Maria Worsham

Summary

Affiliation: Henry Ford Hospital
Country: USA

Publications

  1. ncbi Molecular characterization of head and neck cancer: how close to personalized targeted therapy?
    Maria J Worsham
    Department of OtolaryngologyHead and Neck Surgery, Henry Ford Health System, Detroit, MI 48202, USA
    Mol Diagn Ther 16:209-22. 2012
  2. ncbi Disparate molecular, histopathology, and clinical factors in head and neck squamous cell carcinoma racial groups
    Maria J Worsham
    Department of Otolaryngology Head and Neck Surgery, Henry Ford Hospital, Detroit, Michigan 48202, USA
    Otolaryngol Head Neck Surg 147:281-8. 2012
  3. ncbi Epigenetic events of disease progression in head and neck squamous cell carcinoma
    Maria J Worsham
    Department of Otolaryngology Head and Neck Surgery and Research Division, Henry Ford Health System, Detroit, Mich, USA
    Arch Otolaryngol Head Neck Surg 132:668-77. 2006
  4. ncbi Breast cancer incidence in a cohort of women with benign breast disease from a multiethnic, primary health care population
    Maria J Worsham
    Henry Ford Hospital, Department of Otolaryngology Head and Neck Surgery, Detroit, Michigan 55905, USA
    Breast J 13:115-21. 2007
  5. ncbi Chromosomal aberrations identified in culture of squamous carcinomas are confirmed by fluorescence in situ hybridisation
    M J Worsham
    Department of Pathology, Henry Ford Hospital, Detroit, MI 48202, USA
    Mol Pathol 52:42-6. 1999
  6. ncbi Multiplicity of benign breast lesions is a risk factor for progression to breast cancer
    Maria J Worsham
    Department of Otolaryngology Head and Neck Surgery, Henry Ford Health System, Detroit, Michigan 48202, USA
    Clin Cancer Res 13:5474-9. 2007
  7. ncbi Risk factors for breast cancer from benign breast disease in a diverse population
    Maria J Worsham
    Department of Otolaryngology Head and Neck Surgery, Henry Ford Health System, 1 Ford Place, 1D, Detroit, MI, 48202, USA
    Breast Cancer Res Treat 118:1-7. 2009
  8. ncbi Novel approaches to global mining of aberrantly methylated promoter sites in squamous head and neck cancer
    Maria J Worsham
    Department of Otolaryngology Head and Neck Surgery, Henry Ford Hospital, Detroit, MI 48202, USA
    Otolaryngol Head Neck Surg 143:116-21, 121.e1-19. 2010
  9. ncbi Race as a social construct in head and neck cancer outcomes
    Maria J Worsham
    Department of Otolaryngology Head and Neck Surgery, Henry Ford Health System, Detroit, MI 48202, USA
    Otolaryngol Head Neck Surg 144:381-9. 2011
  10. ncbi Fine-mapping loss of gene architecture at the CDKN2B (p15INK4b), CDKN2A (p14ARF, p16INK4a), and MTAP genes in head and neck squamous cell carcinoma
    Maria J Worsham
    Department of Otolaryngology Head and Neck Surgery and Research Division, Henry Ford Hospital, Detroit, MI 48202, USA
    Arch Otolaryngol Head Neck Surg 132:409-15. 2006

Research Grants

  1. BENIGN BREAST DISEASE--MOLECULAR DIFFERENTIATION OF RISK
    Maria Worsham; Fiscal Year: 2001
  2. MOLECULAR MODELING OF DIAGNOSIS AND PROGNOSIS IN HNSCC
    Maria Worsham; Fiscal Year: 2009

Collaborators

  • M Lu
  • Jan P Schouten
  • M S Benninger
  • Seema Sethi
  • Marvella E Ford
  • Shijing Qiu
  • Ozlen Saglam
  • F R Miller
  • Josena K Stephen
  • Misa Raitanen
  • Kang Mei Chen
  • Jingfang Cheng
  • Mumtaz Khan
  • Veena Shah
  • Vanessa G Schweitzer
  • Josena Kunjoonju Stephen
  • Kangmei Chen
  • Lori E Vaught
  • Girija Natarajan
  • Josena P Kunjoonju
  • Christian Demanet
  • Ari Wirtschafter
  • Seija Grenman
  • Sandra R Wolman
  • Usha Raju
  • Raja Sawhney
  • Glendon M Gardner
  • Kang M Chen
  • Zizheng Hou
  • Glendon Gardner
  • Fan Zhang
  • Yvette R Johnson
  • Nivedita Tiwari
  • Virpi Rantanen
  • Veronique Deneys
  • Pekka Klemi
  • Frans H Claas
  • Jorma Isola
  • Thomas E Carey
  • Piet Maes
  • Soldano Ferrone
  • Taina Lakkala
  • Arend Mulder
  • Daniel L Van Dyke
  • Tehila Umiel
  • Kathleen Blazoff
  • Thomas J Moss

