Ali S Arbab

Summary

Affiliation: Henry Ford Hospital
Country: USA

Publications

  1. doi request reprint Cellular MRI and its role in stem cell therapy
    Ali S Arbab
    Henry Ford Hospital, Cellular and Molecular Imaging Laboratory, Department of Radiology, 1 Ford Place, 2F Detroit, MI 48202, USA
    Regen Med 3:199-215. 2008
  2. pmc Tracking of In-111-labeled human umbilical tissue-derived cells (hUTC) in a rat model of cerebral ischemia using SPECT imaging
    Ali S Arbab
    Department of Radiology, Cellular and Molecular Imaging Laboratory, Henry Ford Hospital, Detroit, MI 48202, USA
    BMC Med Imaging 12:33. 2012
  3. pmc Activation of alternative pathways of angiogenesis and involvement of stem cells following anti-angiogenesis treatment in glioma
    Ali S Arbab
    Cellular and Molecular Imaging Laboratory, Department of Radiology, Henry Ford Hospital, Detroit, MI 48202, USA
    Histol Histopathol 27:549-57. 2012
  4. ncbi request reprint Magnetically-labeled sensitized splenocytes to identify glioma by MRI: a preliminary study
    Ali S Arbab
    Department of Radiology, Henry Ford Hospital, Detroit, Michigan 48202, USA, and National Institutes of Health, University of Tehran, Iran
    Magn Reson Med 58:519-26. 2007
  5. ncbi request reprint Magnetic resonance imaging and confocal microscopy studies of magnetically labeled endothelial progenitor cells trafficking to sites of tumor angiogenesis
    Ali S Arbab
    Experimental Neuroimaging Section, Laboratory of Diagnostic Radiology Research, National Institutes of Health, Bethesda, Maryland, USA
    Stem Cells 24:671-8. 2006
  6. pmc Differentiation of glioma and radiation injury in rats using in vitro produce magnetically labeled cytotoxic T-cells and MRI
    Ali S Arbab
    Cellular and Molecular Imaging Laboratory, Department of Radiology, Henry Ford Hospital, Detroit, Michigan, United States of America
    PLoS ONE 5:e9365. 2010
  7. ncbi request reprint A model of lysosomal metabolism of dextran coated superparamagnetic iron oxide (SPIO) nanoparticles: implications for cellular magnetic resonance imaging
    Ali S Arbab
    Experimental Neuroimaging Section, Laboratory of Diagnostic Radiology Research, National Institutes of Health, Bethesda, Maryland, USA
    NMR Biomed 18:383-9. 2005
  8. pmc MRI to assess chemoprevention in transgenic adenocarcinoma of mouse prostate (TRAMP)
    Ali S Arbab
    Department of Radiology, Henry Ford Hospital, 1 Ford Place, 2F, Detroit, MI 48202, USA
    BMC Med Imaging 11:21. 2011
  9. ncbi request reprint Cellular magnetic resonance imaging: current status and future prospects
    Ali S Arbab
    Henry Ford Health System, Radiology Research, Detroit, MI 48202, USA
    Expert Rev Med Devices 3:427-39. 2006
  10. pmc Detection of migration of locally implanted AC133+ stem cells by cellular magnetic resonance imaging with histological findings
    Ali S Arbab
    Department of Radiology, Henry Ford Health System, 1 Ford Pl, 2F, Box 82, Detroit, MI 48202, USA
    FASEB J 22:3234-46. 2008

Collaborators

Detail Information

Publications71

  1. doi request reprint Cellular MRI and its role in stem cell therapy
    Ali S Arbab
    Henry Ford Hospital, Cellular and Molecular Imaging Laboratory, Department of Radiology, 1 Ford Place, 2F Detroit, MI 48202, USA
    Regen Med 3:199-215. 2008
    ..In this review, we will discuss the status and future prospect of stem cell tracking by cellular MRI for cell-based therapy...
  2. pmc Tracking of In-111-labeled human umbilical tissue-derived cells (hUTC) in a rat model of cerebral ischemia using SPECT imaging
    Ali S Arbab
    Department of Radiology, Cellular and Molecular Imaging Laboratory, Henry Ford Hospital, Detroit, MI 48202, USA
    BMC Med Imaging 12:33. 2012
    ....
