Research Topics
| Kelly H ZouSummaryAffiliation: Harvard University Country: USA Publications
| Collaborators
|
Detail Information
Publications
Is intracranial atherosclerosis an independent risk factor for cerebral atrophy? A retrospective evaluationS Erbay
Department of Radiology, Tufts New England Medical Center, Boston, MA, USA
BMC Neurol 8:51. 2008..Our purpose was to study the association between the intracranial atherosclerosis as measured by cavernous carotid artery calcification (ICAC) observed on head CT and atrophic changes of supra-tentorial brain demonstrated by MRI...
Detection of prostate cancer by integration of line-scan diffusion, T2-mapping and T2-weighted magnetic resonance imaging; a multichannel statistical classifierIan Chan
Surgical Planning Laboratory, Department of Radiology, Division of MRI, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Med Phys 30:2390-8. 2003....
Validation of image segmentation by estimating rater bias and varianceSimon K Warfield
Computational Radiology Laboratory, Department of Radiology, Children s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
Philos Trans A Math Phys Eng Sci 366:2361-75. 2008....
Receiver-operating characteristic analysis for evaluating diagnostic tests and predictive modelsKelly H Zou
Children's Hospital Boston, Boston, MA, USA
Circulation 115:654-7. 2007
Whole-body MRI in suspected infant abuseJeannette M Perez-Rossello
Department of Radiology, Children s Hospital Boston and Harvard Medical School, 300 Longwood Ave, Boston, MA 02115, USA
AJR Am J Roentgenol 195:744-50. 2010..The purpose of our study was to examine the utility of whole-body MRI (WB-MRI) in the detection of skeletal and soft-tissue injuries in suspected infant abuse...
A global goodness-of-fit test for receiver operating characteristic curve analysis via the bootstrap methodKelly H Zou
Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, MIT, MA, USA
J Biomed Inform 38:395-403. 2005..The main objective was to develop a global statistical hypothesis test for assessing the goodness-of-fit (GOF) for parametric ROC curves via the bootstrap...
A Bayesian hierarchical non-linear regression model in receiver operating characteristic analysis of clustered continuous diagnostic dataKelly H Zou
Department of Health Care Policy, Harvard Medical School, 180 Longwood Avenue, Boston, MA 02115, USA
Biom J 47:417-27. 2005..A hierarchical regression analysis incorporating the effects of cluster (clinical center) and cancer risk (low, intermediate, and high) was performed, and the area under the ROC curve (AUC) was estimated...
Gender differences in research grant applications and funding outcomes for medical school facultySusan E Waisbren
Children s Hospital, Boston, Massachusetts, USA
J Womens Health (Larchmt) 17:207-14. 2008..To evaluate whether there were differences in acquisition of research grant support between male and female faculty at eight Harvard Medical School-affiliated institutions...
Assessment of multiple sclerosis lesions with spherical harmonics: comparison of MR imaging and pathologic findingsDaniel Goldberg-Zimring
Department of Biomedical Engineering, Technion, Israel Institute of Technology, Haifa, Israel
Radiology 235:1036-44. 2005..Mean DSC was significantly higher than 70% (P < .001). SH method provided unbiased lesion volume and added geometric information that may enable a better understanding of the pathogenesis and lesion evolution over time...
Statistical validation of brain tumor shape approximation via spherical harmonics for image-guided neurosurgeryDaniel Goldberg-Zimring
Department of Radiology, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
Acad Radiol 12:459-66. 2005..We performed a preliminary evaluation of the use of spherical harmonics (SH) in approximating the 3D shape and estimating the volume of brain tumors of varying characteristics...
Three-dimensional assessment of MR imaging-guided percutaneous cryotherapy using multi-performer repeated segmentations: the value of supervised learningKelly H Zou
Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Acad Radiol 12:444-50. 2005..We evaluated whether supervised learning methods would improve multiperformer repeated segmentations of magnetic resonance images (MRI) obtained before and after MRI-guided cryotherapy of renal cell carcinoma...
