S L Brown

Summary

Affiliation: Henry Ford Hospital
Country: USA

Publications

  1. pmc Inhibition of HSP27 alone or in combination with pAKT inhibition as therapeutic approaches to target SPARC-induced glioma cell survival
    Chad R Schultz
    The Barbara Jane Levy Laboratory of Molecular Neuro Oncology, Henry Ford Hospital, Detroit, MI 48202, USA
    Mol Cancer 11:20. 2012
  2. pmc Radiation-induced skin injury in the animal model of scleroderma: implications for post-radiotherapy fibrosis
    Sanath Kumar
    Department of Radiation Oncology, Henry Ford Health System, Detroit, MI, USA
    Radiat Oncol 3:40. 2008
  3. pmc Ramipril mitigates radiation-induced impairment of neurogenesis in the rat dentate gyrus
    Kenneth A Jenrow
    Department of Neurosurgery, Henry Ford Hospital, Detroit, Michigan 48202, USA
    Radiat Oncol 5:6. 2010
  4. ncbi request reprint Reporter gene imaging using radiographic contrast from nonradioactive iodide sequestered by the sodium-iodide symporter
    Stephen L Brown
    Department of Radiation Oncology, Henry Ford Health System, Detroit, MI 48202, USA
    Contrast Media Mol Imaging 2:240-7. 2007
  5. pmc Histone deacetylase inhibitors protect against and mitigate the lethality of total-body irradiation in mice
    Stephen L Brown
    Department of Radiation Oncology, Henry Ford Hospital, Detroit, Michigan 48202, USA
    Radiat Res 169:474-8. 2008
  6. ncbi request reprint Sickle red blood cells accumulate in tumor
    S L Brown
    Department of Radiation Oncology, Henry Ford Health System, Detroit, Michigan 48202, USA
    Magn Reson Med 50:1209-14. 2003
  7. pmc Antioxidant diet supplementation starting 24 hours after exposure reduces radiation lethality
    Stephen L Brown
    Henry Ford Hospital, Department of Radiation Oncology, Detroit, Michigan 48202, USA
    Radiat Res 173:462-8. 2010
  8. pmc Efficacy of suicide gene therapy in hypoxic rat 9L glioma cells
    S Kumar
    Department of Radiation Oncology, Henry Ford Health System, Detroit, MI 48202, USA
    J Neurooncol 90:19-24. 2008
  9. ncbi request reprint Synergistic interaction with arsenic trioxide and fractionated radiation in locally advanced murine tumor
    Young S Lew
    Department of Radiation Oncology, Henry Ford Health System, Detroit, Michigan 48202, USA
    Cancer Res 62:4202-5. 2002
  10. ncbi request reprint Magnetically-labeled sensitized splenocytes to identify glioma by MRI: a preliminary study
    Ali S Arbab
    Department of Radiology, Henry Ford Hospital, Detroit, Michigan 48202, USA, and National Institutes of Health, University of Tehran, Iran
    Magn Reson Med 58:519-26. 2007

Collaborators

Detail Information

Publications42

  1. pmc Inhibition of HSP27 alone or in combination with pAKT inhibition as therapeutic approaches to target SPARC-induced glioma cell survival
    Chad R Schultz
    The Barbara Jane Levy Laboratory of Molecular Neuro Oncology, Henry Ford Hospital, Detroit, MI 48202, USA
    Mol Cancer 11:20. 2012
    ..As HSP27 and AKT interact to regulate the activity of each other, we determined whether inhibition of HSP27 was better than targeting SPARC as a therapeutic approach to inhibit both SPARC-induced glioma cell invasion and survival...
  2. pmc Radiation-induced skin injury in the animal model of scleroderma: implications for post-radiotherapy fibrosis
    Sanath Kumar
    Department of Radiation Oncology, Henry Ford Health System, Detroit, MI, USA
    Radiat Oncol 3:40. 2008
    ..If TSK mice are shown to have radiation sensitive skin, they may prove to be a useful model to examine the mechanisms underlying skin radiation injury, protection, mitigation and treatment...
