K J Tracey

Summary

Affiliation: Highway Safety North
Country: USA

Publications

  1. ncbi request reprint The vagus nerve and nicotinic receptors modulate experimental pancreatitis severity in mice
    David J van Westerloo
    Laboratory of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Gastroenterology 130:1822-30. 2006
  2. pmc Pharmacological stimulation of the cholinergic antiinflammatory pathway
    Thomas R Bernik
    Laboratory of Biomedical Science, North Shore LIJ Research Institute, 350 Community Drive, Manhasset, NY 11030, USA
    J Exp Med 195:781-8. 2002
  3. ncbi request reprint The inflammatory reflex
    Kevin J Tracey
    Laboratory of Biomedical Science, North Shore LIJ Research Institute, Manhasset, New York 11030, USA
    Nature 420:853-9. 2002
  4. ncbi request reprint The cholinergic anti-inflammatory pathway
    Valentin A Pavlov
    Laboratory of Biomedical Science, Institute for Medical Research North Shore LIJ Health System, Manhasset, NY 11030, USA
    Brain Behav Immun 19:493-9. 2005
  5. ncbi request reprint Mind over immunity
    K J Tracey
    Laboratory of Biomedical Science, North Shore University Hospital, New York University, Manhasset, New York 11030, USA
    FASEB J 15:1575-6. 2001
  6. ncbi request reprint Lethal weight loss: the focus shifts to signal transduction
    Kevin J Tracey
    North Shore Long Island Jewish Research Institute, Manhasset, NY 11020, USA
    Sci STKE 2002:pe21. 2002
  7. ncbi request reprint HMG-1 as a late mediator of endotoxin lethality in mice
    H Wang
    Department of Emergency Medicine and Department of Surgery, North Shore University Hospital New York University School of Medicine, Manhasset, NY 11030, USA
    Science 285:248-51. 1999
  8. ncbi request reprint Role of vagus nerve signaling in CNI-1493-mediated suppression of acute inflammation
    L V Borovikova
    The Picower Institute for Medical Research, Manhasset, NY 11030, USA
    Auton Neurosci 85:141-7. 2000
  9. pmc Spermine inhibition of monocyte activation and inflammation
    M Zhang
    The Picower Institute for Medical Research, Manhasset, New York 11030, USA
    Mol Med 5:595-605. 1999
  10. doi request reprint Cholinergic control of inflammation
    M Rosas-Ballina
    The Feinstein Institute for Medical Research, North Shore LIJ Health System, Manhasset, NY 11030, USA
    J Intern Med 265:663-79. 2009

Collaborators

Detail Information

Publications71

  1. ncbi request reprint The vagus nerve and nicotinic receptors modulate experimental pancreatitis severity in mice
    David J van Westerloo
    Laboratory of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Gastroenterology 130:1822-30. 2006
    ..This anti-inflammatory effect is mediated by an interaction of acetylcholine, the principal neurotransmitter of the vagus nerve, with macrophage cholinergic nicotinic receptors expressing the alpha7 subunit...
  2. pmc Pharmacological stimulation of the cholinergic antiinflammatory pathway
    Thomas R Bernik
    Laboratory of Biomedical Science, North Shore LIJ Research Institute, 350 Community Drive, Manhasset, NY 11030, USA
    J Exp Med 195:781-8. 2002
    ..Together, these results indicate that stimulation of the cholinergic antiinflammatory pathway by either pharmacological or electrical methods can attenuate the systemic inflammatory response to endotoxin-induced shock...
  3. ncbi request reprint The inflammatory reflex
    Kevin J Tracey
    Laboratory of Biomedical Science, North Shore LIJ Research Institute, Manhasset, New York 11030, USA
    Nature 420:853-9. 2002
    ..The opportunity now exists to apply this insight to the treatment of inflammation through selective and reversible 'hard-wired' neural systems...
