Xiao Ping Yang

Summary

Affiliation: Henry Ford Hospital
Country: USA

Publications

  1. pmc Role of inflammation in the development of renal damage and dysfunction in angiotensin II-induced hypertension
    Tang Dong Liao
    Hypertension and Vascular Research Division, Henry Ford Hospital, 2799 West Grand Blvd, Detroit MI 48202 2689, USA
    Hypertension 52:256-63. 2008
  2. pmc Effects of cardiac overexpression of the angiotensin II type 2 receptor on remodeling and dysfunction in mice post-myocardial infarction
    Jiang Xu
    Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, E and R 7081, 2799 W Grand Boulevard, Detroit, MI 48202 2689
    Hypertension 63:1251-9. 2014
  3. ncbi request reprint Endothelial nitric oxide gene knockout mice: cardiac phenotypes and the effect of angiotensin-converting enzyme inhibitor on myocardial ischemia/reperfusion injury
    X P Yang
    Hypertension and Vascular Research Division, Henry Ford Hospital, Detroit, MI, USA
    Hypertension 34:24-30. 1999
  4. ncbi request reprint Echocardiographic assessment of cardiac function in conscious and anesthetized mice
    X P Yang
    Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, Detroit, Michigan 48202, USA
    Am J Physiol 277:H1967-74. 1999
  5. ncbi request reprint Diminished cardioprotective response to inhibition of angiotensin-converting enzyme and angiotensin II type 1 receptor in B(2) kinin receptor gene knockout mice
    X P Yang
    Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, Detroit, MI 48202, USA
    Circ Res 88:1072-9. 2001
  6. pmc Estrogen, hormonal replacement therapy and cardiovascular disease
    Xiao Ping Yang
    Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, 2799 West Grand Boulevard, Detroit, MI 48202 2689, USA
    Curr Opin Nephrol Hypertens 20:133-8. 2011
  7. ncbi request reprint Role of the B1 kinin receptor in the regulation of cardiac function and remodeling after myocardial infarction
    Jiang Xu
    Hypertension and Vascular Research Division, Henry Ford Hospital, Detroit, Mich 48202 2689, USA
    Hypertension 45:747-53. 2005
  8. ncbi request reprint Role of AT2 receptors in the cardioprotective effect of AT1 antagonists in mice
    Jiang Xu
    Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, Detroit, Mich 48202 2689, USA
    Hypertension 40:244-50. 2002
  9. ncbi request reprint Dual inhibition of ACE and NEP provides greater cardioprotection in mice with heart failure
    Jiang Xu
    Hypertension and Vascular Research Division, Henry Ford Hospital, 2799 West Grand Boulevard, Detroit, MI 48202 2689, USA
    J Card Fail 10:83-9. 2004
  10. pmc Local angiotensin II aggravates cardiac remodeling in hypertension
    Jiang Xu
    Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, Detroit, Michigan 48202 2689, USA
    Am J Physiol Heart Circ Physiol 299:H1328-38. 2010

Research Grants

Collaborators

Detail Information

Publications70

  1. pmc Role of inflammation in the development of renal damage and dysfunction in angiotensin II-induced hypertension
    Tang Dong Liao
    Hypertension and Vascular Research Division, Henry Ford Hospital, 2799 West Grand Blvd, Detroit MI 48202 2689, USA
    Hypertension 52:256-63. 2008
    ..We concluded that, in Ang II-induced hypertension, CCR2 activation plays an important role in the development of hypertensive nephropathy via increased oxidative stress and inflammation...
  2. pmc Effects of cardiac overexpression of the angiotensin II type 2 receptor on remodeling and dysfunction in mice post-myocardial infarction
    Jiang Xu
    Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, E and R 7081, 2799 W Grand Boulevard, Detroit, MI 48202 2689
    Hypertension 63:1251-9. 2014
    ..We thus conclude that whether overexpression of AT2R is beneficial or detrimental to the heart is largely dependent on expression levels and possibly via regulations of Nox2 and transforming growth factor β1 signaling pathways...
  3. ncbi request reprint Endothelial nitric oxide gene knockout mice: cardiac phenotypes and the effect of angiotensin-converting enzyme inhibitor on myocardial ischemia/reperfusion injury
    X P Yang
    Hypertension and Vascular Research Division, Henry Ford Hospital, Detroit, MI, USA
    Hypertension 34:24-30. 1999
    ....
