Research Topics
Species | Peter HauserSummaryCountry: USA Publications
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Publications
Neuropsychiatric side effects of HCV therapy and their treatment: focus on IFN alpha-induced depressionPeter Hauser
Oregon Health Science University, and Behavioral Health and Clincial Neurosciences Division, Portland VA Medical Center, 97239, USA
Gastroenterol Clin North Am 33:S35-50. 2004....
Antiviral completion rates and sustained viral response in hepatitis C patients with and without preexisting major depressive disorderPeter Hauser
Northwest Hepatitis C Resource Center, Portland VA Medical Center, Portland, OR 97202, USA
Psychosomatics 50:500-5. 2009..Despite evidence suggesting that the majority of patients with hepatitis C virus (HCV) have psychiatric and substance use disorders, patients with these comorbidities have historically been excluded from antiviral therapy for HCV...- The influence of antiviral therapy on psychiatric symptoms among patients with hepatitis C and schizophreniaMarilyn Huckans
Northwest Hepatitis C Resource Center, Portland VA Medical Center, Portland, OR, USA
Antivir Ther 15:111-9. 2010..The aim of this study was to determine whether antiviral therapy is associated with higher rates of psychiatric symptoms in patients with schizophrenia (SCHZ)... - Interferon alpha therapy for hepatitis C: treatment completion and response rates among patients with substance use disordersMarilyn S Huckans
Northwest Hepatitis C Resource Center, Portland VA Medical Center, Portland, USA
Subst Abuse Treat Prev Policy 2:4. 2007.... - Prophylactic antidepressant treatment in patients with hepatitis C on antiviral therapy: a double-blind, placebo-controlled trialBenjamin J Morasco
Behavioral Health and Clinical Neurosciences Division, Portland VA Medical Center, Portland, OR 97239, USA
Psychosomatics 51:401-8. 2010..Approximately one-third of patients undergoing interferon-α (IFN-α) therapy for treatment of the hepatitis C virus (HCV) develop major depression, which decreases functioning and may lead to the reduction or discontinuation of treatment... - Predictors of pain intensity and pain functioning in patients with the hepatitis C virusBenjamin J Morasco
Northwest Hepatitis C Resource Center and Mental Health and Clinical Neurosciences Division, Portland VA Medical Center, Portland, OR 97239, USA
Gen Hosp Psychiatry 32:413-8. 2010..To examine the relationships among biological and psychological variables with pain intensity and pain functioning in patients with the hepatitis C virus (HCV)... 
Screening for depression in patients with hepatitis C using the Beck Depression Inventory-II: do somatic symptoms compromise validity?Alexander L Patterson
Mental Health and Clinical Neurosciences Division, Portland VA Medical Center, Portland, OR, USA
Gen Hosp Psychiatry 33:354-62. 2011..The objective of the study was to evaluate the validity of the Beck Depression Inventory-II (BDI-II) when used to measure depression in patients with hepatitis C virus (HCV)...- Hepatitis C testing and infection rates in bipolar patients with and without comorbid substance use disordersAnnette M Matthews
Northwest Hepatitis C Resource Center, and Behaviorual Health and Clinical Neurosciences Division, Portland VA Medical Center, Portland, OR 97202, USA
Bipolar Disord 10:266-70. 2008..Our hypothesis was that HCV antibody testing rates and HCV prevalence would be higher in the BD, SUD, and DD groups than the control group... - The cognitive effects of hepatitis C in the presence and absence of a history of substance use disorderMarilyn Huckans
Northwest Hepatitis C Resource Center, Portland VA Medical Center, Portland, Oregon 97239, USA
J Int Neuropsychol Soc 15:69-82. 2009..Results indicate that chronic HCV is associated with cognitive impairment in the absence of a history of SUD. The most robust deficits appear to be in verbal learning and reasoning/mental flexibility. (JINS, 2009, 15, 69-82.)... - Relapse to opioid use after treatment of chronic hepatitis C with pegylated interferon and ribavirinAnnette M Matthews
Portland VA Medical Center, 3710 S.W. U.S. Veteran Hospital Rd, P.O. Box 1035 (V3MHC, Portland, OR 97202, USA
Am J Psychiatry 163:1342-7; quiz 1479. 2006 - Vulnerability to somatic symptoms of depression during interferon-alpha therapy for hepatitis C: a 16-week prospective studyJennifer M Loftis
Research and Development Service, Portland VA Medical Center, Portland, OR, USA
J Psychosom Res 74:57-63. 2013..e., cognitive-affective and somatic) in Veterans with hepatitis C viral infection (HCV) before and during interferon-alpha (IFN) based antiviral therapy... - Psychiatric management of the hepatitis C patientMuhamad Aly Rifai
Northwest Hepatitis C Resource Center, Portland VA Medical Center, Behavioral Health and Clinical Neurosciences Division, PO Box 1034 P3MHADM, Portland, OR 97239, USA
Curr Treat Options Gastroenterol 9:508-19. 2006..In this review, we discuss the process of pretreatment assessment of patients with HCV and psychiatric illness and specifically address IFN- and RBV-induced depression in patients receiving HCV treatment... - Pain, substance use disorders and opioid analgesic prescription patterns in veterans with hepatitis CAshlee J Whitehead