Detail Information

Publications28

  1. ncbi Molecular characterization of head and neck cancer: how close to personalized targeted therapy?
    Maria J Worsham
    Department of OtolaryngologyHead and Neck Surgery, Henry Ford Health System, Detroit, MI 48202, USA
    Mol Diagn Ther 16:209-22. 2012
    ..This opinion offers a snapshot of the evolution of molecular subtyping in HNSCC and its current clinical applicability, as well as new emergent paradigms with implications for controlling this disease in the future...
  2. ncbi Disparate molecular, histopathology, and clinical factors in head and neck squamous cell carcinoma racial groups
    Maria J Worsham
    Department of Otolaryngology Head and Neck Surgery, Henry Ford Hospital, Detroit, Michigan 48202, USA
    Otolaryngol Head Neck Surg 147:281-8. 2012
    ..We examined a comprehensive array of risk factors influencing health and disease in an access-to-care, racially diverse, primary HNSCC cohort...
  3. ncbi Epigenetic events of disease progression in head and neck squamous cell carcinoma
    Maria J Worsham
    Department of Otolaryngology Head and Neck Surgery and Research Division, Henry Ford Health System, Detroit, Mich, USA
    Arch Otolaryngol Head Neck Surg 132:668-77. 2006
    ..To examine the promoter methylation status of the 22 cancer genes and their contribution to disease progression in 6 head and neck squamous cell carcinoma (HNSCC) cell lines...
  4. ncbi Breast cancer incidence in a cohort of women with benign breast disease from a multiethnic, primary health care population
    Maria J Worsham
    Henry Ford Hospital, Department of Otolaryngology Head and Neck Surgery, Detroit, Michigan 55905, USA
    Breast J 13:115-21. 2007
    ..The risks associated with BBD histological classifications were not different across races...
  5. ncbi Chromosomal aberrations identified in culture of squamous carcinomas are confirmed by fluorescence in situ hybridisation
    M J Worsham
    Department of Pathology, Henry Ford Hospital, Detroit, MI 48202, USA
    Mol Pathol 52:42-6. 1999
    ....
  6. ncbi Multiplicity of benign breast lesions is a risk factor for progression to breast cancer
    Maria J Worsham
    Department of Otolaryngology Head and Neck Surgery, Henry Ford Health System, Detroit, Michigan 48202, USA
    Clin Cancer Res 13:5474-9. 2007
    ..There is very limited information with regard to the issue of BBD lesion multiplicity and breast cancer risk...
  7. ncbi Risk factors for breast cancer from benign breast disease in a diverse population
    Maria J Worsham
    Department of Otolaryngology Head and Neck Surgery, Henry Ford Health System, 1 Ford Place, 1D, Detroit, MI, 48202, USA
    Breast Cancer Res Treat 118:1-7. 2009
    ..Information on breast cancer risk factors in larger, multi-ethnic populations should facilitate the development of appropriate and targeted risk reduction strategies...
  8. ncbi Novel approaches to global mining of aberrantly methylated promoter sites in squamous head and neck cancer
    Maria J Worsham
    Department of Otolaryngology Head and Neck Surgery, Henry Ford Hospital, Detroit, MI 48202, USA
    Otolaryngol Head Neck Surg 143:116-21, 121.e1-19. 2010
    ..We examined promoter methylation status of 1143 cancer-associated genes to perform a global but unbiased inspection of methylated regions in head and neck squamous cell carcinoma (HNSCC)...
  9. ncbi Race as a social construct in head and neck cancer outcomes
    Maria J Worsham
    Department of Otolaryngology Head and Neck Surgery, Henry Ford Health System, Detroit, MI 48202, USA
    Otolaryngol Head Neck Surg 144:381-9. 2011
    ..The authors examined ancestry informative markers (AIMs) to estimate the amount of population admixture and control for this heterogeneity for stage and survival in a primary head and neck squamous cell carcinoma (HNSCC) cohort...
  10. ncbi Fine-mapping loss of gene architecture at the CDKN2B (p15INK4b), CDKN2A (p14ARF, p16INK4a), and MTAP genes in head and neck squamous cell carcinoma
    Maria J Worsham
    Department of Otolaryngology Head and Neck Surgery and Research Division, Henry Ford Hospital, Detroit, MI 48202, USA