  3. pmc Activation of alternative pathways of angiogenesis and involvement of stem cells following anti-angiogenesis treatment in glioma
    Ali S Arbab
    Cellular and Molecular Imaging Laboratory, Department of Radiology, Henry Ford Hospital, Detroit, MI 48202, USA
    Histol Histopathol 27:549-57. 2012
    ....
  4. ncbi request reprint Magnetically-labeled sensitized splenocytes to identify glioma by MRI: a preliminary study
    Ali S Arbab
    Department of Radiology, Henry Ford Hospital, Detroit, Michigan 48202, USA, and National Institutes of Health, University of Tehran, Iran
    Magn Reson Med 58:519-26. 2007
    ..In conclusion, the immunogenic reaction can be exploited to delineate recurrent glioma using MRI following systemically delivered magnetically labeled sensitized splenocytes or T-cells...
  5. ncbi request reprint Magnetic resonance imaging and confocal microscopy studies of magnetically labeled endothelial progenitor cells trafficking to sites of tumor angiogenesis
    Ali S Arbab
    Experimental Neuroimaging Section, Laboratory of Diagnostic Radiology Research, National Institutes of Health, Bethesda, Maryland, USA
    Stem Cells 24:671-8. 2006
    ....
  6. pmc Differentiation of glioma and radiation injury in rats using in vitro produce magnetically labeled cytotoxic T-cells and MRI
    Ali S Arbab
    Cellular and Molecular Imaging Laboratory, Department of Radiology, Henry Ford Hospital, Detroit, Michigan, United States of America
    PLoS ONE 5:e9365. 2010
    ....
  7. ncbi request reprint A model of lysosomal metabolism of dextran coated superparamagnetic iron oxide (SPIO) nanoparticles: implications for cellular magnetic resonance imaging
    Ali S Arbab
    Experimental Neuroimaging Section, Laboratory of Diagnostic Radiology Research, National Institutes of Health, Bethesda, Maryland, USA
    NMR Biomed 18:383-9. 2005
    ..The studies presented represent a first step in identifying the important cellular environmental parameters affecting the integrity of FE-TA complexes...
  8. pmc MRI to assess chemoprevention in transgenic adenocarcinoma of mouse prostate (TRAMP)
    Ali S Arbab
    Department of Radiology, Henry Ford Hospital, 1 Ford Place, 2F, Detroit, MI 48202, USA
    BMC Med Imaging 11:21. 2011
    ..The purpose of this study was to determine whether in vivo magnetic resonance imaging (MRI) using a 3 tesla clinical MRI system can be used to follow the effect of chemoprevention in TRAMP model of mouse CaP...
  9. ncbi request reprint Cellular magnetic resonance imaging: current status and future prospects
    Ali S Arbab
    Henry Ford Health System, Radiology Research, Detroit, MI 48202, USA
    Expert Rev Med Devices 3:427-39. 2006
    ....
  10. pmc Detection of migration of locally implanted AC133+ stem cells by cellular magnetic resonance imaging with histological findings
    Ali S Arbab
    Department of Radiology, Henry Ford Health System, 1 Ford Pl, 2F, Box 82, Detroit, MI 48202, USA
    FASEB J 22:3234-46. 2008
    ..HIF-1alpha was expressed at both the periphery and central parts of the tumor. This work demonstrates that magnetically labeled cells can be used as probes for MRI and histological identification of administered cells...
  11. ncbi request reprint Labeling of cells with ferumoxides-protamine sulfate complexes does not inhibit function or differentiation capacity of hematopoietic or mesenchymal stem cells
    Ali S Arbab
    Radiology Research, Henry Ford Health System, Detroit, MI 48202, USA
    NMR Biomed 18:553-9. 2005
    ..These data increase confidence that MRI studies of FePro-labeled HSC or MSC will provide an accurate representation of in vivo trafficking of unlabeled cells...
  12. pmc MRI tracking of FePro labeled fresh and cryopreserved long term in vitro expanded human cord blood AC133+ endothelial progenitor cells in rat glioma
    Branislava Janic
    Cellular and Molecular Imaging Laboratory, Department of Radiology, Henry Ford Hospital, Detroit, Michigan, United States of America
    PLoS ONE 7:e37577. 2012
    ....
  13. pmc Optimization and validation of FePro cell labeling method
    Branislava Janic
    Cellular and Molecular Imaging Laboratory, Department of Radiology, Henry Ford Hospital, Detroit, MI, USA
    PLoS ONE 4:e5873. 2009
    ..The new technique with short incubation time using 100 microg/ml of Fe and 3 microg/ml of Pro is effective in labeling cells for cellular MRI...
