CARL PETER BLOBEL

Summary

Affiliation: Hospital for Special Surgery
Country: USA

Publications

  1. ncbi request reprint ADAMs: key components in EGFR signalling and development
    Carl P Blobel
    Arthritis and Tissue Degeneration Program and Cell Biology Program, Hospital for Special Surgery, Weill Medical College of Cornell University, 535 East 70th Street, New York, New York 10021, USA
    Nat Rev Mol Cell Biol 6:32-43. 2005
  2. pmc Interleukin-1 stimulates ADAM17 through a mechanism independent of its cytoplasmic domain or phosphorylation at threonine 735
    Katherine C Hall
    Arthritis and Tissue Degeneration Program, The Hospital for Special Surgery, New York, New York, United States of America
    PLoS ONE 7:e31600. 2012
  3. pmc The role of protease activity in ErbB biology
    Carl P Blobel
    Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, Department of Medicine, Weil Medical College of Cornell University, New York, NY 10021, USA
    Exp Cell Res 315:671-82. 2009
  4. ncbi request reprint A novel regulatory role for stromal-derived factor-1 signaling in bone morphogenic protein-2 osteogenic differentiation of mesenchymal C2C12 cells
    Wei Zhu
    Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, New York, New York 10021, USA
    J Biol Chem 282:18676-85. 2007
  5. pmc Substrate selectivity of epidermal growth factor-receptor ligand sheddases and their regulation by phorbol esters and calcium influx
    Keisuke Horiuchi
    Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, New York, NY 10021, USA
    Mol Biol Cell 18:176-88. 2007
  6. pmc Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands
    Umut Sahin
    Cell Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, Box 368, 1275 York Avenue, New York, NY 10021, USA
    J Cell Biol 164:769-79. 2004
  7. ncbi request reprint Ectodomain shedding of the EGF-receptor ligand epigen is mediated by ADAM17
    Umut Sahin
    Arthritis and Tissue Degeneration Program, Caspary Research Building, Room 426, Hospital for Special Surgery, New York, NY 10021, USA
    FEBS Lett 581:41-4. 2007
  8. ncbi request reprint Metalloprotease-disintegrin ADAM8: expression analysis and targeted deletion in mice
    Kristine Kelly
    Cell Biology Program, Sloan Kettering Institute, New York, New York, USA
    Dev Dyn 232:221-31. 2005
  9. ncbi request reprint A sensitive method to monitor ectodomain shedding of ligands of the epidermal growth factor receptor
    Umut Sahin
    Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, Weill Medical College of Cornell University, New York, NY, USA
    Methods Mol Biol 327:99-113. 2006
  10. doi request reprint Characterization of the catalytic activity of the membrane-anchored metalloproteinase ADAM15 in cell-based assays
    Thorsten Maretzky
    Arthritis and Tissue Degeneration Program, Hospital for Special Surgery at Weill Medical College of Cornell University, 535 E 70th Street, New York, NY 10021, USA
    Biochem J 420:105-13. 2009

Research Grants

  1. Functional and biochemical studies of ADAM19
    Carl Blobel; Fiscal Year: 2005
  2. ADAMs: Key regulators of EGFR signaling
    Carl Blobel; Fiscal Year: 2007
  3. ADAMs: Key regulators of EGFR signaling
    Carl Blobel; Fiscal Year: 2009
  4. METALLOPROTEASE DISINTEGRIN MDC9
    Carl Blobel; Fiscal Year: 1999
  5. Role of ADAMs 9 and 15 in Proliferative Retinopathy
    Carl Blobel; Fiscal Year: 2009
  6. Functional and biochemical studies of ADAM19
    Carl Blobel; Fiscal Year: 2004
  7. METALLOPROTEASE DISINTEGRIN MDC9
    Carl Blobel; Fiscal Year: 2000
  8. Functional and biochemical studies of ADAM19
    Carl Blobel; Fiscal Year: 2003
  9. METALLOPROTEASE DISINTEGRIN MDC9
    Carl Blobel; Fiscal Year: 2001
  10. Role of ADAMs 9 and 15 in Proliferative Retinopathy
    Carl Blobel; Fiscal Year: 2007

