THOMAS D ROTH

Summary

Affiliation: Henry Ford Hospital
Country: USA

Publications

  1. ncbi request reprint Hypnotic residual effects of benzodiazepines with repeated administration
    T Roehrs
    Henry Ford Hospital, Sleep Disorders and Research Center, Detroit, Michigan 48202
    Sleep 9:309-16. 1986
  2. ncbi request reprint A review of the effects of pregabalin on sleep disturbance across multiple clinical conditions
    Thomas Roth
    Division of Sleep Medicine and Research Center, Henry Ford Health System, 2799 West Grand Boulevard, Detroit, MI 48202, USA Electronic address
    Sleep Med Rev 18:261-71. 2014
  3. pmc Disrupted nighttime sleep in narcolepsy
    Thomas Roth
    Sleep Disorders and Research Center, Henry Ford Hospital, Detroit, MI 48202, USA
    J Clin Sleep Med 9:955-65. 2013
  4. pmc Novel sublingual low-dose zolpidem tablet reduces latency to sleep onset following spontaneous middle-of-the-night awakening in insomnia in a randomized, double-blind, placebo-controlled, outpatient study
    Thomas Roth
    Henry Ford Hospital, Detroit, MI 48202 2691, USA
    Sleep 36:189-96. 2013
  5. doi request reprint Appropriate therapeutic selection for patients with shift work disorder
    Thomas Roth
    Henry Ford Hospital, Sleep Disorders and Research Center, Detroit, MI 48202, USA
    Sleep Med 13:335-41. 2012
  6. doi request reprint Effect of pregabalin on sleep in patients with fibromyalgia and sleep maintenance disturbance: a randomized, placebo-controlled, 2-way crossover polysomnography study
    Thomas Roth
    Sleep Disorders and Research Center, Henry Ford Health System, Detroit, Michigan, USA
    Arthritis Care Res (Hoboken) 64:597-606. 2012
  7. pmc Effect of lisdexamfetamine dimesylate on sleep in adults with attention-deficit/hyperactivity disorder
    Lenard A Adler
    Department of Psychiatry and Child and Adolescent Psychiatry, New York University School of Medicine, NY, USA
    Behav Brain Funct 5:34. 2009
  8. ncbi request reprint Measuring treatment efficacy in insomnia
    Thomas Roth
    Henry Ford Hospital Sleep Center, Detroit, MI, USA
    J Clin Psychiatry 65:8-12. 2004
  9. ncbi request reprint A physiologic basis for the evolution of pharmacotherapy for insomnia
    Thomas Roth
    Sleep Disorders and Research Center, Henry Ford Hospital, Detroit, MI 48202, USA
    J Clin Psychiatry 68:13-8. 2007
  10. ncbi request reprint Understanding neuronal pathways: novel targets for the management of insomnia
    Thomas Roth
    Sleep Disorders and Research Center, Henry Ford Hospital, Detroit, MI 48202, USA
    J Clin Psychiatry 68:4-5. 2007

Detail Information

Publications72

  1. ncbi request reprint Hypnotic residual effects of benzodiazepines with repeated administration
    T Roehrs
    Henry Ford Hospital, Sleep Disorders and Research Center, Detroit, Michigan 48202
    Sleep 9:309-16. 1986
    ..During the late phase, flurazepam did not disrupt performance but still affected the MSLT. Temazepam affected neither index the next day during the late phase...
  2. ncbi request reprint A review of the effects of pregabalin on sleep disturbance across multiple clinical conditions
    Thomas Roth
    Division of Sleep Medicine and Research Center, Henry Ford Health System, 2799 West Grand Boulevard, Detroit, MI 48202, USA Electronic address
    Sleep Med Rev 18:261-71. 2014
    ..Polysomnographic data reveal that pregabalin primarily affects sleep maintenance. The evidence indicates that pregabalin has a direct effect on sleep that is distinct from its analgesic, anxiolytic and anticonvulsant effects. ..
  3. pmc Disrupted nighttime sleep in narcolepsy
    Thomas Roth
    Sleep Disorders and Research Center, Henry Ford Hospital, Detroit, MI 48202, USA
    J Clin Sleep Med 9:955-65. 2013
    ..Characterize disrupted nighttime sleep (DNS) in narcolepsy, an important symptom of narcolepsy...
