Douglas M Heuman

Summary

Country: USA

Publications

  1. ncbi Persistent ascites and low serum sodium identify patients with cirrhosis and low MELD scores who are at high risk for early death
    Douglas M Heuman
    Department of Medicine, Virginia Commonwealth University School of Medicine, Richmond, VA, USA
    Hepatology 40:802-10. 2004
  2. ncbi Driving simulation can improve insight into impaired driving skills in cirrhosis
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, 1201 Broad Rock Boulevard, Richmond, VA 23249, USA
    Dig Dis Sci 57:554-60. 2012
  3. ncbi A longitudinal systems biology analysis of lactulose withdrawal in hepatic encephalopathy
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, 23249, USA
    Metab Brain Dis 27:205-15. 2012
  4. ncbi Rifaximin improves driving simulator performance in a randomized trial of patients with minimal hepatic encephalopathy
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, Virginia 23249, USA
    Gastroenterology 140:478-487.e1. 2011
  5. ncbi Minimal hepatic encephalopathy is associated with motor vehicle crashes: the reality beyond the driving test
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, VA 23221, USA
    Hepatology 50:1175-83. 2009
  6. ncbi Colonic mucosal microbiome differs from stool microbiome in cirrhosis and hepatic encephalopathy and is linked to cognition and inflammation
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University, Richmond, 23249, USA
    Am J Physiol Gastrointest Liver Physiol 303:G675-85. 2012
  7. ncbi The multi-dimensional burden of cirrhosis and hepatic encephalopathy on patients and caregivers
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology, and Nutrition, Virginia Commonwealth University, McGuire VA Medical Center, Richmond, Virginia 23249, USA
    Am J Gastroenterol 106:1646-53. 2011
  8. ncbi Effect of hyponatraemia on outcomes following orthotopic liver transplantation
    William A Hackworth
    Liver Transplant Program, Hume Lee Transplant Center, Virginia Commonwealth University Medical Center, Richmond, VA, USA
    Liver Int 29:1071-7. 2009
  9. ncbi Diagnosis and treatment of minimal hepatic encephalopathy to prevent motor vehicle accidents: a cost-effectiveness analysis
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, VA 23249, USA
    Hepatology 55:1164-71. 2012
  10. ncbi Asymmetric dimethylarginine is strongly associated with cognitive dysfunction and brain MR spectroscopic abnormalities in cirrhosis
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, VA 23249, USA
    J Hepatol 58:38-44. 2013