  4. ncbi request reprint The cholinergic anti-inflammatory pathway
    Valentin A Pavlov
    Laboratory of Biomedical Science, Institute for Medical Research North Shore LIJ Health System, Manhasset, NY 11030, USA
    Brain Behav Immun 19:493-9. 2005
    ..We also discuss possible clinical implications of vagus nerve stimulation and cholinergic modalities in the treatment of inflammatory diseases...
  5. ncbi request reprint Mind over immunity
    K J Tracey
    Laboratory of Biomedical Science, North Shore University Hospital, New York University, Manhasset, New York 11030, USA
    FASEB J 15:1575-6. 2001
    ..This newly appreciated cholinergic anti-inflammatory pathway provides a neural substrate to study brain-immune interactions and might be harnessed for therapy of cytokine-mediated disease...
  6. ncbi request reprint Lethal weight loss: the focus shifts to signal transduction
    Kevin J Tracey
    North Shore Long Island Jewish Research Institute, Manhasset, NY 11020, USA
    Sci STKE 2002:pe21. 2002
    ..Furthermore, soluble factors including TNF and proteolysis-inducing factor may enhance protein degradation through the ubiquitin-proteosome pathway...
  7. ncbi request reprint HMG-1 as a late mediator of endotoxin lethality in mice
    H Wang
    Department of Emergency Medicine and Department of Surgery, North Shore University Hospital New York University School of Medicine, Manhasset, NY 11030, USA
    Science 285:248-51. 1999
    ..Septic patients who succumbed to infection had increased serum HMG-1 levels, suggesting that this protein warrants investigation as a therapeutic target...
  8. ncbi request reprint Role of vagus nerve signaling in CNI-1493-mediated suppression of acute inflammation
    L V Borovikova
    The Picower Institute for Medical Research, Manhasset, NY 11030, USA
    Auton Neurosci 85:141-7. 2000
    ..These results now identify a previously unrecognized role of efferent vagus nerve activity in mediating the central action of an anti-inflammatory agent...
  9. pmc Spermine inhibition of monocyte activation and inflammation
    M Zhang
    The Picower Institute for Medical Research, Manhasset, New York 11030, USA
    Mol Med 5:595-605. 1999
    ..Administration of BAP in vivo significantly augmented the development of carrageenan-induced paw edema and nitric oxide release. Thus, endogenous spermine normally inhibits the innate inflammatory response by restraining macrophages...
  10. doi request reprint Cholinergic control of inflammation
    M Rosas-Ballina
    The Feinstein Institute for Medical Research, North Shore LIJ Health System, Manhasset, NY 11030, USA
    J Intern Med 265:663-79. 2009
    ..We discuss potential therapeutic applications to treat diseases characterized by acute or chronic inflammation, including autoimmune diseases, and propose future research directions...
  11. ncbi request reprint HMG-1 rediscovered as a cytokine
    H Yang
    Laboratory of Biomedical Science, North Shore University Hospital, Manhasset, New York 11030, USA
    Shock 15:247-53. 2001
    ..When released by activated monocytes, it participates in the development of lethality and it activates downstream cytokine release. This review covers the general features of HMG-1 and its newly appreciated role as a cytokine...
  12. pmc Fetuin (alpha2-HS-glycoprotein) opsonizes cationic macrophagedeactivating molecules
    H Wang
    Department of Emergency Medicine, North Shore University Hospital New York University School of Medicine, Manhasset, NY 11030, USA
    Proc Natl Acad Sci U S A 95:14429-34. 1998
    ..g., spermine) and pharmacologic (e.g., CNI-1493). This role of fetuin as an opsonic participant in macrophage-deactivating mechanisms has implications for understanding and manipulating the innate immune response...
  13. ncbi request reprint Fetuin, a negative acute phase protein, attenuates TNF synthesis and the innate inflammatory response to carrageenan
    M Ombrellino
    Department of Surgery, North Shore University Hospital-New York University School of Medicine, Manhasset, New York 11030, USA
    Shock 15:181-5. 2001
    ..These results now reveal a previously unrecognized anti-inflammatory role of fetuin in counter-regulating the innate immune response, and suggest that it may be possible to use fetuin as an experimental anti-inflammatory agent...