  4. pmc Novel sublingual low-dose zolpidem tablet reduces latency to sleep onset following spontaneous middle-of-the-night awakening in insomnia in a randomized, double-blind, placebo-controlled, outpatient study
    Thomas Roth
    Henry Ford Hospital, Detroit, MI 48202 2691, USA
    Sleep 36:189-96. 2013
    ..5-mg zolpidem tartrate sublingual tablets (ZST) on latency to sleep onset after middle-of-the-night (MOTN) awakenings in patients with insomnia characterized by difficulty returning to sleep after MOTN awakenings...
  5. doi request reprint Appropriate therapeutic selection for patients with shift work disorder
    Thomas Roth
    Henry Ford Hospital, Sleep Disorders and Research Center, Detroit, MI 48202, USA
    Sleep Med 13:335-41. 2012
    ..SWD is associated with a higher risk of occupational and motor vehicle accidents, and thus poses a public health risk...
  6. doi request reprint Effect of pregabalin on sleep in patients with fibromyalgia and sleep maintenance disturbance: a randomized, placebo-controlled, 2-way crossover polysomnography study
    Thomas Roth
    Sleep Disorders and Research Center, Henry Ford Health System, Detroit, Michigan, USA
    Arthritis Care Res (Hoboken) 64:597-606. 2012
    ..To assess the effect of pregabalin on polysomnographic (PSG) measures of sleep and patient-rated sleep, tiredness, and pain in fibromyalgia patients...
  7. pmc Effect of lisdexamfetamine dimesylate on sleep in adults with attention-deficit/hyperactivity disorder
    Lenard A Adler
    Department of Psychiatry and Child and Adolescent Psychiatry, New York University School of Medicine, NY, USA
    Behav Brain Funct 5:34. 2009
    ..abstract:..
  8. ncbi request reprint Measuring treatment efficacy in insomnia
    Thomas Roth
    Henry Ford Hospital Sleep Center, Detroit, MI, USA
    J Clin Psychiatry 65:8-12. 2004
    ....
  9. ncbi request reprint A physiologic basis for the evolution of pharmacotherapy for insomnia
    Thomas Roth
    Sleep Disorders and Research Center, Henry Ford Hospital, Detroit, MI 48202, USA
    J Clin Psychiatry 68:13-8. 2007
    ..Thus, the GABA agonists may not simply promote sleep, but consolidate it as well. The clinical utility of the increase in slow-wave sleep and the sleep consolidation it produces warrants further investigation...
  10. ncbi request reprint Understanding neuronal pathways: novel targets for the management of insomnia
    Thomas Roth
    Sleep Disorders and Research Center, Henry Ford Hospital, Detroit, MI 48202, USA
    J Clin Psychiatry 68:4-5. 2007
  11. ncbi request reprint A 2-night, 3-period, crossover study of ramelteon's efficacy and safety in older adults with chronic insomnia
    Thomas Roth
    Sleep Disorders and Research Center, Detroit, MI 48202, USA
    Curr Med Res Opin 23:1005-14. 2007
    ..To assess the efficacy and safety of ramelteon, a selective melatonin MT1/MT2-receptor agonist, for insomnia treatment in older adults...
  12. ncbi request reprint Efficacy and safety of zolpidem-MR: a double-blind, placebo-controlled study in adults with primary insomnia
    Thomas Roth
    Henri Ford Hospital, Detroit, MI 48202, USA
    Sleep Med 7:397-406. 2006
    ..To evaluate the clinical efficacy and safety of modified-release zolpidem (zolpidem-MR 12.5mg) for the treatment of primary insomnia in adults...
  13. ncbi request reprint Effects of ramelteon on patient-reported sleep latency in older adults with chronic insomnia
    Thomas Roth
    Sleep Disorders and Research Center, Henry Ford Hospital, 2799 West Grand Boulevard, CFP 3, Detroit, MI 48202, USA
    Sleep Med 7:312-8. 2006
    ..To assess the efficacy and safety of ramelteon, a selective MT(1)/MT(2) receptor agonist, for chronic insomnia treatment...