  4. ncbi request reprint Echocardiographic assessment of cardiac function in conscious and anesthetized mice
    X P Yang
    Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, Detroit, Michigan 48202, USA
    Am J Physiol 277:H1967-74. 1999
    ..We believe this is the first study to demonstrate the feasibility of using echocardiography to assess cardiovascular function in the nonanesthetized mouse...
  5. ncbi request reprint Diminished cardioprotective response to inhibition of angiotensin-converting enzyme and angiotensin II type 1 receptor in B(2) kinin receptor gene knockout mice
    X P Yang
    Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, Detroit, MI 48202, USA
    Circ Res 88:1072-9. 2001
    ....
  6. pmc Estrogen, hormonal replacement therapy and cardiovascular disease
    Xiao Ping Yang
    Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, 2799 West Grand Boulevard, Detroit, MI 48202 2689, USA
    Curr Opin Nephrol Hypertens 20:133-8. 2011
    ..This review highlights the factors that may contribute to this divergent outcome and could reveal why young or premenopausal women are protected from CVD and yet postmenopausal women do not benefit from HRT...
  7. ncbi request reprint Role of the B1 kinin receptor in the regulation of cardiac function and remodeling after myocardial infarction
    Jiang Xu
    Hypertension and Vascular Research Division, Henry Ford Hospital, Detroit, Mich 48202 2689, USA
    Hypertension 45:747-53. 2005
    ..Dual blockade of both B1 and B2 eliminates this compensation, leading to further deterioration of cardiac dysfunction and remodeling after myocardial infarction...
  8. ncbi request reprint Role of AT2 receptors in the cardioprotective effect of AT1 antagonists in mice
    Jiang Xu
    Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, Detroit, Mich 48202 2689, USA
    Hypertension 40:244-50. 2002
    ....
  9. ncbi request reprint Dual inhibition of ACE and NEP provides greater cardioprotection in mice with heart failure
    Jiang Xu
    Hypertension and Vascular Research Division, Henry Ford Hospital, 2799 West Grand Boulevard, Detroit, MI 48202 2689, USA
    J Card Fail 10:83-9. 2004
    ..11 (NEP-24.11), thereby inhibiting the renin-angiotensin system and enhancing vasodilator and natriuretic substances such as kinins and natriuretic peptides...
  10. pmc Local angiotensin II aggravates cardiac remodeling in hypertension
    Jiang Xu
    Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, Detroit, Michigan 48202 2689, USA
    Am J Physiol Heart Circ Physiol 299:H1328-38. 2010
    ..However, in animals with hypertension, cardiac ANG II, acting via AT(1)R, enhances inflammation, oxidative stress, and cell death (most likely via downregulation of PI 3-kinase and Akt), contributing to cardiac hypertrophy and fibrosis...
  11. doi request reprint N-acetyl-seryl-aspartyl-lysyl-proline reduces cardiac collagen cross-linking and inflammation in angiotensin II-induced hypertensive rats
    Germán E González
    Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, 2799 West Grand Boulevard, Detroit, MI 48202, U S A
    Clin Sci (Lond) 126:85-94. 2014
    ..In conclusion, the effect of Ac-SDKP on collagen cross-linking and total collagen may be due to reduced TGFβ1, LOXL1, and lymphocyte and macrophage infiltration, and its effect on inflammation could be due to lower NF-κB. ..
  12. pmc Ac-SDKP reverses inflammation and fibrosis in rats with heart failure after myocardial infarction
    Fang Yang
    Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, Detroit, Mich 48202 2689, USA
    Hypertension 43:229-36. 2004
    ..We concluded that Ac-SDKP has an anti-inflammatory effect in HF that may contribute to its antifibrotic effect; however, this decrease in fibrosis without changes in LVH was not accompanied by an improvement in cardiac function...
  13. pmc Role of cardiac overexpression of ANG II in the regulation of cardiac function and remodeling postmyocardial infarction
    Jiang Xu
    Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, Wayne State University, Detroit MI 48202 2689, USA
    Am J Physiol Heart Circ Physiol 293:H1900-7. 2007
    ....