Northwest Hepatitis C Resource Center, Portland, OR, USA
J Pain Symptom Manage 36:39-45. 2008..13.4 days, P<0.001). These data demonstrate that pain and SUD diagnoses were common among HCV+ patients, and that opioids were frequently prescribed. Co-occurring SUD was not associated with indicators of prescription opioid misuse... - Antiviral therapy completion and response rates among hepatitis C patients with and without schizophreniaMarilyn Huckans
Department of Psychiatry, Oregon Health and Science University, Portland, Oregon, USA
Schizophr Bull 36:165-72. 2010..Despite disproportionately high rates of hepatitis C (HCV) among patients with severe mental illness, to date, there is scant empirical data available regarding antiviral therapy outcomes within this population... - Psychiatric and substance use disorders comorbidities in veterans with hepatitis C virus and HIV coinfectionBret E Fuller
Mental Health Division, Portland Veterans Affairs Medical Center, Portland, Oregon 97210, USA
Curr Opin Psychiatry 22:401-8. 2009..This review covers timely research relative to comorbid conditions that are common in this population including psychiatric diagnoses, substance use disorders and neurocognitive problems... - Management of hepatitis C disease among VA patients with schizophrenia and substance use disordersMarilyn S Huckans
Northwest Hepatitis C Resource Center, Portland Veterans Affairs Medical Center, and Department of Psychiatry at Oregon Health and Science University 97239, USA
Psychiatr Serv 57:403-6. 2006.... - Treatment outcomes in depression: comparison of remote treatment through telepsychiatry to in-person treatmentPaul E Ruskin
VA Capitol Network Mental Illness Research Education and Clinical Center, Baltimore, MD, USA
Am J Psychiatry 161:1471-6. 2004.... - Administration of pegylated interferon-alpha-2a or -2b does not induce sickness behavior in Lewis ratsJennifer M Loftis
Behavioral Health and Clinical Neurosciences Division, Portland VA Medical Center, 3710 SW US Veteran s Hospital Road, Portland, OR 97239, USA
Psychoneuroendocrinology 31:1289-94. 2006..Collectively, our data suggest that Lewis rats are likely not a useful model to study IFN-induced depression... - Depressive symptoms in patients with chronic hepatitis C are correlated with elevated plasma levels of interleukin-1beta and tumor necrosis factor-alphaJennifer M Loftis
Behavioral Health and Clinical Neurosciences Division, Portland VA Medical Center, Department of Psychiatry, Oregon Health and Science University, Portland, OR 97239, USA
Neurosci Lett 430:264-8. 2008..Future studies should investigate how inflammatory mediators play a role in the expression of specific depressive symptoms in patients with chronic infection. Patients with HCV represent an interesting model to examine this relationship... - The phenomenology and treatment of interferon-induced depressionJennifer M Loftis
Behavioral Health and Clinical Neurosciences Division, Portland VA Medical Center, Portland, OR, USA
J Affect Disord 82:175-90. 2004..Screening and monitoring, ideally using symptom rating scales for depression, and early antidepressant treatment intervention appear necessary to optimize IFN therapy for the majority of patients... - Association of interferon-alpha-induced depression and improved treatment response in patients with hepatitis CJennifer M Loftis
Portland VA Medical Center, Behavioral Health and Clinical Neurosciences Division, OR, USA
Neurosci Lett 365:87-91. 2004..In conclusion, our findings suggest that IFN-alpha-induced MDD may be a predictor of a positive response to IFN-alpha therapy, or an indication of optimal dosing... - Integrated hepatitis C virus treatment: addressing comorbid substance use disorders and HIV infectionMarilyn S Huckans
Northwest Hepatitis C Resource Center, Portland VA Medical Center, Portland, OR 97239, USA
AIDS 19:S106-15. 2005..Increased infection rates among patients with SUD also warrant integration of HCV and HIV screening and testing into mental health and addiction programmes... - Psychiatric and substance use disorders in individuals with hepatitis C: epidemiology and managementJennifer M Loftis
Department of Psychiatry, Oregon Health and Science University, Portland, Oregon, USA
Drugs 66:155-74. 2006.... - Addressing tri-morbidity (hepatitis C, psychiatric disorders, and substance use): the importance of routine mental health screening as a component of a comanagement model of careMarian Fireman
Northwest Hepatitis C Resource Center and Behavioral Health and Neurosciences Division, Portland, OR 97239, USA
Clin Infect Dis 40:S286-91. 2005..Comanagement treatment models involving mental health care may expand the pool of patients eligible to receive treatment with IFN, as well as enhance treatment outcomes... - Appreciation of research information in patients with bipolar disorderSahana Misra
Portland Veterans Affairs Medical Center, Portland, OR, USA