  14. ncbi request reprint Effect of tiagabine on sleep in elderly subjects with primary insomnia: a randomized, double-blind, placebo-controlled study
    Thomas Roth
    Sleep Disorders and Research Center, Henry Ford Hospital, 2799 West Grand Boulevard, CFP 3, Detroit, MI 48202, USA
    Sleep 29:335-41. 2006
    ..This study further evaluated the effects of tiagabine on sleep in elderly subjects with primary insomnia...
  15. ncbi request reprint Prevalence, associated risks, and treatment patterns of insomnia
    Thomas Roth
    Henry Ford Hospital Sleep Center, Detroit, MI 48202, USA
    J Clin Psychiatry 66:10-3; quiz 42-3. 2005
    ..Because the majority of individuals who have trouble sleeping attempt to treat the problem independently using over-the-counter medications or alcohol, insomnia is undertreated by health care providers, despite its serious consequences...
  16. ncbi request reprint An evaluation of the efficacy and safety of eszopiclone over 12 months in patients with chronic primary insomnia
    Thomas Roth
    Henry Ford Hospital Sleep Center, 2799 West Grand Blvd, CFP 3, Detroit, MI 48202, USA
    Sleep Med 6:487-95. 2005
    ..A double-blind placebo-controlled study of eszopiclone found significant, sustained improvement in sleep and daytime function. The 6-month open-label extension phase is described herein...
  17. ncbi request reprint Insomnia: epidemiology, characteristics, and consequences
    Thomas Roth
    Division of Sleep Medicine, Sleep Disorders and Research Center, Henry Ford Hospital, Detroit, Michigan, USA
    Clin Cornerstone 5:5-15. 2003
    ..The most consistent impact of insomnia is a high risk of depression...
  18. ncbi request reprint Ramelteon (TAK-375), a selective MT1/MT2-receptor agonist, reduces latency to persistent sleep in a model of transient insomnia related to a novel sleep environment
    Thomas Roth
    Sleep Disorders and Research Center, Henry Ford Hospital, Detroit, MI 48202, USA
    Sleep 28:303-7. 2005
    ..Evaluate the efficacy of ramelteon, an MT/1MT2-receptor agonist, for the treatment of transient insomnia in healthy adults...
  19. ncbi request reprint Evolution of insomnia: current status and future direction
    Thomas Roth
    Sleep Disorders Centre, Department of Psychiatry and Behavioral Neurosciences, Henry Ford Hospital, Detroit, MI 48202, USA
    Sleep Med 5:S23-30. 2004
    ..This review summarizes the current available data on the evolution of insomnia and proposes a model that warrants further research attention and discussion...
  20. pmc Insomnia: definition, prevalence, etiology, and consequences
    Thomas Roth
    Sleep Disorders and Research Center at Henry Ford Health System, Henry Ford Hospital Sleep Center, 2799 West Grand Blvd, Detroit, MI 48202, USA
    J Clin Sleep Med 3:S7-10. 2007
  21. pmc Armodafinil improves wakefulness and long-term episodic memory in nCPAP-adherent patients with excessive sleepiness associated with obstructive sleep apnea
    Thomas Roth
    Henry Ford Hospital, Detroit, MI 48202, USA
    Sleep Breath 12:53-62. 2008
    ..Armodafinil also reduced patient-reported fatigue and was well tolerated...
  22. pmc Daytime pharmacodynamic and pharmacokinetic evaluation of low-dose sublingual transmucosal zolpidem hemitartrate
    Thomas Roth
    Henry Ford Hospital, Sleep Disorders and Research Center, Detroit, MI 48202, USA
    Hum Psychopharmacol 23:13-20. 2008
    ..The objective of this double-blind placebo-controlled cross-over study (n = 24) was to evaluate the pharmacokinetics (PK) and daytime-sedative profile of 1.0, 1.75, and 3.5 mg dose of the formulation...