  14. ncbi request reprint Effect of ACE inhibitors and angiotensin II type 1 receptor antagonists on endothelial NO synthase knockout mice with heart failure
    Yun He Liu
    Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, Detroit, MI 48202 2689, USA
    Hypertension 39:375-81. 2002
    ..1 +/- 1.6% versus -3.8 +/- 3.1%, respectively [P<0.01]). Our data suggest that the absence of NO does not alter the development of HF after MI; however, it significantly decreases the cardioprotective effects of ACEi or AT(1)-ant...
  15. ncbi request reprint Myocardial infarction and cardiac remodelling in mice
    Fang Yang
    Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, Detroit, MI, USA
    Exp Physiol 87:547-55. 2002
    ..This study provides important qualitative and quantitative information about the natural history of cardiac remodelling after MI in mice...
  16. ncbi request reprint Role of a selective aldosterone blocker in mice with chronic heart failure
    Dahai Wang
    Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, 2799 West Grand Boulevard, Detroit, MI 48202 2689, USA
    J Card Fail 10:67-73. 2004
    ....
  17. ncbi request reprint Long-term effects of selective and nonselective endothelin receptor antagonists in mice with heart failure
    Maria A Cavasin
    Hypertension and Vascular Research Division, Henry Ford Health System, Detroit, Michigan 48202, USA
    J Card Fail 8:254-61. 2002
    ..We hypothesized that blockade of ET(A) receptors may improve cardiac function and prevent left ventricular remodeling in mice with HF, and these effects may be mediated in part by activation of ET(B)...
  18. ncbi request reprint Estrogen and testosterone have opposing effects on chronic cardiac remodeling and function in mice with myocardial infarction
    Maria A Cavasin
    Hypertension and Vascular Research Division, Henry Ford Health System, 2799 West Grand Boulevard, Detroit, MI 48202, USA
    Am J Physiol Heart Circ Physiol 284:H1560-9. 2003
    ..Our data suggest that estrogen prevents deterioration of cardiac function and remodeling after MI, but testosterone worsens cardiac dysfunction and remodeling and has a pronounced effect when estrogen levels are reduced...
  19. ncbi request reprint Lack of inducible NO synthase reduces oxidative stress and enhances cardiac response to isoproterenol in mice with deoxycorticosterone acetate-salt hypertension
    Ying Sun
    Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Health System, Wayne State University, Detroit, MI 48202 2689, USA
    Hypertension 46:1355-61. 2005
    ....
  20. pmc The kinin B1 receptor contributes to the cardioprotective effect of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in mice
    Jiang Xu
    Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, 2799 West Grand Boulevard, Detroit, MI 48202 2689, USA
    Exp Physiol 94:322-9. 2009
    ..Our data suggest that kinins, acting via the B(1)R, participate in the cardioprotective effects of ACEi and ARB...
  21. ncbi request reprint Reduction of cardiac fibrosis decreases systolic performance without affecting diastolic function in hypertensive rats
    Oscar H Cingolani
    Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Health System, Detroit, Mich, USA
    Hypertension 43:1067-73. 2004
    ..In HHD, other factors besides collagen quantity, such as myocyte hypertrophy and/or collagen type or cross-link, might be targeted to improve cardiac function...
  22. ncbi request reprint Gender differences in cardiac function during early remodeling after acute myocardial infarction in mice
    Maria A Cavasin
    Hypertension and Vascular Research Division, Henry Ford Health System, Henry Ford Hospital, 2799 West Grand Blvd, Detroit, MI 48202, USA
    Life Sci 75:2181-92. 2004
    ..In conclusion, males have delayed myocardial healing, resulting in cardiac rupture, and the survivors have poorer cardiac function and pronounced maladaptive remodeling, whereas females show a better outcome during the development of HF...
  23. pmc Protective role of AT(2) and B(1) receptors in kinin B(2)-receptor-knockout mice with myocardial infarction
    Jiang Xu
    Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, Detroit, MI, USA
    Clin Sci (Lond) 124:87-96. 2013
    ....
  24. pmc Gene expression profiling of dilated cardiomyopathy in older male EP4 knockout mice
    Pamela Harding
    Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, Detroit, Michigan, USA
    Am J Physiol Heart Circ Physiol 298:H623-32. 2010
    ..Early overexpression of GDF-15 in hearts of male KO mice may contribute to or be a marker of the disease phenotype. The absence of serious cardiac dysfunction in aged female mice suggests a sexual dimorphism in the phenotype...
