G Girardi

Summary

Affiliation: Hospital for Special Surgery
Country: USA

Publications

  1. pmc Complement C3 activation is required for antiphospholipid antibody-induced fetal loss
    V Michael Holers
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Exp Med 195:211-20. 2002
  2. pmc Complement activation induces dysregulation of angiogenic factors and causes fetal rejection and growth restriction
    Guillermina Girardi
    Autoimmunity and Inflammation Program, Hospital for Special Surgery, Weill Medical College, Cornell University, New York, NY 10021, USA
    J Exp Med 203:2165-75. 2006
  3. ncbi request reprint Requirement of activation of complement C3 and C5 for antiphospholipid antibody-mediated thrombophilia
    Silvia S Pierangeli
    Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, Georgia 30310 1495, USA
    Arthritis Rheum 52:2120-4. 2005
  4. ncbi request reprint The complement system in the pathophysiology of pregnancy
    Guillermina Girardi
    Department of Medicine, Hospital for Special Surgery, Weill Medical College of Cornell University, New York, NY 10021, USA
    Mol Immunol 43:68-77. 2006
  5. pmc Antiphospholipid antibodies and pregnancy loss: a disorder of inflammation
    Jane E Salmon
    Autoimmunity and Inflammation Program, Hospital for Special Surgery, Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA
    J Reprod Immunol 77:51-6. 2008
  6. ncbi request reprint Heparin treatment in pregnancy loss: Potential therapeutic benefits beyond anticoagulation
    Guillermina Girardi
    Department of Medicine, Hospital for Special Surgery Weill Medical College of Cornell University, New York, NY 10021, USA
    J Reprod Immunol 66:45-51. 2005
  7. doi request reprint Guilty as charged: all available evidence implicates complement's role in fetal demise
    Guillermina Girardi
    Department of Medicine, Hospital for Special Surgery, Weill Medical College of Cornell University, New York, NY, USA
    Am J Reprod Immunol 59:183-92. 2008
  8. doi request reprint Pravastatin prevents miscarriages in antiphospholipid antibody-treated mice
    Guillermina Girardi
    Hospital for Special Surgery, Department of Medicine, Weill Medical College of Cornell University, New York, NY, USA
    J Reprod Immunol 82:126-31. 2009
  9. pmc Tissue factor in antiphospholipid antibody-induced pregnancy loss: a pro-inflammatory molecule
    G Girardi
    Department of Medicine, Hospital for Special Surgery, Weill Medical College of Cornell University, New York, USA
    Lupus 17:931-6. 2008
  10. doi request reprint Complement inhibition keeps mothers calm and avoids fetal rejection
    Guillermina Girardi
    Hospital for Special Surgery, Department of Medicine, Weill Medical College of Cornell University, NewYork, New York 10065, USA
    Immunol Invest 37:645-59. 2008