Collaborators

Detail Information

Publications25

  1. ncbi Persistent ascites and low serum sodium identify patients with cirrhosis and low MELD scores who are at high risk for early death
    Douglas M Heuman
    Department of Medicine, Virginia Commonwealth University School of Medicine, Richmond, VA, USA
    Hepatology 40:802-10. 2004
    ....
  2. ncbi Driving simulation can improve insight into impaired driving skills in cirrhosis
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, 1201 Broad Rock Boulevard, Richmond, VA 23249, USA
    Dig Dis Sci 57:554-60. 2012
    ..Minimal hepatic encephalopathy (MHE) is associated with poor driving skills and insight. Increasing insight may improve receptiveness for therapy or driving restrictions...
  3. ncbi A longitudinal systems biology analysis of lactulose withdrawal in hepatic encephalopathy
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, 23249, USA
    Metab Brain Dis 27:205-15. 2012
    ..HE recurrence post-lactulose withdrawal can be predicted by baseline cognitive performance and is accompanied by disrupted choline metabolism...
  4. ncbi Rifaximin improves driving simulator performance in a randomized trial of patients with minimal hepatic encephalopathy
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, Virginia 23249, USA
    Gastroenterology 140:478-487.e1. 2011
    ..We evaluated whether performance on a driving simulator improves in patients with MHE after treatment with rifaximin...
  5. ncbi Minimal hepatic encephalopathy is associated with motor vehicle crashes: the reality beyond the driving test
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, VA 23221, USA
    Hepatology 50:1175-83. 2009
    ..ICT, but not SPT performance is significantly associated with prior and future crashes and violations. There was an excellent agreement between self- and DOT-reports...
  6. ncbi Colonic mucosal microbiome differs from stool microbiome in cirrhosis and hepatic encephalopathy and is linked to cognition and inflammation
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University, Richmond, 23249, USA
    Am J Physiol Gastrointest Liver Physiol 303:G675-85. 2012
    ....
  7. ncbi The multi-dimensional burden of cirrhosis and hepatic encephalopathy on patients and caregivers
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology, and Nutrition, Virginia Commonwealth University, McGuire VA Medical Center, Richmond, Virginia 23249, USA
    Am J Gastroenterol 106:1646-53. 2011
    ..The aim was to study the emotional and socioeconomic burden of cirrhosis and HE on patients and informal caregivers...
  8. ncbi Effect of hyponatraemia on outcomes following orthotopic liver transplantation
    William A Hackworth
    Liver Transplant Program, Hume Lee Transplant Center, Virginia Commonwealth University Medical Center, Richmond, VA, USA
    Liver Int 29:1071-7. 2009
    ..Aims: To assess impact of pretransplant hyponatraemia on post-transplant outcomes...
  9. ncbi Diagnosis and treatment of minimal hepatic encephalopathy to prevent motor vehicle accidents: a cost-effectiveness analysis
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, VA 23249, USA
    Hepatology 55:1164-71. 2012
    ..Conclusion: Detection of MHE, especially using the ICT, and subsequent treatment with lactulose could substantially reduce societal costs by preventing MVAs...
  10. ncbi Asymmetric dimethylarginine is strongly associated with cognitive dysfunction and brain MR spectroscopic abnormalities in cirrhosis
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, VA 23249, USA
    J Hepatol 58:38-44. 2013
    ..We aimed at evaluating the association of ADMA with cognition and brain MR spectroscopy (MRS) in cirrhosis...
  11. ncbi Persistence of cognitive impairment after resolution of overt hepatic encephalopathy
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology, and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, Virginia 23249, USA
    Gastroenterology 138:2332-40. 2010
    ..In patients with cirrhosis, hepatic encephalopathy (HE) has acute but reversible as well as chronic components. We investigated the extent of residual cognitive impairment following clinical resolution of overt HE (OHE)...
  12. ncbi MELD-XI: a rational approach to "sickest first" liver transplantation in cirrhotic patients requiring anticoagulant therapy
    Douglas M Heuman
    Virginia Commonwealth University Health System, Richmond, VA, USA
    Liver Transpl 13:30-7. 2007
    ..In patients treated with oral anticoagulants, substitution of MELD-XI for MELD may permit more accurate assessment of risk and more rational assignment of "sickest first" priority for LT...
  13. ncbi Cognitive performance as a predictor of hepatic encephalopathy in pretransplant patients with cirrhosis receiving psychoactive medications: a prospective study
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology, and Nutrition, Virginia Commonwealth University McGuire VA Medical Center, Richmond, VA 23249, USA
    Liver Transpl 18:1179-87. 2012
    ..In conclusion, cognitive tests (particularly the ICT) remain valid predictors of HE in the face of psychiatric diseases and medications. SSRI use is associated with better cognitive performance and a reduced likelihood of developing HE...
