hospital Schleswig Holstein, Campus Kiel, Arnold Heller Strasse 7, 24105 Kiel, Germany
Arthritis Res Ther 8:R189. 2006..Our findings indicate ROS-mediated induction of VEGF and VEGF receptors in chondrocytes and cartilage explants. These results demonstrate a relationship between ROS and VEGF as multiplex mediators in articular cartilage degeneration...
- Up-regulation of microsomal prostaglandin E synthase 1 in osteoarthritic human cartilage: critical roles of the ERK-1/2 and p38 signaling pathwaysKayo Masuko-Hongo
UMR CNRS 7079, , Paris, France
Arthritis Rheum 50:2829-38. 2004..We postulate that mPGES-1 may be a novel target for OA therapy...
- Increased expression of the collagen receptor discoidin domain receptor 2 in articular cartilage as a key event in the pathogenesis of osteoarthritisLin Xu
Department of Developmental Biology, Harvard School of Dental Medicine, 188 Longwood Avenue, Boston, MA 02115, USA
Arthritis Rheum 56:2663-73. 2007..To investigate the role of the collagen receptor discoidin domain receptor 2 (DDR-2) in the pathogenesis of osteoarthritis (OA)...
- Differential expression of GADD45beta in normal and osteoarthritic cartilage: potential role in homeostasis of articular chondrocytesKosei Ijiri
Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
Arthritis Rheum 58:2075-87. 2008..This study was undertaken, therefore, to investigate whether GADD45beta plays a role in adult articular cartilage...
- A novel role for GADD45beta as a mediator of MMP-13 gene expression during chondrocyte terminal differentiationKosei Ijiri
Beth Israel Deaconess Medical Center, New England Baptist Bone and Joint Institute, and Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 280:38544-55. 2005..These observations indicated that GADD45beta plays an essential role during chondrocyte terminal differentiation...
- Divergent responses of chondrocytes and endothelial cells to shear stress: cross-talk among COX-2, the phase 2 response, and apoptosisZachary R Healy
Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, MD 21218, USA
Proc Natl Acad Sci U S A 102:14010-5. 2005....
- Inhibitors of mitogen-activated protein kinases downregulate COX-2 expression in human chondrocytesRiina Nieminen
The Immunopharmacology Research Group, Medical School, University of Tampere, and Tampere University Hospital, Research Unit, Finland
Mediators Inflamm 2005:249-55. 2005....
- Are bone morphogenetic proteins effective inducers of cartilage repair? Ex vivo transduction of muscle-derived stem cellsMary B Goldring
Arthritis Rheum 54:387-9. 2006
- ESE-1 is a potent repressor of type II collagen gene (COL2A1) transcription in human chondrocytesHaibing Peng
Department of Medicine, Beth Israel Deaconess Medical Center, New England Baptist Bone and Joint Institute, Boston, Massachusetts, USA
J Cell Physiol 215:562-73. 2008..Intracellular ESE-1 staining in chondrocytes in cartilage from patients with osteoarthritis (OA), but not in normal cartilage, further suggests a fundamental role for ESE-1 in cartilage degeneration and suppression of repair...
- Selection of reliable reference genes for qPCR studies on chondroprotective actionStefan Toegel
Department of Pharmaceutical Technology and Biopharmaceutics, University of Vienna, Althanstrasse 14, A 1090 Vienna, Austria
BMC Mol Biol 8:13. 2007....
- Relationship between cartilage stiffness and dGEMRIC index: correlation and predictionMarta Baldassarri
New England Baptist Bone and Joint Institute, Boston, Massachusetts, USA
J Orthop Res 25:904-12. 2007..A generalized relationship was found to provide good correspondence across sources and regions. Use of the dGEMRIC index as a predictive measure of stiffness is possible, depending on the application's acceptable error...
- Endoglin is expressed on human chondrocytes and forms a heteromeric complex with betaglycan in a ligand and type II TGFbeta receptor independent mannerWendy L Parker
Division of Plastic Surgery, Department of Surgery, McGill University, Montreal, Quebec, Canada
J Bone Miner Res 18:289-302. 2003....
- Polyamine depletion inhibits apoptosis following blocking of survival pathways in human chondrocytes stimulated by tumor necrosis factor-alphaIvana Stanic
Dipartimento di Biochimica G. Moruzzi, University of Bologna, Bologna, Italy
J Cell Physiol 206:138-46. 2006..These results suggest that the intracellular depletion of polyamines in chondrocytes can inhibit both the death receptor pathway by reducing the level of procaspase-8, and the apoptotic mitochondrial pathway by activating Akt...