  25. pmc Dose-dependent toxic effects of high-dose estrogen on renal and cardiac injury in surgically postmenopausal mice
    Xiaomei Meng
    Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, Detroit, Michigan, USA
    Life Sci 88:178-86. 2011
    ..In the present study we questioned whether E2-induced renal damage predisposes to rather than results from its adverse effects on the heart...
  26. ncbi request reprint Role of inducible nitric oxide synthase in cardiac function and remodeling in mice with heart failure due to myocardial infarction
    Yun He Liu
    Hypertension and Vascular Research Div, Henry Ford Hospital, 2799 W Grand Blvd, Detroit, MI 48202 2689, USA
    Am J Physiol Heart Circ Physiol 289:H2616-23. 2005
    ..Decreased oxidative stress and other adaptive mechanisms independent of NOS may be partially responsible for such an effect, which needs to be studied further...
  27. pmc N-acetyl-seryl-aspartyl-lysyl-proline attenuates renal injury and dysfunction in hypertensive rats with reduced renal mass: council for high blood pressure research
    Tang Dong Liao
    Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, Detroit, Mich 48202 2689, USA
    Hypertension 55:459-67. 2010
    ..We concluded that Ac-SDKP greatly attenuates albuminuria and renal fibrosis and improves renal function in rats with 5/6Nx. These effects may be related to decreased inflammation (macrophages) and increased nephrin protein...
  28. pmc Deletion of inducible nitric oxide synthase provides cardioprotection in mice with 2-kidney, 1-clip hypertension
    Ying Sun
    Hypertension and Vascular Research Division, Henry Ford Hospital, 2799 West Grand Blvd, Detroit, Mich 48202 2689, USA
    Hypertension 53:49-56. 2009
    ....
  29. ncbi request reprint Inhibition of p38 mitogen-activated protein kinase protects the heart against cardiac remodeling in mice with heart failure resulting from myocardial infarction
    Yun He Liu
    Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, Detroit, MI 48202 2689, USA
    J Card Fail 11:74-81. 2005
    ....
  30. pmc Angiotensin II-induced dilated cardiomyopathy in Balb/c but not C57BL/6J mice
    Hongmei Peng
    Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, Detroit, MI 48202, USA
    Exp Physiol 96:756-64. 2011
    ....
  31. ncbi request reprint NAD(P)H oxidase mediates angiotensin II-induced vascular macrophage infiltration and medial hypertrophy
    Jianhua Liu
    Hypertension and Vascular Research Division and the Biostatistics Department, Henry Ford Hospital, 2799 West Grand Blvd, Detroit, Mich 48202 2689, USA
    Arterioscler Thromb Vasc Biol 23:776-82. 2003
    ....
  32. ncbi request reprint Inhibition of cyclooxygenase-2 improves cardiac function after myocardial infarction in the mouse
    Margot C LaPointe
    Hypertension and Vascular Research Division, Henry Ford Hospital, Detroit, MI 48202 2689, USA
    Am J Physiol Heart Circ Physiol 286:H1416-24. 2004
    ..These results suggest that COX-2 products contribute to cardiac remodeling and functional deficits after MI. Thus selected inhibition of COX-2 may be a therapeutic target for reducing myocyte damage after MI...
  33. pmc Reduced cardiac remodeling and function in cardiac-specific EP4 receptor knockout mice with myocardial infarction
    Jian Yong Qian
    Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, 2799 W Grand Blvd, Detroit, MI 48202 2689, USA
    Hypertension 51:560-6. 2008
    ..However, cardiac function was unexpectedly worsened in these mice. We conclude that cardiac myocyte EP(4) plays a role in hypertrophy via activation of Stat-3, a process that seems to be cardioprotective...
  34. pmc Dose-dependent cardiac effect of oestrogen replacement in mice post-myocardial infarction
    Enbo Zhan
    Hypertension and Vascular Research Division, Department of Medicine, Henry Ford Hospital and Wayne State University, 2799 West Grand Boulevard, Detroit, MI 48202, USA
    Exp Physiol 93:982-93. 2008
    ..Our data suggest that dosage should be an important consideration when studying the effect of oestrogen replacement on the heart...
