F Cosman

Summary

Affiliation: Helen Hayes Hospital
Country: USA

Publications

  1. ncbi request reprint Effects of intermittent parathyroid hormone administration on bone mineralization density in iliac crest biopsies from patients with osteoporosis: a paired study before and after treatment
    Barbara M Misof
    Ludwig Boltzmann Institute of Osteology and Fourth Medical Department, Hanusch Hospital and UKH Meidling, A 1140 Vienna, Austria
    J Clin Endocrinol Metab 88:1150-6. 2003
  2. doi request reprint Hip and spine strength effects of adding versus switching to teriparatide in postmenopausal women with osteoporosis treated with prior alendronate or raloxifene
    Felicia Cosman
    Helen Hayes Hospital, West Haverstraw, NY, USA
    J Bone Miner Res 28:1328-36. 2013
  3. doi request reprint Determinants of stress fracture risk in United States Military Academy cadets
    Felicia Cosman
    Helen Hayes Hospital, West Haverstraw, NY 10993, USA
    Bone 55:359-66. 2013
  4. doi request reprint Changes in vitamin D metabolites during teriparatide treatment
    Felicia Cosman
    Clinical Research Center, Helen Hayes Hospital, West Haverstraw, NY 10993, USA
    Bone 50:1368-71. 2012
  5. pmc The influence of lifestyle, menstrual function and oral contraceptive use on bone mass and size in female military cadets
    Jamie A Ruffing
    Clinical Research and Regional Bone Centers, Helen Hayes Hospital, West Haverstraw, NY, USA
    Nutr Metab (Lond) 4:17. 2007
  6. ncbi request reprint Short-term effects of estrogen, tamoxifen and raloxifene on hemostasis: a randomized-controlled study and review of the literature
    F Cosman
    Clinical Research Regional Bone Centers, Helen Hayes Hospital, West Haverstraw, NY 10993, USA
    Thromb Res 116:1-13. 2005
  7. doi request reprint Parathyroid hormone treatment for osteoporosis
    Felicia Cosman
    Columbia College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Curr Opin Endocrinol Diabetes Obes 15:495-501. 2008
  8. ncbi request reprint Therapeutic potential of parathyroid hormone
    Felicia Cosman
    Regional Bone Center, Helen Hayes Hospital, Route 9W, West Haverstraw, New York, NY 10993, USA
    Curr Osteoporos Rep 2:5-11. 2004
  9. ncbi request reprint Daily and cyclic parathyroid hormone in women receiving alendronate
    Felicia Cosman
    Clinical Research Center, Helen Hayes Hospital, West Haverstraw, NY 10993, USA
    N Engl J Med 353:566-75. 2005
  10. ncbi request reprint Anabolic therapy for osteoporosis: parathyroid hormone
    Felicia Cosman
    Regional Bone Center, Helen Hayes Hospital, Route 9W, West Haverstraw, New York, NY 10993, USA
    Curr Osteoporos Rep 3:143-9. 2005

