Douglas M Heuman

Summary

Country: USA

Publications

  1. ncbi request reprint Persistent ascites and low serum sodium identify patients with cirrhosis and low MELD scores who are at high risk for early death
    Douglas M Heuman
    Department of Medicine, Virginia Commonwealth University School of Medicine, Richmond, VA, USA
    Hepatology 40:802-10. 2004
  2. pmc Differential impact of hyponatremia and hepatic encephalopathy on health-related quality of life and brain metabolite abnormalities in cirrhosis
    Vishwadeep Ahluwalia
    Radiology, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, VA, USA
    J Hepatol 59:467-73. 2013
  3. pmc Asymmetric dimethylarginine is strongly associated with cognitive dysfunction and brain MR spectroscopic abnormalities in cirrhosis
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, VA 23249, USA
    J Hepatol 58:38-44. 2013
  4. pmc Cognitive performance as a predictor of hepatic encephalopathy in pretransplant patients with cirrhosis receiving psychoactive medications: a prospective study
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology, and Nutrition, Virginia Commonwealth University McGuire VA Medical Center, Richmond, VA 23249, USA
    Liver Transpl 18:1179-87. 2012
  5. pmc Driving simulation can improve insight into impaired driving skills in cirrhosis
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, 1201 Broad Rock Boulevard, Richmond, VA 23249, USA
    Dig Dis Sci 57:554-60. 2012
  6. doi request reprint A longitudinal systems biology analysis of lactulose withdrawal in hepatic encephalopathy
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, 23249, USA
    Metab Brain Dis 27:205-15. 2012
  7. pmc Rifaximin improves driving simulator performance in a randomized trial of patients with minimal hepatic encephalopathy
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, Virginia 23249, USA
    Gastroenterology 140:478-487.e1. 2011
  8. pmc Minimal hepatic encephalopathy is associated with motor vehicle crashes: the reality beyond the driving test
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, VA 23221, USA
    Hepatology 50:1175-83. 2009
  9. pmc The Stroop smartphone application is a short and valid method to screen for minimal hepatic encephalopathy
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology, and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, VA, USA
    Hepatology 58:1122-32. 2013
  10. pmc Colonic mucosal microbiome differs from stool microbiome in cirrhosis and hepatic encephalopathy and is linked to cognition and inflammation
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University, Richmond, 23249, USA
    Am J Physiol Gastrointest Liver Physiol 303:G675-85. 2012

