LEONARD IRA ZON

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Zebrafish as a model for normal and malignant hematopoiesis
    Lili Jing
    Stem Cell Program and Division of Hematology Oncology, Children s Hospital Boston and Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Dis Model Mech 4:433-8. 2011
  2. pmc A new system for the rapid collection of large numbers of developmentally staged zebrafish embryos
    Isaac Adatto
    Stem Cell Program and Division of Hematology Oncology, Children s Hospital and Dana Farber Cancer Institute, Boston, Massachusetts, United States of America
    PLoS ONE 6:e21715. 2011
  3. pmc The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset
    Craig J Ceol
    Stem Cell Program and Hematology Oncology, Children s Hospital Boston, Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 471:513-7. 2011
  4. pmc The histone methyltransferase SUV39H1 suppresses embryonal rhabdomyosarcoma formation in zebrafish
    Colleen E Albacker
    Stem Cell Program and Division of Hematology Oncology, Boston Children s Hospital and Dana Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 8:e64969. 2013
  5. ncbi request reprint Translational research: the path for bringing discovery to patients
    Leonard Zon
    Stem Cell Program and Hematology Oncology, Children s Hospital and Dana Farber Cancer Institute, HHMI, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA Electronic address
    Cell Stem Cell 14:146-8. 2014
  6. doi request reprint Potential of zebrafish for anticancer drug screening
    Leonard I Zon
    Stem Cell Program and Hematology Oncology, Children s Hospital Howard Hughes Medical Institute Harvard Medical School, Boston, MA 02115, USA 1 617 919 2069 1 617 730 0222
    Expert Opin Drug Discov 3:1451-60. 2008
  7. pmc Hematopoietic stem cells, hematopoiesis and disease: lessons from the zebrafish model
    Corey S Martin
    Stem Cell Program and Division of Hematology Oncology, Children s Hospital Boston, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA
    Genome Med 3:83. 2011
  8. pmc Zebrafish orthologs of human muscular dystrophy genes
    Leta S Steffen
    Children s Hospital, Program in Genomics, Boston, MA, USA
    BMC Genomics 8:79. 2007
  9. pmc Definition of the zebrafish genome using flow cytometry and cytogenetic mapping
    Jennifer L Freeman
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    BMC Genomics 8:195. 2007
  10. pmc The zebrafish moonshine gene encodes transcriptional intermediary factor 1gamma, an essential regulator of hematopoiesis
    David G Ransom
    Division of Hematology Oncology, Children s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    PLoS Biol 2:E237. 2004

Research Grants

  1. EMBRYONIC HEMATOPOIESIS
    LEONARD IRA ZON; Fiscal Year: 2010
  2. International Society for Stem Cell Research Meeting
    Leonard Zon; Fiscal Year: 2006
  3. Cancer Biology in the Zebrafish
    Leonard Zon; Fiscal Year: 2006
  4. Fetal Globin Silencing
    Leonard Zon; Fiscal Year: 2006
  5. A Comparative Approach to Globin Regulation/Thalassemia
    Leonard Zon; Fiscal Year: 2006
  6. Red Cell Gordon Conference
    Leonard Zon; Fiscal Year: 2005
  7. Cancer Biology in the Zebrafish
    Leonard Zon; Fiscal Year: 2005
  8. Fetal Globin Silencing
    Leonard Zon; Fiscal Year: 2005
  9. Cancer Biology in the Zebrafish
    Leonard Zon; Fiscal Year: 2004
  10. EMBRYONIC HEMATOPOIESIS
    Leonard Zon; Fiscal Year: 2004