- CITED2-mediated regulation of MMP-1 and MMP-13 in human chondrocytes under flow shearHiroki Yokota
Biomedical Engineering Program, Indiana University Purdue University Indianapolis, Indianapolis, IN 46202, USA
J Biol Chem 278:47275-80. 2003..These results indicate that CITED2 plays a major role in shear-induced down-regulation of MMP-1 and MMP-13 via a transforming growth factor-beta-dependent pathway...
- Exploring the role of 5' alternative splicing and of the 3'-untranslated region of cathepsin B mRNARoman Zwicky
Institute of Biochemistry, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland
Biol Chem 384:1007-18. 2003..The increased biosynthetic rate and abnormal trafficking of cathepsin B observed in pathologies such as cancer and osteoarthritis may depend on alternative splicing of pre-mRNA...
- Responses to the proinflammatory cytokines interleukin-1 and tumor necrosis factor alpha in cells derived from rheumatoid synovium and other joint tissues involve nuclear factor kappaB-mediated induction of the Ets transcription factor ESE-1Franck Grall
New England Baptist Bone and Joint Institute, Beth Israel Deaconess Medical Center and Harvard Medical School, and Beth Israel Deaconess Medical Center Genomics Center, Boston, Massachusetts 02115, USA
Arthritis Rheum 48:1249-60. 2003..ESE-1 may play a role in mediating some effects of proinflammatory stimuli in cells at sites of inflammation...
- Egr-1 mediates transcriptional repression of COL2A1 promoter activity by interleukin-1betaLujian Tan
Rheumatology Division, Beth Israel Deaconess Medical Center and New England Baptist Bone and Joint Institute, Harvard Institutes of Medicine, Boston, Massachusetts 02115, USA
J Biol Chem 278:17688-700. 2003....
- The TATA-containing core promoter of the type II collagen gene (COL2A1) is the target of interferon-gamma-mediated inhibition in human chondrocytes: requirement for Stat1 alpha, Jak1 and Jak2Makoto Osaki
Beth Israel Deaconess Medical Center, Rheumatology Division, and New England Baptist Bone and Joint Institute, Harvard Institutes of Medicine, Boston, MA 02115, USA
Biochem J 369:103-15. 2003....
- Light-activated gene transduction enhances adeno-associated virus vector-mediated gene expression in human articular chondrocytesMichael Ulrich-Vinther
The Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, New York 14642, USA
Arthritis Rheum 46:2095-104. 2002..To evaluate the effects of ultraviolet (UV) light as an adjuvant for recombinant adeno-associated virus (rAAV) transduction in human articular chondrocytes...
- Cathepsin B expression and down-regulation by gene silencing and antisense DNA in human chondrocytesRoman Zwicky
Institute of Biochemistry, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
Biochem J 367:209-17. 2002....
- Production of interleukin-1 receptor antagonist by human articular chondrocytesGaby Palmer
Division of Rheumatology, University Hospital, Geneva, Switzerland
Arthritis Res 4:226-31. 2002..In conclusion, human articular chondrocytes produce sIL-1Ra in response to IL-1beta and IL-6. The production of sIL-1Ra by chondrocytes may have a protective effect against articular inflammatory and catabolic responses...
- WISP3-dependent regulation of type II collagen and aggrecan production in chondrocytesMalini Sen
University of California, San Diego, CA 92093 0663, USA
Arthritis Rheum 50:488-97. 2004..WISP3 mutations have been linked to progressive pseudorheumatoid dysplasia (PPRD). The present study was conducted to investigate whether WISP3 is responsible for the expression of cartilage-specific molecules...
- Immortalization of human articular chondrocytes for generation of stable, differentiated cell linesMary B Goldring
Division of Rheumatology, Beth Israel Deaconess Medical Center, New England Baptist Bone and Joint Institute, Harvard Institutes of Medicine, Boston, MA, USA
Methods Mol Med 100:23-36. 2004..Although immortalized chondrocytes should not be considered as substitutes for primary chondrocytes, they may be useful tools for evaluating and further validating mechanisms relevant to cartilage biology...
- Culture of immortalized chondrocytes and their use as models of chondrocyte functionMary B Goldring
Division of Rheumatology, Beth Israel Deaconess Medical Center, New England Baptist Bone and Joint Institute, Harvard Institutes of Medicine, Boston, MA, USA
Methods Mol Med 100:37-52. 2004..Thus, approaches for studying transcriptional regulation by transfection of promoter-driven reporter genes and cotransfection of expression vectors for wild-type or mutant proteins are also described...