Capturing intraoperative deformations: research experience at Brigham and Women's HospitalSimon K Warfield
Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
Med Image Anal 9:145-62. 2005..This paper reviews the experience at Brigham and Women's Hospital through the process of developing and applying novel algorithms for capturing intraoperative deformations in support of image guided therapy...
The use of receiver operating characteristic curves in biomedical informaticsThomas A Lasko
Decision Systems Group, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
J Biomed Inform 38:404-15. 2005..In this article, we review the basic concepts of ROC analysis, illustrate their use with sample calculations, make recommendations drawn from the literature, and list readily available software...
Bayesian multivariate hierarchical transformation models for ROC analysisA James O'Malley
Department of Health Care Policy, Harvard Medical School, Boston, MA 02115, USA
Stat Med 25:459-79. 2006..The proposed methodology is illustrated on prostate cancer biopsy data from a multi-centre clinical trial...
Statistical combination schemes of repeated diagnostic test dataKelly H Zou
Department of Radiology L 2, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
Acad Radiol 13:566-72. 2006..When diagnostic tests are repeated and combined, a number of schemes may be adopted. Guidelines for their interpretations are required...
Combining classifiers using their receiver operating characteristics and maximum likelihood estimationSteven Haker
Surgical Planning Lab, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, 02115, USA
Med Image Comput Comput Assist Interv 8:506-14. 2005..We offer some insights into the use of ROC analysis in the field of medical imaging...
Rater-dependent accuracy in predicting the spatial location of functional centers on anatomical MR imagesHillary K Rolls
Harvard Medical School, Boston, MA, USA
Clin Neurol Neurosurg 109:225-35. 2007..This study examined the abilities of medical personnel of various backgrounds to predict the location of functional cortex using anatomical information provided by MR imaging...
Validation of image segmentation by estimating rater bias and varianceSimon K Warfield
Computational Radiology Laboratory, Dept Radiology, Children s Hospital 2 Dept Radiology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
Med Image Comput Comput Assist Interv 9:839-47. 2006....
Volumetric assessment of tumor infiltration of adjacent white matter based on anatomic MRI and diffusion tensor tractographyIon Florin Talos
Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
Acad Radiol 14:431-6. 2007..We hypothesized that white matter infiltration may be common among different types of tumor...
Role of endorectal coil magnetic resonance imaging in treatment of patients with prostate cancer and in determining radical prostatectomy surgical margin status: report of a single surgeon's practiceJian Qing Zhang
Department of Radiology, Brigham and Women s Hospital and Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
Urology 69:1134-7. 2007..To evaluate the role of the combination of endorectal coil and external multicoil array magnetic resonance imaging (MRI) in the management of prostate cancer and predicting the surgical margin status in a single-surgeon practice...
Axial oblique CT to assess femoral anteversionDelma Y Jarrett
Department of Radiology, Children s Hospital Boston, Harvard Medical School, 300 Longwood Ave, Boston, MA 02115, USA
AJR Am J Roentgenol 194:1230-3. 2010..Centers should consider replacing the standard straight axial technique with the axial oblique method for CT determination of femoral anteversion...
Reproducibility of functional MR imaging: preliminary results of prospective multi-institutional study performed by Biomedical Informatics Research NetworkKelly H Zou
Surgical Planning Laboratory, Dept of Radiology, Brigham and Women s Hosp, Harvard Medical School, Boston, MA 02115, USA
Radiology 237:781-9. 2005....
Functional MRI of auditory verbal working memory: long-term reproducibility analysisXingchang Wei
Center for Neurological Imaging, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
Neuroimage 21:1000-8. 2004..The quantitative estimation of the proportions of within-subject and between-subject variabilities in the overall variability may be helpful for the design of future studies...
Sample size considerations in observational health care quality studiesSharon Lise T Normand
Department of Health Care Policy, Harvard Medical School, Boston, MA 02115, USA
Stat Med 21:331-45. 2002..If researchers are interested in comparing clusters, hierarchical models are preferred...