  14. ncbi request reprint CNI-1493 attenuates hemodynamic and pro-inflammatory responses to LPS
    P E Molina
    Department of Surgery, North Shore University Hospital, Manhasset, New York 11030, USA
    Shock 10:329-34. 1998
    ..These results suggest diverse effects of CNI-1493 that are tissue specific and that confer protection against the hemodynamic and inflammatory responses to LPS...
  15. ncbi request reprint Autonomic neural regulation of immunity
    C J Czura
    North Shore LIJ Research Institute, Center for Patient Oriented Research, Manhasset, NY, USA
    J Intern Med 257:156-66. 2005
    ..The description of the cholinergic anti-inflammatory now brings to the fore several new therapeutic strategies for inflammatory disease, and suggests that many of these diseases may actually be diseases of autonomic dysfunction...
  16. ncbi request reprint Prevention and treatment of experimental autoimmune encephalomyelitis by CNI-1493, a macrophage-deactivating agent
    J A Martiney
    The Picower Institute for Medical Research, Manhasset, NY 11030, USA
    J Immunol 160:5588-95. 1998
    ..Moreover, drug treatment during the chronic phase resulted in amelioration of clinical signs. The data presented here should prove useful in developing novel chemotherapeutic approaches for the treatment of MS...
  17. ncbi request reprint Neural regulators of innate immune responses and inflammation
    V A Pavlov
    Laboratory of Biomedical Science, North Shore LIJ Research Institute, 350 Community Drive, Manhasset, New York 11030, USA
    Cell Mol Life Sci 61:2322-31. 2004
    ..The clinical implications of the recently discovered anti-inflammatory role of the efferent vagus nerve are also discussed...
  18. ncbi request reprint Extracellular role of HMGB1 in inflammation and sepsis
    H Wang
    Laboratory of Emergency Medicine, North Shore LIJ Research Institute, Manhasset, NY 11030, USA
    J Intern Med 255:320-31. 2004
    ..Strategies to inhibit HMGB1 activity and release are being investigated in these and other preclinical models of acute and chronic inflammation...
  19. ncbi request reprint Controlling inflammation: the cholinergic anti-inflammatory pathway
    V A Pavlov
    Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA
    Biochem Soc Trans 34:1037-40. 2006
    ....
  20. ncbi request reprint Dual roles for HMGB1: DNA binding and cytokine
    C J Czura
    Laboratory of Biomedical Science, North Shore/Long Island Jewish Research Institute, Manhasset, New York 11030, USA
    J Endotoxin Res 7:315-21. 2001
    ..The delayed kinetics of HMGB1 release indicate that it may be useful to target this toxic cytokine in the development of future therapies...
  21. ncbi request reprint Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin
    L V Borovikova
    The Picower Institute for Medical Research, Manhasset, New York 11030, USA
    Nature 405:458-62. 2000
    ..Direct electrical stimulation of the peripheral vagus nerve in vivo during lethal endotoxaemia in rats inhibited TNF synthesis in liver, attenuated peak serum TNF amounts, and prevented the development of shock...
  22. pmc Cholinergic agonists attenuate renal ischemia-reperfusion injury in rats
    M M Yeboah
    Laboratory of Medicinal Biochemistry, The Feinstein Institute for Medical Research, North Shore LIJ Health System, Manhasset, New York 11030, USA
    Kidney Int 74:62-9. 2008
    ..Cholinergic stimulation significantly decreased tubular necrosis in vagotomized rats after injury, implying an intact vagus nerve is not required for this renoprotective effect...
  23. doi request reprint HMGB1 mediates splenomegaly and expansion of splenic CD11b+ Ly-6C(high) inflammatory monocytes in murine sepsis survivors
    S I Valdes-Ferrer
    The Laboratory of Biomedical Sciences, The Feinstein Institute for Medical Research, Manhasset, NY, USA The Elmezzi Graduate School of Molecular Medicine, Manhasset, NY, USA
    J Intern Med 274:381-90. 2013
    ..To investigate the mechanisms underlying persistent functional impairment in sepsis survivors, here we developed a model to study severe sepsis survivors following cecal ligation and puncture (CLP)...