  3. pmc Ramipril mitigates radiation-induced impairment of neurogenesis in the rat dentate gyrus
    Kenneth A Jenrow
    Department of Neurosurgery, Henry Ford Hospital, Detroit, Michigan 48202, USA
    Radiat Oncol 5:6. 2010
    ..Here we investigate the angiotensin converting enzyme (ACE) inhibitor, ramipril, as a mitigator of radiation injury in this context...
  4. ncbi request reprint Reporter gene imaging using radiographic contrast from nonradioactive iodide sequestered by the sodium-iodide symporter
    Stephen L Brown
    Department of Radiation Oncology, Henry Ford Health System, Detroit, MI 48202, USA
    Contrast Media Mol Imaging 2:240-7. 2007
    ..Radiographic contrast due to NIS gene expression that was observed indicates the technique has potential for use in preclinical rodent tumor studies but probably lacks sensitivity for human use...
  5. pmc Histone deacetylase inhibitors protect against and mitigate the lethality of total-body irradiation in mice
    Stephen L Brown
    Department of Radiation Oncology, Henry Ford Hospital, Detroit, Michigan 48202, USA
    Radiat Res 169:474-8. 2008
    ..HDAC inhibitors were effective at reducing lethality when given either 24 h before or 1 h after TBI. The results indicate that HDAC inhibitors have potential for protecting against and mitigating radiation-induced lethality...
  6. ncbi request reprint Sickle red blood cells accumulate in tumor
    S L Brown
    Department of Radiation Oncology, Henry Ford Health System, Detroit, Michigan 48202, USA
    Magn Reson Med 50:1209-14. 2003
    ..The application of the noninvasive measurement of sickle cells for imaging tumor neovasculature, or as a delivery tool for therapy, requires further study...
  7. pmc Antioxidant diet supplementation starting 24 hours after exposure reduces radiation lethality
    Stephen L Brown
    Henry Ford Hospital, Department of Radiation Oncology, Detroit, Michigan 48202, USA
    Radiat Res 173:462-8. 2010
    ..A diet supplemented with antioxidants administered starting 24 h after total-body irradiation improved bone marrow cell survival and mitigated lethality, with a radiation protection factor of approximately 1.18...
  8. pmc Efficacy of suicide gene therapy in hypoxic rat 9L glioma cells
    S Kumar
    Department of Radiation Oncology, Henry Ford Health System, Detroit, MI 48202, USA
    J Neurooncol 90:19-24. 2008
    ..These studies support the use of SGT utilizing either TK or CD gene strategies even when tumors are characterized by a hypoxic microenvironment...
  9. ncbi request reprint Synergistic interaction with arsenic trioxide and fractionated radiation in locally advanced murine tumor
    Young S Lew
    Department of Radiation Oncology, Henry Ford Health System, Detroit, Michigan 48202, USA
    Cancer Res 62:4202-5. 2002
    ..The present results indicate that tumor response was better with combined treatment than with either treatment alone, suggesting that ATO has potential as an adjuvant to radiotherapy...
  10. ncbi request reprint Magnetically-labeled sensitized splenocytes to identify glioma by MRI: a preliminary study
    Ali S Arbab
    Department of Radiology, Henry Ford Hospital, Detroit, Michigan 48202, USA, and National Institutes of Health, University of Tehran, Iran
    Magn Reson Med 58:519-26. 2007
    ..In conclusion, the immunogenic reaction can be exploited to delineate recurrent glioma using MRI following systemically delivered magnetically labeled sensitized splenocytes or T-cells...
  11. ncbi request reprint A model for optimizing adenoviral delivery in human cancer gene therapy trials
    Kenneth N Barton
    Department of Radiation Oncology, Henry Ford Health System, Detroit, MI 48202, USA
    Hum Gene Ther 18:562-72. 2007
    ....
  12. ncbi request reprint Design considerations for incorporating sodium iodide symporter reporter gene imaging into prostate cancer gene therapy trials
    Farzan Siddiqui
    Department of Radiation Oncology, Henry Ford Health System, Detroit, MI 48202
    Hum Gene Ther 18:312-22. 2007
    ....
  13. doi request reprint Does hyperthermia increase adenoviral transgene expression or dissemination in tumors?
    Farzan Siddiqui
    Department of Radiation Oncology, Henry Ford Health System, Detroit, Michigan 48202, USA
    Int J Hyperthermia 25:273-9. 2009
    ..We studied the role of hyperthermia (HT) in vitro and in vivo in an attempt to achieve higher transfection rates (especially, larger volume of spread)...