Providing concept-oriented views for clinical data using a knowledge-based system: an evaluationQing Zeng
Decision System Group, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Am Med Inform Assoc 9:294-305. 2002..g., laboratory, radiology). This study evaluates the functionality and utility of a knowledge-based system that generates concept-oriented views (organized around clinical concepts such as disease or organ system) of clinical data...
Hypothesis testing I: proportionsKelly H Zou
Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Radiology 226:609-13. 2003..The statistical formulas used for these analyses are explained and demonstrated. These methods may enable systematic analysis of proportions and may be applied to many other radiologic investigations...
Correlation and simple linear regressionKelly H Zou
Department of Radiology, Brigham and Women s Hospital, Boston, MA 02115, USA
Radiology 227:617-22. 2003..These statistical methods are important for exploring the relationships between variables and can be applied to many radiologic studies...
Simultaneous truth and performance level estimation (STAPLE): an algorithm for the validation of image segmentationSimon K Warfield
Harvard Medical School and the Department of Radiology of Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
IEEE Trans Med Imaging 23:903-21. 2004..STAPLE is straightforward to apply to clinical imaging data, it readily enables assessment of the performance of an automated image segmentation algorithm, and enables direct comparison of human rater and algorithm performance...
What is evidence-based medicine?Kelly H Zou
Radiology Management Group, Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Acad Radiol 11:127-33. 2004..In this review article, we present the definition and useful concepts of evidence-based medicine (EBM). The principles of EBM are provided and major steps of practicing EBM are described...
Three validation metrics for automated probabilistic image segmentation of brain tumoursKelly H Zou
Department of Radiology, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115, U S A
Stat Med 23:1259-82. 2004..The performances of these validation metrics were also investigated via Monte Carlo simulation. Extensions of incorporating spatial correlation structures using a Markov random field model were considered...
Supratentorial low-grade glioma resectability: statistical predictive analysis based on anatomic MR features and tumor characteristicsIon-Florin Talos
Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
Radiology 239:506-13. 2006..01), and oligodendroglioma histopathologic type (P = .02). CONCLUSION: The main variables associated with incomplete tumor resection in 101 patients were identified by using statistical predictive analyses...
Three-dimensional magnetic resonance imaging technique for myocardial-delayed hyperenhancement: a comparison with the two-dimensional techniqueServet Tatli
Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
J Magn Reson Imaging 20:378-82. 2004..To compare two-dimensional and three-dimensional techniques in the detection of myocardial infarction (MI) and in the grading transmural extent (TE)...
Decreases in ventricular volume correlate with decreases in ventricular pressure in idiopathic normal pressure hydrocephalus patients who experienced clinical improvement after implantation with adjustable valve shuntsKathleen A McConnell
Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
Neurosurgery 55:582-92; discussion 592-3. 2004..This suggests that positive clinical responders retained parenchymal elasticity, emphasizing the importance of dynamic changes in this cohort...
Tumor detection by virtual cystoscopy with color mapping of bladder wall thicknessJulia R Fielding
Department of Radiology and Division of Urologic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
J Urol 167:559-62. 2002..The low specificity of color mapped 3-D renderings makes the technique inappropriate for screening. It may valuable for guiding urologists to additional suspicious sites in a patient with a known tumor...
Statistical validation of image segmentation quality based on a spatial overlap indexKelly H Zou
Department of Radiology and Surgical Planning Laboratory, Brigham and Women's Hospital, Harvard Medical School, 75 Francis St (Floor L-l, Boston, MA 02115, USA
Acad Radiol 11:178-89. 2004..We observed generally satisfactory but variable validation results in two clinical applications. This metric may be adapted for similar validation tasks...
Practice management performance indicators in academic radiology departmentsSilvia Ondategui-Parra
Radiology Management Group, Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
Radiology 233:716-22. 2004..To determine the management performance indicators most frequently utilized in academic radiology departments in the United States...
Quantitative MR imaging assessment of prostate gland deformation before and during MR imaging-guided brachytherapyMasanori Hirose
Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
Acad Radiol 9:906-12. 2002..5-T studies) and/or changes in patient position (supine vs lithotomy). These findings suggest that pretreatment images alone may not be reliable for accurate therapy planning. It may be useful to integrate pre-and intraoperative data...