Bipolar Disord 10:635-46. 2008..We compared the abilities of euthymic and manic bipolar patients to appreciate and make voluntary decisions regarding research participation... - Co-occurring Hepatitis C, substance use, and psychiatric illness: treatment issues and developing integrated models of careDiana L Sylvestre
Department of Medicine, University of California, San Francisco, California, USA
J Urban Health 81:719-34. 2004..This conference report summarizes current data, medical management issues, and strategies discussed... - Comments on the paper 'The effect of a herbal medicine (Mao-to) for the prevention of interferon-induced psychiatric complications in chronic hepatitis C: a pilot study'Jennifer M Loftis
Hum Psychopharmacol 20:211-2; author reply 213. 2005 - Safety of the treatment of interferon-alpha-induced depressionJennifer M Loftis
Psychosomatics 44:524-6. 2003 - Depression comorbidity and antidepressant use in veterans with chronic hepatitis C: results from a retrospective chart reviewJulie A Nelligan
Northwest Hepatitis C Resource Center, Behavioral Health and Clinical Neurosciences Division, Portland Department of Veterans Affairs VA Medical Center, Oregon Health and Science University, Portland, Oregon 97207, USA
J Clin Psychiatry 69:810-6. 2008..In this study we characterize the prevalence and severity of co-morbid depression, as well as antidepressant and other psychotropic prescribing patterns, in a sample of U.S. veterans with HCV... - A randomized trial of paroxetine to prevent interferon-alpha-induced depression in patients with hepatitis CBenjamin J Morasco
Behavioral Health and Clinical Neurosciences Division, Portland VA Medical Center, Oregon, United States
J Affect Disord 103:83-90. 2007..This study examined the efficacy of paroxetine in preventing the development of depression during antiviral therapy... - Hepatitis C treatment of veterans with psychiatric illnessMuhamad Aly Rifai
Am J Gastroenterol 101:673-4; author reply 674-5. 2006 - The association between viral clearance and depression in patients with hepatitis C receiving interferon-alpha and ribavirinJennifer M Loftis
Brain Behav Immun 19:271-2; author reply 273-4. 2005 - Lamotrigine-associated Stevens-Johnson syndrome after discontinuation of interferon, ribavirin, and filgrastim: a case reportAnnette M Matthews
J Clin Psychiatry 68:637-8. 2007 - Can rodents be used to model interferon-alpha-induced depressive symptoms?Jennifer M Loftis
Prog Neuropsychopharmacol Biol Psychiatry 30:1364-5; author reply 1366. 2006 - Interferon-alpha treatment of patients with Hepatitis C: the role of a comprehensive risk-benefit assessmentMuhamad Aly Rifai
CNS Drugs 19:719-21; author reply 721-2. 2005 - Strategies to decrease costs of prescribing selective serotonin reuptake inhibitors at a VA Medical CenterSteven K Dobscha
Portland Veterans Affairs Medical Center, Oregon 97207, USA
Psychiatr Serv 54:195-200. 2003..The authors examined the efficacy of a multifaceted intervention designed to contain the cost of prescribing selective serotonin reuptake inhibitors (SSRIs) to inpatients and outpatients served by a Veterans Affairs (VA) medical center... - Serotonin gene polymorphisms and bipolar I disorder: focus on the serotonin transporterHader A Mansour
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, U S A
Ann Med 37:590-602. 2005..Our analyses do not support association between SLC6A4 and BDI families. Further studies using sub-groups of BDI are worthwhile... - Influence of mood state on capacity to consent to research in patients with bipolar disorderSahana Misra
Portland Veterans Affairs Medical Center, OR 97239, USA
Bipolar Disord 10:303-9. 2008..We compared 25 euthymic bipolar and 26 manic bipolar patients in their understanding of three hypothetical studies of varying complexity... - Effectiveness of adjunctive antidepressant treatment for bipolar depressionGary S Sachs
Bipolar Clinic and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
N Engl J Med 356:1711-22. 2007..Our study was designed to determine whether adjunctive antidepressant therapy reduces symptoms of bipolar depression without increasing the risk of mania... - Relationship of white matter hyperintensities to cerebrospinal fluid glucose polyol pathway metabolites-a pilot study in treatment-resistant affective disorder patientsWilliam T Regenold
Division of Geriatric Psychiatry, Department of Psychiatry, University of Maryland School of Medicine, and Research Service, VA Maryland Healthcare System, Baltimore, MD 21201, USA
J Affect Disord 85:341-50. 2005..More extensive studies are necessary to determine whether this preliminary finding represents a pathogenetic relationship... - Treatment of cytokine-induced depressionLucile Capuron
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Drive, Suite 4000, Atlanta, GA 30322, USA
Brain Behav Immun 16:575-80. 2002.... - Whole-genome association study of bipolar disorderP Sklar
Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
Mol Psychiatry 13:558-69. 2008..Given the heritability of BP disorder, the lack of agreement between studies emphasizes that susceptibility alleles are likely to be modest in effect size and require even larger samples for detection...