Samuel B Ho

Summary

Country: USA

Publications

  1. ncbi request reprint Characterization of the mouse Muc3 membrane bound intestinal mucin 5' coding and promoter regions: regulation by inflammatory cytokines
    Laurie L Shekels
    Department of Medicine, University of Minnesota and VA Medical Center, Research 151, 1 Veterans Drive, Minneapolis, MN 55417, USA
    Biochim Biophys Acta 1627:90-100. 2003
  2. ncbi request reprint Neutrophil elastase induces mucus cell metaplasia in mouse lung
    Judith A Voynow
    Department of Pediatrics, Duke University Medical Center, Box 2994, Durham, NC 27710, USA
    Am J Physiol Lung Cell Mol Physiol 287:L1293-302. 2004
  3. ncbi request reprint Prospective multicenter study of eligibility for antiviral therapy among 4,084 U.S. veterans with chronic hepatitis C virus infection
    Edmund J Bini
    VA New York Harbor Healthcare System and NYU School of Medicine, New York, New York 10010, USA
    Am J Gastroenterol 100:1772-9. 2005
  4. ncbi request reprint Alcohol use and treatment of hepatitis C virus: results of a national multicenter study
    Bhupinder S Anand
    Department of Medicine, Michael E DeBakey VA Medical Center, Houston, Texas, USA
    Gastroenterology 130:1607-16. 2006
  5. ncbi request reprint Clinical implications of hepatic steatosis in patients with chronic hepatitis C: a multicenter study of U.S. veterans
    Ke Qin Hu
    Loma Linda VA Medical Center, Loma Linda, CA, USA
    Dig Dis Sci 52:570-8. 2007
  6. pmc Intestinal goblet cells and mucins in health and disease: recent insights and progress
    Young S Kim
    Genemed Biotechnologies, 458 Carlton Court, South San Francisco, CA 94080, USA
    Curr Gastroenterol Rep 12:319-30. 2010
  7. pmc Activity of recombinant cysteine-rich domain proteins derived from the membrane-bound MUC17/Muc3 family mucins
    Samuel B Ho
    Department of Medicine, University of California San Diego, San Diego, CA, USA
    Biochim Biophys Acta 1800:629-38. 2010
  8. ncbi request reprint Cysteine-rich domains of muc3 intestinal mucin promote cell migration, inhibit apoptosis, and accelerate wound healing
    Samuel B Ho
    Department of Medicine, Veterans Affairs Medical Center and University of Minnesota, Minneapolis, Minnesota, USA
    Gastroenterology 131:1501-17. 2006
  9. pmc U.S. multicenter pilot study of daily consensus interferon (CIFN) plus ribavirin for "difficult-to-treat" HCV genotype 1 patients
    Samuel B Ho
    VA San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
    Dig Dis Sci 56:880-8. 2011
  10. ncbi request reprint Outcomes of a Hepatitis C screening program at a large urban VA medical center
    Holly Groom
    Department of Medicine, University of Minnesota, Minneapolis, MN, USA
    J Clin Gastroenterol 42:97-106. 2008

Detail Information

Publications48

  1. ncbi request reprint Characterization of the mouse Muc3 membrane bound intestinal mucin 5' coding and promoter regions: regulation by inflammatory cytokines
    Laurie L Shekels
    Department of Medicine, University of Minnesota and VA Medical Center, Research 151, 1 Veterans Drive, Minneapolis, MN 55417, USA
    Biochim Biophys Acta 1627:90-100. 2003
    ..TNF alpha and IFN gamma showed lesser stimulation. These data indicate that cytokines and growth factors are capable of regulating Muc3 gene expression, suggesting that this protein may play an active role in intestinal mucosal defense...
  2. ncbi request reprint Neutrophil elastase induces mucus cell metaplasia in mouse lung
    Judith A Voynow
    Department of Pediatrics, Duke University Medical Center, Box 2994, Durham, NC 27710, USA
    Am J Physiol Lung Cell Mol Physiol 287:L1293-302. 2004
    ..The addition of AAPV-CMK reduced these measures of inflammation to control levels. These experiments suggest that NE proteolytic activity initiates an inflammatory process leading to goblet cell metaplasia...