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Persistent ascites and low serum sodium identify patients with cirrhosis and low MELD scores who are at high risk for early death
    Douglas M Heuman
    Department of Medicine, Virginia Commonwealth University School of Medicine, Richmond, VA, USA
    Hepatology 40:802-10. 2004
    ....
  2. pmc Differential impact of hyponatremia and hepatic encephalopathy on health-related quality of life and brain metabolite abnormalities in cirrhosis
    Vishwadeep Ahluwalia
    Radiology, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, VA, USA
    J Hepatol 59:467-73. 2013
    ..We aimed at studying the effect of hyponatremia on cognition, HRQOL, and brain MR spectroscopy (MRS) independent of HE...
  3. pmc Asymmetric dimethylarginine is strongly associated with cognitive dysfunction and brain MR spectroscopic abnormalities in cirrhosis
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, VA 23249, USA
    J Hepatol 58:38-44. 2013
    ..We aimed at evaluating the association of ADMA with cognition and brain MR spectroscopy (MRS) in cirrhosis...
  4. pmc Cognitive performance as a predictor of hepatic encephalopathy in pretransplant patients with cirrhosis receiving psychoactive medications: a prospective study
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology, and Nutrition, Virginia Commonwealth University McGuire VA Medical Center, Richmond, VA 23249, USA
    Liver Transpl 18:1179-87. 2012
    ..In conclusion, cognitive tests (particularly the ICT) remain valid predictors of HE in the face of psychiatric diseases and medications. SSRI use is associated with better cognitive performance and a reduced likelihood of developing HE...
  5. pmc Driving simulation can improve insight into impaired driving skills in cirrhosis
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, 1201 Broad Rock Boulevard, Richmond, VA 23249, USA
    Dig Dis Sci 57:554-60. 2012
    ..Minimal hepatic encephalopathy (MHE) is associated with poor driving skills and insight. Increasing insight may improve receptiveness for therapy or driving restrictions...
  6. doi request reprint A longitudinal systems biology analysis of lactulose withdrawal in hepatic encephalopathy
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, 23249, USA
    Metab Brain Dis 27:205-15. 2012
    ..HE recurrence post-lactulose withdrawal can be predicted by baseline cognitive performance and is accompanied by disrupted choline metabolism...
  7. pmc Rifaximin improves driving simulator performance in a randomized trial of patients with minimal hepatic encephalopathy
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, Virginia 23249, USA
    Gastroenterology 140:478-487.e1. 2011
    ..We evaluated whether performance on a driving simulator improves in patients with MHE after treatment with rifaximin...
  8. pmc Minimal hepatic encephalopathy is associated with motor vehicle crashes: the reality beyond the driving test
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, VA 23221, USA
    Hepatology 50:1175-83. 2009
    ..03) but MHESPT did not. MHEICT (Odds ratio: 4.51) and prior year crash/violation (Odds ratio: 2.96) were significantly associated with future crash/violation occurrence...
  9. pmc The Stroop smartphone application is a short and valid method to screen for minimal hepatic encephalopathy
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology, and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, VA, USA
    Hepatology 58:1122-32. 2013
    ..App result patterns were similar between the centers. Test-retest reliability in controls and those without previous OHE was good; a learning effect on Ontime in patients with cirrhosis without previous OHE was noted...
  10. pmc Colonic mucosal microbiome differs from stool microbiome in cirrhosis and hepatic encephalopathy and is linked to cognition and inflammation
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University, Richmond, 23249, USA
    Am J Physiol Gastrointest Liver Physiol 303:G675-85. 2012
    ....
  11. doi request reprint Effect of hyponatraemia on outcomes following orthotopic liver transplantation
    William A Hackworth
    Liver Transplant Program, Hume Lee Transplant Center, Virginia Commonwealth University Medical Center, Richmond, VA, USA
    Liver Int 29:1071-7. 2009
    ..Aims: To assess impact of pretransplant hyponatraemia on post-transplant outcomes...
  12. pmc The multi-dimensional burden of cirrhosis and hepatic encephalopathy on patients and caregivers
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology, and Nutrition, Virginia Commonwealth University, McGuire VA Medical Center, Richmond, Virginia 23249, USA
    Am J Gastroenterol 106:1646-53. 2011
    ..The aim was to study the emotional and socioeconomic burden of cirrhosis and HE on patients and informal caregivers...
  13. pmc Diagnosis and treatment of minimal hepatic encephalopathy to prevent motor vehicle accidents: a cost-effectiveness analysis
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, VA 23249, USA
    Hepatology 55:1164-71. 2012
    ..Conclusion: Detection of MHE, especially using the ICT, and subsequent treatment with lactulose could substantially reduce societal costs by preventing MVAs...
  14. pmc Persistence of cognitive impairment after resolution of overt hepatic encephalopathy
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology, and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, Virginia 23249, USA
    Gastroenterology 138:2332-40. 2010
    ..In patients with cirrhosis, hepatic encephalopathy (HE) has acute but reversible as well as chronic components. We investigated the extent of residual cognitive impairment following clinical resolution of overt HE (OHE)...
  15. ncbi request reprint MELD-XI: a rational approach to "sickest first" liver transplantation in cirrhotic patients requiring anticoagulant therapy
    Douglas M Heuman
    Virginia Commonwealth University Health System, Richmond, VA, USA
    Liver Transpl 13:30-7. 2007
    ..In patients treated with oral anticoagulants, substitution of MELD-XI for MELD may permit more accurate assessment of risk and more rational assignment of "sickest first" priority for LT...
  16. doi request reprint Surveillance for hepatocellular carcinoma in patients with cirrhosis improves outcome
    Richard Todd Stravitz
    Section of Hepatology, Hume Lee Transplant Center of Virginia Commonwealth University, Richmond, VA 23298 0341, USA
    Am J Med 121:119-26. 2008
    ..We hypothesized that the quality of surveillance for hepatocellular carcinoma influences prognosis by affecting access to liver transplantation...