  14. ncbi Surveillance for hepatocellular carcinoma in patients with cirrhosis improves outcome
    Richard Todd Stravitz
    Section of Hepatology, Hume Lee Transplant Center of Virginia Commonwealth University, Richmond, VA 23298 0341, USA
    Am J Med 121:119-26. 2008
    ..We hypothesized that the quality of surveillance for hepatocellular carcinoma influences prognosis by affecting access to liver transplantation...
  15. ncbi Linkage of gut microbiome with cognition in hepatic encephalopathy
    Jasmohan S Bajaj
    Div of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth Univ and McGuire VA Medical Ctr, 1201, Broad Rock Blvd, Richmond, VA 23249, USA
    Am J Physiol Gastrointest Liver Physiol 302:G168-75. 2012
    ..Specific bacterial families (Alcaligeneceae, Porphyromonadaceae, Enterobacteriaceae) are strongly associated with cognition and inflammation in HE...
  16. ncbi The effect of fatigue on driving skills in patients with hepatic encephalopathy
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, Virginia 23249, USA
    Am J Gastroenterol 104:898-905. 2009
    ..Hepatic encephalopathy, both overt (OHE) and minimal (MHE), is associated with poor quality of life and fatigue. The aim of this study was to define the effect of fatigue on driving skills in MHE and OHE patients...
  17. ncbi High-density lipoprotein cholesterol as an indicator of liver function and prognosis in noncholestatic cirrhotics
    Adil Habib
    Department of Medicine, Virginia Commonwealth University Health Systems, Richmond, Virginia, USA
    Clin Gastroenterol Hepatol 3:286-91. 2005
    ..CONCLUSIONS: HDL cholesterol in noncholestatic cirrhotic patients is a liver function test and an indicator of prognosis...
  18. ncbi Association of proton pump inhibitor therapy with spontaneous bacterial peritonitis in cirrhotic patients with ascites
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, McGuire VA Medical Center, Virginia Commonwealth University, Richmond, Virginia 23221, USA
    Am J Gastroenterol 104:1130-4. 2009
    ..The aim of this study was to determine whether PPI use in cirrhotics with ascites is associated with SBP...
  19. ncbi Safety of an immune-enhancing nutrition supplement in cirrhotic patients with history of encephalopathy
    Souheil G Abou-Assi
    Department of Medicine, Virginia Commonwealth University Health System and McGuire Veteran Affairs Medical Center, Richmond, VA 23236, USA
    JPEN J Parenter Enteral Nutr 30:91-6. 2006
    ..Further studies are justified to assess potential efficacy of long-term IENS in preventing infection and slowing progression in advanced cirrhosis...
  20. ncbi Mikulicz syndrome associated with a malignant large cell gastric lymphoma: a case report and review of the literature
    Anastasios A Mihas
    Division of Gastroenterology, Virginia Commonwealth University Health System and the McGuire Veterans Affairs Medical Center, Richmond, Virginia 23249, USA
    Int J Gastrointest Cancer 33:123-7. 2003
    ....
  21. ncbi Should a radiological diagnosis of hepatocellular carcinoma be routinely confirmed by a biopsy? No
    Douglas M Heuman
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and Hunter Holmes McGuire Department of Veterans Affairs Medical Center, Richmond, VA 23249, USA
    Eur J Intern Med 23:37-9. 2012
    ..Biopsy for assessment of tumor molecular markers is promising but remains investigational. When diagnosis of HCC is clinically evident by imaging criteria, tumor biopsy should not be required prior to initiating treatment...
  22. ncbi 25-Hydroxycholesterol-3-sulfate attenuates inflammatory response via PPARγ signaling in human THP-1 macrophages
    Leyuan Xu
    Department of Medicine, Virginia Commonwealth University, Richmond, VA 23249, USA
    Am J Physiol Endocrinol Metab 302:E788-99. 2012
    ..We conclude that 25HC3S acts in macrophages as a PPARγ ligand and suppresses inflammatory responses via the PPARγ/IκB/NF-κB signaling pathway...
  23. ncbi Effects of interferon treatment on liver histology and allograft rejection in patients with recurrent hepatitis C following liver transplantation
    R Todd Stravitz
    Section of Hepatology, Medical College of Virginia of Virginia Commonwealth University, Richmond, VA 23298 0341, USA
    Liver Transpl 10:850-8. 2004
    ..In conclusion, interferon treatment of recurrent hepatitis C does not consistently improve histologic disease after virologic response, and it may increase the risk of allograft rejection...
  24. ncbi Fructose diphosphate attenuates the acetaminophen-induced liver injury in the rat evidence for involvement of nitric oxide
    Anastasios A Mihas
    Department of Medicine, University of Mississippi Medical Center Jackson, Mississippi, USA
    Res Commun Mol Pathol Pharmacol 113:253-66. 2003
    ..Pretreatment of the animals with the iNOS inhibitor L-NAME abolished this hepatoprotection. These findings suggest that FDP protects against acetaminophen-induced liver injury, at least partly, by stimulating production of nitric oxide...
  25. ncbi Utility of the MELD score for assessing 3-month survival in patients with liver cirrhosis: one more positive answer
    Douglas M Heuman
    Gastroenterology 125:992-3; author reply 994-5. 2003