Research Topics
| H E ScharfmanSummaryAffiliation: Helen Hayes Hospital Country: USA Publications
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Publications
Spontaneous limbic seizures after intrahippocampal infusion of brain-derived neurotrophic factorHelen E Scharfman
Center for Neural Recovery and Rehabilitation Research, Helen Hayes Hospital, West Haverstraw, New York, 10993-1195, USA
Exp Neurol 174:201-14. 2002..These data support the hypothesis that intrahippocampal BDNF infusion can facilitate, and potentially initiate, seizure activity in adult hippocampus...
Seizure susceptibility in intact and ovariectomized female rats treated with the convulsant pilocarpineHelen E Scharfman
Center for Neural Recovery and Rehabilitation Research CNRRR, Helen Hayes Hospital, New York State Department of Health, Rte 9W, West Haverstraw, NY 10993 1195, USA
Exp Neurol 196:73-86. 2005..This dissociation between incidence vs. progression provides new insight into the influence of estrogen and progesterone on seizures...- Increased neurogenesis and the ectopic granule cells after intrahippocampal BDNF infusion in adult ratsHelen Scharfman
Center for Neural Recovery and Rehabilitation Research, Helen Hayes Hospital, NY State Department of Health, Rte 9W, West Haverstraw, NY 10993 1195, USA
Exp Neurol 192:348-56. 2005.... - Hippocampal excitability increases during the estrous cycle in the rat: a potential role for brain-derived neurotrophic factorHelen E Scharfman
Center for Neural Recovery and Rehabilitation Research, Helen Hayes Hospital, New York State Department of Health, West Haverstraw, New York 10993 1195, USA
J Neurosci 23:11641-52. 2003..Periovulatory changes in hippocampal function may, thus, involve estrogen-induced increases in BDNF expression... - Perforant path activation of ectopic granule cells that are born after pilocarpine-induced seizuresH E Scharfman
Center for Neural Recovery and Rehabilitation Research, Helen Hayes Hospital, New York State Department of Health, Route 9W, West Haverstraw, NY 10993 1195, USA
Neuroscience 121:1017-29. 2003.... - Electrophysiological evidence of monosynaptic excitatory transmission between granule cells after seizure-induced mossy fiber sproutingHelen E Scharfman
Center for Neural Recovery and Rehabilitation Research, Helen Hayes Hospital, New York State Department of Health, West Haverstraw 10993 1195, USA
J Neurophysiol 90:2536-47. 2003..These characteristics may contribute to the empirical observation that the sprouted dentate gyrus does not normally generate epileptiform discharges... - The influence of gonadal hormones on neuronal excitability, seizures, and epilepsy in the femaleHelen E Scharfman
Department of Pharmacology, Columbia University, College of Physicians and Surgeons, New York, USA
Epilepsia 47:1423-40. 2006..quot; Clinical and animal research, designed with the relevant endocrinological and neurobiological issues in mind, will help advance this field in the future... - Structural and functional asymmetry in the normal and epileptic rat dentate gyrusHelen E Scharfman
Center for Neural Recovery and Rehabilitation Research, Helen Hayes Hospital, West Haverstraw, New York 10993 1195, USA
J Comp Neurol 454:424-39. 2002..Taken together, the results suggest that supra- and infrapyramidal blades of the dentate gyrus could have different circuit functions and that the infrapyramidal blade may play a greater role in activating the hippocampus... - Estrogen and brain-derived neurotrophic factor (BDNF) in hippocampus: complexity of steroid hormone-growth factor interactions in the adult CNSHelen E Scharfman
Center for Neural Recovery and Rehabilitation Research, Helen Hayes Hospital, West Haverstraw, NY 10093 1195, USA
Front Neuroendocrinol 27:415-35. 2006.... - Spontaneous recurrent seizures after pilocarpine-induced status epilepticus activate calbindin-immunoreactive hilar cells of the rat dentate gyrusH E Scharfman
Center for Neural Recovery and Rehabilitation Research, Helen Hayes Hospital, West Haverstraw, NY 10993 1195, USA