  14. ncbi request reprint Replication-competent adenovirus-mediated suicide gene therapy with radiation in a preclinical model of pancreatic cancer
    Svend O Freytag
    Department of Radiation Oncology, Henry Ford Health System, Detroit, Michigan 48202, USA
    Mol Ther 15:1600-6. 2007
    ..Hence they provide the scientific basis for an ongoing Phase I trial in pancreatic cancer...
  15. doi request reprint Decreasing the adverse effects of cancer therapy: National Cancer Institute guidance for the clinical development of radiation injury mitigators
    Benjamin Movsas
    Department of Radiation Oncology, Henry Ford Hospital, Detroit, Michigan 48202, USA
    Clin Cancer Res 17:222-8. 2011
    ..Ultimately, the goal is to be able to apply such promising agents to improve the quality of life for patients receiving radiotherapy or chemoradiotherapy for cancer...
  16. pmc A novel method of boron delivery using sodium iodide symporter for boron neutron capture therapy
    Sanath Kumar
    Department of Radiation Oncology, Henry Ford Health System, Detroit, MI, USA
    J Radiat Res 51:621-6. 2010
    ..We conclude that adenovirus expressing NIS has the potential to be used as a novel boron delivery agent and should be explored for future clinical applications...
  17. ncbi request reprint Phase I trial of replication-competent adenovirus-mediated suicide gene therapy combined with IMRT for prostate cancer
    Svend O Freytag
    Department of Radiation Oncology, Henry Ford Health System, Detroit, Michigan 48202, USA
    Mol Ther 15:1016-23. 2007
    ..01). These results further demonstrate the safety of this investigational approach and raise the possibility that it may have the potential to improve the outcome of conformal radiotherapy in select patient groups...
  18. ncbi request reprint Gene therapy strategies to improve the effectiveness of cancer radiotherapy
    Svend O Freytag
    Department of Radiation Oncology, Henry Ford Health System, Detroit, MI 48202 3405, USA
    Expert Opin Biol Ther 4:1757-70. 2004
    ..Here, the results of the clinical trials conducted so far will be reviewed, followed by a description of new approaches under development at present...
  19. ncbi request reprint A quantitative method for measuring gene expression magnitude and volume delivered by gene therapy vectors
    Kenneth N Barton
    Department of Radiation Oncology, Henry Ford Health System, Detroit, MI 48202, USA
    Mol Ther 9:625-31. 2004
    ..The method developed here could be applied to other reporter gene systems in which the readout can be digitized from thin tissue sections...
  20. ncbi request reprint Modification of radiation injury by ramipril, inhibitor of angiotensin-converting enzyme, on optic neuropathy in the rat
    Jae Ho Kim
    Departments of Radiation Oncology, Neurosurgery and Medicine, Henry Ford Health System, Detroit, MI 48202, USA
    Radiat Res 161:137-42. 2004
    ..The study represents the first demonstration of prophylaxis of radiation injury by a carboxyl-containing ACE inhibitor, providing a pharmacological strategy designed to reduce radiation-induced normal tissue damage...
  21. ncbi request reprint Arsenic trioxide enhances radiation response of 9L glioma in the rat brain
    Jae Ho Kim
    Department of Radiation Oncology, Henry Ford Health System, Detroit, Michigan 48202, USA
    Radiat Res 160:662-6. 2003
    ..Last, the use of diffusion magnetic resonance imaging as an early surrogate marker of therapeutic efficacy corroborated the effects of drug with and without radiation on brain histology and animal survival...
  22. ncbi request reprint Gene therapy strategies to enhance the effectiveness of cancer radiotherapy
    Svend O Freyta
    Henry Ford Health System, Department of Radiation Oncology, 1 Ford Place, Detroit, MI 48202, USA
    Curr Opin Mol Ther 6:513-24. 2004
    ..Results of the clinical trials conducted to date are reviewed, followed by a description of new approaches currently under development...