  23. doi request reprint Excessive sleepiness: under-recognized and essential marker for sleep/wake disorder management
    T Roth
    Henry Ford Hospital, Sleep Disorders Center, Detroit, MI 48202, USA
    Curr Med Res Opin 26:S3-24; quiz S25-7. 2010
    ..Yet assessment of sleep/wakefulness and associated symptoms can often be easily conducted in the primary care setting, providing valuable information to facilitate the diagnosis and management of sleep/wake disorders...
  24. doi request reprint Efficacy and safety of doxepin 6 mg in a model of transient insomnia
    Thomas Roth
    Henry Ford Health Systems, Detroit, MI 48202, USA
    Sleep Med 11:843-7. 2010
    ..The efficacy and safety of doxepin (DXP) 6mg tablets were evaluated in healthy adults in a model of transient insomnia...
  25. doi request reprint The effect of pregabalin on pain-related sleep interference in diabetic peripheral neuropathy or postherpetic neuralgia: a review of nine clinical trials
    Thomas Roth
    Division of Sleep Medicine and Research Center, Henry Ford Health System, Detroit, MI 48202, USA
    Curr Med Res Opin 26:2411-9. 2010
    ..The objective of this review is to summarize the efficacy and safety of pregabalin in painful diabetic peripheral neuropathy and postherpetic neuralgia and the effect of pregabalin on sleep interference in these patients...
  26. doi request reprint Does effective management of sleep disorders reduce substance dependence?
    Thomas Roth
    Sleep Disorders and Research Center, Henry Ford Health System, Detroit, Michigan 48202, USA
    Drugs 69:65-75. 2009
    ..Further research is therefore required to increase our understanding of the impact of insomnia on patients with substance dependence...
  27. ncbi request reprint Comorbid insomnia: current directions and future challenges
    Thomas Roth
    Henry Ford Hospital Sleep Disorders and Research Center, 2799 W Grand Blvd, Detroit, MI 48202, USA
    Am J Manag Care 15:S6-13. 2009
    ..Recent studies, however, suggest this approach is not the most appropriate. Instead, treating both conditions simultaneously may improve the outcomes for each...
  28. pmc Low-dose sublingual zolpidem tartrate is associated with dose-related improvement in sleep onset and duration in insomnia characterized by middle-of-the-night (MOTN) awakenings
    Thomas Roth
    Henry Ford Hospital Sleep Disorders and Research, Detroit, MI 48202, USA
    Sleep 31:1277-84. 2008
    ....
  29. doi request reprint Hypnotic use for insomnia management in chronic obstructive pulmonary disease
    Thomas Roth
    Sleep Disorders and Research Center, Henry Ford Hospital, 2799 West Grand Boulevard, CFP 3 Detroit, MI 48202, USA
    Sleep Med 10:19-25. 2009
    ....
  30. pmc Efficacy and safety of as-needed, post bedtime dosing with indiplon in insomnia patients with chronic difficulty maintaining sleep
    Thomas Roth
    Sleep Disorders and Research Center, Department of Psychiatry and Behavioral Neurosciences Henry Ford Hospital, 2799 West Grand Blvd, CEP 3, Detroit, MI 48202, USA
    Sleep 30:1731-8. 2007
    ....
  31. ncbi request reprint Narcolepsy: treatment issues
    Thomas Roth
    Sleep Disorders and Research Center, Henry Ford Hospital, Detroit, MI 48202, USA
    J Clin Psychiatry 68:16-9. 2007
    ..Sodium oxybate is the only drug approved for treating both cataplexy and EDS. Modafinil and sodium oxybate have similar, long-term efficacies in treating EDS at prescribed doses...
  32. ncbi request reprint Introduction: narcolepsy and excessive daytime sleepiness: from the bench to the bedside
    Thomas Roth
    Sleep Disorders and Research Center, Henry Ford Hospital, Detroit, MI 48202, USA
    J Clin Psychiatry 68:4. 2007
  33. pmc Efficacy and safety of doxepin 1 mg, 3 mg, and 6 mg in adults with primary insomnia
    Thomas Roth
    Henri Ford Hospital, Detroit, MI 48202, USA
    Sleep 30:1555-61. 2007
    ..To evaluate the efficacy and safety of doxepin 1, 3, and 6 mg in insomnia patients...