  24. ncbi request reprint Cholinergic antiinflammatory pathway inhibition of tumor necrosis factor during ischemia reperfusion
    Thomas R Bernik
    Division of Vascular Surgery, North Shore University, 300 Community Drive, Manhasset, NY 11030, USA
    J Vasc Surg 36:1231-6. 2002
    ..VNS protects against endotoxin-induced shock by inhibiting hepatic and cardiac synthesis of TNF. Here, the effects of VNS on suppression of ischemia-reperfusion injury and cytokine release were studied in a rat model of aortic occlusion...
  25. pmc Cholinergic stimulation blocks endothelial cell activation and leukocyte recruitment during inflammation
    Rubina W Saeed
    Laboratory of Medicinal Biochemistry, Institute for Medical Research at North Shore LIJ, Manhasset, NY 11030, USA
    J Exp Med 201:1113-23. 2005
    ..These findings identify the endothelium, a key regulator of leukocyte trafficking during inflammation, as a target of anti-inflammatory cholinergic mediators...
  26. ncbi request reprint Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation
    Hong Wang
    Laboratory of Biomedical Science, North Shore Long Island Jewish Research Institute, 350 Community Drive, Manhasset, New York 11030, USA
    Nature 421:384-8. 2003
    ..Thus, the nicotinic acetylcholine receptor alpha7 subunit is essential for inhibiting cytokine synthesis by the cholinergic anti-inflammatory pathway...
  27. pmc Central muscarinic cholinergic regulation of the systemic inflammatory response during endotoxemia
    Valentin A Pavlov
    Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA
    Proc Natl Acad Sci U S A 103:5219-23. 2006
    ..The role of central muscarinic receptors in activating the cholinergic antiinflammatory pathway is of interest for the use of centrally acting muscarinic cholinergic enhancers as antiinflammatory agents...
  28. pmc Fat meets the cholinergic antiinflammatory pathway
    Kevin J Tracey
    North Shore LIJ Research Institute, Manhassset, NY 11030, USA
    J Exp Med 202:1017-21. 2005
    ..Here we discuss this new data and its potential implications for dietary intervention in the treatment of inflammatory diseases...
  29. ncbi request reprint Suppressor alphabeta T lymphocytes control innate resistance to endotoxic shock
    Jessica Jones-Carson
    Departments of Medicine, and Microbiology, University of Colorado Health Sciences Center, Denver, USA
    J Infect Dis 192:1039-46. 2005
    ..These observations suggest that suppressor alphabeta T lymphocytes protect against the proinflammatory cascade unleashed during the innate stages of endotoxemia...
  30. pmc Role of HMGB1 in apoptosis-mediated sepsis lethality
    Shixin Qin
    Critical Therapeutics, Inc, Lexington, MA 02421, USA
    J Exp Med 203:1637-42. 2006
    ..Thus, our data indicate that HMGB1 production is downstream of apoptosis on the final common pathway to organ damage in severe sepsis...
  31. ncbi request reprint Elevated high-mobility group box 1 levels in patients with cerebral and myocardial ischemia
    Richard S Goldstein
    Department of Emergency Medicine, North Shore University Hospital, North Shore LIJ, Manhasset, NY 11030, USA
    Shock 25:571-4. 2006
    ..8+/-10.9 ng/mL, vs. cerebral ischemia serum HMGB1, 218+/-18.8 ng/mL; P<0.001). These results suggest that systemic HMGB1 levels are elevated in human ischemic disease...