    Arch Otolaryngol Head Neck Surg 132:409-15. 2006
    ..This complex region encodes the tumor suppressor genes cyclin-dependent kinase 2B (CDKN2B) (p15(INK4b)) and CDKN2A (p14(ARF), p16(INK4a)) and the housekeeping gene methylthioadenosine phosphorylase (MTAP)...
  11. ncbi High-resolution mapping of molecular events associated with immortalization, transformation, and progression to breast cancer in the MCF10 model
    Maria J Worsham
    Department of Otolaryngology, Head and Neck Surgery, Wayne State School of Medicine, Henry Ford Hospital, Detroit, MI 48202, USA
    Breast Cancer Res Treat 96:177-86. 2006
    ....
  12. ncbi Molecular approaches to identification of tissue contamination in surgical pathology sections
    M J Worsham
    Department of Pathology, Henry Ford Hospital, 2799 W Grand Blvd, Detroit, MI 48202, USA
    J Mol Diagn 3:11-5. 2001
    ..They are important adjuncts to histology for the anatomical pathologist when faced with the diagnostic problems of tissue contamination encountered in routine practice...
  13. ncbi Establishing a molecular continuum in breast cancer DNA microarrays and benign breast disease
    Maria J Worsham
    Department of Otolaryngology, Henry Ford Health System, Detroit, Michigan 48202, USA
    Cytometry 47:56-9. 2002
    ..Both her benign and malignant lesions showed molecularly identical TP53 mutations, indicating that significant genetic alterations can occur in BBD and supporting the clonal evolution from BBD to malignancy...
  14. ncbi Delineating genetic pathways of disease progression in head and neck squamous cell carcinoma
    Maria J Worsham
    Department of Otolaryngology Head and Neck Surgery, Research Division, Henry Ford Health System, Detroit, MI 48202, USA
    Arch Otolaryngol Head Neck Surg 129:702-8. 2003
    ..Identification of key molecular events may be useful for more accurate distinction of prognostic groups for selection and targeting of therapy...
  15. ncbi Epigenetic events underlie the pathogenesis of sinonasal papillomas
    Josena K Stephen
    Department of Otolaryngology Head and Neck Surgery, Henry Ford Hospital, Detroit, MI 48202, USA
    Mod Pathol 20:1019-27. 2007
    ..As a consistent target of aberrant promoter hypermethylation, CDKN2B may serve as an important epigenetic biomarker for gene reactivation studies...
  16. ncbi Noninvasive molecular detection of head and neck squamous cell carcinoma: an exploratory analysis
    Seema Sethi
    Departments of Otolaryngology and Biostatistics, Henry Ford Hospital, Detroit, MI 48202, USA
    Diagn Mol Pathol 18:81-7. 2009
    ..Noninvasive identification of HNSCC-specific genetic alterations using saliva would have immense potential in early diagnosis and screening, particularly among high-risk patients...
  17. ncbi Patient and tumor factors at diagnosis in a multi-ethnic primary head and neck squamous cell carcinoma cohort
    Seema Sethi
    Department of Otolaryngology Head and Neck Surgery, Henry Ford Health Systems, Detroit, MI 48202, USA
    J Surg Oncol 99:104-8. 2009
    ..This study examined histopathology and demographic variables at primary diagnosis (early vs. late stage) in a HNSCC patient population with a higher than usual percentage of African American (AA) subjects...
  18. ncbi Characterization of 10 vulvar carcinoma cell lines by karyotyping, comparative genomic hybridization and flow cytometry
    Misa Raitanen
    Cancer Genetics Research, Department of Otolaryngology, Henry Ford Health System, Detroit, MI 48202, USA
    Gynecol Oncol 93:155-63. 2004
    ..CONCLUSIONS: CGH and karyotyping showed concordance in defining copy number imbalances, thus supporting the accuracy of CGH to detect chromosome imbalances in tumors that cannot be karyotyped...
  19. ncbi Benign breast disease heterogeneity: association with histopathology, age, and ethnicity
    Jingfang Cheng
    Department of Otolaryngolog, Head and Neck Surgery, Henry Ford Hospital, Detroit, MI, USA
    Breast Cancer Res Treat 111:289-96. 2008