Detail Information

Publications86

  1. pmc Zebrafish as a model for normal and malignant hematopoiesis
    Lili Jing
    Stem Cell Program and Division of Hematology Oncology, Children s Hospital Boston and Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Dis Model Mech 4:433-8. 2011
    ....
  2. pmc A new system for the rapid collection of large numbers of developmentally staged zebrafish embryos
    Isaac Adatto
    Stem Cell Program and Division of Hematology Oncology, Children s Hospital and Dana Farber Cancer Institute, Boston, Massachusetts, United States of America
    PLoS ONE 6:e21715. 2011
    ..This system overcomes major space and labor restrictions inherent in spawning equipment currently used in the field, and will greatly accelerate efforts to improve the scale and throughput of experiments...
  3. pmc The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset
    Craig J Ceol
    Stem Cell Program and Hematology Oncology, Children s Hospital Boston, Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 471:513-7. 2011
    ..Our studies establish SETDB1 as an oncogene in melanoma and underscore the role of chromatin factors in regulating tumorigenesis...
  4. pmc The histone methyltransferase SUV39H1 suppresses embryonal rhabdomyosarcoma formation in zebrafish
    Colleen E Albacker
    Stem Cell Program and Division of Hematology Oncology, Boston Children s Hospital and Dana Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 8:e64969. 2013
    ..Gene expression profiling at these stages revealed that in the context of KRAS(G12D) overexpression, SUV39H1 may suppress cell cycle progression. Our studies provide evidence for the role of SUV39H1 as a tumor suppressor...
  5. ncbi request reprint Translational research: the path for bringing discovery to patients
    Leonard Zon
    Stem Cell Program and Hematology Oncology, Children s Hospital and Dana Farber Cancer Institute, HHMI, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA Electronic address
    Cell Stem Cell 14:146-8. 2014
    ..Here, I highlight some key insights for navigating such challenges based on recent clinical trials initiated by basic research from my lab. ..
  6. doi request reprint Potential of zebrafish for anticancer drug screening
    Leonard I Zon
    Stem Cell Program and Hematology Oncology, Children s Hospital Howard Hughes Medical Institute Harvard Medical School, Boston, MA 02115, USA 1 617 919 2069 1 617 730 0222
    Expert Opin Drug Discov 3:1451-60. 2008
    ..Conclusion: Current developments in improving cancer models and automated imaging technology have the potential of finding novel compounds that disrupt tumor biology...
  7. pmc Hematopoietic stem cells, hematopoiesis and disease: lessons from the zebrafish model
    Corey S Martin
    Stem Cell Program and Division of Hematology Oncology, Children s Hospital Boston, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA
    Genome Med 3:83. 2011
    ..We also highlight the recent discovery of small molecules with clinical promise, such as dimethyl prostaglandin E2, 3F8, and thiazole-carboxamide 10A...
  8. pmc Zebrafish orthologs of human muscular dystrophy genes
    Leta S Steffen
    Children s Hospital, Program in Genomics, Boston, MA, USA
    BMC Genomics 8:79. 2007
    ..To aid in the identification of new causative genes, this study identifies and maps zebrafish orthologs for all known human muscular dystrophy genes...
  9. pmc Definition of the zebrafish genome using flow cytometry and cytogenetic mapping
    Jennifer L Freeman
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    BMC Genomics 8:195. 2007
    ..Cytogenetic approaches provide "anchors" that can be integrated with accumulating genomic data...
  10. pmc The zebrafish moonshine gene encodes transcriptional intermediary factor 1gamma, an essential regulator of hematopoiesis
    David G Ransom
    Division of Hematology Oncology, Children s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    PLoS Biol 2:E237. 2004
    ..Our results establish a major role for this transcriptional intermediary factor in the differentiation of hematopoietic cells in vertebrates...
  11. doi request reprint Intrinsic and extrinsic control of haematopoietic stem-cell self-renewal
    Leonard I Zon
    Stem Cell Program and Division of Hematology Oncology, Children s Hospital Boston, Karp 7, 1 Blackfan Circle, Boston, Massachusetts 02115, USA
    Nature 453:306-13. 2008
    ..Establishing the principles of self-renewal in haematopoietic stem cells will lead to insights into the mechanisms of self-renewal in other tissues...
  12. ncbi request reprint The zebrafish mutant gene chardonnay (cdy) encodes divalent metal transporter 1 (DMT1)
    Adriana Donovan
    Department of Hematology Oncology, and Howard Hughes Medical Institute, Children s Hospital, Boston, MA 02115, USA
    Blood 100:4655-9. 2002
    ..Our studies further demonstrate the conservation of iron metabolism in vertebrates and suggest the existence of an alternative pathway of intestinal and red blood cell iron uptake...
  13. ncbi request reprint Loss of gata1 but not gata2 converts erythropoiesis to myelopoiesis in zebrafish embryos