  14. pmc Human cord blood-derived AC133+ progenitor cells preserve endothelial progenitor characteristics after long term in vitro expansion
    Branislava Janic
    Cellular and Molecular Imaging Laboratory, Department of Radiology, Henry Ford Hospital, Detroit, Michigan, United States of America
    PLoS ONE 5:e9173. 2010
    ..Therefore, the objective of this study was to evaluate the capacity of cord blood (CB)-derived AC133+ cells to differentiate, in vitro, towards functional, mature endothelial cells (ECs) after long term in vitro expansion...
  15. ncbi request reprint Efficient magnetic cell labeling with protamine sulfate complexed to ferumoxides for cellular MRI
    Ali S Arbab
    Laboratory of Diagnostic Radiology Research, National Institutes of Health, Building 10, Room no B1N256, Bethesda, MD 20892, USA
    Blood 104:1217-23. 2004
    ..94 +/- 1.86 pg for MSCs with 100% of cells labeled. Cell labeling using these agents should facilitate the translation of this method to clinical trials for evaluation of trafficking of infused or transplanted cells by MRI...
  16. pmc Treatment with bone marrow-derived stromal cells accelerates wound healing in diabetic rats
    David S Kwon
    Department of General Surgery, Henry Ford Health System, Detroit, MI, USA
    Int Wound J 5:453-63. 2008
    ..These data suggest that cell therapy with BMSCs has the potential to augment healing of the diabetic wounds...
  17. pmc Endothelial progenitor cells (EPCs) as gene carrier system for rat model of human glioma
    Nadimpalli Ravi S Varma
    Cellular and Molecular Imaging Laboratory, Department of Radiology, Henry Ford Hospital, Detroit, Michigan, United States of America
    PLoS ONE 7:e30310. 2012
    ....
  18. pmc AC133+ progenitor cells as gene delivery vehicle and cellular probe in subcutaneous tumor models: a preliminary study
    Ali M Rad
    Department of Radiology, Henry Ford Hospital, Detroit, Michigan, USA
    BMC Biotechnol 9:28. 2009
    ..In vivo real time tracking of these cells was performed by MRI and expression of hNIS was determined by Tc-99m pertechnetate (Tc-99m) scan...
  19. pmc Intravenous administration of human umbilical cord blood-derived AC133+ endothelial progenitor cells in rat stroke model reduces infarct volume: magnetic resonance imaging and histological findings
    Asm Iskander
    Department of Radiology, Henry Ford Hospital, Detroit, MI, USA
    Stem Cells Transl Med 2:703-14. 2013
    ..We conclude that transplanted cells selectively migrated to the ischemic brain parenchyma, where they exerted a therapeutic effect on the extent of tissue damage, regeneration, and time course of stroke resolution...
  20. ncbi request reprint Quantification of superparamagnetic iron oxide (SPIO)-labeled cells using MRI
    Ali M Rad
    Department of Radiology, Henry Ford Health System, Detroit, Michigan 48202, USA
    J Magn Reson Imaging 26:366-74. 2007
    ..To show the feasibility of using magnetic resonance imaging (MRI) to quantify superparamagnetic iron oxide (SPIO)-labeled cells...
  21. ncbi request reprint Effect of human stem cells labeled with ferumoxides-poly-L-lysine on hematologic and biochemical measurements in rats
    Gene T Yocum
    Experimental Neuroimaging Section, Laboratory of Diagnostic Radiology Research, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    Radiology 235:547-52. 2005
    ....
  22. pmc Investigation of relationships between transverse relaxation rate, diffusion coefficient, and labeled cell concentration in ischemic rat brain using MRI
    Hemanthkumar Athiraman
    Department of Neurology, Henry Ford Health System, Detroit, Michigan 48202, USA
    Magn Reson Med 61:587-94. 2009
    ..Our study suggests that MRI parameters have the potential to quantitatively determine labeled cell concentration in vivo...
  23. doi request reprint Bone marrow-derived stromal cells (BMSCs) interact with fibroblasts in accelerating wound healing
    Deborah Dulchavsky
    Department of General Surgery, Henry Ford Health System, Detroit, Michigan, USA
    J Invest Surg 21:270-9. 2008
    ..This study demonstrates that BMSCs significantly augment healing of cutaneous and fascial wounds in vivo at least in part through interaction with fibroblasts in which BMSCs promote growth and chemotaxis of fibroblasts...