Research Grants

  1. Early effects of PTH on the proximal femur
    Felicia Cosman; Fiscal Year: 2010

Collaborators

Detail Information

Publications43

  1. ncbi request reprint Effects of intermittent parathyroid hormone administration on bone mineralization density in iliac crest biopsies from patients with osteoporosis: a paired study before and after treatment
    Barbara M Misof
    Ludwig Boltzmann Institute of Osteology and Fourth Medical Department, Hanusch Hospital and UKH Meidling, A 1140 Vienna, Austria
    J Clin Endocrinol Metab 88:1150-6. 2003
    ..The findings confirm the observations that PTH stimulates skeletal remodeling, resulting in an increased percentage of newly formed bone matrix of lower mineral density...
  2. doi request reprint Hip and spine strength effects of adding versus switching to teriparatide in postmenopausal women with osteoporosis treated with prior alendronate or raloxifene
    Felicia Cosman
    Helen Hayes Hospital, West Haverstraw, NY, USA
    J Bone Miner Res 28:1328-36. 2013
    ..Increases in hip strength were more variable. In RLX-treated women, strength increased more quickly in the Add group; in ALN-treated women, a significant increase in strength compared with baseline was seen only in the Add group...
  3. doi request reprint Determinants of stress fracture risk in United States Military Academy cadets
    Felicia Cosman
    Helen Hayes Hospital, West Haverstraw, NY 10993, USA
    Bone 55:359-66. 2013
    ..Prior studies have identified some risk factors for stress fracture in athletes and military recruits...
  4. doi request reprint Changes in vitamin D metabolites during teriparatide treatment
    Felicia Cosman
    Clinical Research Center, Helen Hayes Hospital, West Haverstraw, NY 10993, USA
    Bone 50:1368-71. 2012
    ..001) in the teriparatide group versus an increase of 1% (P=0.20) in the placebo group (P=0.003). Therefore, treatment with teriparatide increases 1,25(OH)(2)D concentrations and decreases 25(OH)D concentrations...
  5. pmc The influence of lifestyle, menstrual function and oral contraceptive use on bone mass and size in female military cadets
    Jamie A Ruffing
    Clinical Research and Regional Bone Centers, Helen Hayes Hospital, West Haverstraw, NY, USA
    Nutr Metab (Lond) 4:17. 2007
    ..To determine the influence of menstrual irregularity, oral contraceptive use and other factors on bone mineral density (BMD) and bone size at different skeletal sites in 135 college-aged fit women...
  6. ncbi request reprint Short-term effects of estrogen, tamoxifen and raloxifene on hemostasis: a randomized-controlled study and review of the literature
    F Cosman
    Clinical Research Regional Bone Centers, Helen Hayes Hospital, West Haverstraw, NY 10993, USA
    Thromb Res 116:1-13. 2005
    ..The objectives of this investigation were to compare the effects of these three treatments on hemostasis in a head to head randomized placebo-controlled trial...
  7. doi request reprint Parathyroid hormone treatment for osteoporosis
    Felicia Cosman
    Columbia College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Curr Opin Endocrinol Diabetes Obes 15:495-501. 2008
    ..There are no other anabolic agents on the horizon at the current time but clearly there are a large number of questions that remain about this powerful agent for osteoporosis...
  8. ncbi request reprint Therapeutic potential of parathyroid hormone
    Felicia Cosman
    Regional Bone Center, Helen Hayes Hospital, Route 9W, West Haverstraw, New York, NY 10993, USA
    Curr Osteoporos Rep 2:5-11. 2004
    ....
  9. ncbi request reprint Daily and cyclic parathyroid hormone in women receiving alendronate
    Felicia Cosman
    Clinical Research Center, Helen Hayes Hospital, West Haverstraw, NY 10993, USA
    N Engl J Med 353:566-75. 2005
    ....
  10. ncbi request reprint Anabolic therapy for osteoporosis: parathyroid hormone
    Felicia Cosman
    Regional Bone Center, Helen Hayes Hospital, Route 9W, West Haverstraw, New York, NY 10993, USA
    Curr Osteoporos Rep 3:143-9. 2005
    ....
  11. ncbi request reprint Effect of prior and ongoing raloxifene therapy on response to PTH and maintenance of BMD after PTH therapy
    F Cosman
    Clinical Research Center, Helen Hayes Hospital, West Haverstraw, NY 10993, USA
    Osteoporos Int 19:529-35. 2008