  23. ncbi request reprint 9L gliosarcoma cell proliferation and tumor growth in rats are suppressed by N-hydroxy-N'-(4-butyl-2-methylphenol) formamidine (HET0016), a selective inhibitor of CYP4A
    Meng Guo
    Eye Care Services, Henry Ford Hospital, Detroit, MI 48202 3450, USA
    J Pharmacol Exp Ther 317:97-108. 2006
    ..In vivo, it may act in part by inhibiting the formation of 20-HETE by the surrounding tissue. However, the antiproliferative effects of HET0016 on 9L cells in vitro seem unrelated to its ability to inhibit the formation of 20-HETE...
  24. ncbi request reprint GENIS: gene expression of sodium iodide symporter for noninvasive imaging of gene therapy vectors and quantification of gene expression in vivo
    Kenneth N Barton
    Department of Radiation Oncology, Detroit, Michigan 48202, USA
    Mol Ther 8:508-18. 2003
    ..Implementation of the GENIS (gene expression of Na/I symporter) technology in the clinic will facilitate optimization of future human gene therapy trials...
  25. ncbi request reprint Noninvasive detection of radiation-induced optic neuropathy by manganese-enhanced MRI
    Samuel Ryu
    Department of Radiation Oncology, Henry Ford Hospital, Detroit, Michigan 48202, USA
    Radiat Res 157:500-5. 2002
    ..This study represents the first demonstration of MR imaging of radiation-induced neuronal damage and could provide a means to explore the biological and functional integrity of neuronal pathways...
  26. ncbi request reprint Mitigation of radiation-induced optic neuropathy in rats by ACE inhibitor ramipril: importance of ramipril dose and treatment time
    Samuel Ryu
    Department of Radiation Oncology and Neurosurgery, Henry Ford Hospital, 2799 West Grand Boulevard, Detroit, Michigan 48202, USA
    J Neurooncol 82:119-24. 2007
    ..This study was to determine the optimum dose and administration time of ramipril for mitigating radiation-induced optic neuropathy...
  27. pmc Differentiation of glioma and radiation injury in rats using in vitro produce magnetically labeled cytotoxic T-cells and MRI
    Ali S Arbab
    Cellular and Molecular Imaging Laboratory, Department of Radiology, Henry Ford Hospital, Detroit, Michigan, United States of America
    PLoS ONE 5:e9365. 2010
    ....
  28. doi request reprint Mitigation of radiation-induced skin injury by AAV2-mediated MnSOD gene therapy
    Shiqing Yan
    Department of Radiation Oncology, Henry Ford Health System, Detroit, MI 48202, USA
    J Gene Med 10:1012-8. 2008
    ..Radiation-induced, long-lived free radicals, reactive oxygen species and pro-inflammatory cytokines have been implicated in the resultant tissue injury after exposure to ionizing radiation...
  29. ncbi request reprint Five-year follow-up of trial of replication-competent adenovirus-mediated suicide gene therapy for treatment of prostate cancer
    Svend O Freytag
    Department of Radiation Oncology, Henry Ford Health System, Detroit, Michigan, USA
    Mol Ther 15:636-42. 2007
    ..Given the high morbidity associated with AST, we believe this approach could provide an attractive treatment option for selection of patients experiencing PSA relapse following definitive therapy...
  30. ncbi request reprint Model selection in magnetic resonance imaging measurements of vascular permeability: Gadomer in a 9L model of rat cerebral tumor
    James R Ewing
    Department of Neurology, Henry Ford Health Systems, University of Michigan, Detroit, 48202, USA
    J Cereb Blood Flow Metab 26:310-20. 2006
    ..We conclude that employing nested models enables accurate assessment of transfer constants among areas where BBB permeability, contrast agent distribution volumes, and signal-to-noise vary...
  31. ncbi request reprint Application of arsenazo III in the preparation and characterization of an albumin-linked, gadolinium-based macromolecular magnetic resonance contrast agent
    Tavarekere N Nagaraja
    Department of Anesthesiology, Henry Ford Health System, Detroit, MI 48202, USA
    J Neurosci Methods 157:238-45. 2006
    ..These results suggest that the arsenazo III method is applicable in preparing Gd-BSA to image brain tumors and their response to treatment. This simple method may also be useful for preparing other gadolinium-linked MMCAs...