  24. ncbi request reprint MRI detects white matter reorganization after neural progenitor cell treatment of stroke
    Quan Jiang
    Department of Neurology, Henry Ford Health Sciences Center, Henry Ford Hospital, 2799 West Grand Boulevard, Detroit, MI 48202, USA
    Neuroimage 32:1080-9. 2006
    ..Our data demonstrate that FA and FT identify and characterize cerebral tissue undergoing white matter reorganization after stroke and treatment with neural progenitor cells...
  25. pmc Self-assembling nanocomplexes by combining ferumoxytol, heparin and protamine for cell tracking by magnetic resonance imaging
    Mya S Thu
    Frank Laboratory and Laboratory of Diagnostic Radiology Research, Department of Radiology and Imaging Sciences, US National Institutes of Health, Bethesda, Maryland, USA
    Nat Med 18:463-7. 2012
    ..In vivo MRI detected 1,000 HPF-labeled cells implanted in rat brains. This HPF labeling method should facilitate the monitoring by MRI of infused or implanted cells in clinical trials...
  26. ncbi request reprint Expression of transferrin receptor and ferritin following ferumoxides-protamine sulfate labeling of cells: implications for cellular magnetic resonance imaging
    Edyta Pawelczyk
    Laboratory of Diagnostic Radiology Research, Experimental Neuroimaging Section, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    NMR Biomed 19:581-92. 2006
    ..No changes in MTT and ROS analysis were noted. In conclusion, FE-Pro labeling elicited physiological changes of iron metabolism or storage, validating the safety of this procedure for cellular tracking by MRI...
  27. ncbi request reprint Intracytoplasmic tagging of cells with ferumoxides and transfection agent for cellular magnetic resonance imaging after cell transplantation: methods and techniques
    Ali S Arbab
    Experimental Neuroimaging Section, Laboratory of Diagnostic Radiology Research, National Institutes of Health, Bethesda, MD 20892, USA
    Transplantation 76:1123-30. 2003
    ..The purpose of this study is to present protocols using SPIO and a polycationic transfection agent for magnetic labeling of cells as a basis for cellular MRI...
  28. ncbi request reprint Characterization of biophysical and metabolic properties of cells labeled with superparamagnetic iron oxide nanoparticles and transfection agent for cellular MR imaging
    Ali S Arbab
    Experimental Neuroimaging Section, Laboratory of Diagnostic Radiology Research, National Institutes of Health, 10 Center Dr, Rm B1N256, Bethesda, MD 20892, USA
    Radiology 229:838-46. 2003
    ..To evaluate the effect of using the ferumoxides-poly-l-lysine (PLL) complex for magnetic cell labeling on the long-term viability, function, metabolism, and iron utilization of mammalian cells...
  29. ncbi request reprint Preparation of magnetically labeled cells for cell tracking by magnetic resonance imaging
    Jeff W M Bulte
    Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Methods Enzymol 386:275-99. 2004
  30. pmc Expression of CYP4A1 in U251 human glioma cell induces hyperproliferative phenotype in vitro and rapidly growing tumors in vivo
    Austin M Guo
    Henry Ford Hospital, Detroit, Michigan 48202, USA
    J Pharmacol Exp Ther 327:10-9. 2008
    ..This suggests that 20-HETE may have proto-oncogenic properties in U251 human gliomas. Further studies are needed to determine whether 20-HETE plays a role promoting growth of some human gliomas...
  31. pmc Effects of ferumoxides-protamine sulfate labeling on immunomodulatory characteristics of macrophage-like THP-1 cells
    Branislava Janic
    Cellular and Molecular Imaging Laboratory, Department of Radiology, Henry Ford Hospital, Detroit, Michigan, United States of America
    PLoS ONE 3:e2499. 2008
    ..To better mimic the complex in vivo scenario, this model may be further exploited by introducing additional cellular and biological, immunologically relevant, components...
  32. doi request reprint In vitro model of bromodeoxyuridine or iron oxide nanoparticle uptake by activated macrophages from labeled stem cells: implications for cellular therapy
    Edyta Pawelczyk
    Experimental Neuroimaging Section, Laboratory of Diagnostic Radiology Research, Clinical Center, Henry Ford Health System, Detroit, Michigan, USA
    Stem Cells 26:1366-75. 2008
    ....