  34. pmc Evaluation of the safety of modafinil for treatment of excessive sleepiness
    Thomas Roth
    Henry Ford Sleep Disorders Center, Detroit, MI 48202, USA
    J Clin Sleep Med 3:595-602. 2007
    ..Safety and tolerability data from 6 randomized, double-blind, placebo-controlled studies were combined to evaluate modafinil across these different patient populations...
  35. ncbi request reprint Assessment of sleepiness and unintended sleep in Parkinson's disease patients taking dopamine agonists
    Thomas Roth
    Henry Ford Hospital, Sleep Disorders and Research Center, Clara Ford Pavilion, 3rd Floor, 2799 West Grand Boulevard CFP 3, Detroit, MI 48202, USA
    Sleep Med 4:275-80. 2003
    ....
  36. pmc Nonrestorative sleep as a distinct component of insomnia
    Thomas Roth
    Sleep Center, Henry Ford Hospital, 2799 W Grand Blvd, Detroit, MI 48202, USA
    Sleep 33:449-58. 2010
    ....
  37. ncbi request reprint New trends in insomnia management
    T Roth
    Henry Ford Hospital, Sleep Disorders and Research Center, Detroit, Michigan 48202, USA
    J Psychopharmacol 13:S37-40. 1999
    ..These may have very different consequences in terms of abuse liability and patients' perceptions of efficacy, and thus permit a more effective and appropriate use of this drug class...
  38. ncbi request reprint Effects of armodafinil in the treatment of residual excessive sleepiness associated with obstructive sleep apnea/hypopnea syndrome: a 12-week, multicenter, double-blind, randomized, placebo-controlled study in nCPAP-adherent adults
    Thomas Roth
    Henry Ford Sleep Disorders Center, Detroit, Michigan 48202, USA
    Clin Ther 28:689-706. 2006
    ..Some patients with obstructive sleep apnea/hypopnea syndrome (OSA/HS) experience excessive sleepiness (ES) that might not resolve with nasal continuous positive airway pressure (nCPAP) treatment...
  39. ncbi request reprint Experimental sleep fragmentation
    T Roehrs
    Henry Ford Hospital, Sleep Disorders and Research Center, Detroit, Michigan 48202
    Sleep 17:438-43. 1994
    ....
  40. ncbi request reprint Polysomnographic, performance, and personality differences of sleepy and alert normals
    T Roehrs
    Henry Ford Hospital, Sleep Disorders and Research Center, Detroit, Michigan 48202
    Sleep 13:395-402. 1990
    ..The data were interpreted as indicating that the sleepy subjects had a sleep debt due to chronic sleep restriction...
  41. ncbi request reprint Sleep extension in sleepy and alert normals
    T Roehrs
    Sleep Disorders and Research Center, Henry Ford Hospital, Detroit, MI 48202
    Sleep 12:449-57. 1989
    ..However, sleepy subjects never achieved the baseline level of sleepiness/alertness seen in the alert subjects...
  42. ncbi request reprint The alerting effects of short and long naps in narcoleptic, sleep deprived, and alert individuals
    T Helmus
    Sleep Disorders and Research Center, Henry Ford Hospital, Detroit, MI 48202, USA
    Sleep 20:251-7. 1997
    ..In contrast, for narcoleptic patients the beneficial effects of the nap were lost when tested 3 hours later. These results show that narcoleptic patients benefit from a longer nap but that these benefits are short-lived...
  43. ncbi request reprint Effects of rapid versus slow accumulation of eight hours of sleep loss
    C L Drake
    Sleep Disorders and Research Center, Henry Ford Hospital, Detroit, MI 48202, USA
    Psychophysiology 38:979-87. 2001
    ..The impairing effects of sleep loss vary as a function of rate, suggesting the presence of a compensatory adaptive mechanism operating in conjunction with the accumulation of a sleep debt...
  44. ncbi request reprint Zolpidem in the treatment of transient insomnia: a double-blind, randomized comparison with placebo
    T Roth
    Sleep Disorders and Research Center, Henry Ford Hospital, Detroit, Michigan 48202, USA
    Sleep 18:246-51. 1995
    ..5-mg and 10-mg zolpidem dose groups and placebo. This study demonstrates that zolpidem at 7.5 mg and 10 mg is effective in the treatment of transient insomnia...