  17. pmc Altered profile of human gut microbiome is associated with cirrhosis and its complications
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, VA, United States Electronic address
    J Hepatol 60:940-7. 2014
    ..We aimed to study changes in the microbiome over cirrhosis severity, its stability over time and its longitudinal alterations with decompensation...
  18. pmc Linkage of gut microbiome with cognition in hepatic encephalopathy
    Jasmohan S Bajaj
    Div of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth Univ and McGuire VA Medical Ctr, 1201, Broad Rock Blvd, Richmond, VA 23249, USA
    Am J Physiol Gastrointest Liver Physiol 302:G168-75. 2012
    ..Specific bacterial families (Alcaligeneceae, Porphyromonadaceae, Enterobacteriaceae) are strongly associated with cognition and inflammation in HE...
  19. ncbi request reprint High-density lipoprotein cholesterol as an indicator of liver function and prognosis in noncholestatic cirrhotics
    Adil Habib
    Department of Medicine, Virginia Commonwealth University Health Systems, Richmond, Virginia, USA
    Clin Gastroenterol Hepatol 3:286-91. 2005
    ..The liver plays a central role in production and degradation of lipoproteins. Declining lipoprotein cholesterol may reflect deteriorating liver function...
  20. doi request reprint The effect of fatigue on driving skills in patients with hepatic encephalopathy
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, Virginia 23249, USA
    Am J Gastroenterol 104:898-905. 2009
    ..Hepatic encephalopathy, both overt (OHE) and minimal (MHE), is associated with poor quality of life and fatigue. The aim of this study was to define the effect of fatigue on driving skills in MHE and OHE patients...
  21. doi request reprint Association of proton pump inhibitor therapy with spontaneous bacterial peritonitis in cirrhotic patients with ascites
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, McGuire VA Medical Center, Virginia Commonwealth University, Richmond, Virginia 23221, USA
    Am J Gastroenterol 104:1130-4. 2009
    ..The aim of this study was to determine whether PPI use in cirrhotics with ascites is associated with SBP...
  22. pmc Modulation of the fecal bile acid profile by gut microbiota in cirrhosis
    Genta Kakiyama
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, VA 23249, United States
    J Hepatol 58:949-55. 2013
    ..We aimed at studying the linkage between fecal BAs and gut microbiota in cirrhosis since this could help understand cirrhosis progression...
  23. ncbi request reprint Safety of an immune-enhancing nutrition supplement in cirrhotic patients with history of encephalopathy
    Souheil G Abou-Assi
    Department of Medicine, Virginia Commonwealth University Health System and McGuire Veteran Affairs Medical Center, Richmond, VA 23236, USA
    JPEN J Parenter Enteral Nutr 30:91-6. 2006
    ..Further studies are justified to assess potential efficacy of long-term IENS in preventing infection and slowing progression in advanced cirrhosis...
  24. ncbi request reprint Mikulicz syndrome associated with a malignant large cell gastric lymphoma: a case report and review of the literature
    Anastasios A Mihas
    Division of Gastroenterology, Virginia Commonwealth University Health System and the McGuire Veterans Affairs Medical Center, Richmond, Virginia 23249, USA
    Int J Gastrointest Cancer 33:123-7. 2003
    ....
  25. pmc Effect of obstructive sleep apnea on the sleep architecture in cirrhosis
    Matthew R Kappus
    Division of Gastroenterology, Hepatology, and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, VA 23249, USA
    J Clin Sleep Med 9:247-51. 2013
    ..We aimed to evaluate the additional effect of cirrhosis with and without prior HE on the sleep architecture and perceived sleep disturbances of OSA patients...
  26. doi request reprint Should a radiological diagnosis of hepatocellular carcinoma be routinely confirmed by a biopsy? No
    Douglas M Heuman
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and Hunter Holmes McGuire Department of Veterans Affairs Medical Center, Richmond, VA 23249, USA
    Eur J Intern Med 23:37-9. 2012
    ..Biopsy for assessment of tumor molecular markers is promising but remains investigational. When diagnosis of HCC is clinically evident by imaging criteria, tumor biopsy should not be required prior to initiating treatment...
  27. doi request reprint Coronary events in patients undergoing orthotopic liver transplantation: perioperative evaluation and management
    Asghar Ali
    Department of Medicine, Virginia Commonwealth University, Richmond, VA 23249, USA
    Clin Transplant 27:E207-15. 2013
    ..Thorough screening and optimal management of underlying cardiovascular pathology and cardiovascular risk factors should decrease the incidence of new cardiac events in liver transplant recipients...
  28. pmc 25-Hydroxycholesterol-3-sulfate attenuates inflammatory response via PPARγ signaling in human THP-1 macrophages
    Leyuan Xu
    Department of Medicine, Virginia Commonwealth University, Richmond, VA 23249, USA
    Am J Physiol Endocrinol Metab 302:E788-99. 2012
    ..We conclude that 25HC3S acts in macrophages as a PPARγ ligand and suppresses inflammatory responses via the PPARγ/IκB/NF-κB signaling pathway...
  29. ncbi request reprint Effects of interferon treatment on liver histology and allograft rejection in patients with recurrent hepatitis C following liver transplantation
    R Todd Stravitz
    Section of Hepatology, Medical College of Virginia of Virginia Commonwealth University, Richmond, VA 23298 0341, USA
    Liver Transpl 10:850-8. 2004
    ..In conclusion, interferon treatment of recurrent hepatitis C does not consistently improve histologic disease after virologic response, and it may increase the risk of allograft rejection...
  30. ncbi request reprint Fructose diphosphate attenuates the acetaminophen-induced liver injury in the rat evidence for involvement of nitric oxide
    Anastasios A Mihas
    Department of Medicine, University of Mississippi Medical Center Jackson, Mississippi, USA
    Res Commun Mol Pathol Pharmacol 113:253-66. 2003
    ..Pretreatment of the animals with the iNOS inhibitor L-NAME abolished this hepatoprotection. These findings suggest that FDP protects against acetaminophen-induced liver injury, at least partly, by stimulating production of nitric oxide...
  31. ncbi request reprint Utility of the MELD score for assessing 3-month survival in patients with liver cirrhosis: one more positive answer
    Douglas M Heuman
    Gastroenterology 125:992-3; author reply 994-5. 2003