  33. ncbi request reprint Noninvasive MR imaging of magnetically labeled stem cells to directly identify neovasculature in a glioma model
    Stasia A Anderson
    Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1074, USA
    Blood 105:420-5. 2005
    ..This technique can be used to directly identify neovasculature in vivo and to facilitate gene therapy by noninvasively monitoring these cells as gene delivery vectors...
  34. pmc Inhibition of telomerase activity by oleanane triterpenoid CDDO-Me in pancreatic cancer cells is ROS-dependent
    Dorrah Deeb
    Department of General Surgery, Henry Ford Health System, Detroit, MI 48202, USA
    Molecules 18:3250-65. 2013
    ....
  35. pmc Synthetic triterpenoid CDDO prevents the progression and metastasis of prostate cancer in TRAMP mice by inhibiting survival signaling
    Dorrah Deeb
    Department of Surgery, Henry Ford Health System, Detroit, MI 48202, USA
    Carcinogenesis 32:757-64. 2011
    ..Thus, these studies show for the first time the potential of CDDO for chemoprevention of human prostate cancer...
  36. ncbi request reprint Therapeutic efficacy of curcumin/TRAIL combination regimen for hormone-refractory prostate cancer
    Tanja Andrzejewski
    Department of Surgery, Henry Ford Health System, Detroit, MI, USA
    Oncol Res 17:257-67. 2008
    ..Based on the significant efficacy in this preclinical model, combined curcumin/TRAIL regimen may be an effective adjuvant therapy for hormone-refractory prostate cancer...
  37. ncbi request reprint In vivo trafficking and targeted delivery of magnetically labeled stem cells
    Ali S Arbab
    Experimental Neuroimaging Section, Laboratory of Diagnostic Radiology Research, National Institutes of Health, Bethesda, MD 20892, USA
    Hum Gene Ther 15:351-60. 2004
    ..The external magnets influenced the movement of labeled MSCs such that the cells were retained in the region of interest. These results potentially open a new area of investigation for delivering stem cells or genetically altered cells...
  38. pmc Gliosarcoma stem cells undergo glial and mesenchymal differentiation in vivo
    Ana C deCarvalho
    Department of Neurosurgery, Henry Ford Hospital, Detroit, Michigan 48202 2689, USA
    Stem Cells 28:181-90. 2010
    ..The GS experimental tumors phenocopied the parental tumor, exhibiting biphasic glial and mesenchymal components, constituting a clinically relevant model to investigate mesenchymal differentiation in GBMs...
  39. ncbi request reprint Measurement of quantity of iron in magnetically labeled cells: comparison among different UV/VIS spectrometric methods
    Ali M Rad
    Henry Ford Hospital, Detroit, MI 48188, USA
    Biotechniques 43:627-8, 630, 632 passim. 2007
    ..Methods based on the use of 10 M hydrochloric acid underestimated iron concentration in all experiments; for this method to give an accurate measurement, iron concentration in sample needs to be at least 3 microg/mL...
  40. pmc MRI detects brain reorganization after human umbilical tissue-derived cells (hUTC) treatment of stroke in rat
    Quan Jiang
    Department of Neurology, Henry Ford Health System, Detroit, Michigan, United States of America
    PLoS ONE 7:e42845. 2012
    ..MRI ventricular volumes provided the most sensitive index in monitoring brain remodeling and treatment effects and highly correlated with histological and functional measurements...
  41. pmc Model selection for DCE-T1 studies in glioblastoma
    Hassan Bagher-Ebadian
    Department of Neurology, Henry Ford Hospital, Detroit, Michigan 48202, USA
    Magn Reson Med 68:241-51. 2012
    ..99). We conclude that the three parameters of the standard model are sufficient to fit dynamic contrast enhanced T(1) data in glioblastoma under the conditions of the experiment...
  42. pmc Changes in vascular permeability and expression of different angiogenic factors following anti-angiogenic treatment in rat glioma
    Meser M Ali
    Cellular and Molecular Imaging Laboratory, Department of Radiology, Henry Ford Hospital, Detroit, Michigan, United States of America
    PLoS ONE 5:e8727. 2010
    ..The findings were validated with histochemical and western blot studies...
