S A Rempel

Summary

Affiliation: Henry Ford Hospital
Country: USA

Publications

  1. ncbi SPARC: a potential diagnostic marker of invasive meningiomas
    S A Rempel
    Henry Ford Midwest Neuro Oncology Center and the Department of Neurosurgery, Henry Ford Health Sciences Center, Detroit, Michigan 48202, USA
    Clin Cancer Res 5:237-41. 1999
  2. ncbi Identification and localization of the cytokine SDF1 and its receptor, CXC chemokine receptor 4, to regions of necrosis and angiogenesis in human glioblastoma
    S A Rempel
    Henry Ford Midwest Neuro Oncology Center, Department of Neurosurgery, Henry Ford Health Sciences Center, Detroit, Michigan 48202, USA
    Clin Cancer Res 6:102-11. 2000
  3. ncbi SPARC modulates cell growth, attachment and migration of U87 glioma cells on brain extracellular matrix proteins
    S A Rempel
    Department of Neurosurgery, Henry Ford Health Sciences Center, Detroit, MI 48202, USA
    J Neurooncol 53:149-60. 2001
  4. ncbi Molecular biology of nervous system tumors
    S A Rempel
    Barbara Jane Levy Laboratory of Molecular Neuro Oncology, Hermelin Brain Tumor Center, Department of Neurosurgery, Henry Ford Hospital, Detroit, Michigan, USA
    Hematol Oncol Clin North Am 15:979-1006. 2001
  5. ncbi Splenic and immune alterations of the Sparc-null mouse accompany a lack of immune response
    S A Rempel
    Department of Neurosurgery, Barbara Jane Levy Laboratory of Molecular Neuro Oncology, Hermelin Brain Tumor Center, Henry Ford Hospital, Detroit, MI, USA
    Genes Immun 8:262-74. 2007
  6. ncbi Carboxyamido-triazole induces apoptosis in bovine aortic endothelial and human glioma cells
    S Ge
    Department of Neurosurgery, Henry Ford Health Science Center, Detroit, Michigan 48202, USA
    Clin Cancer Res 6:1248-54. 2000
  7. ncbi Cellular uptake of a novel cytotoxic agent, cryptophycin-52, by human THP-1 leukemia cells and H-125 lung tumor cells
    B D Chen
    Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA
    Int J Cancer 77:869-73. 1998
  8. ncbi Differential expression of mast cell growth factor receptor (c-kit) by peritoneal connective tissue-type mast cells and tissue culture-derived mast cells
    B Chen
    Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan 48202
    J Leukoc Biol 55:596-602. 1994

Research Grants

  1. ROLE OF SPARC IN GLIOMA INVASION
    Sandra Rempel; Fiscal Year: 2003
  2. THE ROLE OF SPARC IN GLIOMA INVASION
    Sandra Rempel; Fiscal Year: 2007

Collaborators

Detail Information

Publications8

  1. ncbi SPARC: a potential diagnostic marker of invasive meningiomas
    S A Rempel
    Henry Ford Midwest Neuro Oncology Center and the Department of Neurosurgery, Henry Ford Health Sciences Center, Detroit, Michigan 48202, USA
    Clin Cancer Res 5:237-41. 1999
    ....
  2. ncbi Identification and localization of the cytokine SDF1 and its receptor, CXC chemokine receptor 4, to regions of necrosis and angiogenesis in human glioblastoma
    S A Rempel
    Henry Ford Midwest Neuro Oncology Center, Department of Neurosurgery, Henry Ford Health Sciences Center, Detroit, Michigan 48202, USA
    Clin Cancer Res 6:102-11. 2000
    ....
  3. ncbi SPARC modulates cell growth, attachment and migration of U87 glioma cells on brain extracellular matrix proteins
    S A Rempel
    Department of Neurosurgery, Henry Ford Health Sciences Center, Detroit, MI 48202, USA
    J Neurooncol 53:149-60. 2001
    ..These data suggest that SPARC may modulate glioma proliferation and invasion by modulating both the growth and migration of glioma cells...
  4. ncbi Molecular biology of nervous system tumors
    S A Rempel
    Barbara Jane Levy Laboratory of Molecular Neuro Oncology, Hermelin Brain Tumor Center, Department of Neurosurgery, Henry Ford Hospital, Detroit, Michigan, USA
    Hematol Oncol Clin North Am 15:979-1006. 2001
    ..cDNA arrays and tissue arrays will permit the construction of CNS-specific screening tools that will permit the identification of tumor-specific mutations and alterations so that patient-specific therapies can be designed...
  5. ncbi Splenic and immune alterations of the Sparc-null mouse accompany a lack of immune response
    S A Rempel
    Department of Neurosurgery, Barbara Jane Levy Laboratory of Molecular Neuro Oncology, Hermelin Brain Tumor Center, Henry Ford Hospital, Detroit, MI, USA
    Genes Immun 8:262-74. 2007
    ..Finally, Sparc-null mice were unable to mount an immune response following footpad lipopolysaccharide challenge. These data confirm that Sparc-null mice have an impaired immune system...
  6. ncbi Carboxyamido-triazole induces apoptosis in bovine aortic endothelial and human glioma cells
    S Ge
    Department of Neurosurgery, Henry Ford Health Science Center, Detroit, Michigan 48202, USA
    Clin Cancer Res 6:1248-54. 2000
    ..Here we report that the kinetics of CAI-induced apoptosis in bovine aortic endothelial cells and glioma cells was determined to be both dose and time dependent in micromolar concentrations achievable in brain tissue in vivo...
  7. ncbi Cellular uptake of a novel cytotoxic agent, cryptophycin-52, by human THP-1 leukemia cells and H-125 lung tumor cells
    B D Chen
    Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA
    Int J Cancer 77:869-73. 1998
    ..Further, it suggests that, in addition to tubulin, other intracellular and/or membrane components are involved in mediating the binding of CP-52...
  8. ncbi Differential expression of mast cell growth factor receptor (c-kit) by peritoneal connective tissue-type mast cells and tissue culture-derived mast cells
    B Chen
    Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan 48202
    J Leukoc Biol 55:596-602. 1994
    ..Thus, diminished expression of MGFR is one of the phenotypic characteristics associated with CDMCs...

Research Grants7

  1. ROLE OF SPARC IN GLIOMA INVASION
    Sandra Rempel; Fiscal Year: 2003
    ..Direct effects of SPARC on cell cycle progression will be monitored for changes in cyclin A, tk, and p107 expression and/or phosphorylation. ..
  2. THE ROLE OF SPARC IN GLIOMA INVASION
    Sandra Rempel; Fiscal Year: 2007
    ..We will also determine whether SPARC's regulation of the phenotypes results from differences in cellular versus extracellular localization. ..