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Genomes and Genes | Naomi BreslauSummaryAffiliation: Henry Ford Hospital Country: USA Publications
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Publications
Epidemiologic studies of trauma, posttraumatic stress disorder, and other psychiatric disordersNaomi Breslau
Department of Psychiatry, Department of Biostatistics and Epidemiology, Henry Ford Health System, One Ford Place, 3A, Detroit, MI 48202 3450, USA
Can J Psychiatry 47:923-9. 2002..Trauma victims who do not succumb to PTSD are not at an elevated risk for the subsequent onset of major depression or substance use disorders, compared with unexposed persons...
Nicotine dependence and comorbid psychiatric disorders: examination of specific genetic variants in the CHRNA5-A3-B4 nicotinic receptor genesLi Shiun Chen
Department of Psychiatry, Washington University, St Louis, MO 63110, USA
Drug Alcohol Depend 123:S42-51. 2012..We examined whether these genetic variants were associated with comorbid disorders and whether comorbid psychiatric disorders modified the genetic risk of nicotine dependence...- Further evidence for an association between the gamma-aminobutyric acid receptor A, subunit 4 genes on chromosome 4 and Fagerström Test for Nicotine DependenceArpana Agrawal
Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
Addiction 104:471-7. 2009..In the present report, we extend the previous study by expanding our genotyping efforts significantly for these two genes... - Incorporating age at onset of smoking into genetic models for nicotine dependence: evidence for interaction with multiple genesRichard A Grucza
Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Ave, St Louis, MO 63110, USA
Addict Biol 15:346-57. 2010..Incorporation of logically chosen interaction parameters, such as AOS, into genetic models of substance use disorders may increase the degree of explained phenotypic variation and constitutes a promising avenue for gene discovery... - Variants in nicotinic receptors and risk for nicotine dependenceLaura Jean Bierut
Department of Psychiatry, Washington University School of Medicine, Box 8134, 660 South Euclid Ave, St Louis, MO 63110, USA
Am J Psychiatry 165:1163-71. 2008.... 
Gamma-aminobutyric acid receptor genes and nicotine dependence: evidence for association from a case-control studyArpana Agrawal
Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
Addiction 103:1027-38. 2008....- Novel genes identified in a high-density genome wide association study for nicotine dependenceLaura Jean Bierut
Department of Psychiatry, Washington University School of Medicine, 660 South Euclid, Box 8134, St Louis, MO 63110, USA
Hum Mol Genet 16:24-35. 2007..This work anticipates the future directions of large-scale genome wide association studies with state-of-the-art methodological approaches and sharing of data with the scientific community... - Rare missense variants in CHRNB4 are associated with reduced risk of nicotine dependenceGabe Haller
Department of Psychiatry, Washington University, St Louis, MO 63110, USA
Hum Mol Genet 21:647-55. 2012..01, T91I P = 0.02, R37H P = 0.003), but the largest effect on in vitro receptor activity was seen in the presence of both CHRNB4 T91I and CHRNA3 R37H (P = 2 × 10(-6))... - A genome-wide association study of alcohol dependenceLaura J Bierut
Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 107:5082-7. 2010..11 and 1.16. Further dissection of the alcoholism phenotype, to disentangle the influence of comorbid substance-use disorders, will be a next step in identifying genetic variants associated with alcohol dependence... - Posttraumatic stress disorder and the incidence of nicotine, alcohol, and other drug disorders in persons who have experienced traumaNaomi Breslau
Department of Psychiatry, Henry Ford Health System, Detroit, MI 48202 3450, USA
Arch Gen Psychiatry 60:289-94. 2003..We examine whether exposure to traumatic events increases the risk for nicotine dependence or alcohol or other drug use disorders, independent of posttraumatic stress disorder (PTSD)... - Cigarette smoking reduction and changes in nicotine dependenceMarc E Mooney
Department of Psychiatry, University of Minnesota, F 256 2B West, 2450 Riverside Ave, Minneapolis, MN 55454, USA
Nicotine Tob Res 13:426-30. 2011..The relationship of nicotine dependence (ND) to smoking behavior and cessation has been well characterized. However, little is known about the association between smoking reduction (SR) and ND... - The 10-year risk of verified motor vehicle crashes in relation to physiologic sleepinessChristopher Drake
Sleep Disorders and Research Center, Henry Ford Hospital, 2799 West Grand Blvd, CFP3, Detroit, MI 48202, USA