  43. pmc Oleanane triterpenoid CDDO-Me inhibits growth and induces apoptosis in prostate cancer cells through a ROS-dependent mechanism
    Dorrah Deeb
    Department of Surgery, Henry Ford Health System, Detroit, MI 48202, USA
    Biochem Pharmacol 79:350-60. 2010
    ..NAC also prevented the inhibition of constitutively active Akt, NF-kappaB and mTOR by CDDO-Me. Together, these data indicate that ROS plays an essential role in the induction of apoptosis by CDDO-Me in prostate cancer cells...
  44. pmc Differential biodistribution of intravenously administered endothelial progenitor and cytotoxic T-cells in rat bearing orthotopic human glioma
    Nadimpalli Ravi S Varma
    Cellular and Molecular Imaging Laboratory, Radiology, Henry Ford Hospital, Detroit, MI, USA
    BMC Med Imaging 13:17. 2013
    ..In this study, we evaluate the dynamic biodistribution of systemic injected labeled cells [human cord blood derived endothelial progenitor cells (EPCs) and cytotoxic T-cells (CTLs)] in rat glioma model with in vivo SPECT imaging...
  45. pmc Telomerase reverse transcriptase (TERT) is a therapeutic target of oleanane triterpenoid CDDO-Me in prostate cancer
    Yongbo Liu
    Department of General Surgery, Henry Ford Health System, Detroit, MI 48202, USA
    Molecules 17:14795-809. 2012
    ..These data provide evidence that telomerase is a potential target of CDDO-Me for the prevention and treatment of prostate cancer...
  46. pmc ROS mediate proapoptotic and antisurvival activity of oleanane triterpenoid CDDO-Me in ovarian cancer cells
    Xiaohua Gao
    Surgical Research 4D, Henry Ford Health System, One Ford Place, Detroit, MI 48202, USA
    Anticancer Res 33:215-21. 2013
    ....
  47. pmc A nano-sized PARACEST-fluorescence imaging contrast agent facilitates and validates in vivo CEST MRI detection of glioma
    Meser M Ali
    Henry Ford Hospital, Detroit, MI 48202, USA
    Nanomedicine (Lond) 7:1827-37. 2012
    ..The authors have investigated the usefulness of in vivo chemical exchange saturation transfer MRI for detecting gliomas using a dual-modality imaging contrast agent...
  48. pmc Development of a novel animal model to differentiate radiation necrosis from tumor recurrence
    Sanath Kumar
    Department of Radiation Oncology, Henry Ford Health System, Detroit, MI 48202, USA
    J Neurooncol 108:411-20. 2012
    ..Luxol fast blue and lectin staining showed demyelination and vascular injury in brain tissue consistent with radiation necrosis. We have developed a novel model of radiation necrosis in rats bearing glioma...
  49. pmc Synthetic oleanane triterpenoid, CDDO-Me, induces apoptosis in ovarian cancer cells by inhibiting prosurvival AKT/NF-κB/mTOR signaling
    Xiaohua Gao
    Department of Surgery, Henry Ford Health System, Detroit, MI, USA
    Anticancer Res 31:3673-81. 2011
    ....
  50. ncbi request reprint Activation of vascular endothelial growth factor through reactive oxygen species mediates 20-hydroxyeicosatetraenoic acid-induced endothelial cell proliferation
    Austin M Guo
    Henry Ford Hospital, One Ford Place, 4D, Detroit, MI, USA
    J Pharmacol Exp Ther 321:18-27. 2007
    ..Thus, 20-HETE may be involved in the regulation of EC functions, such as angiogenesis...
  51. ncbi request reprint Color transformation and fluorescence of Prussian blue-positive cells: implications for histologic verification of cells labeled with superparamagnetic iron oxide nanoparticles
    Joseph A Frank
    Experimental Neuroimaging Section, Laboratory of Diagnostic Radiology Research and Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Instituets of Health, Bethesda, MD 20892, USA
    Mol Imaging 6:212-8. 2007
    ....
  52. pmc Late gadolinium-enhancement cardiac magnetic resonance identifies postinfarction myocardial fibrosis and the border zone at the near cellular level in ex vivo rat heart
    Erik B Schelbert
    Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 1061, USA
    Circ Cardiovasc Imaging 3:743-52. 2010
    ....
  53. pmc Anticancer agent xanthohumol inhibits IL-2 induced signaling pathways involved in T cell proliferation
    Yongbo Liu
    Department of Surgery, Henry Ford Health System, Detroit, MI 48202, USA
    J Exp Ther Oncol 10:1-8. 2012
    ..Thus, understanding of IL-2 induced cell signaling pathways in normal T cells, which are constitutively turned on in T cell lymphomas may facilitate development of XN for the treatment of hematologic cancers...
