Fred Apple

Summary

Affiliation: Hennepin County Medical Center
Country: USA

Publications

  1. ncbi National Academy of Clinical Biochemistry and IFCC Committee for Standardization of Markers of Cardiac Damage Laboratory Medicine Practice Guidelines: Analytical issues for biochemical markers of acute coronary syndromes
    Fred S Apple
    Hennepin County Medical Center, Minneapolis, MN, USA
    Circulation 115:e352-5. 2007
  2. ncbi Validation of the 99th percentile cutoff independent of assay imprecision (CV) for cardiac troponin monitoring for ruling out myocardial infarction
    Fred S Apple
    Hennepin County Medical Center and University of Minnesota School of Medicine, Minneapolis, 55415, USA
    Clin Chem 51:2198-200. 2005
  3. ncbi Plasma 99th percentile reference limits for cardiac troponin and creatine kinase MB mass for use with European Society of Cardiology/American College of Cardiology consensus recommendations
    Fred S Apple
    Department of Laboratory Medicine and Pathology, Hennepin County Medical Center and the University of Minnesota School of Medicine, 701 Park Avenue, Minneapolis, MN 55415, USA
    Clin Chem 49:1331-6. 2003
  4. ncbi Future biomarkers for detection of ischemia and risk stratification in acute coronary syndrome
    Fred S Apple
    Department of Laboratory Medicine and Pathology, Clinical Laboratories, Hennepin County Medical Center, Minneapolis, MN 55415, USA
    Clin Chem 51:810-24. 2005
  5. ncbi Diagnostic and prognostic value of cardiac troponin I assays in patients admitted with symptoms suggestive of acute coronary syndrome
    Fred S Apple
    Department of Laboratory Medicine and Pathology, Hennepin County Medical Center, University of Minnesota School of Medicine, Minneapolis 55415, USA
    Arch Pathol Lab Med 128:430-4. 2004
  6. ncbi Analytical performance of the i-STAT cardiac troponin I assay
    Fred S Apple
    Department of Laboratory Medicine and Pathology, Hennepin County Medical Center and University of Minnesota School of Medicine, Clinical Labs P4, 701 Park Avenue, Minneapolis, MN 55415, USA
    Clin Chim Acta 345:123-7. 2004
  7. ncbi Multi-biomarker risk stratification of N-terminal pro-B-type natriuretic peptide, high-sensitivity C-reactive protein, and cardiac troponin T and I in end-stage renal disease for all-cause death
    Fred S Apple
    Hennepin County Medical Center, University of Minnesota School of Medicine, Minneapolis, MN 55415, USA
    Clin Chem 50:2279-85. 2004
  8. ncbi Clinical biomarkers of cardiac injury: cardiac troponins and natriuretic peptides
    Fred S Apple
    Clinical Laboratories, Hennepin County Medical Center, Minneapolis, Minnesota 55415, USA
    Toxicol Pathol 34:91-3. 2006
  9. ncbi Cardiac troponin and creatine kinase MB monitoring during in-hospital myocardial reinfarction
    Fred S Apple
    Department of Laboratory Medicine and Pathology, Hennepin County Medical Center and University of Minnesota School of Medicine, Minneapolis, MN 55415, USA
    Clin Chem 51:460-3. 2005
  10. ncbi Analytical issues for cardiac troponin
    Fred S Apple
    Hennepin County Medical Center, University of Minnesota School of Medicine, Department of Laboratory Medicine, 701 Park Ave, Clinical Laboratories P 4, Minneapolis, MN 55415, USA
    Prog Cardiovasc Dis 47:189-95. 2004

Research Grants

Detail Information

Publications81

  1. ncbi National Academy of Clinical Biochemistry and IFCC Committee for Standardization of Markers of Cardiac Damage Laboratory Medicine Practice Guidelines: Analytical issues for biochemical markers of acute coronary syndromes
    Fred S Apple
    Hennepin County Medical Center, Minneapolis, MN, USA
    Circulation 115:e352-5. 2007
  2. ncbi Validation of the 99th percentile cutoff independent of assay imprecision (CV) for cardiac troponin monitoring for ruling out myocardial infarction
    Fred S Apple
    Hennepin County Medical Center and University of Minnesota School of Medicine, Minneapolis, 55415, USA
    Clin Chem 51:2198-200. 2005
  3. ncbi Plasma 99th percentile reference limits for cardiac troponin and creatine kinase MB mass for use with European Society of Cardiology/American College of Cardiology consensus recommendations
    Fred S Apple
    Department of Laboratory Medicine and Pathology, Hennepin County Medical Center and the University of Minnesota School of Medicine, 701 Park Avenue, Minneapolis, MN 55415, USA
    Clin Chem 49:1331-6. 2003
    ..The purpose of this study was to determine the plasma (heparin) 99th percentile reference limits for the leading in vitro diagnostic cardiac troponin and CKMB mass assays...