  35. pmc Fractalkine depresses cardiomyocyte contractility
    David Taube
    Hypertension and Vascular Research Division, Henry Ford Hospital, Detroit, Michigan, USA
    PLoS ONE 8:e69832. 2013
    ..We therefore hypothesized that fractalkine is regulated by PGE2 and contributes to depressed contractility via alterations in intracellular calcium...
  36. ncbi request reprint N-acetyl-seryl-aspartyl-lysyl-proline stimulates angiogenesis in vitro and in vivo
    Dahai Wang
    Hypertension and Vascular Research Division, Henry Ford Hospital, 2799 W Grand Blvd, Detroit, MI 48202 2689, USA
    Am J Physiol Heart Circ Physiol 287:H2099-105. 2004
    ..Furthermore, because Ac-SDKP is mainly cleaved by ACE, it may partially mediate the cardioprotective effect of ACE inhibitors...
  37. ncbi request reprint Prolyl oligopeptidase is involved in release of the antifibrotic peptide Ac-SDKP
    Maria A Cavasin
    Hypertension and Vascular Research Division, Henry Ford Health System, 2799 West Grand Blvd, E and R 7115, Detroit, Mich 4820, USA
    Hypertension 43:1140-5. 2004
    ..We concluded that POP is the main enzyme responsible for synthesis of the antifibrotic peptide Ac-SDKP...
  38. ncbi request reprint Left ventricular targeting of reporter gene expression in vivo by human BNP promoter in an adenoviral vector
    Margot C LaPointe
    Hypertension and Vascular Research Division, Henry Ford Hospital, Detroit, Michigan 48202, USA
    Am J Physiol Heart Circ Physiol 283:H1439-45. 2002
    ..Thus the use of the proximal hBNP promoter in recombinant adenoviral vectors may allow cardiac-specific and inducible expression of therapeutic genes in vivo and prevent some of the side effects of systemic adenovirus administration...
  39. pmc Angiotensin II type 2 receptor-stimulated activation of plasma prekallikrein and bradykinin release: role of SHP-1
    Liping Zhu
    Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, Detroit, Michigan 48202 2689, USA
    Am J Physiol Heart Circ Physiol 302:H2553-9. 2012
    ..These findings support our hypothesis that stimulation of AT(2)R activates a PRCP-dependent plasma prekallikrein pathway, releasing bradykinin. Activation of SHP-1 may also play an important role in AT(2)R-induced PRCP activation...
  40. doi request reprint N-acetyl-Ser-Asp-Lys-Pro inhibits interleukin-1β-mediated matrix metalloproteinase activation in cardiac fibroblasts
    Nour Eddine Rhaleb
    Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, E and R 7121, 2799 West Grand Boulevard, Detroit, MI, 48202, USA
    Pflugers Arch 465:1487-95. 2013
    ..These pharmacological effects of Ac-SDKP may be linked to the inhibition of MAPK and NFκB pathway...
  41. ncbi request reprint Augmented healing process in female mice with acute myocardial infarction
    Fangfei Wang
    Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, and Department of Biology, Wayne State University, Detroit, Michigan 48202 2689, USA
    Gend Med 4:230-47. 2007
    ....
  42. ncbi request reprint Decreased endogenous levels of Ac-SDKP promote organ fibrosis
    Maria A Cavasin
    Hypertension and Vascular Research Division, Henry Ford Sciences Center, Henry Ford Health System, Detroit, MI 48202, USA
    Hypertension 50:130-6. 2007
    ..We believe this is the first study showing that this peptide plays a physiological role at basal concentrations, preventing organ collagen accumulation...
  43. pmc Female adult mouse cardiomyocytes are protected against oxidative stress
    Fangfei Wang
    Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, 2799 West Grand Blvd, Detroit, MI 48202 2689, USA
    Hypertension 55:1172-8. 2010
    ..This may be attributable to activation of Akt and inhibition of GSK-3beta and caspase 3 through an estrogen receptor-alpha-mediated mechanism...
  44. ncbi request reprint Effects of pre-existing left ventricular hypertrophy on ventricular dysfunction and remodeling following myocardial infarction in rats
    Omar Nass
    Division of Cardiovascular Medicine, Henry Ford Heart and Vascular Institute, Detroit, Michigan 48202, USA
    J Heart Lung Transplant 21:1113-9. 2002
    ..In the present study, we examine the effects of pre-existing left ventricular hypertrophy (LVH) on LV function and chamber enlargement following MI in inbred Lewis rats...
