Jieli Chen


Affiliation: Henry Ford Hospital
Country: USA


  1. Cui C, Ye X, Chopp M, Venkat P, Zacharek A, Yan T, et al. miR-145 Regulates Diabetes-Bone Marrow Stromal Cell-Induced Neurorestorative Effects in Diabetes Stroke Rats. Stem Cells Transl Med. 2016;5:1656-1667 pubmed
    ..microRNA-145 mediated the benefits induced by DM-BMSC treatment. ..
  2. Li R, Venkat P, Chopp M, Zhang Q, Yan T, Chen J. RP001 hydrochloride improves neurological outcome after subarachnoid hemorrhage. J Neurol Sci. 2019;399:6-14 pubmed publisher
    ..Our findings indicate that low-dose of RP001 alleviates neurological damage after SAH, in part by decreasing neuroinflammation. ..
  3. Zhao Q, Yan T, Li L, Chopp M, Venkat P, Qian Y, et al. Immune response mediates cardiac dysfunction after traumatic brain injury. J Neurotrauma. 2018;: pubmed publisher
    ..Splenectomy decreases heart inflammation and improves cardiac function after TBI. Immune response may contribute to TBI-induced cardiac dysfunction. ..
  4. Venkat P, Chopp M, Chen J. Models and mechanisms of vascular dementia. Exp Neurol. 2015;272:97-108 pubmed publisher
    ..This review article discusses VaD, its risk factors, induced cognitive disability, various animal (rodent) models of VaD, pathology, and mechanisms of VaD and treatment options. ..
  5. Yan T, Venkat P, Chopp M, Zacharek A, Ning R, Cui Y, et al. Neurorestorative Therapy of Stroke in Type 2 Diabetes Mellitus Rats Treated With Human Umbilical Cord Blood Cells. Stroke. 2015;46:2599-606 pubmed publisher
    ..HUCBC reduction of neuroinflammation and increased vascular and white matter axonal remodeling may contribute to the HUCBC-induced beneficial effects in T2DM stroke rats. ..
  6. Chen J, Cui X, Zacharek A, Roberts C, Chopp M. eNOS mediates TO90317 treatment-induced angiogenesis and functional outcome after stroke in mice. Stroke. 2009;40:2532-8 pubmed publisher
    ..These data indicate that TO901317 treatment increases serum HDL-C level, which promotes angiogenesis through eNOS and leads to improvement of functional outcome after stroke. ..
  7. Cui X, Chopp M, Zacharek A, Cui C, Yan T, Ning R, et al. D-4F Decreases White Matter Damage After Stroke in Mice. Stroke. 2016;47:214-20 pubmed publisher
    ..D-4F-induced increase in IGF1 may contribute to D-4F-induced neurite/axonal outgrowth after stroke. ..
  8. Venkat P, Chopp M, Zacharek A, Cui C, Zhang L, Li Q, et al. White matter damage and glymphatic dysfunction in a model of vascular dementia in rats with no prior vascular pathologies. Neurobiol Aging. 2017;50:96-106 pubmed publisher
    ..The MMI model in RB rats decreases Aquaporin-4 and induces glymphatic dysfunction which may play an important role in MMI-induced axonal/WM damage and cognitive deficits. ..
  9. Yan T, Venkat P, Chopp M, Zacharek A, Ning R, Roberts C, et al. Neurorestorative Responses to Delayed Human Mesenchymal Stromal Cells Treatment of Stroke in Type 2 Diabetic Rats. Stroke. 2016;47:2850-2858 pubmed
    ..Increasing brain platelet-derived growth factor expression may contribute to hMSC-induced neurorestoration. ..

More Information


  1. Venkat P, Chopp M, Chen J. New insights into coupling and uncoupling of cerebral blood flow and metabolism in the brain. Croat Med J. 2016;57:223-8 pubmed
    ..Disruption of the glymphatic system burdens the brain with accumulating waste and has been reported in aging as well as several neurological diseases. ..
  2. Wang D, Li T, Wei H, Wang Y, Yang G, Tian Y, et al. Atorvastatin enhances angiogenesis to reduce subdural hematoma in a rat model. J Neurol Sci. 2016;362:91-9 pubmed publisher
    ..The low-dose atorvastatin is effective in reducing SDH and improving neurological deficits in a rat model, primarily by promoting angiogenesis and vascular maturation. ..
  3. Yan T, Chopp M, Chen J. Experimental animal models and inflammatory cellular changes in cerebral ischemic and hemorrhagic stroke. Neurosci Bull. 2015;31:717-34 pubmed publisher
  4. Chen J, Cui X, Zacharek A, Chopp M. Increasing Ang1/Tie2 expression by simvastatin treatment induces vascular stabilization and neuroblast migration after stroke. J Cell Mol Med. 2009;13:1348-57 pubmed publisher
    ..Ang1/Tie2 expression induced by simvastatin treatment promotes neuroblast micro-vascular coupling after stroke. ..
  5. Chen J, Cui C, Yang X, Xu J, Venkat P, Zacharek A, et al. MiR-126 Affects Brain-Heart Interaction after Cerebral Ischemic Stroke. Transl Stroke Res. 2017;8:374-385 pubmed publisher
    ..Ischemic stroke directly induces cardiac dysfunction. Decreasing miR-126 expression may contribute to cardiac dysfunction after stroke in mice. ..
  6. Ning R, Chopp M, Zacharek A, Yan T, Zhang C, Roberts C, et al. Neamine induces neuroprotection after acute ischemic stroke in type one diabetic rats. Neuroscience. 2014;257:76-85 pubmed publisher
    ..Neamine treatment of stroke is neuroprotective in T1DM rats. Inhibition of neuroinflammatory factor expression and decrease of BBB leakage may contribute to Neamine-induced neuroprotective effects after stroke in T1DM rats. ..
  7. Chen J, Ye X, Yan T, Zhang C, Yang X, Cui X, et al. Adverse effects of bone marrow stromal cell treatment of stroke in diabetic rats. Stroke. 2011;42:3551-8 pubmed publisher
    ..Thus, BMSC treatment starting 24 hours after MCAO may not be beneficial for diabetic subjects with stroke. ..
  8. Chen J, Zacharek A, Cui X, Shehadah A, Jiang H, Roberts C, et al. Treatment of stroke with a synthetic liver X receptor agonist, TO901317, promotes synaptic plasticity and axonal regeneration in mice. J Cereb Blood Flow Metab. 2010;30:102-9 pubmed publisher
    ..These data indicate that TO901317 promotes synaptic plasticity and axonal regeneration, and that PI3K/Akt signaling activity contributes to neurite outgrowth. ..
  9. Chen J, Cui X, Zacharek A, Ding G, Shehadah A, Jiang Q, et al. Niaspan treatment increases tumor necrosis factor-alpha-converting enzyme and promotes arteriogenesis after stroke. J Cereb Blood Flow Metab. 2009;29:911-20 pubmed publisher
    ..Knockdown of Notch1 marginally decreased arterial sprouting and VSMC migration compared with scrambled control. Niaspan promotes arteriogenesis, which is mediated, in part, by TACE. ..
  10. Zacharek A, Chen J, Cui X, Yang Y, Chopp M. Simvastatin increases notch signaling activity and promotes arteriogenesis after stroke. Stroke. 2009;40:254-60 pubmed publisher
    ..These data indicate that simvastatin increases arteriogenesis after stroke, and that simvastatin upregulation of PS1 expression and Notch signaling activity may facilitate an increase in arteriogenesis. ..