  32. ncbi request reprint High mobility group box 1 (HMGB1)
    Huan Yang
    Laboratory of Biomedical Sciences, Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, NY, USA
    Crit Care Med 33:S472-4. 2005
  33. ncbi request reprint HMGB1 activates replication of latent HIV-1 in a monocytic cell-line, but inhibits HIV-1 replication in primary macrophages
    Piotr Nowak
    Division of Clinical Virology, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Cytokine 34:17-23. 2006
    ..Our data suggest that extracellular HMGB1 has a dichotomic effect on the HIV-1 infection in monocytes but not in lymphocytes. Both activation of latent HIV-1 infection and inhibition of active replication can thus be seen in vitro...
  34. ncbi request reprint High mobility group B1 protein suppresses the human plasmacytoid dendritic cell response to TLR9 agonists
    Petar J Popovic
    Division of Surgical Oncology, Department of Surgery and Molecular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15232, USA
    J Immunol 177:8701-7. 2006
    ..Our observations suggest that HMGB1 may play a critical role in regulating the immune response during chronic inflammation and tissue damage through modulation of PDC function...
  35. pmc Splenic nerve is required for cholinergic antiinflammatory pathway control of TNF in endotoxemia
    Mauricio Rosas-Ballina
    Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA
    Proc Natl Acad Sci U S A 105:11008-13. 2008
    ....
  36. pmc Modulation of TNF release by choline requires alpha7 subunit nicotinic acetylcholine receptor-mediated signaling
    William R Parrish
    Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, North Shore LIJ Health System, Manhasset, New York 11030, USA
    Mol Med 14:567-74. 2008
    ..Collectively, these data characterize the anti-inflammatory efficacy of choline and demonstrate that the modulation of TNF release by choline requires alpha7nAChR-mediated signaling...
  37. ncbi request reprint From CNI-1493 to the immunological homunculus: physiology of the inflammatory reflex
    Stacey L Oke
    Feinstein Institute for Medical Research, North Shore LIJ Health System, 350 Community Drive, Manhasset, NY 11030, USA
    J Leukoc Biol 83:512-7. 2008
    ..Receptor-ligand engagement suppresses proinflammatory cytokines and prevents tissue damage. Herein is a review of some of the experimental studies that define the inflammatory reflex and its anatomic and physiologic components...
  38. ncbi request reprint Transcutaneous vagus nerve stimulation reduces serum high mobility group box 1 levels and improves survival in murine sepsis
    Jared M Huston
    Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, Manhasset, NY 11030, USA
    Crit Care Med 35:2762-8. 2007
    ..Here we developed a method of transcutaneous mechanical vagus nerve stimulation and then investigated whether this therapy can protect mice against sepsis lethality...
  39. ncbi request reprint HMGB1 is a bone-active cytokine
    Jieping Yang
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Cell Physiol 214:730-9. 2008
    ..Our data suggest that apoptotic bone cells release HMGB1, that within the marrow HMGB1 is a bone resorption signal, and that intramembraneous and endochondral osteoblasts exhibit differential responses to this cytokine...
  40. ncbi request reprint Systemic inflammation and remote organ injury following trauma require HMGB1
    Ryan M Levy
    Dept of Surgery, F 1200 PUH, Univ of Pittsburgh, 200 Lothrop St, Pittsburgh, PA 15213, USA
    Am J Physiol Regul Integr Comp Physiol 293:R1538-44. 2007
    ..Collectively, these data demonstrate a critical role for a TLR4-HMGB1 pathway in the initiation of systemic inflammation and end-organ injury following isolated peripheral tissue injury...
  41. ncbi request reprint Aerobic exercise attenuates inducible TNF production in humans
    Richard P Sloan
    Division of Behavioral Medicine, Department of Psychiatry, Columbia University, New York, NY 10032, USA
    J Appl Physiol 103:1007-11. 2007
    ..001) decreases in TNF release only in the H group. These data suggest that in healthy young adults, a 12-wk high-intensity aerobic training program downregulates blood monocyte production of stimulated cytokine release...
  42. pmc Cholinergic anti-inflammatory pathway activity and High Mobility Group Box-1 (HMGB1) serum levels in patients with rheumatoid arthritis
    Richard S Goldstein
    The Feinstein Institute for Medical Research, and Department of Emergency Medicine, North Shore University Hospital, Manhasset, NY 11030, USA
    Mol Med 13:210-5. 2007
    ....