Collaborators

  • Keisuke Horiuchi
  • Thomas Ludwig
  • Lawrence Lum
  • C M Overall
  • G Murphy
  • Wei Zhu
  • Andreas Ludwig
  • Wenhui Zhou
  • GRAHAM F CARPENTER
  • Shahin Rafii
  • Adele L Boskey
  • ROLAND E BARON
  • Shigeki Higashiyama
  • Lionel Ivashkiv
  • M Freeman
  • Peter Campochiaro
  • Barbara Hempstead
  • Gisela Weskamp
  • Steven Swendeman
  • Umut Sahin
  • Paul Saftig
  • Thorsten Maretzky
  • Karen Mendelson
  • Sylvain M Le Gall
  • Valerie Chesneau
  • Yufang Zheng
  • Katherine C Hall
  • Dieter Hartmann
  • Kristine Kelly
  • J David Becherer
  • Hong Ming Zhou
  • Katia Manova
  • Victor H Guaiquil
  • Victor Guaiquil
  • Claus Werner Franzke
  • Asheesh Harsha
  • Jörg W Bartsch
  • Atsuko Sehara-Fujisawa
  • Lucie Peduto
  • Johannes Schlondorff
  • Patricio Guaiquil
  • Tsunehiko Yoshida
  • Guangli Yang
  • Susanne Worpenberg
  • Joerg Eder
  • Dylan R Edwards
  • Leena Bruckner-Tuderman
  • Jörg Eder
  • Xiao Da Niu
  • Daniel Conrad
  • Daniel Lundell
  • David R Gibb
  • Ulrich Hassiepen
  • Ouathek Ouerfelli
  • Sai Chavala
  • Karina Reiss
  • Pierre Bobé
  • Xin Yun Huang
  • Susanne Worpenberg-Pietruk
  • Zaruhi Poghosyan
  • Marjana Tomic-Canic
  • Ulla Wewer
  • Cynthia A Loomis
  • Peggy Scherle
  • Andrea Hooper
  • Harold Brem
  • Olivera Stojadinovic
  • Urban Deutsch
  • Jamie Sturgill
  • Jill W Ford
  • Neil Broadway
  • Daniel H Conrad
  • Steve Martin
  • Andrew J P Docherty
  • Shelby Umland
  • Roy A Black
  • Andrea Rittger
  • Daniela Nebenius-Oosthuizen
  • David R Shaffer
  • Gillian Hutchinson
  • Howard I Scher
  • Victor E Reuter
  • Andrew J H Smith
  • Andy J P Docherty
  • Peter Fisher
  • Tae Wan Kim
  • Riccardo Chiusaroli
  • Jacques Peschon
  • Rebecca Hahn
  • Andrea Vortkamp