Neuroscience 111:71-81. 2002.... - Epilepsy as an example of neural plasticityHelen E Scharfman
Center for Neural Recovery and Rehabilitation Research, Helen Hayes Hospital, West Haverstraw, NY 10993 1195, USA
Neuroscientist 8:154-73. 2002..For those interested in plasticity, it is suggested that perhaps the best examples for studying plasticity lie in the field of epilepsy... - Ectopic granule cells of the rat dentate gyrusHelen Scharfman
Department of Pharmacology, Columbia University, New York, NY, USA
Dev Neurosci 29:14-27. 2007..These studies have provided new insight into a rare type of granule cell in the dentate gyrus, and the plastic characteristics of dentate granule cells that appear to depend on the location of the cell body... - Granule-like neurons at the hilar/CA3 border after status epilepticus and their synchrony with area CA3 pyramidal cells: functional implications of seizure-induced neurogenesisH E Scharfman
Center for Neural Recovery and Rehabilitation Research, Helen Hayes Hospital, West Haverstraw, New York 10993 1195, USA
J Neurosci 20:6144-58. 2000.... - Neuroscience. Is more neurogenesis always better?Helen E Scharfman
Departments of Pharmacology and Neurology, Columbia University, and Center for Neural Recovery and Rehabilitation Research, Helen Hayes Hospital, West Haverstraw, NY 10993 1195, USA
Science 315:336-8. 2007 - Similarities between actions of estrogen and BDNF in the hippocampus: coincidence or clue?Helen E Scharfman
Center for Neural Recovery and Rehabilitation Research, Helen Hayes Hospital, Route 9W, West Haverstraw, NY 10993 1195, USA
Trends Neurosci 28:79-85. 2005..Furthermore, disruption of the relationship between estrogen and BDNF could contribute to neurological and psychiatric disorders that have been associated with the hippocampus, such as Alzheimer's disease, depression and epilepsy... - Survival of dentate hilar mossy cells after pilocarpine-induced seizures and their synchronized burst discharges with area CA3 pyramidal cellsH E Scharfman
Center for Neural Recovery and Rehabilitation Research, Helen Hayes Hospital, West Haverstraw, NY 10993 1195, USA
Neuroscience 104:741-59. 2001..The fact that mossy cells have epileptiform bursts, and that they are synchronized with area CA3, suggest a previously unappreciated substrate for hyperexcitability in this animal model... - Pretreatment with L-kynurenine, the precursor to the excitatory amino acid antagonist kynurenic acid, suppresses epileptiform activity in combined entorhinal/hippocampal slicesH E Scharfman
Neurology Research Center, Helen Hayes Hospital, West Haverstraw, NY 10993 1195, USA
Neurosci Lett 224:115-8. 1997..Therefore, manipulation of the kynurenine pathway might constitute a useful new direction for anticonvulsant drug development... - Mossy cell axon synaptic contacts on ectopic granule cells that are born following pilocarpine-induced seizuresJoseph P Pierce
Department of Neurology and Neuroscience, Weill Medical College of Cornell University, 411 E 69th Street, New York, NY 10021, USA
Neurosci Lett 422:136-40. 2007..The results suggest that mossy cells participate in the excitatory circuits which activate EGCs, providing further insight into the network rearrangements that accompany seizure-induced neurogenesis in this animal model of epilepsy... - Vascular endothelial growth factor is up-regulated after status epilepticus and protects against seizure-induced neuronal loss in hippocampusJ N Nicoletti
City University of New York, New York, NY 10016, USA
Neuroscience 151:232-41. 2008..VEGF induced significant preservation of hippocampal neurons, suggesting that VEGF may play a neuroprotective role following status epilepticus... - Changes in hippocampal function of ovariectomized rats after sequential low doses of estradiol to simulate the preovulatory estrogen surgeHelen E Scharfman
Center for Neural Recovery and Rehabilitation Research, Helen Hayes Hospital, West Haverstraw, NY 10962, USA