  43. pmc RR interval variability is inversely related to inflammatory markers: the CARDIA study
    Richard P Sloan
    Behavioral Medicine Program, Department of Psychiatry, Columbia University Medical Center, New York, NY 10032, USA
    Mol Med 13:178-84. 2007
    ..These findings are consistent with the hypothesis that diminished descending vagal anti-inflammatory signals can allow cytokine overproduction in humans...
  44. ncbi request reprint Selective alpha7-nicotinic acetylcholine receptor agonist GTS-21 improves survival in murine endotoxemia and severe sepsis
    Valentin A Pavlov
    Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, Manhasset, NY, USA
    Crit Care Med 35:1139-44. 2007
    ..Here we studied whether GTS-21, a selective alpha7-nicotinic acetylcholine receptor agonist, inhibits proinflammatory cytokines in vitro and in vivo and improves survival in murine endotoxemia and severe sepsis...
  45. pmc Physiology and immunology of the cholinergic antiinflammatory pathway
    Kevin J Tracey
    The Feinstein Institute for Medical Research, Manhasset, New York 11030, USA
    J Clin Invest 117:289-96. 2007
    ..Herein is a review of this physiological, functional anatomical mechanism for neurological regulation of cytokine-dependent disease that begins to define an immunological homunculus...
  46. ncbi request reprint HMGB1 signals through toll-like receptor (TLR) 4 and TLR2
    Man Yu
    Laboratories of Biomedical Science, The Feinstein Institute for Medical Research, Manhasset, NY 11030, USA
    Shock 26:174-9. 2006
    ..Taken together, our data suggest that there is a differential usage of TLR2 and TLR4 in HMGB1 signaling in primary cells and in established cell lines, adding complexity to studies of HMGB1 signaling which was not previously expected...
  47. ncbi request reprint It takes nerve to dampen inflammation
    Christine N Metz
    Nat Immunol 6:756-7. 2005
  48. pmc The cholinergic anti-inflammatory pathway: a missing link in neuroimmunomodulation
    Valentin A Pavlov
    Laboratory of Biomedical Science, North Shore LIJ Research Institute, Manhasset, NY 11030, USA
    Mol Med 9:125-34. 2003
    ..The clinical implications of this novel mechanism also are discussed...
  49. ncbi request reprint High mobility group box-1 as a therapeutic target downstream of tumor necrosis factor
    Christopher J Czura
    Laboratory of Biomedical Science, North Shore Long Island Jewish Research Institute, Manhasset, New York 11030, USA
    J Infect Dis 187:S391-6. 2003
    ..It will now be important to determine whether this wider window of activity can be translated into therapeutic advantage for human inflammatory disease...
  50. pmc Structural basis for the proinflammatory cytokine activity of high mobility group box 1
    Jianhua Li
    Laboratory of Biomedical Science, North Shore Long Island Jewish Research Institute, 350 Community Drive, Manhasset, NY 11030, USA
    Mol Med 9:37-45. 2003
    ..These results indicate that a proinflammatory domain of HMGB1 maps to the highly conserved DNA-binding B box, making this primary sequence a suitable target in the design of therapeutics...
  51. ncbi request reprint HMGB1 as a cytokine and therapeutic target
    Huan Yang
    Laboratory of Biomedical Science, North Shore Long Island Jewish Research Institute, Manhasset, New York 11030, USA
    J Endotoxin Res 8:469-72. 2002
    ..Thus, strategies that target HMGB1 with specific antibodies or antagonists have potential for treating lethal systemic inflammatory diseases characterized by excessive HMGB1 release...
  52. ncbi request reprint The gesture life of high mobility group box 1
    Steven G Friedman
    Division of Vascular Surgery, North Shore University Hospital, North Shore Long Island Jewish Research Institute, Manhasset, New York, USA
    Curr Opin Clin Nutr Metab Care 6:283-7. 2003
    ..Here, the authors review evidence that the chromosomal protein high mobility group box 1 is a late-acting, downstream mediator of pathological inflammation...