  3. ncbi request reprint Prospective multicenter study of eligibility for antiviral therapy among 4,084 U.S. veterans with chronic hepatitis C virus infection
    Edmund J Bini
    VA New York Harbor Healthcare System and NYU School of Medicine, New York, New York 10010, USA
    Am J Gastroenterol 100:1772-9. 2005
    ..The aims of this study were to determine the proportion of HCV-infected veterans who were eligible for interferon alfa and ribavirin therapy and to evaluate barriers to HCV treatment...
  4. ncbi request reprint Alcohol use and treatment of hepatitis C virus: results of a national multicenter study
    Bhupinder S Anand
    Department of Medicine, Michael E DeBakey VA Medical Center, Houston, Texas, USA
    Gastroenterology 130:1607-16. 2006
    ..The aim of the study was to determine the impact of alcohol use on HCV treatment outcomes...
  5. ncbi request reprint Clinical implications of hepatic steatosis in patients with chronic hepatitis C: a multicenter study of U.S. veterans
    Ke Qin Hu
    Loma Linda VA Medical Center, Loma Linda, CA, USA
    Dig Dis Sci 52:570-8. 2007
    ..We found that steatosis is independently associated with stage III-IV fibrosis. However, only HCV genotype, and not steatosis, obesity, or stage III-IV fibrosis, was associated with SVR to interferon alpha-2b and ribavirin treatment...
  6. pmc Intestinal goblet cells and mucins in health and disease: recent insights and progress
    Young S Kim
    Genemed Biotechnologies, 458 Carlton Court, South San Francisco, CA 94080, USA
    Curr Gastroenterol Rep 12:319-30. 2010
    ..Further elucidation of the regulatory mechanisms involved in mucin changes in cancer and inflammation may lead to the development of novel therapeutic approaches...
  7. pmc Activity of recombinant cysteine-rich domain proteins derived from the membrane-bound MUC17/Muc3 family mucins
    Samuel B Ho
    Department of Medicine, University of California San Diego, San Diego, CA, USA
    Biochim Biophys Acta 1800:629-38. 2010
    ..The purpose of this study was to determine the effect of size, recombinant host source, and external tags on mucin CRD1-L-CRD2 protein activity...
  8. ncbi request reprint Cysteine-rich domains of muc3 intestinal mucin promote cell migration, inhibit apoptosis, and accelerate wound healing
    Samuel B Ho
    Department of Medicine, Veterans Affairs Medical Center and University of Minnesota, Minneapolis, Minnesota, USA
    Gastroenterology 131:1501-17. 2006
    ..Muc3 intestinal mucin contains an extracellular cysteine-rich domain with 2 epidermal growth factor (EGF)-like motifs. The aim of this study was to determine the functional properties of Muc3 proteins...
  9. pmc U.S. multicenter pilot study of daily consensus interferon (CIFN) plus ribavirin for "difficult-to-treat" HCV genotype 1 patients
    Samuel B Ho
    VA San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
    Dig Dis Sci 56:880-8. 2011
    ..The purpose of this pilot study was to determine the efficacy and safety of daily CIFN + RBV for initial treatment of patients with HCV-1 infection...
  10. ncbi request reprint Outcomes of a Hepatitis C screening program at a large urban VA medical center
    Holly Groom
    Department of Medicine, University of Minnesota, Minneapolis, MN, USA
    J Clin Gastroenterol 42:97-106. 2008
    ..To determine the outcomes of implementing clinical care guidelines for Hepatitis C screening, evaluation, and treatment in a large urban Veterans Affairs Medical Center...
  11. pmc Human intestinal MUC17 mucin augments intestinal cell restitution and enhances healing of experimental colitis
    Ying Luu
    Department of Medicine, VA San Diego Healthcare System and University of California San Diego, 3350 La Jolla Village Drive, San Diego, CA 92161, United States
    Int J Biochem Cell Biol 42:996-1006. 2010
    ..The purpose of this study was to determine the functional activity of human MUC17 membrane-bound mucin...