Eur J Neurosci 26:2595-612. 2007.... - Relevance of seizure-induced neurogenesis in animal models of epilepsy to the etiology of temporal lobe epilepsyHelen E Scharfman
Center for Neural Recovery and Rehabilitation Research, Helen Hayes Hospital, New York State Department of Health, West Haverstraw, New York 10993 1195, USA
Epilepsia 48:33-41. 2007..These studies provide new insights into the mechanisms of TLE, and suggest novel strategies for intervention that could be used to prevent or treat TLE... - Acute and chronic responses to the convulsant pilocarpine in DBA/2J and A/J miceM R Winawer
Department of Neurology and G H Sergievsky Center, Columbia University, New York, NY 10032, USA
Neuroscience 149:465-75. 2007..A/J mice provide a potential resource to examine the progression to status. The DBA mouse may be valuable to clarify genes regulating other seizure-associated phenomena, such as seizure-induced neurogenesis and sudden death... - Acute and chronic changes in glycogen phosphorylase in hippocampus and entorhinal cortex after status epilepticus in the adult male ratSusan G Walling
Center for Neural Recovery and Rehabilitation Research, Helen Hayes Hospital, West Haverstraw, New York 10993 1195, USA
Eur J Neurosci 26:178-89. 2007..Taken together, the results suggest that GP is dynamically regulated during and after status in the adult rat, and may have an important role in the pilocarpine model of epilepsy... - Stereological methods reveal the robust size and stability of ectopic hilar granule cells after pilocarpine-induced status epilepticus in the adult ratDaniel P McCloskey
Center for Neural Recovery and Rehabilitation Research, Helen Hayes Hospital, Route 9W, West Haverstraw, NY 10993, USA
Eur J Neurosci 24:2203-10. 2006..The results provide new insight into the potential role of ectopic hilar granule cells in the pilocarpine model of temporal lobe epilepsy... - Depression of synaptic transmission by vascular endothelial growth factor in adult rat hippocampus and evidence for increased efficacy after chronic seizuresDaniel P McCloskey
Center for Neural Recovery and Rehabilitation Research, Helen Hayes Hospital, West Haverstraw, New York 10993, USA
J Neurosci 25:8889-97. 2005..Based on this, we suggest that VEGF or VEGF-related targets could provide useful endpoints to direct novel therapeutic strategies for epilepsy... - Quantitative differences in the effects of de novo produced and exogenous kynurenic acid in rat brain slicesH E Scharfman
Neurology Research Center, Helen Hayes Hospital, West Haverstraw, NY 10993 1195, USA
Neurosci Lett 274:111-4. 1999..20 microM KYNA, there were fewer slices with spontaneous epileptiform activity than slices exposed to 2 microM exogenous KYNA. The results indicate a more potent neuromodulatory action of endogenous KYNA than has been previously realized... - Effects of multiparity on recognition memory, monoaminergic neurotransmitters, and brain-derived neurotrophic factor (BDNF)Abbe H Macbeth
Department of Psychology, Hunter College, CUNY, New York, NY 10021, USA
Horm Behav 54:7-17. 2008.... - The CA3 "backprojection" to the dentate gyrusHelen E Scharfman
Department of Pharmacology and Neurology, Columbia University, New York, NY 10032, USA
Prog Brain Res 163:627-37. 2007..In this case, the backprojection could be important to seizure activity originating in hippocampus, and help explain the seizure susceptibility of ventral hippocampus... - Modulation of vascular endothelial growth factor (VEGF) expression in motor neurons and its electrophysiological effectsDaniel P McCloskey
The College of Staten Island CUNY, Staten Island, NY, United States Helen Hayes Hospital, West Haverstraw, NY, United States
Brain Res Bull 76:36-44. 2008..Failure of this mechanism may contribute to diseases that involve a dysregulation of VEGF, excessive excitation of motor neurons, and motor neuron loss, such as amyotrophic lateral sclerosis (ALS)... - Neuropeptide Y is neuroproliferative for post-natal hippocampal precursor cellsOwain W Howell
Division of Clinical Neurosciences, University of Southampton, Southampton, UK CNRRR, Helen Hayes Hospital, West Haverstraw, New York, USA