  54. pmc Synthetic triterpenoids inhibit growth, induce apoptosis and suppress pro-survival Akt, mTOR and NF-{kappa}B signaling proteins in colorectal cancer cells
    Xiaohua Gao
    Surgical Research 4D, One Ford Place, Detroit, MI 48202, USA
    Anticancer Res 30:785-92. 2010
    ..These studies provide rationale for clinical evaluation of CDDO-Me for the treatment of advanced chemotherapy refractory colorectal cancer...
  55. ncbi request reprint 9L gliosarcoma cell proliferation and tumor growth in rats are suppressed by N-hydroxy-N'-(4-butyl-2-methylphenol) formamidine (HET0016), a selective inhibitor of CYP4A
    Meng Guo
    Eye Care Services, Henry Ford Hospital, Detroit, MI 48202 3450, USA
    J Pharmacol Exp Ther 317:97-108. 2006
    ..In vivo, it may act in part by inhibiting the formation of 20-HETE by the surrounding tissue. However, the antiproliferative effects of HET0016 on 9L cells in vitro seem unrelated to its ability to inhibit the formation of 20-HETE...
  56. pmc Human mesenchymal stem cells exert potent antitumorigenic effects in a model of Kaposi's sarcoma
    Aarif Y Khakoo
    Laboratory of Molecular Biology, Cardiovascular Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 203:1235-47. 2006
    ....
  57. pmc Inhibition of cell proliferation and induction of apoptosis by oleanane triterpenoid (CDDO-Me) in pancreatic cancer cells is associated with the suppression of hTERT gene expression and its telomerase activity
    Dorrah Deeb
    Department of Surgery, Henry Ford Health System, Detroit, MI 48202, USA
    Biochem Biophys Res Commun 422:561-7. 2012
    ..Furthermore, abrogation or overexpression of hTERT protein altered the susceptibility of tumor cells to CDDO-Me. These findings suggest that telomerase (hTERT) is a relevant target of CDDO-Me in pancreatic cancer cells...
  58. ncbi request reprint Gadolinium-fullerenol as a paramagnetic contrast agent for cellular imaging
    Stasia A Anderson
    National Heart, Lung and Blood Institute, Bethesda, Maryland 20892, USA
    Invest Radiol 41:332-8. 2006
    ....
  59. ncbi request reprint Investigation of neural progenitor cell induced angiogenesis after embolic stroke in rat using MRI
    Quan Jiang
    Department of Neurology, Henry Ford Health Sciences Center, Detroit, MI 48202, USA
    Neuroimage 28:698-707. 2005
    ..Our data suggest that select MRI parameters can identify the cerebral tissue destined to undergo angiogenesis after treatment of embolic stroke with cell therapy...
  60. pmc A selective EP4 PGE2 receptor agonist alleviates disease in a new mouse model of X-linked nephrogenic diabetes insipidus
    Jian Hua Li
    Molecular Signaling Section, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, USA
    J Clin Invest 119:3115-26. 2009
    ..These findings illustrate the usefulness of the newly generated V2R mutant mice for elucidating and testing new strategies for the potential treatment of humans with XNDI...
  61. ncbi request reprint Magnetic resonance imaging of labeled T-cells in a mouse model of multiple sclerosis
    Stasia A Anderson
    Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Ann Neurol 55:654-9. 2004
    ..The magnetic labeling of cells opens the possibility of monitoring specific cellular phenotypes or pharmacologically or genetically engineered cells by MRI...
  62. pmc The role and therapeutic potential of endothelial progenitor cells in tumor neovascularization
    Branislava Janic
    Cellular and Molecular Imaging Laboratory, Department of Radiology, Henry Ford Hospital, Detroit, MI, USA
    ScientificWorldJournal 10:1088-99. 2010
    ..Hence, this review focuses on EPCs and their role in tumor angiogenesis with the emphasis on EPC recruitment/migration, and the potential use of EPCs as a therapeutic tool and imaging probe...