Collaborators

Detail Information

Publications26

  1. pmc Complement C3 activation is required for antiphospholipid antibody-induced fetal loss
    V Michael Holers
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Exp Med 195:211-20. 2002
    ..While antigenic epitopes recognized by aPL antibodies are important in the pathogenesis of APS, our data show that in vivo complement activation is required for aPL antibody-induced fetal loss and growth retardation...
  2. pmc Complement activation induces dysregulation of angiogenic factors and causes fetal rejection and growth restriction
    Guillermina Girardi
    Autoimmunity and Inflammation Program, Hospital for Special Surgery, Weill Medical College, Cornell University, New York, NY 10021, USA
    J Exp Med 203:2165-75. 2006
    ..These studies provide the first evidence linking the complement system to angiogenic factor imbalance associated with placental dysfunction, and identify a new effector of immune-triggered pregnancy complications...
  3. ncbi request reprint Requirement of activation of complement C3 and C5 for antiphospholipid antibody-mediated thrombophilia
    Silvia S Pierangeli
    Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, Georgia 30310 1495, USA
    Arthritis Rheum 52:2120-4. 2005
    ..In this study, we tested the hypothesis that aPL are responsible for activation of complement, thus generating split products that induce thrombosis...
  4. ncbi request reprint The complement system in the pathophysiology of pregnancy
    Guillermina Girardi
    Department of Medicine, Hospital for Special Surgery, Weill Medical College of Cornell University, New York, NY 10021, USA
    Mol Immunol 43:68-77. 2006
    ..The role played by the complement system in the fetal damage induced by anti-phospholipid antibodies in a mouse model will be examined...
  5. pmc Antiphospholipid antibodies and pregnancy loss: a disorder of inflammation
    Jane E Salmon
    Autoimmunity and Inflammation Program, Hospital for Special Surgery, Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA
    J Reprod Immunol 77:51-6. 2008
    ..These studies underscore the importance of inflammation in fetal injury associated with aPL antibodies and raise the importance of developing and testing targeted complement inhibitory therapy for patients with APS...
  6. ncbi request reprint Heparin treatment in pregnancy loss: Potential therapeutic benefits beyond anticoagulation
    Guillermina Girardi
    Department of Medicine, Hospital for Special Surgery Weill Medical College of Cornell University, New York, NY 10021, USA
    J Reprod Immunol 66:45-51. 2005
    ....
  7. doi request reprint Guilty as charged: all available evidence implicates complement's role in fetal demise
    Guillermina Girardi
    Department of Medicine, Hospital for Special Surgery, Weill Medical College of Cornell University, New York, NY, USA
    Am J Reprod Immunol 59:183-92. 2008
    ....
  8. doi request reprint Pravastatin prevents miscarriages in antiphospholipid antibody-treated mice
    Guillermina Girardi
    Hospital for Special Surgery, Department of Medicine, Weill Medical College of Cornell University, New York, NY, USA
    J Reprod Immunol 82:126-31. 2009
    ....
  9. pmc Tissue factor in antiphospholipid antibody-induced pregnancy loss: a pro-inflammatory molecule
    G Girardi
    Department of Medicine, Hospital for Special Surgery, Weill Medical College of Cornell University, New York, USA
    Lupus 17:931-6. 2008
    ..The identification of TF, acting as an important pro-inflammatory mediator in aPL-induced fetal injury, provides a new target for therapy to prevent pregnancy loss in the aPL syndrome...
  10. doi request reprint Complement inhibition keeps mothers calm and avoids fetal rejection
    Guillermina Girardi
    Hospital for Special Surgery, Department of Medicine, Weill Medical College of Cornell University, NewYork, New York 10065, USA
    Immunol Invest 37:645-59. 2008
    ....
  11. ncbi request reprint Activation of complement mediates antiphospholipid antibody-induced pregnancy loss
    J E Salmon
    Department of Medicine, Hospital for Special Surgery Weill Medical College, Cornell University, New York, NY 10021, USA
    Lupus 12:535-8. 2003
    ....
  12. doi request reprint Role of tissue factor in feto-maternal development: a xiphos
    G Girardi
    Department of Biology, York College CUNY, Jamaica, NY, USA
    J Thromb Haemost 9:250-6. 2011
    ..In addition, statins, which downregulate TF, may constitute a good therapeutic option for women with pregnancy complications. Clinical trials should be conducted to confirm these observations in women...
  13. pmc Complement activation as a mediator of antiphospholipid antibody induced pregnancy loss and thrombosis
    J E Salmon
    Department of Medicine, Hospital for Special Surgery Weill Medical College, Cornell University, New York 10021, USA
    Ann Rheum Dis 61:ii46-50. 2002
  14. ncbi request reprint The antiphospholipid syndrome as a disorder initiated by inflammation: implications for the therapy of pregnant patients
    Jane E Salmon
    Mary Kirkland Center for Lupus Research, New York, NY, USA
    Nat Clin Pract Rheumatol 3:140-7; quiz 1 p following 187. 2007