    ..Elucidation of the biological characteristics and clinical implications of HBBD may also be relevant to the refinement of risks for BC in women with a BBD diagnosis...
  20. ncbi DNA hypermethylation profiles in squamous cell carcinoma of the vulva
    Josena K Stephen
    Department of Otolaryngology Head and Neck Research, Henry Ford Hospital, Detroit, Michigan 48202, USA
    Int J Gynecol Pathol 28:63-75. 2009
    ..These findings underscore the contribution of both genetic and epigenetic events to the underlying pathogenesis of squamous cell carcinoma of the vulva...
  21. ncbi An epigenetically derived monoclonal origin for recurrent respiratory papillomatosis
    Josena Kunjoonju Stephen
    Department of Otolaryngology Head and Neck Surgery, Henry Ford Hospital, 1 Ford Pl, 1D, Detroit, MI 48202, USA
    Arch Otolaryngol Head Neck Surg 133:684-92. 2007
    ..To investigate the contribution of promoter methylation-mediated epigenetic events in recurrent respiratory papillomatosis tumorigenesis...
  22. ncbi Methylation of multiple genes as diagnostic and therapeutic markers in primary head and neck squamous cell carcinoma
    Kangmei Chen
    Department of Otolaryngology Head and Neck Surgery, Henry Ford Health System, 1 Ford Pl, Detroit, MI 48202, USA
    Arch Otolaryngol Head Neck Surg 133:1131-8. 2007
    ..Changes in DNA methylation have been reported to occur early in carcinogenesis and therefore are potentially important early indicators of existing disease...
  23. ncbi Modifying a breast cancer risk factor survey for African American women
    Marvella E Ford
    Department of Psychiatry and Cancer Research in Diverse Populations, Henry Ford Health System, Detroit, MI, USA. mford@ bcm.tmc.edu
    Oncol Nurs Forum 29:827-34. 2002
    ....
  24. ncbi Micrometastatic tumor detection in patients with head and neck cancer: a preliminary report
    Ari Wirtschafter
    Department of Otolaryngology-Head and Neck Surgery, Henry Ford Hospital, 2799 W Grand Blvd, Detroit, MI 48202, USA
    Arch Otolaryngol Head Neck Surg 128:40-3. 2002
    ..Long-term follow-up may help elucidate the patients in whom conventional treatment may fail and, thus, those who may benefit from different treatment; it may also assist with the detection of recurrence with a simple blood collection...
  25. ncbi Molecular differentiation of early and late stage laryngeal squamous cell carcinoma: an exploratory analysis
    Ozlen Saglam
    Department of Pathology, Henry Ford Hospital, Detroit, MI, USA
    Diagn Mol Pathol 16:218-21. 2007
    ..Thus, multiparametric methods, which rely on many pieces of information, are ideally suited to the grouping of tumor subtypes and the identification of specific patterns of disease progression...
  26. ncbi Real-time polymerase chain reaction for the rapid detection of group B streptococcal colonization in neonates
    Girija Natarajan
    Division of Neonatology, Children's Hospital of Michigan, Detroit, Michigan, USA
    Pediatrics 118:14-22. 2006
    ..Thus, real-time polymerase chain reaction would be a useful clinical tool in the management of those infants potentially at risk for invasive GBS infection and would allow earlier discharge for those found to be not at risk...
  27. ncbi Identification of individual genes altered in squamous cell carcinoma of the vulva
    Josena P Kunjoonju
    Department of Otolaryngology/Head and Neck Research, Henry Ford Health System, Detroit, Michigan 48202, USA
    Genes Chromosomes Cancer 44:185-93. 2005
    ..Understanding the interplay of cancer genes and the pathways they utilize can lead to the detection of novel molecular targets in the diagnosis, prognosis, and treatment of SCV...
  28. ncbi Down-regulation of HLA-A and HLA-Bw6, but not HLA-Bw4, allospecificities in leukemic cells: an escape mechanism from CTL and NK attack?
    Christian Demanet
    HLA Laboratory, Academic Hospital VUB, Brussels, Belgium
    Blood 103:3122-30. 2004
    ....

Research Grants13

  1. BENIGN BREAST DISEASE--MOLECULAR DIFFERENTIATION OF RISK
    Maria Worsham; Fiscal Year: 2001
    ....
  2. MOLECULAR MODELING OF DIAGNOSIS AND PROGNOSIS IN HNSCC
    Maria Worsham; Fiscal Year: 2009
    ..abstract_text> ..