  63. ncbi request reprint Clinically applicable labeling of mammalian and stem cells by combining superparamagnetic iron oxides and transfection agents
    Joseph A Frank
    Laboratory of Diagnostic Radiology Research, Clinical Center, National Institutes of Health, Bldg 10, Rm B1N256, 10 Center Dr, MSC 1074, Bethesda, MD 20892 1074, USA
    Radiology 228:480-7. 2003
    ..To label mammalian and stem cells by combining commercially available transfection agents (TAs) with superparamagnetic iron oxide (SPIO) magnetic resonance (MR) imaging contrast agents...
  64. ncbi request reprint Bone marrow-derived mesenchymal stromal cells accelerate wound healing in the rat
    Kellie McFarlin
    Department of Surgery, Henry Ford Health System, Detroit, Michigan, USA
    Wound Repair Regen 14:471-8. 2006
    ..In addition, BMSC treatment caused more rapid histologic maturation of wounds compared with untreated wounds. These data suggest that cell therapy with BMSCs has the potential to augment healing of surgical and cutaneous wounds...
  65. ncbi request reprint Automatic assessment of dynamic contrast-enhanced MRI in an ischemic rat hindlimb model: an exploratory study of transplanted multipotent progenitor cells
    Li Yueh Hsu
    National Heart Lung and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 1061, USA
    NMR Biomed 21:111-9. 2008
    ..The differences were primarily determined by late contrast enhancement of PBS-treated limbs. These computerized methods appear promising for assessing perfusion and late enhancement in dynamic contrast-enhanced MRI...
  66. ncbi request reprint MRI of mouse models of neurological disorders
    Stasia A Anderson
    Animal MRI Imaging Core, National Heart Lung and Blood Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    NMR Biomed 20:200-15. 2007
    ..This article presents an overview of the use of MRI in mouse models of a variety of neurological disorders and a brief review of cellular imaging using magnetically tagged cells in the mouse central nervous system...
  67. pmc Cardiac-specific NRAP overexpression causes right ventricular dysfunction in mice
    Shajia Lu
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Exp Cell Res 317:1226-37. 2011
    ....
  68. pmc Developmental atlas of the early first trimester human embryo
    Shigehito Yamada
    Laboratory of Developmental Biology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    Dev Dyn 239:1585-95. 2010
    ..Overall, this Human Embryo Atlas is a unique resource that provides morphologic data of human developmental anatomy that can accelerate basic research investigations into developmental mechanisms that underlie human congenital anomalies...
  69. pmc Display of the Viral Epitopes on Lactococcus lactis: A Model for Food Grade Vaccine against EV71
    Nadimpalli Ravi S Varma
    Cellular and Molecular Imaging Laboratory, Department of Radiology, Henry Ford Hospital, Detroit, MI 48202, USA
    Biotechnol Res Int 2013:431315. 2013
    ..We believe that the method of protein docking utilized in this study will allow for more flexible presentations of short peptides and proteins on the surface of to be useful as a delivery vehicle...
  70. pmc p53 improves aerobic exercise capacity and augments skeletal muscle mitochondrial DNA content
    Joon Young Park
    Translational Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Circ Res 105:705-12, 11 p following 712. 2009
    ..Understanding the biology of how p53 improves exercise capacity may provide useful insights for improving both cardiovascular as well as general health...
  71. pmc Magnetic resonance imaging of urea transporter knockout mice shows renal pelvic abnormalities
    Vinitha A Jacob
    Laboratory of Kidney and Electrolyte Metabolism, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 1603, USA
    Kidney Int 74:1202-8. 2008
    ..Our studies show that real time imaging of renal pelvic structure in genetically manipulated mice provides a tool for the non-destructive, temporal evaluation of kidney structure...

Research Grants7

  1. Cellular MRI in Glioma and Radiation Necrosis
    Syed Ali; Fiscal Year: 2007
    ..Early detection of recurrent or metastatic glioma as well as early differentiation of glioma from radiation necrosis will help clinician to tackle the devastating neurological disease. ..
  2. Differentiation of Glioma from Radiation Injury Using Cellular MRI
    Syed Ali; Fiscal Year: 2007
    ..Genetically engineered CTL can also be used. This magnetic labeling technique will also help investigators to track the injected CTL in the body as well as in the targeted areas by magnetic resonance imaging (MRI). ..
  3. Cellular MRI in Glioma and Radiation Necrosis
    Ali Syed Arbab; Fiscal Year: 2010
    ..Early detection of recurrent or metastatic glioma as well as early differentiation of glioma from radiation necrosis will help clinician to tackle the devastating neurological disease. ..