Sleep 33:745-52. 2010..The purpose of this study was to determine the risk of DMV documented crashes as a function of physiological sleepiness in a population-based sample... - CHRNB3 is more strongly associated with Fagerström test for cigarette dependence-based nicotine dependence than cigarettes per day: phenotype definition changes genome-wide association studies resultsJohn P Rice
Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
Addiction 107:2019-28. 2012..e., CPD versus Fagerström test for cigarette dependence (FTCD) score as a measure of nicotine dependence) on genome-wide association studies of nicotine dependence... - Inclusion of African Americans in genetic studies: what is the barrier?Sarah M Hartz
Department of Psychiatry, School of Medicine, Washington University, St Louis, Missouri 63110, USA
Am J Epidemiol 174:336-44. 2011..0001). The results of this study suggest that increasing the number of African Americans in genetic databases may be achieved by increasing efforts to locate and contact them... - Comorbidity of depression with levels of smoking: an exploration of the shared familial risk hypothesisEric O Johnson
Department of Psychiatry, Henry Ford Health Sciences Center, Detroit, MI 48202, USA
Nicotine Tob Res 6:1029-38. 2004..The conflicting findings of the studies that have examined the relationship between smoking and depression may be attributable to differences in definition of the disorders and the methods used to analyze them... - Persistence of cigarette smoking: familial liability and the role of nicotine dependenceEric O Johnson
Department of Psychiatry, Henry Ford Health Sciences Center, Detroit, MI 48202, USA
Addiction 97:1063-70. 2002..We examined alternative ways that familial liability to persistence, nicotine dependence and smoking persistence may be related... - Psychiatric disorders and stages of smokingNaomi Breslau
Department of Psychiatry, Henry Ford Health System, Detroit, Michigan 48202-3450, USA
Biol Psychiatry 55:69-76. 2004.... - Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPsScott F Saccone
Department of Psychiatry, Box 8134, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
Hum Mol Genet 16:36-49. 2007..Other genes among the top signals were KCNJ6 and GABRA4. This study represents one of the most powerful and extensive studies of nicotine dependence to date and has found novel risk loci that require confirmation by replication studies... - Graphing survival curve estimates for time-dependent covariatesLonni R Schultz
Department of Biostatistics and Research Epidemiology, Henry Ford Health Systems, Detroit, MI, USA
Int J Methods Psychiatr Res 11:68-74. 2002..Examples of how the two methods can differ for time dependent covariates in Cox proportional hazards regression analysis are presented... - Sex differences in the polysomnographic sleep of young adults: a community-based studyTimothy Roehrs
Department of Psychiatry and Behavioral Neurosciences, Sleep Disorders and Research Center, School of Medicine, Wayne State University, Henry Ford Hospital, Detroit, MI 48202, USA
Sleep Med 7:49-53. 2006..Given the higher prevalence of sleep-related breathing disturbance in men, this study assessed sex differences in sleep in a large, non-clinical sample of adults and controlled for primary sleep disorders... - Psychiatric morbidity in adult survivors of childhood traumaNaomi Breslau
Department of Psychiatry, Henry Ford Health System, Detroit, MI 48202 3450, USA
Semin Clin Neuropsychiatry 7:80-8. 2002..However, the retrospective nature of data on child abuse, because of legal and ethical restraints on research on children, is a formidable obstacle to advancing knowledge in this field... - Gender differences in trauma and posttraumatic stress disorderNaomi Breslau
Department of Psychiatry, Henry Ford Health System, One Ford Place, 3A, Detroit, MI 48202 3450, USA
J Gend Specif Med 5:34-40. 2002..Research on posttraumatic stress disorder (PTSD) has focused primarily on Vietnam War veterans. A handful of recent studies have been conducted on samples of the general population... - Is the association of smoking and depression a recent phenomenon?Eric O Johnson
Division of Health, Social and Economic Research, Research Triangle Institute International, Research Triangle Park, NC 27709 2194, USA
Nicotine Tob Res 8:257-62. 2006.... - Test of measurement invariance of the FTND across demographic groups: assessment, effect size, and prediction of cessationEric O Johnson
Behavioral Health Epidemiology, Division of Health, Social, and Economic Research, Research Triangle Institute International, PO Box 12194, 3040 Cornwallis Road, Research Triangle Park, NC 27709 2194, USA
Drug Alcohol Depend 93:260-70. 2008.... - A second look at prior trauma and the posttraumatic stress disorder effects of subsequent trauma: a prospective epidemiological studyNaomi Breslau
Department of Epidemiology, Michigan State University, College of Human Medicine, B645 West Fee Hall, East Lansing, MI 48824, USA