Telomerase activity predicts malignancy in percutaneous image-guided needle biopsy specimens of the abdomen and pelvisVikas Kundra
Division of Abdominal Imaging and Intervention, Department of Radiology and Division of Cytology, Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
Radiology 234:941-7. 2005..To determine prospectively if assessment of telomerase activity in percutaneous needle biopsy specimens improves sensitivity and specificity in the diagnosis of abdominal and pelvic malignancy...
Renal cell carcinoma: t1 and t2 signal intensity characteristics of papillary and clear cell types correlated with pathologyM Raquel Oliva
Department of Radiology, Brigham and Women s Hospital, Boston, MA 02115, USA
AJR Am J Roentgenol 192:1524-30. 2009..The objective of our study was to describe the T1 and T2 signal intensity characteristics of papillary renal cell carcinoma (RCC) and clear cell RCC with pathologic correlation...
Multidetector CT of the paranasal sinus: potential for radiation dose reductionMatthias H Brem
Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Radiology 243:847-52. 2007..On the basis of the results, tube currents can be lowered and radiation dose reduced by 20%...
Routine pelvic and lower extremity CT venography in patients undergoing pulmonary CT angiographyAndetta R Hunsaker
Department of Radiology, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
AJR Am J Roentgenol 190:322-6. 2008..The purpose of our study was to assess the utility of performing routine pelvic and lower extremity CT venography (CTV) along with pulmonary CT angiography (CTA) in all patients evaluated for pulmonary embolism...
Quantitative analysis of MRI signal abnormalities of brain white matter with high reproducibility and accuracyXingchang Wei
Center for Neurological Imaging, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Magn Reson Imaging 15:203-9. 2002..49 mL in aging subjects). CONCLUSION: The addition of TDS to the EM segmentation and PVEC algorithms significantly improved the accuracy of WMSA volume measurements, while also improving measurement reproducibility...
Multi-detector row CT urography: comparison of strategies for depicting the normal urinary collecting systemJeffrey D McTavish
Department of Radiology, Division of Abdominal Imaging and Intervention, Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115, USA
Radiology 225:783-90. 2002..CONCLUSION: CT urography with a multi-detector row scanner and supplemental infusion of normal saline reliably displays the opacified urinary collecting system...
Detection of simulated inflicted metaphyseal fractures in a fetal pig model: image optimization and dose reduction with computed radiographyPatricia L Kleinman
Department of Radiology, Children s Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA
Radiology 247:381-90. 2008....
Electrocardiographically gated 16-section CT of the thorax: cardiac motion suppressionLars K Hofmann
Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
Radiology 233:927-33. 2004..Best image quality was achieved by referencing image reconstruction to middiastole (50%-60%) for the left coronary artery, aortic root, and ascending aorta. The pulmonary arteries are best displayed during mid- to late diastole (80%)...
Exploration of a bayesian updating methodology to monitor the safety of interventional cardiovascular proceduresFrederic S Resnic
Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women s Hospital, Tower 3B, 75 Francis Street, Boston, MA 02115, USA
Med Decis Making 24:399-407. 2004....
Evaluation of small (</= 3 cm) renal masses with MDCT: benefits of thin overlapping reconstructionsMasahiro Jinzaki
Department of Radiology, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
AJR Am J Roentgenol 183:223-8. 2004..Our purpose was to determine whether thin overlapping reconstructions using MDCT improve the detection and characterization of small renal masses...
Clinical validity of a negative computed tomography scan in patients with suspected pulmonary embolism: a systematic reviewRene Quiroz
Department of Radiology, Brigham and Women's Hospital, Boston, Mass, USA
JAMA 293:2012-7. 2005..01 (95% CI, 0.01-0.02) and the overall NPV was 99.4% (95% CI, 98.7%-99.9%). CONCLUSION: The clinical validity of using a CT scan to rule out pulmonary embolism is similar to that reported for conventional pulmonary angiography...