Detail Information

Publications27

  1. ncbi request reprint ADAMs: key components in EGFR signalling and development
    Carl P Blobel
    Arthritis and Tissue Degeneration Program and Cell Biology Program, Hospital for Special Surgery, Weill Medical College of Cornell University, 535 East 70th Street, New York, New York 10021, USA
    Nat Rev Mol Cell Biol 6:32-43. 2005
    ..Research on ADAMs and their role in protein ectodomain shedding is emerging as a fertile ground for gathering new insights into the functional regulation of membrane proteins...
  2. pmc Interleukin-1 stimulates ADAM17 through a mechanism independent of its cytoplasmic domain or phosphorylation at threonine 735
    Katherine C Hall
    Arthritis and Tissue Degeneration Program, The Hospital for Special Surgery, New York, New York, United States of America
    PLoS ONE 7:e31600. 2012
    ....
  3. pmc The role of protease activity in ErbB biology
    Carl P Blobel
    Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, Department of Medicine, Weil Medical College of Cornell University, New York, NY 10021, USA
    Exp Cell Res 315:671-82. 2009
    ..The former are the ADAM proteases and the latter are the gamma-secretase complex and the rhomboid proteases. This review discusses the roles of each of these protease systems within the ErbB system...
  4. ncbi request reprint A novel regulatory role for stromal-derived factor-1 signaling in bone morphogenic protein-2 osteogenic differentiation of mesenchymal C2C12 cells
    Wei Zhu
    Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, New York, New York 10021, USA
    J Biol Chem 282:18676-85. 2007
    ..Our data provide the first evidence for a co-requirement of the SDF-1/CXCR4 signaling axis in BMP2-induced osteogenic differentiation of C2C12 and ST2 cells and, thus, uncover a new potential target for modulation of osteogenesis...
  5. pmc Substrate selectivity of epidermal growth factor-receptor ligand sheddases and their regulation by phorbol esters and calcium influx
    Keisuke Horiuchi
    Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, New York, NY 10021, USA
    Mol Biol Cell 18:176-88. 2007
    ....
  6. pmc Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands
    Umut Sahin
    Cell Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, Box 368, 1275 York Avenue, New York, NY 10021, USA
    J Cell Biol 164:769-79. 2004
    ..Identification of EGFR ligand sheddases is a crucial step toward understanding the mechanism underlying ectodomain release, and has implications for designing novel inhibitors of EGFR-dependent tumors...
  7. ncbi request reprint Ectodomain shedding of the EGF-receptor ligand epigen is mediated by ADAM17
    Umut Sahin
    Arthritis and Tissue Degeneration Program, Caspary Research Building, Room 426, Hospital for Special Surgery, New York, NY 10021, USA
    FEBS Lett 581:41-4. 2007
    ..These results suggest that ADAM17 might be a good target to block the release of bioactive epigen, a highly mitogenic ligand of the EGFR which has been implicated in wound healing and cancer...
  8. ncbi request reprint Metalloprotease-disintegrin ADAM8: expression analysis and targeted deletion in mice
    Kristine Kelly
    Cell Biology Program, Sloan Kettering Institute, New York, New York, USA
    Dev Dyn 232:221-31. 2005
    ..Examination of Adam8-/- mice, however, revealed no major defects in these or other structures during development or in adult tissues and no evident pathological phenotypes...
  9. ncbi request reprint A sensitive method to monitor ectodomain shedding of ligands of the epidermal growth factor receptor
    Umut Sahin
    Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, Weill Medical College of Cornell University, New York, NY, USA
    Methods Mol Biol 327:99-113. 2006
    ..This chapter describes a sensitive and semiquantitative method to measure ectodomain shedding of EGFR ligands that was designed to facilitate studies of this process in cells...
  10. doi request reprint Characterization of the catalytic activity of the membrane-anchored metalloproteinase ADAM15 in cell-based assays
    Thorsten Maretzky
    Arthritis and Tissue Degeneration Program, Hospital for Special Surgery at Weill Medical College of Cornell University, 535 E 70th Street, New York, NY 10021, USA
    Biochem J 420:105-13. 2009
    ..A cell-based assay for the catalytic activity of ADAM15 could aid in identifying compounds, which could be used to block the function of ADAM15 in pathological neovascularization and cancer...
  11. pmc ADAMs 10 and 17 represent differentially regulated components of a general shedding machinery for membrane proteins such as transforming growth factor alpha, L-selectin, and tumor necrosis factor alpha
    Sylvain M Le Gall
    Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, New York, NY 10021, USA
    Mol Biol Cell 20:1785-94. 2009
    ..These results have general implications for understanding the substrate selectivity of two major cellular sheddases, ADAMs 10 and 17...
  12. ncbi request reprint Evidence for regulation of the tumor necrosis factor alpha-convertase (TACE) by protein-tyrosine phosphatase PTPH1
    Yufang Zheng
    Graduate Program in Physiology, Biophysics and Molecular Medicine, Weill Graduate School of Medical Science of Cornell University, New York, New York 10021, USA
    J Biol Chem 277:42463-70. 2002
    ..Taken together, these results suggest that PTPH1 may be a negative regulator of TACE levels and function, and thus provide the first evidence for the regulation of TACE through a cytoplasmic protein...
  13. ncbi request reprint Catalytic properties of ADAM19
    Valerie Chesneau
    Cellular Biochemistry and Biophysics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Biol Chem 278:22331-40. 2003
    ..The identification of potential in vitro substrates offers the basis for further functional studies of ADAM19 in cells and in mice...