  45. ncbi request reprint Role of angiotensin II type 2 receptors and kinins in the cardioprotective effect of angiotensin II type 1 receptor antagonists in rats with heart failure
    Yun He Liu
    Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, Detroit, Michigan 48202, USA
    J Am Coll Cardiol 43:1473-80. 2004
    ..We studied the role of angiotensin II type 2 (AT(2)) receptors and kinins in the cardioprotective effect of angiotensin II type 1 antagonists (AT(1)-ant) in rats with heart failure (HF) after myocardial infarction...
  46. ncbi request reprint Increased systolic performance with diastolic dysfunction in adult spontaneously hypertensive rats
    Oscar H Cingolani
    Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, Detroit, MI 48202 2689, USA
    Hypertension 41:249-54. 2003
    ..3+/-1.8 pg/mL for WKY (P<0.02). Taken together, these data suggest that at 10 to 11 months of age, before HF develops, SHR have increased systolic performance accompanied by delayed relaxation and increased diastolic stiffness...
  47. ncbi request reprint Testosterone enhances early cardiac remodeling after myocardial infarction, causing rupture and degrading cardiac function
    Maria A Cavasin
    Hypertension and Vascular Research Division, Henry Ford Health System, Detroit, MI 48202, USA
    Am J Physiol Heart Circ Physiol 290:H2043-50. 2006
    ....
  48. pmc Treatment with N-acetyl-seryl-aspartyl-lysyl-proline prevents experimental autoimmune myocarditis in rats
    Pablo Nakagawa
    Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, Detroit, Michigan 48202, USA
    Am J Physiol Heart Circ Physiol 303:H1114-27. 2012
    ....
  49. pmc Lack of microsomal prostaglandin E synthase-1 reduces cardiac function following angiotensin II infusion
    Pamela Harding
    Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, Detroit, Michigan 48202, USA
    Am J Physiol Heart Circ Physiol 300:H1053-61. 2011
    ..Overall, these results are consistent with a beneficial effect for mPGES-1 in the maintenance of cardiac function in ANG II-dependent hypertension...
  50. ncbi request reprint Temporal changes in matrix metalloproteinase expression and inflammatory response associated with cardiac rupture after myocardial infarction in mice
    Zhen Yin Tao
    Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, 2799 West Grand Boulevard, Detroit, MI 48202 2689, USA
    Life Sci 74:1561-72. 2004
    ....
  51. pmc N-Acetyl-seryl-aspartyl-lysyl-proline inhibits ET-1-induced collagen production by preserving Src homology 2-containing protein tyrosine phosphatase-2 activity in cardiac fibroblasts
    Hongmei Peng
    Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, E and R Bldg 7121, 2799 West Grand Blvd, Detroit, MI, USA
    Pflugers Arch 464:415-23. 2012
    ..Ac-SDKP or its analogs could represent a new therapeutic tool to treat fibrotic diseases in the cardiovascular system...
  52. pmc Role of prolylcarboxypeptidase in angiotensin II type 2 receptor-mediated bradykinin release in mouse coronary artery endothelial cells
    Liping Zhu
    Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, 2799 West Grand Blvd, Detroit, MI 48202 2689, USA
    Hypertension 56:384-90. 2010
    ..These findings suggest that overexpression of AT(2)R in mouse coronary artery endothelial cells increases expression of prolylcarboxypeptidase, which may contribute to kinin release...
  53. ncbi request reprint Impairment of aldehyde dehydrogenase-2 by 4-hydroxy-2-nonenal adduct formation and cardiomyocyte hypertrophy in mice fed a high-fat diet and injected with low-dose streptozotocin
    Vishal R Mali
    Division of Hypertension and Vascular Research, Department of Internal Medicine, Henry Ford Health System, Detroit, MI 48202, USA
    Exp Biol Med (Maywood) 239:610-8. 2014
    ....