  4. ncbi Future biomarkers for detection of ischemia and risk stratification in acute coronary syndrome
    Fred S Apple
    Department of Laboratory Medicine and Pathology, Clinical Laboratories, Hennepin County Medical Center, Minneapolis, MN 55415, USA
    Clin Chem 51:810-24. 2005
    ....
  5. ncbi Diagnostic and prognostic value of cardiac troponin I assays in patients admitted with symptoms suggestive of acute coronary syndrome
    Fred S Apple
    Department of Laboratory Medicine and Pathology, Hennepin County Medical Center, University of Minnesota School of Medicine, Minneapolis 55415, USA
    Arch Pathol Lab Med 128:430-4. 2004
    ..Increasing numbers of patients are presenting to emergency departments with symptoms suggestive of an acute myocardial infarction...
  6. ncbi Analytical performance of the i-STAT cardiac troponin I assay
    Fred S Apple
    Department of Laboratory Medicine and Pathology, Hennepin County Medical Center and University of Minnesota School of Medicine, Clinical Labs P4, 701 Park Avenue, Minneapolis, MN 55415, USA
    Clin Chim Acta 345:123-7. 2004
    ..This study determines the analytical characteristics of the i-STAT cardiac troponin I assay (cTnI; i-STAT, Princeton, NJ), a 10-min POC assay, designed to be performed at the bedside...
  7. ncbi Multi-biomarker risk stratification of N-terminal pro-B-type natriuretic peptide, high-sensitivity C-reactive protein, and cardiac troponin T and I in end-stage renal disease for all-cause death
    Fred S Apple
    Hennepin County Medical Center, University of Minnesota School of Medicine, Minneapolis, MN 55415, USA
    Clin Chem 50:2279-85. 2004
    ..This study determined the prognostic value of multiple biomarkers for all-cause death over 2 years in 399 ESRD patients...
  8. ncbi Clinical biomarkers of cardiac injury: cardiac troponins and natriuretic peptides
    Fred S Apple
    Clinical Laboratories, Hennepin County Medical Center, Minneapolis, Minnesota 55415, USA
    Toxicol Pathol 34:91-3. 2006
    ..This paper will specifically address cardiac troponins and natriuretic peptides...
  9. ncbi Cardiac troponin and creatine kinase MB monitoring during in-hospital myocardial reinfarction
    Fred S Apple
    Department of Laboratory Medicine and Pathology, Hennepin County Medical Center and University of Minnesota School of Medicine, Minneapolis, MN 55415, USA
    Clin Chem 51:460-3. 2005
  10. ncbi Analytical issues for cardiac troponin
    Fred S Apple
    Hennepin County Medical Center, University of Minnesota School of Medicine, Department of Laboratory Medicine, 701 Park Ave, Clinical Laboratories P 4, Minneapolis, MN 55415, USA
    Prog Cardiovasc Dis 47:189-95. 2004
  11. ncbi Quality specifications for B-type natriuretic peptide assays
    Fred S Apple
    Department of Laboratory Medicine and Pathology, Hennepin County Medical Center, Minneapolis, MN 55415, USA
    Clin Chem 51:486-93. 2005
    ....
  12. ncbi The diagnostic utility of cardiac biomarkers in detecting myocardial infarction
    Fred S Apple
    Clinical Laboratories, Hennepin County Medical Center, 701 Park Avenue, Minneapolis, MN 55415, USA
    Clin Cornerstone 7:S25-30. 2005
    ....
  13. ncbi Point-of-care i-STAT cardiac troponin I for assessment of patients with symptoms suggestive of acute coronary syndrome
    Fred S Apple
    Hennepin County Medical Center and University of Minnesota School of Medicine, Department of Laboratory Medicine and Pathology, Minneapolis, MN 55415, USA
    Clin Chem 52:322-5. 2006
    ..Few studies have investigated the role of cardiac troponin point-of-care (POC) testing for predicting adverse outcomes in acute coronary syndrome (ACS) patients. We investigated the use of a POC cTnI assay in ACS patients...