  14. pmc Mice lacking the metalloprotease-disintegrin MDC9 (ADAM9) have no evident major abnormalities during development or adult life
    Gisela Weskamp
    Cellular Biochemistry and Biophysics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Mol Cell Biol 22:1537-44. 2002
    ....
  15. pmc Potential role for ADAM15 in pathological neovascularization in mice
    Keisuke Horiuchi
    Cellular Biochemistry and Biophysics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Mol Cell Biol 23:5614-24. 2003
    ..Since ADAM15 does not appear to be required for developmental angiogenesis or for adult homeostasis, it may represent a novel target for the design of inhibitors of pathological neovascularization...
  16. pmc Stimulation of platelet-derived growth factor receptor beta (PDGFRbeta) activates ADAM17 and promotes metalloproteinase-dependent cross-talk between the PDGFRbeta and epidermal growth factor receptor (EGFR) signaling pathways
    Karen Mendelson
    Arthritis and Tissue Degeneration Program, The Hospital for Special Surgery, New York, New York 10021, USA
    J Biol Chem 285:25024-32. 2010
    ..This study identifies the principal sheddase for the PDGFRbeta and provides new insights into the mechanism of PDGFRbeta-dependent signal transduction and cross-talk with the EGFR...
  17. ncbi request reprint Critical function for ADAM9 in mouse prostate cancer
    Lucie Peduto
    Department of Pathology, Memorial Sloan Kettering Cancer Center, NY 10021, USA
    Cancer Res 65:9312-9. 2005
    ..Taken together, these results suggest that ADAM9 contributes to the pathogenesis of prostate cancer and potentially also other carcinomas, raising the possibility that ADAM9 might be a good target for antitumor drugs...
  18. ncbi request reprint Evaluation of the contributions of ADAMs 9, 12, 15, 17, and 19 to heart development and ectodomain shedding of neuregulins beta1 and beta2
    Keisuke Horiuchi
    Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, Weill Medical College of Cornell University, New York, NY 10021, USA
    Dev Biol 283:459-71. 2005
    ..These results raise the possibility that ADAMs 9, 17, and 19 contribute to heart development in humans and have implications for understanding the mechanisms underlying congenital heart disease...
  19. ncbi request reprint Evidence for a critical role of the tumor necrosis factor alpha convertase (TACE) in ectodomain shedding of the p75 neurotrophin receptor (p75NTR)
    Gisela Weskamp
    Cell Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Biol Chem 279:4241-9. 2004
    ..Because ectodomain shedding of p75NTR releases a soluble ectodomain and could also be a prerequisite for its regulated intramembrane proteolysis, these findings may have important implications for the functional regulation of p75NTR...
  20. pmc ADAM8 is a negative regulator of retinal neovascularization and of the growth of heterotopically injected tumor cells in mice
    Victor H Guaiquil
    Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, Caspary Research Building, Room 426, 535 East 70th Street, New York, NY 10021, USA
    J Mol Med (Berl) 88:497-505. 2010
    ..On the other hand, blocking ADAM8 could be detrimental in the context of rapidly growing tumors...
  21. pmc Shedding of collagen XVII/BP180 in skin depends on both ADAM10 and ADAM9
    Claus Werner Franzke
    Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, New York, New York 10021, USA
    J Biol Chem 284:23386-96. 2009
    ..These results provide critical new insights into the identity and regulation of the major sheddases for collagen XVII in keratinocytes and skin and have implications for the treatment of blistering diseases of the skin...
  22. doi request reprint Src stimulates fibroblast growth factor receptor-2 shedding by an ADAM15 splice variant linked to breast cancer
    Thorsten Maretzky
    Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, and Department of Physiology, Weill Medical College of Cornell University, New York, New York 10021, USA
    Cancer Res 69:4573-6. 2009
    ....
  23. pmc ADAM9 is involved in pathological retinal neovascularization
    Victor Guaiquil
    Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021, USA
    Mol Cell Biol 29:2694-703. 2009
    ..Collectively, these results suggest that ADAM9 could be an attractive target for the prevention of proliferative retinopathies, CNV, and cancer...
  24. pmc VEGF-A stimulates ADAM17-dependent shedding of VEGFR2 and crosstalk between VEGFR2 and ERK signaling
    Steven Swendeman
    Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, Weill Medical College of Cornell University, New York, NY 10021, USA
    Circ Res 103:916-8. 2008
    ..Targeting the sheddases of VEGFR2 or NRP-1 might offer new opportunities to modulate VEGF-A signaling, an already-established target for treatment of pathological neovascularization...
  25. pmc ADAM12: a potential target for the treatment of chronic wounds
    Asheesh Harsha
    Arthritis and Tissue Degeneration Program, Hospital for Special Surgery at Weill Medical College of Cornell University, New York, NY, USA
    J Mol Med (Berl) 86:961-9. 2008
    ....
  26. ncbi request reprint ADAM10 is a principal 'sheddase' of the low-affinity immunoglobulin E receptor CD23
    Gisela Weskamp
    Arthritis and Tissue Degeneration Program, Hospital for Special Surgery and Department of Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
    Nat Immunol 7:1293-8. 2006
    ..Our findings provide a likely target for the treatment of allergic reactions and set the stage for further studies of the involvement of ADAM10 in CD23-dependent pathologies...
  27. pmc Essential role for ADAM19 in cardiovascular morphogenesis
    Hong Ming Zhou
    Cell Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Mol Cell Biol 24:96-104. 2004
    ..Most adam19(-/-) animals die perinatally, likely as a result of their cardiac defects. These findings raise the possibility that mutations in ADAM19 may contribute to human congenital heart valve and septal defects...