  12. ncbi request reprint Suicidal ideation during interferon-alpha2b and ribavirin treatment of patients with chronic hepatitis C
    Eric Dieperink
    Department of Medicine, Veterans Affairs Medical Center, Minneapolis, MN, USA
    Gen Hosp Psychiatry 26:237-40. 2004
    ..No subjects attempted suicide. Although SI in some form is common in hepatitis C patients, in most cases it is mild in nature. With adequate support most patients can successfully complete a full course of antiviral treatment...
  13. doi request reprint The effect of pegylated interferon-alpha2b and ribavirin on posttraumatic stress disorder symptoms
    Eric Dieperink
    Dept of Psychiatry and the Hepatitis C Resource Center at the VA Medical Center, Minneapolis, MN 55417, USA
    Psychosomatics 49:225-9. 2008
    ..Patients with chronic psychiatric diagnoses have a prevalence of chronic hepatitis C (HCV) approximately 11 times higher than the general American population. Posttraumatic stress disorder (PTSD) is particularly common among HCV patients...
  14. doi request reprint Significant reductions in drinking following brief alcohol treatment provided in a hepatitis C clinic
    Eric Dieperink
    Minneapolis Hepatitis C Resource Center, Minneapolis VA Medical Center, University of Minnesota School of Medicine, Minnesota, USA
    Psychosomatics 51:149-56. 2010
    ..Although the hepatitis C virus (HCV) alone increases the risk of cirrhosis, alcohol use is thought to act synergistically with HCV to significantly hasten the development of fibrosis...
  15. ncbi request reprint Integrated psychiatric/medical care in a chronic hepatitis C clinic: effect on antiviral treatment evaluation and outcomes
    Astrid Knott
    Hepatitis C Resource Center, Veterans Affairs Medical Center, Minneapolis, Minnesota, USA
    Am J Gastroenterol 101:2254-62. 2006
    ..We evaluated the effect of integrating psychiatric and medical care on evaluation for and initiation of antiviral treatment in a cohort of 184 patients with chronic hepatitis C...
  16. pmc Cost-effectiveness of a mailed educational reminder to increase colorectal cancer screening
    Jeffrey K Lee
    Department of Medicine, VA San Diego Healthcare System and University of California San Diego, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
    BMC Gastroenterol 11:93. 2011
    ..2% among U.S. Veterans. The aim of our study was to assess the costs and cost-effectiveness of a mailed educational reminder on fecal occult blood test (FOBT) adherence...
  17. doi request reprint Development of the hepatitis C self-management program
    Erik J Groessl
    Health Services Research and Development, VA San Diego Healthcare System, San Diego, CA 92161, USA
    Patient Educ Couns 83:252-5. 2011
    ..Herein, we describe a recently developed self-management program designed to assist HCV-infected patients with adherence and improve their health-related quality of life (HRQOL)...
  18. ncbi request reprint Integrating hepatitis prevention services into a substance use disorder clinic
    Hildi Hagedorn
    Minneapolis Veterans Affairs Medical Center, Minneapolis, MN 55417, USA
    J Subst Abuse Treat 32:391-8. 2007
    ..The importance of providing comprehensive educational sessions and recommendations for how patients with substance use disorders can access hepatitis screening, vaccination, and treatment resources are stressed...
  19. pmc Muc17 protects intestinal epithelial cells from enteroinvasive E. coli infection by promoting epithelial barrier integrity
    Silvia Resta-Lenert
    Department of Medicine, University of California San Diego, USA
    Am J Physiol Gastrointest Liver Physiol 300:G1144-55. 2011
    ..In conclusion, these data suggest that both native and exogenous MUC17 play a role in attachment and invasion of EIEC in colonic cell lines and in maintaining epithelial barrier function...
  20. doi request reprint Long-term outcomes and prognostic factors for patients with endoscopy-negative iron deficiency
    Anny Soon
    Department of Medicine, Gastroenterology 111D, VA San Diego Healthcare System and University of California, San Diego, 3550 La Jolla Village Drive, San Diego, CA 92161, USA
    Dig Dis Sci 58:488-95. 2013
    ..The purpose of this study was to determine the long-term outcomes and predictors of gastrointestinal pathology and death in patients with endoscopy-negative IDA...