  45. pmc Daytime sleepiness: an epidemiological study of young adults
    N Breslau
    Department of Psychiatry, Henry Ford Health Sciences Center, Detroit, Mich 48202 3450, USA
    Am J Public Health 87:1649-53. 1997
    ..This paper examines correlates of and suspected risk factors for daytime sleepiness from a longitudinal epidemiological study of young adults...
  46. ncbi request reprint Fragmenting sleep diminishes its recuperative value
    B Levine
    Henry Ford Hospital, Sleep Disorders and Research Center, Detroit, MI 48202
    Sleep 10:590-9. 1987
    ..Although the natural sleep provided recuperation relative to no sleep or fragmented sleep, it did not restore daytime sleepiness to the screening level...
  47. ncbi request reprint Daytime alertness in patients with chronic insomnia compared with asymptomatic control subjects
    E Stepanski
    Sleep Disorders and Research Center, Henry Ford Hospital, Detroit, Michigan
    Sleep 11:54-60. 1988
    ..This tendency may be exacerbated by other factors (e.g., personality disorder, periodic leg movements) also associated with insomnia...
  48. ncbi request reprint Effects of sleep deprivation on daytime sleepiness in primary insomnia
    E Stepanski
    Sleep Disorders and Research Center, Henry Ford Hospital, Detroit, MI 48202, USA
    Sleep 23:215-9. 2000
    ..This study investigated changes in MSLT scores and recovery sleep following total sleep deprivation in subjects with insomnia as compared to normal sleepers...
  49. ncbi request reprint Daytime sleepiness in young adults
    B Levine
    Sleep Disorders and Research Center, Henry Ford Hospital, Detroit, Michigan
    Sleep 11:39-46. 1988
    ..The relation between nocturnal sleep efficiency and daytime sleepiness suggests that the increased sleepiness of average young adults is due to mild sleep restriction...
  50. ncbi request reprint Scoring reliability of the multiple sleep latency test in a clinical population
    C L Drake
    Sleep Disorders and Research Center, Henry Ford Hospital, Detroit, MI 48202, USA
    Sleep 23:911-3. 2000
    ..To determine intrarater and interrater scoring reliability of the multiple sleep latency test (MSLT) in a population of sleep clinic patients...
  51. ncbi request reprint Effects of an experimentally induced rhinovirus cold on sleep, performance, and daytime alertness
    C L Drake
    Sleep Disorders and Research Center, Henry Ford Hospital, 2799 West Grand Boulevard, CFP3, Detroit, MI 48202, USA
    Physiol Behav 71:75-81. 2000
    ..While several self-report studies suggest that viral illness may influence sleep parameters, no studies have assessed polysomnographically recorded sleep following viral infections...
  52. ncbi request reprint Enforced 24-hour recovery following sleep deprivation
    L Rosenthal
    Sleep Disorders and Research Center, Henry Ford Hospital, Detroit, Michigan 48202
    Sleep 14:448-53. 1991
    ..However, significantly less sleep was found in block 6 following the 48-hr condition. Overall, subjects recovered 72% and 42% of the total amount of sleep lost during the 24- and 48-hr conditions, respectively...
  53. ncbi request reprint Test-retest reliability of the MSLT
    A Zwyghuizen-Doorenbos
    Sleep Disorders and Research Center, Henry Ford Hospital, Detroit, Michigan 48202
    Sleep 11:562-5. 1988
    ..However, as the number of tests comprising the MSLT was reduced below three, the reliability was reduced such that only 50% or less of the variance could be predicted...
  54. ncbi request reprint Level of sleepiness and total sleep time following various time in bed conditions
    L Rosenthal
    Sleep Disorders and Research Center, Henry Ford Hospital, Detroit, Michigan
    Sleep 16:226-32. 1993
    ..Across conditions, subjects slept more during the first 4 hours when compared to blocks 2, 3, 4 and 5. Blocks 1 and 6 were comparable.(ABSTRACT TRUNCATED AT 250 WORDS)..