- Human beta-defensin 3 mediates tissue remodeling processes in articular cartilage by increasing levels of metalloproteinases and reducing levels of their endogenous inhibitorsDeike Varoga
University Hospital Schleswig Holstein, Campus Kiel, Germany
Arthritis Rheum 52:1736-45. 2005..As a result of these findings, we undertook this study to investigate the production of human beta-defensin 3 (HBD-3) in OA cartilage and to determine its influence on chondrocyte function...
- Polyamine depletion inhibits NF-kappaB binding to DNA and interleukin-8 production in human chondrocytes stimulated by tumor necrosis factor-alphaAnnalisa Facchini
Dipartimento di Biochimica G Moruzzi, University of Bologna, Italy
J Cell Physiol 204:956-63. 2005....
- Divergent stress responses to IL-1beta, nitric oxide, and tunicamycin by chondrocytesBonnie L Oliver
Department of BioStructure and Function, School of Dental Medicine, University of Connecticut Heath Center, Farmington, Connecticut, USA
J Cell Physiol 204:45-50. 2005..On the other hand, exposure to high levels of intracellular nitric oxide induce chondrocyte apoptosis as part of the ER stress response...
- Phenotypic characterization of human chondrocyte cell line C-20/A4: a comparison between monolayer and alginate suspension cultureFlorian Finger
Osteoarticular and Arthritis Research, Department of Pathology, University of Erlangen-Nurnberg, Erlangen, Germany
Cells Tissues Organs 178:65-77. 2004..These results indicate that immortalized chondrocyte cell lines, rather than substituting for primary chondrocytes, may serve as models for extending findings on chondrocyte function not achievable by the use of primary chondrocytes...
- Production of endogenous antibiotics in articular cartilageDeike Varoga
Schleswig Holstein University and University Hospital, 24098 Kiel, Germany
Arthritis Rheum 50:3526-34. 2004..The present study was undertaken to investigate whether this may be explained by intraarticular production of gram-negative-specialized antimicrobial peptides...
- Activation of the discoidin domain receptor 2 induces expression of matrix metalloproteinase 13 associated with osteoarthritis in miceLin Xu
Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 280:548-55. 2005..The specific induction of MMP-13 by DDR2 in response to its cartilage-specific ligand, type II collagen, may contribute to cartilage damage in hereditary OA...
- Human chondrocyte cultures as models of cartilage-specific gene regulationMary B Goldring
Beth Israel Deaconess Medical Center, Department of Medicine, Division of Theumatology, New England Baptist Bone and Joint Institute, Harvard Institutes of Medicine, Boston, MA, USA
Methods Mol Med 107:69-95. 2005
- Endostatin/collagen XVIII--an inhibitor of angiogenesis--is expressed in cartilage and fibrocartilageThomas Pufe
Department of Anatomy, Christian Albrechts University, Olshausenstrasse 40, D 24098 Kiel, Germany
Matrix Biol 23:267-76. 2004..We observed a strong endostatin/collagen XVIII production in articular and fibrocartilage and an inhibitory potency concerning the VEGF-signalling pathway...
- Differentiation regulates interleukin-1beta-induced cyclo-oxygenase-2 in human articular chondrocytes: role of p38 mitogen-activated protein kinaseBéatrice Thomas
UPRES A CNRS 7079, Universite Pierre et Marie Curie, 7 quai Saint Bernard, 75252 Paris Cedex 05, France
Biochem J 362:367-73. 2002..Our results suggest that differentiated articular chondrocytes are highly responsive to IL-1beta and that p38 MAPK mediates this response by inducing COX-2 gene expression...
- Epigenetic Regulation of MMP-13MARY GOLDRING; Fiscal Year: 2007..The proposed studies will advance considerably our understanding about the importance of DNA methylation in the pathology of OA. ..
- Role of ESE1 Regulation of Type II Collagen in CartilageMARY GOLDRING; Fiscal Year: 2006..abstract_text> ..
- REGULATION OF MATRIX GENE EXPRESSION IN CHONDROCYTESMARY GOLDRING; Fiscal Year: 2001....
- ESE 1 a novel transcriptional regulator of cartilage remodelingMary B Goldring; Fiscal Year: 2010..These studies will provide understanding of molecular events underlying the initiation and progression and lead to the development of novel targeted therapies for OA due to trauma and aging. ..