  14. ncbi Standardization of cardiac markers
    Fred S Apple
    Clinical Laboratories P4 Hennepin County Medical Center Minneapolis, MN 55415, USA
    Scand J Clin Lab Invest Suppl 240:107-11. 2005
    ....
  15. ncbi Predictive value of cardiac troponin I and T for subsequent death in end-stage renal disease
    Fred S Apple
    Department of Laboratory Medicine and Pathology, Hennepin County Medical Center, University of Minnesota School of Medicine, Minneapolis, Minn 55415, USA
    Circulation 106:2941-5. 2002
    ..This study determined the prevalence of increased cardiac troponin I (cTnI) and T (cTnT) in end-stage renal disease (ESRD) patients and whether an increased troponin was predictive of death...
  16. ncbi Near-bedside whole-blood cardiac troponin I assay for risk assessment of patients with acute coronary syndromes
    Fred S Apple
    Hennepin County Medical Center and University of Minnesota School of Medicine, Department of Laboratory Medicine and Pathology, Minneapolis, MN 55415, USA
    Clin Chem 48:1784-7. 2002
  17. ncbi Release characteristics of cardiac biomarkers and ischemia-modified albumin as measured by the albumin cobalt-binding test after a marathon race
    Fred S Apple
    Department of Laboratory Medicine and Pathology, Hennepin County Medical Center, University of Minnesota School of Medicine, Minneapolis, MN 55415, USA
    Clin Chem 48:1097-100. 2002
  18. ncbi Cardiac troponin I and T alterations in hearts with severe left ventricular remodeling
    V Ricchiuti
    Department of Laboratory Medicine, Hennepin County Medical Center, Minneapolis, MN 55415, USA
    Clin Chem 43:990-5. 1997
    ..The clinical assumption is that the appearance of cTnI and cTnT in the blood is proportional to chronic loss of cTnI and cTnT from injured myocardium associated with left ventricular remodeling...
  19. ncbi Clinical evaluation of the first medical whole blood, point-of-care testing device for detection of myocardial infarction
    F S Apple
    Hennepin County Medical Center, Department of Laboratory Medicine and Pathology, Minneapolis, MN 55415, USA
    Clin Chem 46:1604-9. 2000
    ..Validation of whole blood, point-of-care testing devices for monitoring cardiac markers to aid clinicians in ruling in and ruling out myocardial infarction (MI) is necessary for both laboratory and clinical acceptance...
  20. ncbi The specificity of biochemical markers of cardiac damage: a problem solved
    F S Apple
    Department of Laboratory Medicine and Pathology, Hennepin County Medical Center, University of Minnesota School of Medicine, Minneapolis, USA
    Clin Chem Lab Med 37:1085-9. 1999
    ..Monitoring cTnl and cTnT concentrations in the circulation appears poised as the new standards for detection of myocardial injury...
  21. ncbi Tissue specificity of cardiac troponin I, cardiac troponin T and creatine kinase-MB
    F S Apple
    Department of Laboratory Medicine and Pathology, Hennepin County Medical Center, University of Minnesota School of Medicine, Minneapolis 55415, USA
    Clin Chim Acta 284:151-9. 1999
    ..While cTnT isoforms are expressed in injured skeletal muscle, they are not detected by the diagnostic assays used in clinical practice. Therefore, cTnI or cTnT challenge CK-MB as the new standards for detection of myocardial injury...
  22. ncbi Biochemical markers of thrombolytic success. IFCC Committee on Standardization of Markers of Cardiac Damage
    F S Apple
    Hennepin County Medical Center, University of Minnesota School of Medicine, Minneapolis, USA
    Scand J Clin Lab Invest Suppl 230:60-6. 1999
    ..Monitoring markers after PTCA does appear to assist in short term (30 day) risk stratification. However, more studies are needed to assess the use of cardiac troponins...
  23. ncbi Multicenter clinical and analytical evaluation of the AxSYM troponin-I immunoassay to assist in the diagnosis of myocardial infarction
    F S Apple
    Hennepin County Medical Center, Minneapolis, MN 55415, USA
    Clin Chem 45:206-12. 1999
    ..3%, 95.1%, and 94.3%, respectively, from patients with suspected AMI. The AxSYM cTnI demonstrated excellent clinical specificity, >/=96%, in skeletal muscle injury, chronic renal disease, and same-day noncardiac surgery patients...
  24. ncbi Simultaneous rapid measurement of whole blood myoglobin, creatine kinase MB, and cardiac troponin I by the triage cardiac panel for detection of myocardial infarction
    F S Apple
    Department of Laboratory Medicine and Pathology, Hennepin County Medical Center, Minneapolis, MN 55415, USA
    Clin Chem 45:199-205. 1999
    ..The Triage panel offers clinicians a whole blood, point-of-care analysis of multiple cardiac markers that provides excellent clinical sensitivity and specificity for the detection of acute MI...