Use of productivity and financial indicators for monitoring performance in academic radiology departments: U.S. nationwide surveySilvia Ondategui-Parra
Radiology Management Group, Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, One Brigham Circle, 1620 Tremont St, Boston, MA 02115, USA
Radiology 236:214-9. 2005..To determine how productivity- and finance-related indicators are used by radiology departments to evaluate departmental performance...
Practice patterns of nonvascular interventional radiology procedures at academic centers in the United States?Paul Nikolaidis
Department of Radiology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Acad Radiol 12:1475-82. 2005..To determine and analyze the patterns of practice of nonvascular interventional procedures in academic centers in the United States...
Using the rate of positive high-risk HPV test results for ASC-US together with the ASC-US/SIL ratio in evaluating the performance of cytopathologistsEdmund S Cibas
Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
Am J Clin Pathol 129:97-101. 2008..Both indicators together provide useful feedback to cytopathologists. We provide a working schema for interpreting perturbations in these indicators to assist in improving the quality of gynecologic cytology interpretations...
Three-dimensional fast-recovery fast spin-echo MRCP: comparison with two-dimensional single-shot fast spin-echo techniquesAaron Sodickson
Department of Radiology, Division of Abdominal Imaging and Intervention, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
Radiology 238:549-59. 2006....
Does hands-on obstetric US experience improve performance on the radiology oral board examination?Mary C Frates
Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
Radiology 239:529-32. 2006..To investigate whether the inclusion of hands-on obstetric ultrasonography (US) experience as a formal part of radiology residency affects performance on the US section of the oral board examination...
Clinical operations management in radiologySilvia Ondategui-Parra
Radiology Management Group, Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120 1613, USA
J Am Coll Radiol 1:632-40. 2004..A reference framework for the radiology processes is described, distinguishing two phases in the initial assessment of a unit: the diagnostic phase and the redesign phase...
Comparison of accuracy and interreader agreement in side-by-side versus independent evaluations of MR imaging of the medial collateral ligament of the elbowKelly H Zou
Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
Acad Radiol 9:520-5. 2002..These findings have implications for the design of studies to optimize MR imaging protocols by using multiple pulse sequences and multiple readers...
Does the phase of menstrual cycle affect MR-guided focused ultrasound surgery of uterine leiomyomas?Minna J So
Department of Radiology, Brigham and Women s Hospital Harvard Medical School, Boston, MA, USA
Eur J Radiol 59:203-7. 2006..To determine whether the phase of menstrual cycle at the time of MR-guided focused ultrasound surgery (MRgFUS) treatment for uterine leiomyomas affects treatment outcome...
Statistical validation based on parametric receiver operating characteristic analysis of continuous classification dataKelly H Zou
Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, 180 Longwood Ave, Boston, MA 02115 USA
Acad Radiol 10:1359-68. 2003..The validation metric area under the receiver operating characteristic curves may be generalized to evaluating the performances of several continuous classifiers related to imaging...
Sophisticated diagnostic modalitiesKelly H Zou
Philos Transact A Math Phys Eng Sci 366:2251-2. 2008
Quantitative evaluation of automated skull-stripping methods applied to contemporary and legacy images: effects of diagnosis, bias correction, and slice locationChristine Fennema-Notestine
Laboratory of Cognitive Imaging, Department of Psychiatry, University of California, San Diego, and Veterans Affairs San Diego Healthcare System, San Diego, La Jolla, California 92093, USA
Hum Brain Mapp 27:99-113. 2006..The results of this study may direct users towards a method appropriate to their T1-weighted datasets and improve the efficiency of processing for large, multisite neuroimaging studies...
Sonographic features of benign thyroid nodules: interobserver reliability and overlap with malignancyJeffrey R Wienke
Department of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
J Ultrasound Med 22:1027-31. 2003..CONCLUSIONS: Sixty-nine percent of benign nodules had at least 1 finding reported previously as associated with malignancy. The interobserver reliability of the sonographic findings was good to very good for 3 of the 5 findings assessed...
A modified CT severity index for evaluating acute pancreatitis: improved correlation with patient outcomeKoenraad J Mortele
Department of Radiology, Division of Abdominal Imaging and Intervention, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115
AJR Am J Roentgenol 183:1261-5. 2004....