  53. ncbi request reprint IFN-gamma induces high mobility group box 1 protein release partly through a TNF-dependent mechanism
    Beatriz Rendon-Mitchell
    Center of Immunology and Inflammation, North Shore Long Island Jewish Research Institute, Manhasset, NY 11030, USA
    J Immunol 170:3890-7. 2003
    ..These data suggest that IFN-gamma plays an important role in the regulation of HMGB1 release through a TNF- and Janus kinase 2-dependent mechanism...
  54. ncbi request reprint Targeting high mobility group box 1 as a late-acting mediator of inflammation
    Christopher J Czura
    Laboratory of Biomedical Science, North Shore LIJ Research Institute, 350 Community Drive, Manhasset, NY 11030, USA
    Crit Care Med 31:S46-50. 2003
    ..A candidate mediator of delayed lethality is high mobility group box 1, a cellular and nuclear protein that is now recognized as a cytokine and experimental therapeutic target...
  55. ncbi request reprint HMGB1 as a DNA-binding cytokine
    Ulf Andersson
    Department of Medicine, Rheumatology Research Unit, Karolinska Hospital, Stockholm, Sweden
    J Leukoc Biol 72:1084-91. 2002
    ....
  56. pmc Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation
    Luis Ulloa
    Laboratory of Biomedical Science, North Shore LIJ Research Institute, 350 Community Drive, Manhasset, NY 11030, USA
    Proc Natl Acad Sci U S A 99:12351-6. 2002
    ..EP now warrants further evaluation as an experimental "rescue" therapeutic for sepsis and other potentially fatal systemic inflammatory disorders...
  57. ncbi request reprint HMGB-1, a DNA-binding protein with cytokine activity, induces brain TNF and IL-6 production, and mediates anorexia and taste aversion
    Davide Agnello
    Laboratory of Neuroimmunology, Mario Negri Institute for Pharmacological Research, 20157 Milano, Italy
    Cytokine 18:231-6. 2002
    ..In a model of endotoxemia, passive immunization with anti-HMG-1 antibodies attenuated the development of hypophagia, indicating that HMG-1 is a mediator of sickness behaviour associated with endotoxemia...
  58. ncbi request reprint Further characterization of high mobility group box 1 (HMGB1) as a proinflammatory cytokine: central nervous system effects
    Kevin A O'Connor
    Department of Psychology and Center for Neuroscience, University of Colorado, Boulder, CO 80309, USA
    Cytokine 24:254-65. 2003
    ..Nonetheless, these data suggest that HMGB1 may play a role as an endogenous pyrogen and support the concept that HMGB1 has proinflammatory characteristics within the central nervous system...
  59. ncbi request reprint HMGB1 in sepsis
    Ulf Andersson
    Department of Woman and Child Health, Karolinska Institutet, Astrid Lindgren Children s Hospital, Stockholm, Sweden
    Scand J Infect Dis 35:577-84. 2003
    ..Effectiveness of delayed treatment with HMGB1 blockade up to 24 h after induction of experimental sepsis offers a unique window of opportunities to allow rescue from lethal sepsis...
  60. ncbi request reprint Neural inhibition of inflammation: the cholinergic anti-inflammatory pathway
    Christopher J Czura
    Laboratory of Biomedical Science, North Shore LIJ Research Institute, Manhasset, NY 11030, USA
    J Endotoxin Res 9:409-13. 2003
    ..This newly identified physiological mechanism of maintaining immunological homeostasis suggests that novel therapeutics may effectively modulate inflammatory responses by activating the cholinergic anti-inflammatory pathway...
  61. ncbi request reprint The cholinergic anti-inflammatory pathway regulates the host response during septic peritonitis
    David J van Westerloo
    Laboratory of Experimental Internal Medicine and Department of Gastroenterology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Infect Dis 191:2138-48. 2005
    ..This anti-inflammatory effect is mediated by an interaction between acetylcholine, the principal neurotransmitter of the vagus nerve, and cholinergic nicotinic acetylcholine receptors on macrophages...