    ..6%, hip BMD increased 1.2-3.6% and radius BMD declined 4.3%. During the follow-up year, on continued raloxifene, BMD declined slightly at all sites except the femoral neck...
  12. ncbi request reprint Clinical evaluation of novel bisphosphonate dosing regimens in osteoporosis: the role of comparative studies and implications for future studies
    Felicia Cosman
    Helen Hayes Hospital, West Haverstraw, New York 10993, USA
    Clin Ther 29:1116-27. 2007
    ..Although a number of trial designs can be used to consider the efficacy of therapy, comparing the efficacy of different regimens should only be undertaken in purposefully designed head-to-head studies...
  13. ncbi request reprint Selective estrogen-receptor modulators
    Felicia Cosman
    Helen Hayes Hospital, Route 9W, West Haverstraw, NY 10993, USA
    Clin Geriatr Med 19:371-9. 2003
    ..Raloxifene might not be the treatment of choice for elderly women who are at particularly high risk of hip fracture...
  14. doi request reprint Treatment of osteoporosis and prevention of new fractures: role of intravenously administered bisphosphonates
    Felicia Cosman
    Columbia University, and Regional Bone Center, Helen Hayes Hospital, West Haverstraw, New York 10993, USA
    Endocr Pract 15:483-93. 2009
    ..To evaluate the usefulness of intravenously administered bisphosphonates for improving absorption, tolerability, adherence, and outcomes in the treatment and prevention of osteoporosis...
  15. doi request reprint Effects of teriparatide in postmenopausal women with osteoporosis on prior alendronate or raloxifene: differences between stopping and continuing the antiresorptive agent
    Felicia Cosman
    Helen Hayes Hospital, West Haverstraw, New York 10993, USA
    J Clin Endocrinol Metab 94:3772-80. 2009
    ..The aim of the study was to assess adding vs. switching to teriparatide 20 microg/d in patients on alendronate or raloxifene...
  16. doi request reprint Effects of intravenous zoledronic acid plus subcutaneous teriparatide [rhPTH(1-34)] in postmenopausal osteoporosis
    Felicia Cosman
    Clinical Research Center, Helen Hayes Hospital, West Haverstraw, NY 10993, USA
    J Bone Miner Res 26:503-11. 2011
    ....
  17. pmc Retreatment with teriparatide one year after the first teriparatide course in patients on continued long-term alendronate
    Felicia Cosman
    Clinical Research Center, Helen Hayes Hospital, West Haverstraw, New York 10993, USA
    J Bone Miner Res 24:1110-5. 2009
    ..Retreatment with teriparatide may be a viable option for some patients with severe osteoporosis who have received prior teriparatide therapy...
  18. ncbi request reprint Parathyroid hormone added to established hormone therapy: effects on vertebral fracture and maintenance of bone mass after parathyroid hormone withdrawal
    F Cosman
    Clinical Research Center, Helen Hayes Hospital, New York State Department of Health, West Haverstraw 10993, USA
    J Bone Miner Res 16:925-31. 2001
    ..Furthermore, PTH in combination with hormone therapy is an effective means of increasing bone mass throughout the skeleton and specifically reducing vertebral fracture occurrence by 75-100%, compared with HRT alone...
  19. ncbi request reprint Parathyroid hormone as a therapy for idiopathic osteoporosis in men: effects on bone mineral density and bone markers
    E S Kurland
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Clin Endocrinol Metab 85:3069-76. 2000
    ....
  20. ncbi request reprint Effects of daily treatment with parathyroid hormone on bone microarchitecture and turnover in patients with osteoporosis: a paired biopsy study
    D W Dempster
    Regional Bone Center, Helen Hayes Hospital. New York State Department of Health, West Haverstraw 10993, USA
    J Bone Miner Res 16:1846-53. 2001
    ..The results provide a structural basis for the recent demonstration that PTH treatment reduces the incidence of osteoporosis-related fractures...
  21. ncbi request reprint Calcium potentiates the effect of estrogen and calcitonin on bone mass: review and analysis
    J W Nieves
    Clinical Research Center, Helen Hayes Hospital, West Haverstraw, NY 10993, USA
    Am J Clin Nutr 67:18-24. 1998
    ..2%/y with calcitonin alone. These results suggest that a high calcium intake potentiates the positive effect of estrogen on bone mass at all skeletal sites and perhaps that of calcitonin on bone mass of the spine...
  22. doi request reprint Skeletal effects of vitamin D supplementation in postmenopausal black women