  21. doi request reprint National patterns and predictors of liver biopsy use for management of hepatitis C
    Erik J Groessl
    VA San Diego Healthcare System, San Diego, CA 92161, USA
    J Hepatol 57:252-9. 2012
    ..To identify the factors that influence the use of liver biopsy for HCV patients, we describe variations in liver biopsy use at the delivery system and patient level in a national VA sample...
  22. ncbi request reprint A prospective study of neuropsychiatric symptoms associated with interferon-alpha-2b and ribavirin therapy for patients with chronic hepatitis C
    Eric Dieperink
    Veterans Affairs Medical Center, Minneapolis, MN 55417, USA
    Psychosomatics 44:104-12. 2003
    ..The control group of 13 untreated subjects showed little change over the 24-week period. All symptom scales were highly intercorrelated, suggesting that use of one is sufficient for monitoring symptoms...
  23. doi request reprint Improving the effectiveness of fecal occult blood testing in a primary care clinic by direct colonoscopy referral for positive tests
    Erik Van Kleek
    University of California, San Diego, CA, USA
    J Healthc Qual 32:62-9. 2010
    ..Inappropriate use of FOBT was observed in 49% of patients, indicating that further interventions in primary care clinics to improve the quality of FOBT screening are necessary...
  24. pmc Improving fecal occult blood testing compliance using a mailed educational reminder
    Jeffrey K Lee
    Department of Medicine, VA San Diego Healthcare System and University of California, San Diego, CA 92161, USA
    J Gen Intern Med 24:1192-7. 2009
    ..Randomized controlled trials have shown that annual screening fecal occult blood testing (FOBT) reduces CRC mortality and incidence. However, patient compliance with FOBT is low...
  25. doi request reprint Management of chronic hepatitis C in veterans: the potential of integrated care models
    Samuel B Ho
    Department of Medicine, VA San Diego Healthcare System and University of California, San Diego, California 92161, USA
    Am J Gastroenterol 103:1810-23. 2008
    ....
  26. ncbi request reprint Organizational change in management of hepatitis C: evaluation of a CME program
    Judith Garrard
    Division of Health Services Research, School of Public Health, University of Minnesota, Minneapolis, MN 55455, USA
    J Contin Educ Health Prof 26:145-60. 2006
    ..We describe a continuing medical education (CME) program for clinicians in a nationwide health care system, with emphasis on current treatment practices, multispecialty collaboration, and organizational change...
  27. pmc Deficiency of intestinal mucin-2 ameliorates experimental alcoholic liver disease in mice
    Phillipp Hartmann
    Department of Medicine, University of California San Diego, La Jolla, CA, USA
    Hepatology 58:108-19. 2013
    ..Subsequently, lower amounts of bacterial products such as endotoxin translocate into the systemic circulation, decreasing liver disease...
  28. doi request reprint Increasing antiviral treatment through integrated hepatitis C care: a randomized multicenter trial
    Erik J Groessl
    VA San Diego Healthcare System, USA
    Contemp Clin Trials 35:97-107. 2013
    ..The Integrated Care intervention has the potential to transform HCV antiviral treatment by increasing the number of HCV-infected individuals that can be successfully treated. ..
  29. doi request reprint Quality of polyp resection during colonoscopy: are we achieving polyp clearance?
    Shanglei Liu
    Gastroenterology, Department of Medicine, VA San Diego Healthcare System and University of California, San Diego, San Diego, CA 92161, USA
    Dig Dis Sci 57:1786-91. 2012
    ..The primary aim of this study was to determine the incidence of an incomplete polyp resection despite a perceived complete polypectomy...
  30. pmc Living with hepatitis C: qualitative interviews with hepatitis C-infected veterans
    Erik J Groessl
    Health Services Research and Development, VA San Diego Healthcare System, San Diego, CA
    J Gen Intern Med 23:1959-65. 2008
    ..Chronic hepatitis C (HCV) infection affects millions of people in the USA and prevalence rates are higher in US veterans. The consequences of HCV infection include reduced quality of life, liver damage, and reduced longevity...