  54. ncbi request reprint Reduced inhibitor 1 and 2 activity is associated with increased protein phosphatase type 1 activity in left ventricular myocardium of one-kidney, one-clip hypertensive rats
    Ramesh C Gupta
    Cardiovascular Medicine, Department of Medicine, Henry Ford Heart and Vascular Institute, Henry Ford Health System, Detroit, MI 48202, USA
    Mol Cell Biochem 269:49-57. 2005
    ..The band density of each protein was quantified in densitometric units and normalized to CSQ...
  55. ncbi request reprint Assessment of sarcoplasmic reticulum Ca2+-uptake during the development of left ventricular hypertrophy
    Ramesh C Gupta
    Cardiovascular Medicine Division, Department of Medicine, Henry Ford Heart and Vascular Institute, Henry Ford Health System, 2799 West Grand Boulevard, Detroit, MI 48202, USA
    Biochem Pharmacol 65:933-9. 2003
    ..The increase in Ca(2+)-uptake and CAA expression suggests, at the cellular level, a compensatory response to LV hypertrophy, while the decline at later stages indicates the transition to heart failure...
  56. ncbi request reprint The kallikrein-kinin system as a regulator of cardiovascular and renal function
    Nour Eddine Rhaleb
    Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, Detroit, Michigan, USA
    Compr Physiol 1:971-93. 2011
    ..Thus kinins play an important role in regulation of cardiovascular and renal function as well as many of the beneficial effects of ACE inhibitors and ARBs on target organ damage in hypertension...
  57. pmc Combination treatment with N-acetyl-seryl-aspartyl-lysyl-proline and tissue plasminogen activator provides potent neuroprotection in rats after stroke
    Li Zhang
    From the Department of Neurology L Z, M C, H T, G D, Q J, Z G Z, Hypertension and Vascular Research Division X P Y, N E R, Henry Ford Health Sciences Center, Detroit, MI and Department of Physics M C, Oakland University, Rochester, MI
    Stroke 45:1108-14. 2014
    ..N-acetyl-seryl-aspartyl-lysyl-proline (AcSDKP), an endogenously produced circulating peptide in humans and rodents, exerts anti-inflammatory and cardioprotective activities in various cardiovascular diseases...
  58. pmc Prevention of aortic fibrosis by N-acetyl-seryl-aspartyl-lysyl-proline in angiotensin II-induced hypertension
    Chun Xia Lin
    Hypertension and Vascular Research Div, Henry Ford Hospital, 2799 West Grand Blvd, Detroit, MI 48202 2689, USA
    Am J Physiol Heart Circ Physiol 295:H1253-H1261. 2008
    ..Part of the effect of Ac-SDKP could also be due to reduced expression of the profibrotic cytokine TGF-beta1 and inhibition of Smad2 phosphorylation...
  59. pmc Adverse effects of bone marrow stromal cell treatment of stroke in diabetic rats
    Jieli Chen
    Henry Ford Hospital, E and R Building, 3091, Detroit, MI 48202, USA
    Stroke 42:3551-8. 2011
    ..However, its effect on diabetics with stroke is unknown. This study investigated the effect of BMSCs on stroke outcome in Type 1 diabetic (T1DM) rats...
  60. ncbi request reprint Angiotensin II receptor subtypes involved in the modulation of purinergic and adrenergic vasoconstrictions to periarterial electrical nerve stimulation in the canine splenic artery
    Xiao Ping Yang
    Department of Pharmacology, Shinshu University School of Medicine, Matsumoto, Japan
    J Cardiovasc Pharmacol 41:S49-52. 2003
    ..The results indicate that angiotensin II potentiates sympathetic purinergic and adrenergic vasoconstrictions through the prejunctional angiotensin II type 1 receptor subtype in the canine splenic artery...
  61. ncbi request reprint Phosphodiesterase 5A inhibition induces Na+/H+ exchanger blockade and protection against myocardial infarction
    Nestor G Perez
    Centro de Investigaciones Cardiovasculares, Facultad de Ciencias Medicas, Universidad Nacional de La Plata, La Plata, Argentina
    Hypertension 49:1095-103. 2007
    ..We conclude that increased phosphoglycerate kinase-1 activity after acute phosphodiesterase 5A inhibition blunts NHE-1 activity and protects the heart against post-MI remodeling and dysfunction...