Arch Gen Psychiatry 65:431-7. 2008..The evidence comes chiefly from retrospective data on earlier events, obtained from trauma-exposed persons with and without PTSD. A generally overlooked major limitation is the failure to assess the PTSD response to the prior trauma... - Smoking and the risk of suicidal behavior: a prospective study of a community sampleNaomi Breslau
Department of Epidemiology and Office of the Dean, College of Human Medicine, Michigan State University, East Lansing, USA
Arch Gen Psychiatry 62:328-34. 2005..Recent observations of lower monoamine oxidase activity (which may play a role in central nervous system serotonin metabolism) in current smokers but not ex-smokers might provide clues, but interpretations should proceed cautiously... - Race differences in nicotine dependence in the Collaborative Genetic study of Nicotine Dependence (COGEND)Zhehui Luo
Department of Epidemiology, Michigan State University, MI, USA
Nicotine Tob Res 10:1223-30. 2008..The data support the hypothesis that the relationship between CPD and nicotine dependence as reflected in relapse varies by race, and that Black smokers are dependent at lower levels of CPD than Whites... - Trauma exposure and posttraumatic stress disorder: a study of youths in urban AmericaNaomi Breslau
Department of Epidemiology, Michigan State University, College of Human Medicine, B645 West Fee Hall, East Lansing 48824, USA
J Urban Health 81:530-44. 2004.... - Saliva cortisol in posttraumatic stress disorder: a community epidemiologic studyElizabeth A Young
Department of Psychiatry and Mental Health Research Institute, University of Michigan, Ann Arbor, Michigan, USA
Biol Psychiatry 56:205-9. 2004..To address this question, we collected saliva cortisol at home in a subsample of a longitudinal epidemiologic sample... - Sleep in lifetime posttraumatic stress disorder: a community-based polysomnographic studyNaomi Breslau
Department of Epidemiology, College of Human Medicine, Michigan State University, East Lansing 48824, USA
Arch Gen Psychiatry 61:508-16. 2004..Polysomnographic studies conducted on small samples of subjects with specific traumas have yielded conflicting results. We therefore evaluated polysomnographic sleep disturbances in PTSD... - Cortisol and catecholamines in posttraumatic stress disorder: an epidemiologic community studyElizabeth A Young
Department of Psychiatry and Mental Health Research Institute, University of Michigan, Ann Arbor, 48109 0720, USA
Arch Gen Psychiatry 61:394-401. 2004..Prior research has connected posttraumatic stress disorder (PTSD) to increased levels of catecholamines. However, studies of cortisol levels have produced mixed results... - Low birth weight as a vulnerability marker for early drug useHoward D Chilcoat
Department of Mental Hygiene, Johns Hopkins University, Baltimore, Maryland 21205, USA
Exp Clin Psychopharmacol 10:104-12. 2002..These findings suggest that LBW is a useful vulnerability marker for early drug use among boys, independent of the antecedents and sequelae of LBW... - Incidence of drug problems in young adults exposed to trauma and posttraumatic stress disorder: do early life experiences and predispositions matter?Philip L Reed
Biomedical Research and Informatics Center, Michigan State University, 100 Conrad Hall, East Lansing, MI 48824 1327, USA
Arch Gen Psychiatry 64:1435-42. 2007.... - Intelligence and other predisposing factors in exposure to trauma and posttraumatic stress disorder: a follow-up study at age 17 yearsNaomi Breslau
Department of Epidemiology, College of Human Medicine, Michigan State University, East Lansing 48824, USA
Arch Gen Psychiatry 63:1238-45. 2006..Prospective data on standardized measures of early predispositions would allow a strong test of hypotheses about suspected risk factors of posttraumatic stress disorder (PTSD) and exposure to traumatic events... - The association of insomnia with anxiety disorders and depression: exploration of the direction of riskEric O Johnson
Behavioral Health Epidemiology Program, Triangle Institute International, PO Box 12194, 3040 Cornwallis Road, Research Triangle Park, NC, USA
J Psychiatr Res 40:700-8. 2006..Additionally insomnia may have independent, and potentially etiologically distinct, directional associations with anxiety disorders versus depression... - Prenatal smoking exposure, low birth weight, and disruptive behavior disordersJoel T Nigg
Department of Psychology, Michifan State University, 115 Psychology Building, East Lansing, MI 48824 1116, USA
J Am Acad Child Adolesc Psychiatry 46:362-9. 2007..A key question concerns whether etiological contributors are shared across the broad range of disruptive psychopathology or are partially or largely distinct... - The structure of posttraumatic stress disorder: latent class analysis in 2 community samplesNaomi Breslau
Department of Epidemiology, College of Human Medicine, Michigan State University, B645 West Fee Hall, East Lansing, MI 48824, USA