Research Grants22

  1. Functional and biochemical studies of ADAM19
    Carl Blobel; Fiscal Year: 2005
    ....
  2. ADAMs: Key regulators of EGFR signaling
    Carl Blobel; Fiscal Year: 2007
    ..Because EGFR-signaling has a crucial role in diseases such as cancer, we hope this work will uncover new targets for the design of drugs that can affect EGFR signaling. ..
  3. ADAMs: Key regulators of EGFR signaling
    Carl Blobel; Fiscal Year: 2009
    ..Because EGFR-signaling has a crucial role in diseases such as cancer, we hope this work will uncover new targets for the design of drugs that can affect EGFR signaling. ..
  4. METALLOPROTEASE DISINTEGRIN MDC9
    Carl Blobel; Fiscal Year: 1999
    ....
  5. Role of ADAMs 9 and 15 in Proliferative Retinopathy
    Carl Blobel; Fiscal Year: 2009
    ..abstract_text> ..
  6. Functional and biochemical studies of ADAM19
    Carl Blobel; Fiscal Year: 2004
    ....
  7. METALLOPROTEASE DISINTEGRIN MDC9
    Carl Blobel; Fiscal Year: 2000
    ....
  8. Functional and biochemical studies of ADAM19
    Carl Blobel; Fiscal Year: 2003
    ....
  9. METALLOPROTEASE DISINTEGRIN MDC9
    Carl Blobel; Fiscal Year: 2001
    ....
  10. Role of ADAMs 9 and 15 in Proliferative Retinopathy
    Carl Blobel; Fiscal Year: 2007
    ..abstract_text> ..
  11. Role of ADAMs 9 and 15 in Proliferative Retinopathy
    Carl Blobel; Fiscal Year: 2006
    ..abstract_text> ..
  12. ADAMs: Key regulators of EGFR signaling
    Carl Blobel; Fiscal Year: 2006
    ..Because EGFR-signaling has a crucial role in diseases such as cancer, we hope this work will uncover new targets for the design of drugs that can affect EGFR signaling. ..
  13. METALLOPROTEASE DISINTEGRIN MDC9
    Carl Blobel; Fiscal Year: 2002
    ....
  14. Functional and biochemical studies of ADAM19
    Carl Blobel; Fiscal Year: 2004
    ....
  15. Role of ADAMs 9 and 15 in Proliferative Retinopathy
    Carl Blobel; Fiscal Year: 2005
    ..abstract_text> ..
  16. ADAMs: Key regulators of EGFR signaling
    Carl Blobel; Fiscal Year: 2009
    ..Because EGFR-signaling has a crucial role in diseases such as cancer, we hope this work will uncover new targets for the design of drugs that can affect EGFR signaling. ..
  17. Role of ADAMs 9 and 15 in Proliferative Retinopathy
    Carl Blobel; Fiscal Year: 2004
    ..abstract_text> ..
  18. Role of ADAMs 9 and 15 in Proliferative Retinopathy
    Carl Blobel; Fiscal Year: 2004
    ..abstract_text> ..
  19. Functional and biochemical studies of ADAM19
    Carl Blobel; Fiscal Year: 2002
    ....
  20. Role of ADAMs 9 and 15 in Proliferative Retinopathy
    Carl Blobel; Fiscal Year: 2005
    ..abstract_text> ..