  25. ncbi Assessment of left ventricular function using serum cardiac troponin I measurements following myocardial infarction
    F S Apple
    Department of Laboratory Medicine and Pathology, Hennepin County Medical Center, the University of Minnesota School of Medicine, Minneapolis 55455, USA
    Clin Chim Acta 272:59-67. 1998
    ..46, p = 0.04). Based on these findings, cTnI shows excellent promise as a useful marker of infarct size, for the assessment of left ventricular function, and may potentially replace CK MB as the cardiac-specific marker for AMI detection...
  26. ncbi Improved detection of minor ischemic myocardial injury with measurement of serum cardiac troponin I
    F S Apple
    Clinical Laboratories 812, Hennepin County Medical Center, Minneapolis, MN, USA
    Clin Chem 43:2047-51. 1997
    ..2% to 100%], compared with 81.8% (CI: 67.3% to 91.8%) for CK-MB. Thus, cTnI was more sensitive than CK-MB mass for detection of myocardial injury in patients with small increases of total CK...
  27. ncbi Cardiac troponin: redefining the detection of myocardial infarction
    Fred S Apple
    Hennepin County Medical Center, University of Minnesota School of Medicine, 701 Park Ave, Minneapolis, MN 55415, USA
    Am Clin Lab 21:32-4. 2002
  28. doi Assessment of the multiple-biomarker approach for diagnosis of myocardial infarction in patients presenting with symptoms suggestive of acute coronary syndrome
    Fred S Apple
    Department of Laboratory Medicine, Hennepin County Medical Center, University of Minnesota School of Medicine, Minneapolis, MN, USA
    Clin Chem 55:93-100. 2009
    ..Cardiac troponin is the preferred biomarker for detecting acute myocardial injury and infarction (MI). We studied whether multiple biomarkers of numerous pathophysiological pathways would increase the diagnostic accuracy for detecting MI...
  29. ncbi Prognostic value of the Ortho Vitros cardiac troponin I assay in patients with symptoms of myocardial ischemia. Risk stratification using European Society of Cardiology/American College of Cardiology recommended cutoff values
    Fred S Apple
    Department of Laboratory Medicine and Pathology, Hennepin County Medical Center, University of Minnesota School of Medicine, Minneapolis, USA
    Am J Clin Pathol 120:114-20. 2003
    ..08 microgram/L) group for cTnI, with directionally similar results for cTnT. Our findings validate the Ortho cTnI assay as a risk stratification biomarker in patients with symptoms of myocardial ischemia...
  30. ncbi Outcome of low-risk patients discharged home after a normal cardiac troponin I
    Stephen W Smith
    Department of Emergency Medicine, Hennepin County Medical Center, Minneapolis, Minnesota 55415, USA
    J Emerg Med 26:401-6. 2004
    ..At our institution, low-risk patients with symptoms suggestive of ACS who are discharged home after a normal cTnI drawn 6-9 h after symptom onset have a very low incidence of cardiac events at 30 days...
  31. doi Use of the Centaur TnI-Ultra assay for detection of myocardial infarction and adverse events in patients presenting with symptoms suggestive of acute coronary syndrome
    Fred S Apple
    Department of Laboratory Medicine, Hennepin County Medical Center, University of Minnesota School of Medicine, Minneapolis, MN 55415, USA
    Clin Chem 54:723-8. 2008
    ..We determined the diagnostic accuracy of the Advia Centaur TnI-Ultra assay for detecting myocardial infarction (MI) and assessing risk of adverse events in patients presenting with ischemic symptoms suggestive of acute coronary syndrome...
  32. ncbi Rates of positive cardiac troponin I and creatine kinase MB mass among patients hospitalized for suspected acute coronary syndromes
    Joseph C Lin
    Division of Cardiology, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Clin Chem 50:333-8. 2004
    ....
  33. ncbi Multiple biomarker use for detection of adverse events in patients presenting with symptoms suggestive of acute coronary syndrome
    Fred S Apple
    Department of Laboratory Medicine and Pathology, Hennepin County Medical Center, University of Minnesota School of Medicine, Minneapolis, MN, USA
    Clin Chem 53:874-81. 2007
    ..We investigated multiple biomarkers of various pathophysiologic pathways to determine their relationships with adverse outcomes in patients presenting with symptoms of acute coronary syndrome...