    J W Nieves
    Clinical Research and Regional Bone Centres, Helen Hayes Hospital, Route 9W, West Haverstraw, NY 10993, USA
    Calcif Tissue Int 91:316-24. 2012
    ..Vitamin D supplementation does not appear to influence bone loss in black women. However, in the FF polymorphism of the VDR gene group, vitamin D supplementation may retard the higher rate of bone loss...
  23. doi request reprint Atypical subtrochanteric and femoral shaft fractures and possible association with bisphosphonates
    Jeri W Nieves
    Clinical Research Center, Helen Hayes Hospital, Route 9W, West Haverstraw, NY 10993, USA
    Curr Osteoporos Rep 8:34-9. 2010
    ..There is no rationale to withhold bisphosphonate therapy from patients with osteoporosis, although continued use of bisphosphonate therapy beyond a treatment period of 3 to 5 years should be re-evaluated annually...
  24. ncbi request reprint The effects of combination of alendronate and human parathyroid hormone(1-34) on bone strength are synergistic in the lumbar vertebra and additive in the femur of C57BL/6J mice
    Sara Johnston
    Helen Hayes Hospital, Regional Bone Center, 51 North Route 9W, West Haverstraw, New York 10993, USA
    Endocrinology 148:4466-74. 2007
    ....
  25. ncbi request reprint Effects of a one-month treatment with PTH(1-34) on bone formation on cancellous, endocortical, and periosteal surfaces of the human ilium
    Robert Lindsay
    Clinical Research Center, Helen Hayes Hospital, West Haverstraw, NY 10993, USA
    J Bone Miner Res 22:495-502. 2007
    ..Enhanced bone formation was associated with an increase in osteoblast apoptosis...
  26. ncbi request reprint The importance of bisphosphonate therapy in maintaining bone mass in men after therapy with teriparatide [human parathyroid hormone(1-34)]
    Etah S Kurland
    Department of Medicine, Columbia University College of Physicians and Surgeons, 630 West 168th Street, PH 8 West 864, New York, NY 10032, USA
    Osteoporos Int 15:992-7. 2004
    ..The immediate use of bisphosphonates after teriparatide withdrawal may help to optimize gains in bone density at the lumbar spine...
  27. ncbi request reprint Effects of cyclic vs. daily treatment with human parathyroid hormone (1-34) on murine bone structure and cellular activity
    Akiko Iida-Klein
    Helen Hayes Hospital, Regional Bone Center, West Haverstraw, NY 10993, USA
    Bone 40:391-8. 2007
    ..A cyclic PTH regimen was as effective as a daily regimen in improving cancellous and cortical bone microarchitecture and cellular activity in the murine vertebra...
  28. ncbi request reprint A novel tetracycline labeling schedule for longitudinal evaluation of the short-term effects of anabolic therapy with a single iliac crest bone biopsy: early actions of teriparatide
    Robert Lindsay
    Clinical Research Center, New York State Department of Health, Helen Hayes Hospital, West Haverstraw, New York 10993, USA
    J Bone Miner Res 21:366-73. 2006
    ..We show that 1 month of hPTH(1-34) treatment extends the bone-forming surface, increases mineral apposition rate, and initiates modeling-based formation...
  29. ncbi request reprint Effects of cyclic versus daily hPTH(1-34) regimens on bone strength in association with BMD, biochemical markers, and bone structure in mice
    Akiko Iida-Klein
    Regional Bone Center, Helen Hayes Hospital, West Haverstraw, New York 10993, USA
    J Bone Miner Res 21:274-82. 2006
    ..The study supports further exploration of cyclic PTH regimens for the treatment of osteoporosis...
  30. ncbi request reprint Normal human osteoclasts formed from peripheral blood monocytes express PTH type 1 receptors and are stimulated by PTH in the absence of osteoblasts
    David W Dempster
    Regional Bone Center, Helen Hayes Hospital, New York State Department of Health, West Haverstraw, New York 10993, USA
    J Cell Biochem 95:139-48. 2005
    ..This suggests a dual regulatory mechanism, whereby PTH acts both directly on osteoclasts and also, indirectly, via osteoblasts...
  31. doi request reprint Fragility fractures of the hip and femur: incidence and patient characteristics
    J W Nieves
    Department of Epidemiology, Columbia University, New York, NY, USA
    Osteoporos Int 21:399-408. 2010