  31. ncbi request reprint Use of alveolar carbon monoxide to measure the effect of ribavirin on red blood cell survival
    Mark A Virtue
    Minneapolis Veterans Affairs Medical Center, Minneapolis, Minnesota 55417, USA
    Am J Hematol 76:107-13. 2004
    ..We conclude that RBV-associated anemia consistently is associated with reduced RBC survival as determined from breath CO measurements and that this reduced survival frequently is not associated with an elevated reticulocyte count...
  32. ncbi request reprint The adherent gastric mucous layer is composed of alternating layers of MUC5AC and MUC6 mucin proteins
    Samuel B Ho
    Department of Medicine, Veterans Affairs Medical Center, University of Minnesota, Minneapolis, Minnesota 55417, USA
    Dig Dis Sci 49:1598-606. 2004
    ..The physical stratification of mucin proteins may confer increased strength to the mucous layer or represent independent and redundant protection...
  33. ncbi request reprint Spectrum of disease in U.S. veteran patients with hepatitis C
    Huy A Nguyen
    Department of Medicine, Veterans Affairs Medical Center, University of Minnesota, Minneapolis 55417, USA
    Am J Gastroenterol 97:1813-20. 2002
    ..The purpose of this study was to examine the risk factors, psychiatric and substance abuse conditions, and severity of liver disease in veterans with HCV...
  34. pmc Glycosyltransferase function in core 2-type protein O glycosylation
    Erica L Stone
    Howard Hughes Medical Institute, Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California 92093, USA
    Mol Cell Biol 29:3770-82. 2009
    ..Although the absence of C2GnT and C4GnT activities is tolerable in vivo, core 2 O glycosylation exerts a significant influence on O-glycan biosynthesis and is important in multiple physiological processes...
  35. ncbi request reprint Evaluating follow-up of positive fecal occult blood test results: lessons learned
    Z John Chen
    Minnesota Gastroenterology, P A, Minneapolis, MN, USA
    J Healthc Qual 29:16-20, 34. 2007
    ..Primary care providers often lacked knowledge regarding appropriate follow-up testing. More direct follow-up of positive FOBT results is recommended...
  36. ncbi request reprint Quantification of colorectal cancer micrometastases in lymph nodes by nested and real-time reverse transcriptase-PCR analysis for carcinoembryonic antigen
    Samuel B Ho
    Departments of Medicine, Surgery, and Laboratory Medicine, Veterans Affairs Medical Center, Minneapolis, MN, USA
    Clin Cancer Res 10:5777-84. 2004
    ..These assays are not quantitative and can be confounded by false-positive results. The purpose of this study was to determine whether quantification of CEA in lymph nodes could more readily identify clinically relevant groups...
  37. ncbi request reprint Respiratory syncytial virus infection in the absence of STAT 1 results in airway dysfunction, airway mucus, and augmented IL-17 levels
    Koichi Hashimoto
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
    J Allergy Clin Immunol 116:550-7. 2005
    ....
  38. ncbi request reprint Efficacy of daily induction dosing vs standard thrice weekly dosing of interferon-alpha2B for initial treatment of chronic hepatitis C
    Hernando J Gonzalez
    Veterans Affairs Medical Center and the University of Minnesota, Minneapolis, 55417, USA
    Dig Dis Sci 47:784-92. 2002
    ..9%) in the induction group compared with 13/68 (19.1%) in the noninduction group. These results indicate that an initial four week period of daily interferon confers no benefit in the treatment of patients with chronic hepatitis C...
  39. pmc Optimizing the dose and duration of therapy for chronic hepatitis C
    Nipaporn Pichetshote
    Department of Medicine, Health Services Research and Development, VA San Diego Healthcare System, and University of California, San Diego, CA and Hepatitis C Resource Center, VA Medical Center, San Francisco, CA, USA
    Gut Liver 3:1-13. 2009
    ..Individualized treatment based on viral genotype, viral load, the presence of advanced fibrosis, and initial virologic response can improve therapy for some patients and save resources in others...