    ..This Review describes the potential mechanisms of tissue injury by antiphospholipid antibodies, the management of pregnant patients with APS and how heparin therapy might inhibit the pathogenic mediators of disease...
  15. pmc Tissue factor: a link between C5a and neutrophil activation in antiphospholipid antibody induced fetal injury
    Patricia Redecha
    Hospital for Special Surgery, Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA
    Blood 110:2423-31. 2007
    ..The identification of TF as an important mediator of C5a-induced oxidative burst in neutrophils in aPL-induced fetal injury provides a new target for therapy to prevent pregnancy loss in the antiphospholipid syndrome...
  16. pmc Theodore E. Woodward Award: antiphospholipid syndrome revisited: a disorder initiated by inflammation
    Jane E Salmon
    Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA
    Trans Am Clin Climatol Assoc 118:99-114. 2007
    ..Our studies underscore the importance of inflammation in fetal injury associated with aPL antibodies and emphasize the importance of developing and testing targeted complement inhibitory therapy for patients with APS...
  17. pmc Neutrophil activation by the tissue factor/Factor VIIa/PAR2 axis mediates fetal death in a mouse model of antiphospholipid syndrome
    Patricia Redecha
    Hospital for Special Surgery, Weill Medical College of Cornell University, New York, New York, USA
    J Clin Invest 118:3453-61. 2008
    ..Our results suggest that TF/FVIIa/PAR2 signaling mediates neutrophil activation and fetal death in APS and that statins may be a good treatment for women with aPL-induced pregnancy complications...
  18. ncbi request reprint Complement activation: a novel pathogenic mechanism in the antiphospholipid syndrome
    Silvia S Pierangeli
    Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, GA 30310 1495, USA
    Ann N Y Acad Sci 1051:413-20. 2005
    ..Our data show that complement activation mediates two important effectors of aPL antibodies: induction of thrombosis and endothelial activation...
  19. ncbi request reprint The role of complement in pregnancy and fetal loss
    Guillermina Girardi
    Department of Medicine, Hospital for Special Surgery, Weill Medical College of Cornell University, 535 East 70th Street, New York, NY 10021, USA
    Autoimmunity 36:19-26. 2003
    ....
  20. pmc Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome
    Guillermina Girardi
    Department of Medicine, Hospital for Special Surgery Weill Medical College, Cornell University, 535 East 70th Street, New York, New York 10021, USA
    J Clin Invest 112:1644-54. 2003
    ..Our findings identify the key innate immune effectors engaged by pathogenic autoantibodies that mediate poor pregnancy outcomes in APS and provide novel and important targets for prevention of pregnancy loss in APS...
  21. ncbi request reprint The role of complement in the antiphospholipid syndrome
    Jane E Salmon
    Department of Medicine, Hospital for Special Surgery Weill Medical College of Cornell University, New York, N Y, USA
    Curr Dir Autoimmun 7:133-48. 2004
    ....
  22. ncbi request reprint A novel inhibitor of the alternative complement pathway prevents antiphospholipid antibody-induced pregnancy loss in mice
    Joshua M Thurman
    Division of Nephrology and Hypertension, University of Colorado Health Sciences Center, 4200 E 9th Avenue, B 115, Denver, CO 80262, USA
    Mol Immunol 42:87-97. 2005
    ..The mAb protects mice in an in vivo model of antiphospholipid antibody syndrome, demonstrating the therapeutic potential for the inhibition of factor B in this disease...
  23. ncbi request reprint Heparin prevents antiphospholipid antibody-induced fetal loss by inhibiting complement activation
    Guillermina Girardi
    Department of Medicine, Hospital for Special Surgery and Weill Medical College, Cornell University, 535 East 70th Street, New York, New York 10021, USA
    Nat Med 10:1222-6. 2004
    ..Our data indicate that heparins prevent obstetrical complications in women with APS because they block activation of complement induced by aPL antibodies targeted to decidual tissues, rather than by their anticoagulant effects...
  24. ncbi request reprint TNF-alpha is a critical effector and a target for therapy in antiphospholipid antibody-induced pregnancy loss
    Jessica Berman
    Department of Medicine, Hospital for Special Surgery Weill Medical College of Cornell University, 535 East 70th Street, New York, NY 10021, USA
    J Immunol 174:485-90. 2005
    ..Our results suggest that TNF-alpha links pathogenic aPL Abs to fetal damage and identify TNF blockade as a potential therapy for the pregnancy complications of APS...
  25. ncbi request reprint Anti-phospholipid antibodies restore mesenteric ischemia/reperfusion-induced injury in complement receptor 2/complement receptor 1-deficient mice
    Sherry D Fleming
    Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
    J Immunol 173:7055-61. 2004
    ..We conclude that anti-phospholipid Abs can bind to tissues subjected to I/R insult and mediate tissue damage...
  26. pmc Fetal gene defects precipitate platelet-mediated pregnancy failure in factor V Leiden mothers
    Rashmi Sood
    Blood Research Institute, Blood Center of Wisconsin, Milwaukee, WI 53226, USA
    J Exp Med 204:1049-56. 2007
    ..e., thrombosis or pregnancy loss), depending on the vascular bed in which this interaction occurs...