  34. doi Role of monitoring changes in sensitive cardiac troponin I assay results for early diagnosis of myocardial infarction and prediction of risk of adverse events
    Fred S Apple
    Department of Laboratory Medicine and Pathology and Emergency Medicine, Hennepin County Medical Center and University of Minnesota, Minneapolis, MN 55415, USA
    Clin Chem 55:930-7. 2009
    ....
  35. ncbi National Academy of Clinical Biochemistry and IFCC Committee for Standardization of Markers of Cardiac Damage Laboratory Medicine practice guidelines: Analytical issues for biomarkers of heart failure
    Fred S Apple
    Hennepin County Medical Center, Minneapolis, Minn, USA
    Circulation 116:e95-8. 2007
  36. ncbi European Society of Cardiology and American College of Cardiology guidelines for redefinition of myocardial infarction: how to use existing assays clinically and for clinical trials
    Fred S Apple
    Department of Laboratory Medicine and Pathology, Hennepin County Medical Center and University of Minnesota School of Medicine, Minneapolis, Minn, USA
    Am Heart J 144:981-6. 2002
    ..The Clinical Outcomes Utilizing Revascularization and Aggressive druG Evaluation (COURAGE) trial asked for recommendations concerning the use of troponin assays for the trial...
  37. ncbi Decreased patient charges following implementation of point-of-care cardiac troponin monitoring in acute coronary syndrome patients in a community hospital cardiology unit
    Fred S Apple
    Department of Laboratory Medicine and Pathology, Hennepin County Medical Center, Minneapolis, MN 55415, USA
    Clin Chim Acta 370:191-5. 2006
    ....
  38. ncbi Cardiac troponin risk stratification based on 99th percentile reference cutoffs in patients with ischemic symptoms suggestive of acute coronary syndrome: influence of estimated glomerular filtration rates
    Fred S Apple
    The Department of Laboratory Medicine and Pathology, Hennepin County Medical Center and the University of Minnesota School of Medicine, Minneapolis, MN 55415, USA
    Am J Clin Pathol 127:598-603. 2007
    ..9% to 50.8% compared with 4.9% to 6.6% for a normal troponin level and an eGFR greater than 60 mL/min/1.73 m2 (P < .05). The eGFR in combination with an increased cTn level demonstrated the most powerful stratification...
  39. doi Analytical characteristics of commercial cardiac troponin I and T immunoassays in serum from rats, dogs, and monkeys with induced acute myocardial injury
    Fred S Apple
    Department of Laboratory Medicine and Pathology, Hennepin County Medical Center and the University of Minnesota School of Medicine, Minneapolis, MN 55415, USA
    Clin Chem 54:1982-9. 2008
    ..Information is needed regarding analytical characteristics of cardiac troponin (cTn) assays used in preclinical studies...
  40. pmc Etiology of sudden death in the community: results of anatomical, metabolic, and genetic evaluation
    A Selcuk Adabag
    Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN 55417, USA
    Am Heart J 159:33-9. 2010
    ..Identifying persons at risk for sudden cardiac death (SCD) is challenging. A comprehensive evaluation may reveal clues about the clinical, anatomical, genetic, and metabolic risk factors for SCD...
  41. ncbi National Academy of Clinical Biochemistry and IFCC Committee for Standardization of Markers of Cardiac Damage Laboratory Medicine Practice Guidelines: analytical issues for biomarkers of heart failure
    Fred S Apple
    Hennepin County Medical Center, Minneapolis, MN, USA
    Clin Biochem 41:222-6. 2008
  42. doi Predictors and outcomes of a perioperative myocardial infarction following elective vascular surgery in patients with documented coronary artery disease: results of the CARP trial
    Edward O McFalls
    Division of Cardiology 111C, VA Medical Center, 1 Veterans Drive, Minneapolis, MN 55417, USA
    Eur Heart J 29:394-401. 2008
    ....
  43. ncbi B-type natriuretic peptide (BNP) and N-terminal pro-BNP in obese patients without heart failure: relationship to body mass index and gastric bypass surgery
    John V St Peter
    College of Pharmacy and School of Medicine, University of Minnesota, Minneapolis, 55455 0343, USA
    Clin Chem 52:680-5. 2006
    ..Further investigations are warranted to better characterize variables that may confound the clinical interpretation of plasma natriuretic peptide measurements, which are increasingly recognized to have diagnostic and predictive importance...
