Andrey A Komissarov

Summary

Affiliation: Henry Ford Hospital
Country: USA

Publications

  1. ncbi Protonation state of a single histidine residue contributes significantly to the kinetics of the reaction of plasminogen activator inhibitor-1 with tissue-type plasminogen activator
    Andrey A Komissarov
    Division of Biochemical Research, Department of Pathology, Henry Ford Health System, Detroit, Michigan 48202, USA
    J Biol Chem 279:23007-13. 2004
  2. ncbi Additivity in effects of vitronectin and monoclonal antibodies against alpha-helix F of plasminogen activator inhibitor-1 on its reactions with target proteinases
    Andrey A Komissarov
    Division of Biochemical Research, Department of Pathology, Henry Ford Health System, Detroit, Michigan 48202, USA
    J Biol Chem 280:1482-9. 2005
  3. ncbi Mechanisms of conversion of plasminogen activator inhibitor 1 from a suicide inhibitor to a substrate by monoclonal antibodies
    Andrey A Komissarov
    Division of Biochemical Research, Henry Ford Health System, Detroit, Michigan 48202, USA
    J Biol Chem 277:43858-65. 2002
  4. ncbi Modulation of serpin reaction through stabilization of transient intermediate by ligands bound to alpha-helix F
    Andrey A Komissarov
    Department of Chemistry, Portland State University, Portland, Oregon 97207 0751, USA
    J Biol Chem 282:26306-15. 2007
  5. ncbi Redirection of the reaction between activated protein C and a serpin to the substrate pathway
    Andrey A Komissarov
    Department of Chemistry, Portland State University, P O Box 751, Portland, OR 97207 0751, USA
    Thromb Res 122:397-404. 2008
  6. ncbi Alkyl-CoA disulfides as inhibitors and mechanistic probes for FabH enzymes
    Mamoun M Alhamadsheh
    Department of Chemistry, Portland State University, Portland, OR 97207, USA
    Chem Biol 14:513-24. 2007

Collaborators

  • Julie S Bødker
  • Aiwu Zhou
  • Mamoun M Alhamadsheh
  • H Tonie Wright
  • Galina Florova
  • Neel Scarsdale
  • Faik Musayev
  • Sarbjot Sachdeva
  • Kevin A Reynolds

Detail Information

Publications6

  1. ncbi Protonation state of a single histidine residue contributes significantly to the kinetics of the reaction of plasminogen activator inhibitor-1 with tissue-type plasminogen activator
    Andrey A Komissarov
    Division of Biochemical Research, Department of Pathology, Henry Ford Health System, Detroit, Michigan 48202, USA
    J Biol Chem 279:23007-13. 2004
    ..Changes in the protonation state of His(188), which is placed closely to the S1 site and is unique for tPA, has been proposed to contribute to the observed pH dependences of k(lim) and K(0.5)...
  2. ncbi Additivity in effects of vitronectin and monoclonal antibodies against alpha-helix F of plasminogen activator inhibitor-1 on its reactions with target proteinases
    Andrey A Komissarov
    Division of Biochemical Research, Department of Pathology, Henry Ford Health System, Detroit, Michigan 48202, USA
    J Biol Chem 280:1482-9. 2005
    ..These results demonstrate that mAbs represent a valid approach for inactivation of vitronectin-bound PAI-1 in vivo...
  3. ncbi Mechanisms of conversion of plasminogen activator inhibitor 1 from a suicide inhibitor to a substrate by monoclonal antibodies
    Andrey A Komissarov
    Division of Biochemical Research, Henry Ford Health System, Detroit, Michigan 48202, USA
    J Biol Chem 277:43858-65. 2002
    ..The strong functional additivity observed for MA-8H9D4 and MA-55F4C12 demonstrates that these mAbs interact independently and affect different steps of the PAI-1 reaction mechanism...
  4. ncbi Modulation of serpin reaction through stabilization of transient intermediate by ligands bound to alpha-helix F
    Andrey A Komissarov
    Department of Chemistry, Portland State University, Portland, Oregon 97207 0751, USA
    J Biol Chem 282:26306-15. 2007
    ....
  5. ncbi Redirection of the reaction between activated protein C and a serpin to the substrate pathway
    Andrey A Komissarov
    Department of Chemistry, Portland State University, P O Box 751, Portland, OR 97207 0751, USA
    Thromb Res 122:397-404. 2008
    ..Intermolecular mechanisms were employed to redirect the reaction between APC and PAI-1 from the inhibitory to the substrate pathway, which results in the catalytic neutralization of the serpin...
  6. ncbi Alkyl-CoA disulfides as inhibitors and mechanistic probes for FabH enzymes
    Mamoun M Alhamadsheh
    Department of Chemistry, Portland State University, Portland, OR 97207, USA
    Chem Biol 14:513-24. 2007
    ....