J Neurochem 86:646-59. 2003..These studies suggest that the proliferation of hippocampal neuroblasts and precursor cells is increased by neuropeptide Y and, therefore, that hippocampal learning and memory may be modulated by neuropeptide Y-releasing interneurones... - Functional implications of seizure-induced neurogenesisHelen E Scharfman
Center for Neural Recovery and Rehabilitation Research, Helen Hayes Hospital, New York State Department of Health, West Haverstraw, USA
Adv Exp Med Biol 548:192-212. 2004..Yet neurogenesis has been shown to occur in humans throughout adult life. What might be the reasons for these seemingly disparate results?.. - The neurobiology of epilepsyHelen E Scharfman
Nathan Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Building 35, Orangetown, NY 10962, USA
Curr Neurol Neurosci Rep 7:348-54. 2007..However, the critical control points for the emergence of chronic seizures in temporal lobe epilepsy, as well as their persistence, frequency, and severity, are questions that remain unresolved... - Neuropeptide Y is important for basal and seizure-induced precursor cell proliferation in the hippocampusOwain W Howell
Division of Clinical Neurosciences, University of Southampton, Room LD70, D Level, South Academic Block, Southampton General Hospital, Southampton SO16 6YD, UK
Neurobiol Dis 26:174-88. 2007..We confirm an effect on proliferation in the cSVZ/SCZ of Y(1) receptor(-/-) mice and demonstrate a significant reduction in basal and seizure-induced proliferation in the DG of NPY(-/-) mice... - Mossy fibers are the primary source of afferent input to ectopic granule cells that are born after pilocarpine-induced seizuresJoseph P Pierce
Department of Neurology and Neuroscience, Weill Medical College of Cornell University, NY 10021, USA
Exp Neurol 196:316-31. 2005.... - Kynurenate and 7-chlorokynurenate formation in chronically epileptic ratsHui-Qiu Wu
Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD 21228, U.S.A
Epilepsia 46:1010-6. 2005..Astrogliosis probably accounts for their enhanced production in chronically epileptic rats. These results bode well for the use of 4-chlorokynurenine in the treatment of chronic seizure disorders... - Neuropeptide Y stimulates neuronal precursor proliferation in the post-natal and adult dentate gyrusOwain W Howell
Division of Clinical Neurosciences, University of Southampton, Southampton, UK
J Neurochem 93:560-70. 2005..These results show that NPY stimulates neuronal precursor proliferation in the dentate gyrus and suggest that NPY-releasing interneurons may modulate dentate neurogenesis... - Brain-derived neurotrophic factorDevin K Binder
Department of Neurological Surgery, M779 Moffitt Hospital, Box 0112, University of California, San Francisco, CA 94143 0112, USA
Growth Factors 22:123-31. 2004.... - The dentate gyrus: fundamental neuroanatomical organization (dentate gyrus for dummies)David G Amaral
Department of Psychiatry and Behavioral Sciences, The M I N D Institute and the California National Primate Research Center, UC Davis, Davis, CA, USA
Prog Brain Res 163:3-22. 2007..Together, this information provides essential information that can serve as an introduction to the dentate gyrus--a "dentate gyrus for dummies.".. - L-4-chlorokynurenine attenuates kainate-induced seizures and lesions in the ratHui Qui Wu
Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, Maryland 21228, USA
Exp Neurol 177:222-32. 2002..Taken together, these data suggest that a prodrug approach using 4-Cl-KYN might offer advantages in the treatment of temporal lobe epilepsy... - Vascular endothelial growth factor (VEGF) in seizures: a double-edged swordSusan D Croll
Department of Psychology, Queens College and the Graduate Center of the City University of New York, Flushing, USA
Adv Exp Med Biol 548:57-68. 2004..Although only further research will determine the exact nature of VEGF's role after seizures, preliminary data indicate that VEGF plays a protective role after seizures...