  44. doi Defining the serum 99th percentile in a normal reference population measured by a high-sensitivity cardiac troponin I assay
    Fred S Apple
    Hennepin County Medical Center and the University of Minnesota, Department of Laboratory Medicine and Pathology, Minneapolis, MN, USA
    Clin Biochem 43:1034-6. 2010
    ..This study determined the serum 99th percentile reference value for cTnI measured using the high sensitivity Erenna cTnI assay...
  45. ncbi Clinical and analytical review of ischemia-modified albumin measured by the albumin cobalt binding test
    Fred S Apple
    Hennepin County Medical Center Department of Laboratory Medicine and Pathology, University of Minnesota School of Medicine, Minneapolis, Minnesota 55415, USA
    Adv Clin Chem 39:1-10. 2005
    ..The ACB test has barely begun the exploration of the exciting challenges and discoveries that lie ahead in assisting clinicians in the early detection of myocardial ischemia to assist and improve patient triage, therapy, and management...
  46. ncbi Methadone-related deaths in Hennepin County, Minnesota: 1992-2002
    Angelique Gagajewski
    Hennepin County Medical Center, Minneapolis, MN 55415, USA
    J Forensic Sci 48:668-71. 2003
    ..18-3.03 mg/L) with no definable lethal level. Interpretation of methadone blood concentrations must be done in the context of the clinical history for determining cause of death, and may be confounded by postmortem redistribution...
  47. doi Use of the bioMérieux VIDAS troponin I ultra assay for the diagnosis of myocardial infarction and detection of adverse events in patients presenting with symptoms suggestive of acute coronary syndrome
    Fred S Apple
    Department of Laboratory Medicine and Pathology, Hennepin County Medical Center, University of Minnesota School of Medicine, Minneapolis, MN, USA
    Clin Chim Acta 390:72-5. 2008
    ..We demonstrate the performance of the bioMérieux VIDAS Troponin I Ultra assay for diagnostic accuracy for detection of myocardial infarction (MI) and risk stratification...
  48. ncbi Free oxycodone concentrations in 67 postmortem cases from the Hennepin County medical examiner's office
    Jonathan G Thompson
    Hennepin County Medical Examiner s Office, Minneapolis, Minnesota, USA
    J Anal Toxicol 32:673-9. 2008
    ..Free oxycodone concentrations in postmortem cases must be interpreted in the context of the deceased's past medical history and autopsy findings...
  49. doi Postmortem redistribution of fentanyl in blood
    Kalen N Olson
    Hennepin County Medical Center, Clinical Laboratories, 701 Park Avenue, Minneapolis, MN 55415, USA
    Am J Clin Pathol 133:447-53. 2010
    ..7 mg/kg, and 103.4 mg/kg, respectively. The fentanyl HB/FB1 ratio (mean, 8.39) was higher compared with the corresponding HB/FB2 ratio (mean, 3.48). These results suggest that postmortem redistribution of fentanyl can occur in FB...
  50. ncbi National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines: clinical utilization of cardiac biomarker testing in heart failure
    W H Wilson Tang
    Cleveland Clinic, Foundation, Cleveland, OH, USA
    Clin Biochem 41:210-21. 2008
  51. ncbi Case definitions for acute coronary heart disease in epidemiology and clinical research studies: a statement from the AHA Council on Epidemiology and Prevention; AHA Statistics Committee; World Heart Federation Council on Epidemiology and Prevention; the
    Russell V Luepker
    Circulation 108:2543-9. 2003
  52. ncbi Operationalizing cardiac troponin I testing along ESC/ACC consensus guidelines for defining myocardial infarction: increasing rate of detection
    Fred S Apple
    Clin Chim Acta 331:165-6. 2003
  53. doi Cross-reactivity of BNP, NT-proBNP, and proBNP in commercial BNP and NT-proBNP assays: preliminary observations from the IFCC Committee for Standardization of Markers of Cardiac Damage
    Kristin N Luckenbill
    Clin Chem 54:619-21. 2008
  54. ncbi Biochemical markers of cardiac injury in normal, surviving septic, or nonsurviving septic neonatal foals
    Jo Ann Slack
    Section of Large Animal Internal Medicine, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706, USA
    J Vet Intern Med 19:577-80. 2005
    ..These findings suggest that myocardial injury occurs during septicemia in neonatal foals but that the injury is not associated with survival among septic foals...
  55. doi Cardiac troponin and outcome in acute heart failure
    W Frank Peacock
    Department of Emergency Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    N Engl J Med 358:2117-26. 2008
    ..The purpose of our study was to describe the association between elevated cardiac troponin levels and adverse events in hospitalized patients with acute decompensated heart failure...