  62. ncbi request reprint Persistent elevation of high mobility group box-1 protein (HMGB1) in patients with severe sepsis and septic shock
    Jonas Sunden-Cullberg
    Department of Medicine, Center for Infectious Medicine, Karolinska Institute at Karolinska University Hospital Huddinge, Stockholm, Sweden
    Crit Care Med 33:564-73. 2005
    ....
  63. ncbi request reprint The cytokine activity of HMGB1
    Huan Yang
    Laboratory of Biomedical Science, Institute for Medical Research at North Shore Long Island Jewish System, Manhasset, NY 11030, USA
    J Leukoc Biol 78:1-8. 2005
    ..Finally, the therapeutic potential of blocking HMGB1 in the treatment of inflammatory diseases is discussed...
  64. ncbi request reprint Adrenomedullin and its binding protein attenuate the proinflammatory response after hemorrhage
    Xiaoxuan Cui
    Division of Surgical Research, North Shore University Hospital and Long Island Jewish Medical Center, Manhasset, NY, USA
    Crit Care Med 33:391-8. 2005
    ..We therefore hypothesized that administration of AM/AMBP-1 during fluid resuscitation in hemorrhaged animals (i.e., posttreatment) attenuates tissue injury and the proinflammatory response...
  65. ncbi request reprint Suppression of HMGB1 release by stearoyl lysophosphatidylcholine:an additional mechanism for its therapeutic effects in experimental sepsis
    Guoqian Chen
    Department of Emergency Medicine, North Shore University Hospital, New York University School of Medicine, Manhasset, NY 11030, USA
    J Lipid Res 46:623-7. 2005
    ..Thus, stearoyl LPC confers protection against lethal experimental sepsis partly by facilitating the elimination of the invading pathogens and partly by inhibiting endotoxin-induced release of a late proinflammatory cytokine, HMGB1...
  66. ncbi request reprint Ethanol blocks leukocyte recruitment and endothelial cell activation in vivo and in vitro
    Rubina W Saeed
    Laboratories of Medical Biochemistry, North Shore Long Island Jewish Research Institute, 350 Community Drive, Manhasset, NY 11030, USA
    J Immunol 173:6376-83. 2004
    ....
  67. ncbi request reprint Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis
    Hong Wang
    The Center for Immunology and Inflammation, North Shore LIJ Research Institute, North Shore University Hospital, 350 Community Drive, Manhasset, New York 11030, USA
    Nat Med 10:1216-21. 2004
    ....
  68. ncbi request reprint Bacterial endotoxin stimulates macrophages to release HMGB1 partly through CD14- and TNF-dependent mechanisms
    Guoqian Chen
    Department of Emergency Medicine, North Shore University Hospital, New York University School of Medicine, 350 Community Drive, Manhasset, NY 11030, USA
    J Leukoc Biol 76:994-1001. 2004
    ..g., 10 ng/ml). Taken together, these data suggest that LPS stimulates macrophages to release HMGB1 partly through CD14- and TNF-dependent mechanisms...
  69. ncbi request reprint HMGB1 in the immunology of sepsis (not septic shock) and arthritis
    Christopher J Czura
    Laboratory of Biomedical Science, North Shore LIJ Research Institute, Manhasset, New York, USA
    Adv Immunol 84:181-200. 2004
  70. ncbi request reprint Human genetics: an inflammatory issue
    Kevin J Tracey
    Nature 429:35-7. 2004
  71. ncbi request reprint Globin attenuates the innate immune response to endotoxin
    Huan Yang
    Laboratory of Biomedical Science, North Shore University Hospital New York University School of Medicine, New York 11030, USA
    Shock 17:485-90. 2002
    ..Thus, the heme-iron moiety of hemoglobin, and not the binding of LPS to globin, enhanced macrophage responses to LPS...