  62. ncbi request reprint [Enhancement of FG020326 on sensitivity of MCF-7/ADR cells to taxotere via enhancing activation of caspase-8 and caspase-3]
    Xiu Wen Wang
    Research Department, Cancer Center, Sun Yat Sen University, Guangzhou, Guangdong, 510060, PR China
    Ai Zheng 23:1379-85. 2004
    ..This study was designed to investigate reversal effect of FG020326, a potent MDR modulator,on drug-resistance of MCF-7/ADR cells towards taxotere,and its mechanism...
  63. ncbi request reprint Reversal of P-gp mediated multidrug resistance in-vitro and in-vivo by FG020318
    Li Ming Chen
    Cancer Center, Sun Yat Sen University, Guangzhou 510060, PR China
    J Pharm Pharmacol 56:1061-6. 2004
    ..The reversal of drug resistance by FG020318 was probably related to the increased anticancer drug accumulation and its inhibition of P-gp function of MDR tumour cells...
  64. ncbi request reprint [Antitumor and anti-angiogenic effects of manumycin on human hepatocellular carcinoma HepG2 xenografts in nude mice]
    Jun Min Zhou
    Skate Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat Sen University, Guangzhou, Guangdong, P R China
    Ai Zheng 24:935-9. 2005
    ..This study was to examine the antitumor and anti-angiogenic effects of manumycin on HepG2 xenografts in nude mice...
  65. pmc RAP80 responds to DNA damage induced by both ionizing radiation and UV irradiation and is phosphorylated at Ser 205
    Jun Yan
    Cell Biology Section, Laboratory of Respiratory Biology, Division of Intramural Research, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina 27709, USA
    Cancer Res 68:4269-76. 2008
    ..These findings suggest that RAP80 has a more general role in different types of DNA damage responses...
  66. ncbi request reprint [Correlation between inhibitory effect of Manumycin on human hepatoma cancer cell HepG2 and Ras signal transduction pathway]
    Jun Min Zhou
    Cancer Institute, Sun Yat Sen University, Guangzhou 510060, P R China
    Ai Zheng 21:364-8. 2002
    ..This study was designed to investigate the antitumor effect of Manumycin in human hepatoma cell line HepG2 and try to clarify its influence on Ras pathway...
  67. ncbi request reprint [Experimental study on the anti-liver fibrosis effect of guzhang tablet in rats]
    Yu yao Zhao
    Henan Provincial Academy of TCM, Zhengzhou 450004
    Zhongguo Zhong Xi Yi Jie He Za Zhi 23:922-5. 2003
    ..To observe the anti-liver-fibrosis effect of Guzhang Tablet (GZT) and to explore its mechanism...
  68. ncbi request reprint Human renal organic anion transporter 1-dependent uptake and toxicity of mercuric-thiol conjugates in Madin-Darby canine kidney cells
    Amy G Aslamkhan
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
    Mol Pharmacol 63:590-6. 2003
    ..Thus, renal accumulation and toxicity of thiol-Hg(2+) conjugates may depend in part on the activity of the organic transport system...
  69. ncbi request reprint Experimental chemotherapy against xenografts derived from multidrug resistant KBv200 cells and parental drug-sensitive KB cells in nude mice by annonaceous acetogenin 89-2
    Li Wu Fu
    Cancer Center, Sun Yat Sen University, Guangzhou 510060, China
    Yao Xue Xue Bao 38:565-70. 2003
    ..Annonaceous acetogenin 89-2 was obtained from atemoya plant. To investigate the effect of 89-2 on experimental chemotherapy against xenografts derived from multidrug resistant KBv200 cells and parental drug-sensitive KB cells...
  70. ncbi request reprint [Experimental studies on treatment of nasopharyngeal carcinoma with combination regimen of hydroxycamptothecin and etoposide]
    Yong Ju Liang
    Cancer Center, Sun Yat Sen University, Guangzhou, Guangdong, PR China
    Ai Zheng 22:368-71. 2003
    ....

Research Grants4

  1. Gender Influence in Mice with Myocardial Infarction
    Xiao Ping Yang; Fiscal Year: 2006
    ....
  2. Gender Influence in Mice with Myocardial Infarction
    Xiao Ping Yang; Fiscal Year: 2007
    ....
  3. Gender Influence in Mice with Myocardial Infarction
    Xiao Ping Yang; Fiscal Year: 2009
    ....