  55. ncbi request reprint The frequency of multiple sleep onset REM periods among subjects with no excessive daytime sleepiness
    C Bishop
    Sleep Disorders and Research Center, Henry Ford Hospital, Detroit, MI 48202, USA
    Sleep 19:727-30. 1996
    ..Further investigations into the determinants of multiple SOREMPs and their reliability among asymptomatic populations are warranted...
  56. ncbi request reprint A two-week sleep extension in sleepy normals
    T Roehrs
    Henry Ford Hospital, Sleep Disorders and Research Center, Detroit, Michigan 48202, USA
    Sleep 19:576-82. 1996
    ..Their short average daily sleep latency was a result of causes other than chronic insufficient sleep...
  57. ncbi request reprint Effects of sleep loss on waking actigraphy
    T Roehrs
    Henry Ford Hospital, Sleep Disorders and Research Center and Department of Psychiatry and Behavioral Neuroscience, Wayne State University, School of Medicine, Detroit MI 48202, USA
    Sleep 23:793-7. 2000
    ..To assess the effect of sleep loss and the effect of a sedating drug on waking actigraphy..
  58. ncbi request reprint The detection of brief daytime sleep episodes
    L Rosenthal
    Henry Ford Hospital, Sleep Disorders and Research Center, Detroit, Mich, USA
    Sleep 22:211-4. 1999
    ..In the present study we evaluated the characteristics of sleep-onset detection (during daytime nap opportunities) as a function of differing sleep lengths among healthy, asymptomatic subjects...
  59. ncbi request reprint Future directions in the management of insomnia
    G S Richardson
    Sleep Disorders and Research Center, Henry Ford Hospital, Detroit, Mich 48202, USA
    J Clin Psychiatry 62:39-45. 2001
    ..It remains unclear, however, whether this activation is primary or secondary to the insomnia itself. If physiologic hyperarousal causes primary insomnia, it would provide new approaches to the management of this disorder...
  60. ncbi request reprint Daytime CPAP titration: a viable alternative for patients with severe obstructive sleep apnea
    L Rosenthal
    Sleep Disorder and Research Center, Henry Ford Hospital, Detroit, MI, USA
    Chest 114:1056-60. 1998
    ..The objective of the study was to determine if daytime CPAP titration is a viable alternative for the implementation of CPAP treatment in patients with severe OSA...
  61. ncbi request reprint Biperiden administration during REM sleep deprivation diminished the frequency of REM sleep attempts
    R J Salin-Pascual
    Sleep Disorders Center, Henry Ford Hospital, Detroit, Michigan
    Sleep 15:252-6. 1992
    ..The REM sleep latency showed a reduction in the first recovery night in both groups that persisted through the second recovery night. The above findings support the role of biperiden as a REM sleep suppressive drug...
  62. ncbi request reprint Phase advance in moderately sleepy and alert normals
    T Roehrs
    Henry Ford Hospital, Sleep Disorders and Research Center, Detroit, Michigan 48202, USA
    Sleep 19:417-22. 1996
    ....
  63. ncbi request reprint Auditory awakening thresholds in sleepy and alert individuals
    L Rosenthal
    Sleep Disorders and Research Center, Henry Ford Hospital, Detroit, Michigan 48202 USA
    Sleep 19:290-5. 1996
    ..This differential rate of decline in AATs is suggested to be related to the differences in sleep homeostasis among alert and sleepy individuals...
  64. ncbi request reprint Sedative effects and plasma concentrations following single doses of triazolam, diphenhydramine, ethanol and placebo
    T Roehrs
    Sleep Disorders and Research Center, Henry Ford Hospital, Detroit, Michigan 48202
    Sleep 16:301-5. 1993
    ..5 hours. Ethanol reached zero, but triazolam and diphenhydramine did not. Continued sedation (sedative effects after plasma concentration reached zero) was observed with ethanol...
  65. ncbi request reprint Epidemiology of alcohol and medication as aids to sleep in early adulthood
    E O Johnson
    Department of Psychiatry, Henry Ford Health Sciences Center, Detroit, Mich 48202 3450, USA
    Sleep 21:178-86. 1998
    ..2) among those who use these substances for sleep problems, what are the patterns of use? and (3) are there social factors, independent of sleep characteristics, that increase the likelihood of alcohol and medication use to aid sleep?..