  32. ncbi request reprint Arsenic trioxide causes selective necrosis in solid murine tumors by vascular shutdown
    Y S Lew
    Department of Radiation Oncology, Henry Ford Health System, Detroit, Michigan 48202, USA
    Cancer Res 59:6033-7. 1999
    ..Normal skin, muscle, and kidney were relatively unaffected by arsenic trioxide. These results suggest that the drug may be investigated as an adjunct to the standard cancer therapeutic modalities...
  33. ncbi request reprint Extracranial radiosurgery: immobilizing liver motion in dogs using high-frequency jet ventilation and total intravenous anesthesia
    F Yin
    Department of Radiation Oncology, Henry Ford Health System, Detroit, MI 48202 3450, USA
    Int J Radiat Oncol Biol Phys 49:211-6. 2001
    ..The purpose of this study is to quantitatively determine the extent of liver motion in anesthetized dogs with continuous i.v. propofol infusion with or without muscle relaxants and high-frequency jet ventilation...
  34. ncbi request reprint Polyethylene glycol (molecular weight 400 DA) vehicle improves gene expression of adenovirus mediated gene therapy
    K N Barton
    Department of Radiation Oncology, Henry Ford Health System, Detroit, Michigan 48202, USA
    J Urol 175:1921-5. 2006
    ....
  35. pmc Animal models for medical countermeasures to radiation exposure
    Jacqueline P Williams
    Department of Radiation Oncology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 647, Rochester, NY 14642, USA
    Radiat Res 173:557-78. 2010
    ..Discussions covered the most appropriate species and strains available as well as other factors that may affect differential findings between groups and institutions. This report provides the workshop findings...
  36. pmc MRI measurement of change in vascular parameters in the 9L rat cerebral tumor after dexamethasone administration
    James R Ewing
    Department of Neurology, Henry Ford Hospital, Detroit, Michigan 48202, USA
    J Magn Reson Imaging 27:1430-8. 2008
    ..To demonstrate in the rat 9L cerebral tumor model that repeated MRI measurements can quantitate acute changes in the blood-brain distribution of Gadomer after dexamethasone administration...
  37. ncbi request reprint Differential radiation effect in tumor and normal tissue after treatment with ramipril, an angiotensin-converting enzyme inhibitor
    Robert R Kohl
    Department of Radiation Oncology, Henry Ford Hospital, Detroit, Michigan 48202, USA
    Radiat Res 168:440-5. 2007
    ..The results indicate that ramipril could offer therapeutic gain due to its different effect on normal tissues and tumors...
  38. pmc Phase I study of noninvasive imaging of adenovirus-mediated gene expression in the human prostate
    Kenneth N Barton
    Department of Radiation Oncology, Henry Ford Health System, Detroit, Michigan 48202, USA
    Mol Ther 16:1761-9. 2008
    ..The results demonstrate that noninvasive imaging of adenovirus-mediated gene therapy in humans is feasible and safe...
  39. doi request reprint Radiation sensitization of glioblastoma by cilengitide has unanticipated schedule-dependency
    Tom Mikkelsen
    Department of Neurosurgery, Hermelin Brain Tumor Center, Henry Ford Hospital, Detroit, MI 48202, USA
    Int J Cancer 124:2719-27. 2009
    ..Our results demonstrate that blockade of alphav integrins mediates an unanticipated rapid potentiation of radiation, and suggests possible clinical translation for glioma therapy...
  40. doi request reprint Mechanisms of radiation-induced brain toxicity and implications for future clinical trials
    Jae Ho Kim
    Department of Radiation Oncology, Henry Ford Hospital, 2799 West Grand Boulevard, Detroit, MI 48025, USA
    J Neurooncol 87:279-86. 2008
    ..This review highlights preclinical and early clinical data that are translatable for future clinical trials...
  41. ncbi request reprint Vascular targeting therapies for treatment of malignant disease
    Stephen L Brown
    Cancer 104:216-7; author reply 217. 2005
  42. ncbi request reprint Relative distribution of plasma flow markers and red blood cells across BBB openings in acute cerebral ischemia
    Tavarekere N Nagaraja
    Department of Anesthesiology, Henry Ford Health System, Detroit, MI, USA
    Neurol Res 29:78-80. 2007
    ..We postulate that smaller sized openings in BBB at hour 6 limited the leaking of the two large tracers (RBCs and FITC-dextran) and that such size-dependency was lost by 24 hours with the progression of the ischemic injury...