Research Topics
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Publications
Olfaction in neurodegenerative disorderChristopher Hawkes
Essex Centre for Neuroscience, Oldchurch Hospital, Romford, UK
Adv Otorhinolaryngol 63:133-51. 2006....
Parkinson's disease and aging: same or different process?Christopher H Hawkes
Essex Neuroscience Centre, Queen s Hospital, Romford, Essex RM7 0AG
Mov Disord 23:47-53. 2008..On the basis of olfactory measurement, our data are consistent with the proposal that PD starts as an acute event, followed by further disease progression more rapid than simple aging...
Twin studies and the heritability of MS: a conclusionC H Hawkes
Queen Mary University London, Neuroscience Centre, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, London, UK
Mult Scler 15:661-7. 2009..We wish to review all the more informative twin studies on multiple sclerosis (MS)...
MRI and visual-evoked potentials in partners of multiple sclerosis patientsC H Hawkes
Essex Neuroscience Centre, Queens Hospital, Romford, UK
Acta Neurol Scand 125:424-30. 2012..Some epidemiological evidence, particularly concerning the role of Epstein Barr Virus implies that multiple sclerosis (MS) may be transmissible and if correct, this might be revealed by increased prevalence of MS in cohabiting partners...
Smoking is a risk factor for multiple sclerosis: a metanalysisC H Hawkes
Essex Neuroscience Centre, Romford, Essex RM7 0BE, UK
Mult Scler 13:610-5. 2007..A variety of direct causative mechanisms are discussed, but an indirect association through health adverse conduct is favoured...
Parkinson's disease: a dual-hit hypothesisC H Hawkes
Essex Neuroscience Centre, Queen s Hospital, Romford, Essex UK
Neuropathol Appl Neurobiol 33:599-614. 2007..It is concluded that the most parsimonious explanation for the initial events of sporadic Parkinson's disease is pathogenic access to the brain through the stomach and nose - hence the term 'dual-hit'...
The prodromal phase of sporadic Parkinson's disease: does it exist and if so how long is it?Christopher H Hawkes
Neuroscience Centre, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, London, United Kingdom
Mov Disord 23:1799-807. 2008..It is concluded that there probably is an early phase in the disease where a variety of nonmotor features develop, but the sequence and time of onset of such features is not well established...
Parkinson's disease: the dual hit theory revisitedChristopher H Hawkes
Neuroscience Centre, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, London, United Kingdom
Ann N Y Acad Sci 1170:615-22. 2009..It is concluded that the most parsimonious explanation for the initial events of sPD is pathogenic access to the brain through the foregut and nose-hence the term "dual hit."..
A timeline for Parkinson's diseaseChristopher H Hawkes
Neuroscience Centre, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, 4 Newark Street, London E1 2AT, UK
Parkinsonism Relat Disord 16:79-84. 2010..Appreciation of this concept may allow better strategies for slowing or halting disease progression...
The McDonald Criteria for Multiple Sclerosis: time for clarificationChristopher H Hawkes
Queen Mary University of London, Neuroscience and Trauma Centre, Blizard Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, London, UK
Mult Scler 16:566-75. 2010..There was uncertainty about how many multiple sclerosis categories were permitted and whether the terms 'possible' and 'probable' were allowable. Further clarification might allow the criteria to be applied more consistently...
Multiple sclerosis in Latter Day Saints (Mormons)C H Hawkes
Essex Neuroscience Centre, Oldchurch Hospital, Essex, UK
Acta Neurol Scand 115:260-4. 2007..We wished to determine whether multiple sclerosis (MS) was less frequent in this religious body...
Seroprevalence of herpes simplex virus type 2 in multiple sclerosisC H Hawkes
Essex Neuroscience Centre, Oldchurch Hospital, Essex, UK
Acta Neurol Scand 114:363-7. 2006..There is evidence that seropositivity to herpes simplex virus type 2 (HSV-2) correlates well with the number of sexual partners. Accordingly, a raised overall HSV-2 seroprevalence in MS would lend support to this theory...
Olfactory evoked responses and identification tests in neurological diseaseC H Hawkes
Essex Neurosciences Centre, Oldchurch Hospital, Romford, UK
Ann N Y Acad Sci 855:608-15. 1998..To assess the value of smell testing we used olfactory evoked potentials (OEP) and an identification test in multiple sclerosis, Parkinson's disease, motor neuron disease and Alzheimer's disease...
Is Parkinson's disease a primary olfactory disorder?C H Hawkes
Essex Neurosciences Centre, Oldchurch Hospital, Romford, UK
QJM 92:473-80. 1999..It is proposed that the initial causative event in IPD may start in the rhinencephalon (olfactory brain) prior to damage in the basal ganglia...
Is multiple sclerosis a sexually transmitted infection?C H Hawkes
Institute of Neurology, Queen Square, London WC1, UK
J Neurol Neurosurg Psychiatry 73:439-43. 2002..It is hoped this hypothesis might encourage a new direction of neurological research...
Olfactory disorder in motor neuron diseaseC H Hawkes
Department of Clinical Neurology, Ipswich Hospital, Ipswich, IP4 5PD, United Kingdom
Exp Neurol 150:248-53. 1998..Overall we found the degree of olfactory dysfunction in MND to be mild and in contrast with the marked changes described by others...
Olfaction in neurodegenerative disorderChristopher Hawkes
Essex Centre for Neuroscience, Oldchurch Hospital, Romford, Essex, United Kingdom
Mov Disord 18:364-72. 2003..smell testing in HC and MND where abnormality may be found, is not likely to be of clinical value; and 8). biopsy of olfactory nasal neurons shows non-specific changes in PD and AD and at present will not aid diagnosis...
Olfactory testing in parkinsonismChristopher Hawkes
Essex Neuroscience Centre, Oldchurch Hospital, Romford RM7 0BE, UK
Lancet Neurol 3:393-4. 2004
Are multiple sclerosis patients risk-takers?C H Hawkes
Essex Neuroscience Centre, Oldchurch Hospital, Romford, UK
QJM 98:895-911. 2005..There may be a pattern of risk-associated behaviour that characterizes patients with MS and brings them into contact with one or more causative agents. Of the possible agents, viral infection seems the most likely...
Smart handles and red flags in neurological diagnosisChristopher Hawkes
Essex Centre for Neurology and Neurosurgery, Oldchurch Hospital, Romford, Essex RM7 0BE
Hosp Med 63:732-42. 2002..Knowledge of diagnostic short cuts (smart handles) and caveats (red flags) can speed up this process but care is needed as many tips given here have not been validated scientifically...