  56. doi Novel immunoassay for quantification of brain natriuretic peptide and its precursor in human blood
    Natalia N Tamm
    HyTest Ltd, Turku, Finland
    Clin Chem 54:1511-8. 2008
    ..The purpose of our study was to develop a sandwich immunoassay for the precise quantification of BNP and BNP precursor (proBNP) in human blood that is not susceptible to proteolysis...
  57. pmc Cardiac isoenzymes in healthy Holstein calves and calves with experimentally induced endotoxemia
    Simon F Peek
    Large Animal Internal Medicine, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin 53706, USA
    Can J Vet Res 72:356-61. 2008
    ..Total CK values increased significantly following LPS administration. Biochemical evidence of myocardial injury occurs within 3 h following LPS administration to neonatal Holstein calves...
  58. ncbi Myocardial tissue troponins T and I. An immunohistochemical study in experimental models of myocardial ischemia
    Michael C Fishbein
    Division of Anatomic Pathology, Department of Pathology and Laboratory Medicine, UCLA Center for the Health Sciences, A7 149 CHS, 10833 Le Conte Avenue, Los Angeles, CA 90095 1732, USA
    Cardiovasc Pathol 12:65-71. 2003
    ..To date, no immunohistochemical studies have been performed which allow visualization of the time course and pattern of myocardial troponin egress from the myocardium during the early evolution of ischemic injury in experimental systems...
  59. ncbi Multicenter evaluation of an automated assay for troponin I
    Denise Uettwiller-Geiger
    John T Mather Memorial Hospital, Port Jefferson, NY 11777, USA
    Clin Chem 48:869-76. 2002
    ..We describe an assay that overcomes problems of early assays that were often affected by cTnI degradation, assay interference, poor sensitivity, and imprecision...
  60. ncbi Assessment of the diagnostic accuracy of the TDx-FLM II to predict fetal lung maturity
    Corinne R Fantz
    Department of Pathology and Immunology, Division of Laboratory Medicine, Washington University School of Medicine, 660 South Euclid Ave, Box 8118, St Louis, MO 63110, USA
    Clin Chem 48:761-5. 2002
    ..Our objective was to determine the optimal diagnostic cutoff value for the TDx-FLM II assay (Abbott Laboratories) for predicting clinically significant RDS...
  61. ncbi False-positive AxSYM cardiac troponin I results in a 53-year-old woman
    Ronald J Knoblock
    Division of Clinical Pathology, Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, Utah 84108, USA
    Arch Pathol Lab Med 126:606-9. 2002
    ....
  62. ncbi National Academy of Clinical Biochemistry laboratory medicine practice guidelines: use of cardiac troponin and B-type natriuretic peptide or N-terminal proB-type natriuretic peptide for etiologies other than acute coronary syndromes and heart failure
    Alan H B Wu
    University of California at San Francisco, San Francisco, CA, USA
    Clin Chem 53:2086-96. 2007
  63. ncbi Universal definition of myocardial infarction
    Kristian Thygesen
    Circulation 116:2634-53. 2007
  64. ncbi Multi-center validation of the Response Biomedical Corporation RAMP NT-proBNP assay with comparison to the Roche Diagnostics GmbH Elecsys proBNP assay
    Elizabeth Lee-Lewandrowski
    Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Clin Chim Acta 386:20-4. 2007
    ..Point-of-care (POC) assays may provide more timely results and potentially improve patient outcomes...
  65. ncbi Cardiac biomarkers for detection of myocardial infarction: perspectives from past to present
    Sidney B Rosalki
    10 Wimpole News, London, United Kingdom
    Clin Chem 50:2205-13. 2004
    ....
  66. ncbi Serum 99th percentile reference cutoffs for seven cardiac troponin assays
    Fred S Apple
    Clin Chem 50:1477-9. 2004
  67. ncbi Letter regarding article by Khan et al, "prognostic value of troponin T and I among asymptomatic patients with end-stage renal disease: a meta-analysis"
    Fred S Apple
    Circulation 113:e775; author reply e776. 2006
  68. ncbi Biomarkers in acute cardiac disease: the present and the future
    Allan S Jaffe
    Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic and Medical School, Rochester, Minnesota 55905, USA
    J Am Coll Cardiol 48:1-11. 2006
    ..Finally, it reflects on some of the large number of markers that are still in development...