    ..The annual hip fracture incidence declined from 600/100,000 to 400/100,000, without decline in the more rare femur fractures. Incidence rates for subtrochanteric and femoral shaft fractures were each below 20 per 100,000...
  32. ncbi request reprint Bone structure in postmenopausal hyperparathyroid, osteoporotic, and normal women
    M Parisien
    Regional Bone Center, Helen Hayes Hospital, New York State Department of Health, West Haverstraw, USA
    J Bone Miner Res 10:1393-9. 1995
    ..These findings suggest that mild PHPT protects against the loss of cancellous bone structure that normally follows menopause...
  33. ncbi request reprint The anabolic effects of parathyroid hormone
    M R Rubin
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Osteoporos Int 13:267-77. 2002
  34. ncbi request reprint Vitamin D economy in blacks
    Felicia Cosman
    Regional Bone Center and Clinical Research Centers, Helen Hayes Hospital, West Haverstraw, New York, USA
    J Bone Miner Res 22:V34-8. 2007
    ..Benefits of vitamin D supplements in blacks may still play a role, however, in the prevention of other chronic diseases...
  35. pmc Effect of transdermal teriparatide administration on bone mineral density in postmenopausal women
    Felicia Cosman
    Regional Bone Center, Helen Hayes Hospital, West Haverstraw, New York, New York 10993, USA
    J Clin Endocrinol Metab 95:151-8. 2010
    ..A novel transdermal patch, providing a rapid, pulse delivery of TPTD, may provide a desirable alternative...
  36. ncbi request reprint Males have larger skeletal size and bone mass than females, despite comparable body size
    Jeri W Nieves
    Clinical Research and Regional Bone Centers, Helen Hayes Hospital, West Haverstraw, New York 10993, USA
    J Bone Miner Res 20:529-35. 2005
    ..Despite comparable body size, males have greater BMC and BMD at the hip and distal tibia and greater tibial cortical thickness. This may confer greater skeletal integrity in males...
  37. ncbi request reprint The prevention and treatment of osteoporosis: a review
    Felicia Cosman
    Columbia University College of Physicians and Surgeons, New York, NY, USA
    MedGenMed 7:73. 2005
    ..In those with a bone mineral density above the osteoporosis range, treatment may be indicated depending on the number and severity of other risk factors...
  38. ncbi request reprint Osteoporosis options. Choose medication based on age, health, and family history
    Felicia Cosman
    Health News 9:3. 2003
  39. ncbi request reprint Short-term urogenital effects of raloxifene, tamoxifen, and estrogen
    Michael D Vardy
    Department of Obstetrics and Gynecology and Women s Health, Albert Einstein College of Medicine, USA
    Am J Obstet Gynecol 189:81-8. 2003
    ..The purpose of this study was to assess the urogenital effects of raloxifene, tamoxifen, conjugated equine estrogen, and placebo in healthy postmenopausal women...
  40. ncbi request reprint A claims database analysis of persistence with alendronate therapy and fracture risk in post-menopausal women with osteoporosis
    Deborah T Gold
    Duke University Medical Center, Durham, NC 27710, USA
    Curr Med Res Opin 23:585-94. 2007
    ..To explore the relationship between persistence with alendronate therapy and fracture rates in women with postmenopausal osteoporosis...
  41. ncbi request reprint Once-yearly zoledronic acid for treatment of postmenopausal osteoporosis
    Dennis M Black
    University of California, San Francisco, San Francisco, CA 94107, USA
    N Engl J Med 356:1809-22. 2007
    ..We assessed the effects of annual infusions of zoledronic acid on fracture risk during a 3-year period...
  42. ncbi request reprint The effects of hormone replacement on the biomechanical properties of the uterosacral and round ligaments in the monkey model
    Michael D Vardy
    Columbia College of Physicians and Surgeons, New York, NY, USA
    Am J Obstet Gynecol 192:1741-51. 2005
    ....
  43. ncbi request reprint Health professional's guide to rehabilitation of the patient with osteoporosis
    Francis J Bonner
    Medical Director, Rehabilitation Hospital of South Jersey, Vineland, NJ, USA
    Osteoporos Int 14:S1-22. 2003

Research Grants1

  1. Early effects of PTH on the proximal femur
    Felicia Cosman; Fiscal Year: 2010
    ..We will evaluate hip bone samples from patients treated with teriparatide before undergoing hip replacement. The information will help us understand how teriparatide might help reduce hip fracture risk. ..