  66. ncbi request reprint Ethanol and caffeine effects on daytime sleepiness/alertness
    M Lumley
    Sleep Disorders and Research Center, Henry Ford Hospital, Detroit, Michigan 48202
    Sleep 10:306-12. 1987
    ..In this condition latencies were similar to those of the caffeine and 5- or 8-h TIBs...
  67. ncbi request reprint Sleepiness and the reinforcing and subjective effects of methylphenidate
    T Roehrs
    Sleep Disorders and Research Center, Henry Ford Hospital, Detroit, Michigan 48202, USA
    Exp Clin Psychopharmacol 7:145-50. 1999
    ..Drug was chosen on 88% of days after 4 hr, but only 29% of days after 8 hr. Preference for the drug depends on sleepiness and is mediated by performance-enhancing and fatigue-altering effects...
  68. ncbi request reprint Treatment regimen and hypnotic self-administration
    T Roehrs
    Henry Ford Hospital, Sleep Disorders and Research Center, 2799 West Grand Blvd, Detroit, MI 48202, USA
    Psychopharmacology (Berl) 155:11-7. 2001
    ..CONCLUSIONS: The data of this study are consistent with the view that hypnotic self-administration by insomniacs is therapy-seeking behavior and not drug abuse...
  69. ncbi request reprint Neuropsychological function in obstructive sleep apnea syndrome (OSAS) compared to chronic obstructive pulmonary disease (COPD)
    T Roehrs
    Henry Ford Hospital, Sleep Disorders and Research Center, Detroit, Michigan 48202, USA
    Sleep 18:382-8. 1995
    ..These deficits in psychomotor and attention appear to be specifically related to patients group (OSAS vs. COPD), but the other deficits found in complex reasoning and memory are nonspecific...
  70. ncbi request reprint Sleep, sleepiness, and alcohol use
    T Roehrs
    Sleep Disorders and Research Center, Henry Ford Hospital, Department of Psychiatry and Behavioral Neuroscience, Wayne State University, Detroit, Michigan, USA
    Alcohol Res Health 25:101-9. 2001
    ..Alcohol's effects on other physiological functions during sleep have yet to be documented thoroughly and unequivocally...
  71. ncbi request reprint The effects of REM sleep deprivation on the level of sleepiness/alertness
    K Nykamp
    Henry Ford Hospital, Sleep Disorders and Research Center, Detroit, Mich. 48202, USA
    Sleep 21:609-14. 1998
    ..The mechanism by which REM deprivation exerts its alerting effects is unknown and will require future research...

Research Grants5

  1. DAYTIME SLEEPINESS--PREVALENCE, CONSEQUENCES, AND RISKS
    Thomas Roth; Fiscal Year: 2003
    ..The important contribution of the present proposal is that it will be the first population-based study to use laboratory assessments, its consequences and risks to measure sleepiness. ..
  2. DAYTIME SLEEPINESS--PREVALENCE, CONSEQUENCES, AND RISKS
    Thomas Roth; Fiscal Year: 1999
    ..The important contribution of the present proposal is that it will be the first population-based study to use laboratory assessments, its consequences and risks to measure sleepiness. ..
  3. DAYTIME SLEEPINESS--PREVALENCE, CONSEQUENCES, AND RISKS
    Thomas Roth; Fiscal Year: 2000
    ..The important contribution of the present proposal is that it will be the first population-based study to use laboratory assessments, its consequences and risks to measure sleepiness. ..
  4. DAYTIME SLEEPINESS--PREVALENCE, CONSEQUENCES, AND RISKS
    Thomas Roth; Fiscal Year: 2001
    ..The important contribution of the present proposal is that it will be the first population-based study to use laboratory assessments, its consequences and risks to measure sleepiness. ..
  5. DAYTIME SLEEPINESS--PREVALENCE, CONSEQUENCES, AND RISKS
    Thomas Roth; Fiscal Year: 2002
    ..The important contribution of the present proposal is that it will be the first population-based study to use laboratory assessments, its consequences and risks to measure sleepiness. ..