  69. ncbi Toward standardization of cardiac troponin I measurements part II: assessing commutability of candidate reference materials and harmonization of cardiac troponin I assays
    Robert H Christenson
    Department of Pathology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Clin Chem 52:1685-92. 2006
    ..Toward this goal, the AACC cTnI Standardization Committee collaborated with the National Institute of Standards and Technology (NIST) in an earlier study to select 2 candidate reference materials (cRMs)...
  70. ncbi Marathoner's heart?
    Paul D Thompson
    Circulation 114:2306-8. 2006
  71. ncbi Cardiac troponin monitoring for detection of myocardial infarction: newer generation assays are here to stay
    Fred S Apple
    Clin Chim Acta 380:1-3; discussion 245-6. 2007
  72. ncbi Evidence for functional heterogeneity of circulating B-type natriuretic peptide
    Faquan Liang
    Scios, Inc, Fremont, California 94555, USA
    J Am Coll Cardiol 49:1071-8. 2007
    ..These studies describe molecular forms of circulating B-type natriuretic peptide (BNP) as well as their biological activity...
  73. ncbi Evaluation of a point-of-care assay for cardiac markers for patients suspected of acute myocardial infarction
    Alan H B Wu
    Department of Pathology and Laboratory Medicine, Hartford Hospital, 80 Seymour St, Hartford, CT 06102, USA
    Clin Chim Acta 346:211-9. 2004
    ..With new rapid ED assessment protocols, there is increasing pressure to produce results with a short turnaround time (TAT), and point-of-care (POC) testing is one alternative for providing fast results...
  74. ncbi National Academy of Clinical Biochemistry and IFCC Committee for Standardization of Markers of Cardiac Damage Laboratory Medicine Practice Guidelines: analytical issues for biochemical markers of acute coronary syndromes
    Fred S Apple
    Clin Chem 53:547-51. 2007
  75. ncbi National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines: clinical characteristics and utilization of biochemical markers in acute coronary syndromes
    David A Morrow
    Clin Chem 53:552-74. 2007
  76. ncbi Standardization of immunoassays for measurement of myoglobin in serum. Phase I: evaluation of candidate secondary reference materials
    Mauro Panteghini
    Laboratorio Analisi Chimico Cliniche 1, Azienda Ospedaliera Spedali Civili, 25125 Brescia, Italy
    Clin Chim Acta 341:65-72. 2004
    ..Its concentrations in serum can be measured by immunoassays and are used as an early indicator of myocardial necrosis. Since variability among commercial myoglobin assays exists, standardization of myoglobin assays is needed...
  77. ncbi The brain natriuretic peptide (BNP) precursor is the major immunoreactive form of BNP in patients with heart failure
    Karina R Seferian
    HyTest Ltd, Turku, Finland
    Clin Chem 53:866-73. 2007
    ..It remains unclear which forms of these peptides circulate in blood and which forms are measured by assays for these natriuretic peptides...
  78. ncbi Evaluation of imprecision for cardiac troponin assays at low-range concentrations
    Mauro Panteghini
    Laboratorio Analisi Chimico Cliniche 1, Azienda Ospedaliera Spedali Civili, 25125 Brescia, Italy
    Clin Chem 50:327-32. 2004
    ..Pools of human sera containing cardiac troponin concentrations around the MI decision limit were assessed to identify the lowest concentration associated with a 10% CV...
  79. ncbi National Academy of Clinical Biochemistry Laboratory Medicine practice guidelines: Clinical utilization of cardiac biomarker testing in heart failure
    W H Wilson Tang
    Circulation 116:e99-109. 2007
  80. ncbi Multicenter evaluation of the Roche NT-proBNP assay and comparison to the Biosite Triage BNP assay
    Kiang Teck J Yeo
    Department of Pathology, Dartmouth Medical School and Dartmouth Hitchcock Medical Center, 1 Medical Center Drive, Lebanon, NH 03756, USA
    Clin Chim Acta 338:107-15. 2003
    ..Brain natriuretic peptides (BNPs) are useful in the assessment of heart failure, left ventricular dysfunction, and acute coronary syndromes...
  81. doi Immunodetection of glycosylated NT-proBNP circulating in human blood
    Karina R Seferian
    HyTest Ltd, Turku, Finland
    Clin Chem 54:866-73. 2008
    ..Recently it has been shown that proBNP is O-glycosylated in human blood. The goal of this study was to map sites on the NT-proBNP molecule that should be recognized by antibodies used in optimal NT-proBNP assays...

Research Grants1

  1. Cardiac Troponin Testing for Myocardial Infarction
    Fred Apple; Fiscal Year: 2001
    ..abstract_text> ..