Arch Gen Psychiatry 62:1343-51. 2005..Classification of persons exposed to traumatic events into clinically homogeneous groups would facilitate further etiologic and treatment research, as well as research on the relationship of trauma and PTSD with other disorders... - Childhood antecedents of exposure to traumatic events and posttraumatic stress disorderCarla L Storr
Department of Mental Health, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD, USA
Am J Psychiatry 164:119-25. 2007..The authors prospectively examined childhood antecedents of exposure to traumatic events to estimate the risk of posttraumatic stress disorder (PTSD) among those exposed to trauma... - The lingering academic deficits of low birth weight childrenNaomi Breslau
Department of Epidemiology, Michigan State University, College of Human Medicine, B645 West Fee Hall, East Lansing, MI 48824, USA
Pediatrics 114:1035-40. 2004..To estimate the influence of low birth weight (LBW; < or =2500 g) on academic achievement in reading and mathematics in 12th grade in 2 socioeconomically and racially disparate, geographically defined communities... - Gender differences in the sensitivity to posttraumatic stress disorder: An epidemiological study of urban young adultsNaomi Breslau
Department of Epidemiology, Michigan State University, East Lansing, MI 48824, USA
J Abnorm Psychol 116:607-11. 2007..These findings suggest that assaultive violence elicits women's PTSD response directly and by sensitizing them to the effects of subsequent traumatic events of lesser magnitude... - Epidemiology of DSM-IV insomnia in adolescence: lifetime prevalence, chronicity, and an emergent gender differenceEric O Johnson
Substance Abuse Epi, Prevention, and Risk Behavior, Research Triangle Institute International, Research Triangle Park, NC 27709 2194, USA
Pediatrics 117:e247-56. 2006.... - Reports of birthweight by adolescents and their mothers: comparing accuracy and identifying correlatesVictoria C Lucia
Department of Epidemiology, Michigan State University, College of Human Medicine, East Lansing, MI 48824, USA
Paediatr Perinat Epidemiol 20:520-7. 2006..While maternal reports of offspring's birthweight are highly accurate across diverse subgroups of the population, adolescent self-reports of birthweight are unlikely to be useful in medical research... - Troublesome memories: reflections on the futureAllan Young
McGill University, USA
J Anxiety Disord 21:230-2. 2007..Several papers in this collection direct readers' attention to this fundamental problem. We are pessimistic that their insight will lead to positive results... - Family cohesion and children's behavior problems: a longitudinal investigationVictoria C Lucia
Department of Epidemiology, Michigan State University, College of Human Medicine, East Lansing, 48824, USA
Psychiatry Res 141:141-9. 2006..The study highlights an important relationship between family cohesion and children's internalizing and attention problems... - Partial PTSD versus full PTSD: an empirical examination of associated impairmentNaomi Breslau
Department of Epidemiology, Michigan State University, East Lansing, MI 48824, USA
Psychol Med 34:1205-14. 2004..We examined the extent to which partial PTSD is distinguishable from full DSM-PTSD with respect to level of impairment... - Stability of psychiatric outcomes of low birth weight: a longitudinal investigationKIPLING M BOHNERT
Department of Epidemiology, Michigan State University, College of Human Medicine, B645 West Fee Hall, East Lansing, MI 48824, USA
Arch Gen Psychiatry 65:1080-6. 2008.... - Maternal smoking during pregnancy and offspring IQNaomi Breslau
Department of Epidemiology, Michigan State University, College of Human Medicine, East Lansing, MI 48824, USA
Int J Epidemiol 34:1047-53. 2005..Maternal smoking in pregnancy lowers birthweight. It is unclear, however, whether smoking during pregnancy lowers offspring IQ, and, if it does, whether it is through the smoking effect on fetal growth... - Does virtual trauma cause posttraumatic stress disorder?Richard J McNally
Department of Psychology, Harvard University, Cambridge, MA 02138, USA
Am Psychol 63:282-3; discussion 283-5. 2008 - The clinical significance criterion in DSM-IV post-traumatic stress disorderNaomi Breslau
Department of Epidemiology, Michigan State University, College of Human Medicine, East Lansing, MI 48824, USA
Psychol Med 37:1437-44. 2007..The impact of the clinical significance criterion on the lifetime prevalence of PTSD among civilian victims of traumatic events has not been evaluated... - Commentary: Maternal smoking during pregnancy: hazard for what?Naomi Breslau
Department of Epidemiology, Michigan State University, B645 West Fee Hall, East Lansing, MI 48824, USA
Int J Epidemiol 36:832-3. 2007 - Post-traumatic stress disorderNaomi Breslau
N Engl J Med 346:1495-8; author reply 1495-8. 2002