  40. pmc Expression of mucins in mucoid otitis media
    Jizhen Lin
    Department of Otolaryngology, Otitis Media Research Center, University of Minnesota School of Medicine, Minneapolis, MN 55455, USA
    J Assoc Res Otolaryngol 4:384-93. 2003
    ..Further study indicated that the mucin hyperproduction was significantly linked to CD4+ and CD8+ T cells and/or CD68+ monocyte macrophages. It suggests that MUC5B and MUC4 expression may be regulated by the products of these cells...
  41. ncbi request reprint Chronic hepatitis C in Latinos: natural history, treatment eligibility, acceptance, and outcomes
    Ramsey C Cheung
    VA Palo Alto Healthcare System and Stanford University School of Medicine, Palo Alto, California 94304, USA
    Am J Gastroenterol 100:2186-93. 2005
    ..The natural history of chronic hepatitis C and treatment response are different between blacks and Caucasians, but little comparable data is available about Latinos...
  42. ncbi request reprint Respiratory syncytial virus in allergic lung inflammation increases Muc5ac and gob-5
    Koichi Hashimoto
    Vanderbilt University, School of Medicine, Nashville, Tennessee 37232, USA
    Am J Respir Crit Care Med 170:306-12. 2004
    ..The impact of virus infection combined with allergic inflammation on mucus production may partially explain the more severe disease and airway hyperresponsiveness associated with RSV in the setting of atopy...
  43. pmc Differential immune responses and pulmonary pathophysiology are induced by two different strains of respiratory syncytial virus
    Nicholas W Lukacs
    Department of Pathology, University of Michigan Medical School, 1301 Catherine St, Ann Arbor, MI 48109 0602, USA
    Am J Pathol 169:977-86. 2006
    ..These data demonstrate that different RSV strains of the same antigenic subgroup can elicit differential immune responses that impact the phenotypic expression of RSV-induced illness...
  44. ncbi request reprint Selective induction of mucin-3 by hypoxia in intestinal epithelia
    Nancy A Louis
    Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    J Cell Biochem 99:1616-27. 2006
    ..Taken together, these studies implicate the HIF-1alpha mediated hypoxic induced expression of mucin 3 and associated ITF in the maintenance of intestinal barrier function under hypoxic conditions...
  45. ncbi request reprint Surveillance for hepatocellular carcinoma
    Bashar A Aqel
    Division of Gastroenterology and Hepatology, Hepatitis C Resource Center, Veterans Affairs Medical Center, University of Minnesota, Minneapolis 55417, USA
    Postgrad Med 119:19-24. 2006
  46. pmc Chronic exposure to beta-blockers attenuates inflammation and mucin content in a murine asthma model
    Long P Nguyen
    Department of Pharmacological and Pharmaceutical Sciences, University of Houston, College of Pharmacy, 4800 Calhoun, Houston, TX 77204 5037, USA
    Am J Respir Cell Mol Biol 38:256-62. 2008
    ..Similar to heart failure, our results provide a second disease model in which beta-blockers producing an acutely detrimental effect may provide a therapeutically beneficial effect with chronic administration...
  47. doi request reprint Can we predict the degree of fibrosis in chronic hepatitis C patients using routine blood tests in our daily practice?
    Ramsey C Cheung
    VA Palo Alto Healthcare System, Palo Alto, CA 94304, USA
    J Clin Gastroenterol 42:827-34. 2008
    ..To determine the validity of fibrosis indexes based on simple laboratory tests in daily practice...
  48. ncbi request reprint Expression of MUC2 and MUC4 proteins and cytokines: early markers of intestinal graft rejection
    Nir Wasserberg
    Department of Surgery, University of Miami School of Medicine, Miami, FL 33136, USA
    Transplantation 75:1249-55. 2003
    ..Alterations in mucin levels have been demonstrated in bowel diseases. The aim of this study was to detect early markers of intestinal graft rejection based on mucin and cytokine levels...