    Jenna L Galloway
    Stem Cell Program and Division of Hematology Oncology, Children s Hospital Boston, Dana Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
    Dev Cell 8:109-16. 2005
    ..Our studies establish a transcriptional hierarchy of Gata factor dependence during hematopoiesis and demonstrate that gata1 plays an integral role in directing myelo-erythroid lineage fate decisions during embryogenesis...
  14. ncbi request reprint The caudal-related homeobox genes cdx1a and cdx4 act redundantly to regulate hox gene expression and the formation of putative hematopoietic stem cells during zebrafish embryogenesis
    Alan J Davidson
    Division of Hematology Oncology, Children s Hospital and Dana Farber Cancer Institute, Department of Pediatrics and Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
    Dev Biol 292:506-18. 2006
    ..Taken together, these results suggest that the cdx-hox pathway plays an essential role in the formation of both embryonic erythroid cells and definitive HSCs during vertebrate embryogenesis...
  15. pmc Hematopoietic stem cell fate is established by the Notch-Runx pathway
    Caroline Erter Burns
    Stem Cell Program and Division of Hematology Oncology Children s Hospital and Dana Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 19:2331-42. 2005
    ..These data define the Notch-Runx pathway as critical for the developmental specification of HSC fate and the subsequent homeostasis of HSC number, thus providing a mechanism for amplifying stem cells in vivo...
  16. ncbi request reprint Zebrafish scl functions independently in hematopoietic and endothelial development
    Kimberly A Dooley
    Division of Hematology Oncology, Children s Hospital and Dana Farber Cancer Institute and Harvard Medical School, Howard Hughes Medical Institute, Boston, MA 02115, USA
    Dev Biol 277:522-36. 2005
    ..Surprisingly, in cloche, lmo2 was not induced in response to scl over-expression. Taken together, these findings support distinct roles for scl in hematopoietic and endothelial development, downstream of hemangioblast development...
  17. pmc Ferroportin1 is required for normal iron cycling in zebrafish
    Paula G Fraenkel
    Division of Hematology Oncology, Children s Hospital, Karp Research Laboratories, Boston, Massachusetts 02115, USA
    J Clin Invest 115:1532-41. 2005
    ....
  18. ncbi request reprint cdx4 mutants fail to specify blood progenitors and can be rescued by multiple hox genes
    Alan J Davidson
    Department of Medicine, Division of Hematology Oncology, Children s Hospital and Dana Farber Cancer Institute, Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA
    Nature 425:300-6. 2003
    ..Taken together, these findings demonstrate that cdx4 regulates hox genes and is necessary for the specification of haematopoietic cell fate during vertebrate embryogenesis...
  19. pmc Combinatorial regulation of novel erythroid gene expression in zebrafish
    Jenna L Galloway
    Stem Cell Program and Division of Hematology Oncology, Children s Hospital Boston and Dana Farber Cancer Institute, Boston, Mass, USA
    Exp Hematol 36:424-32. 2008
    ....
  20. ncbi request reprint The 'definitive' (and 'primitive') guide to zebrafish hematopoiesis
    Alan J Davidson
    Division of Hematology Oncology, Department of Medicine, Children s Hospital, Howard Hughes Medical Institute, Boston, MA 02115, USA
    Oncogene 23:7233-46. 2004
    ....
  21. ncbi request reprint Non-cell autonomous requirement for the bloodless gene in primitive hematopoiesis of zebrafish
    Eric C Liao
    Division of Hematology Oncology, Children s Hospital, Department of Pediatrics and Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
    Development 129:649-59. 2002
    ..These observations demonstrate that the bls gene product is uniquely required in a non-cell autonomous manner for primitive hematopoiesis, potentially acting via regulation of scl...
  22. pmc A non-canonical function of zebrafish telomerase reverse transcriptase is required for developmental hematopoiesis
    Shintaro Imamura
    Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA
    PLoS ONE 3:e3364. 2008
    ..The data also provide insights into a non-canonical pathway by which TERT functions to modulate specification of hematopoietic stem/progenitor cells during vertebrate development. (276 words)...
  23. pmc montalcino, A zebrafish model for variegate porphyria
    Kimberly A Dooley
    Division of Hematology Oncology, Children s Hospital, Howard Hughes Medical Institute, Boston, MA 02115, USA
    Exp Hematol 36:1132-42. 2008
    ..The objective of this study was to identify the defective gene and characterize the phenotype of the zebrafish mutant...
  24. ncbi request reprint Mitoferrin is essential for erythroid iron assimilation
    George C Shaw
    Division of Hematology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 440:96-100. 2006
    ..Our data show that mfrn functions as the principal mitochondrial iron importer essential for haem biosynthesis in vertebrate erythroblasts...
  25. doi request reprint BMP and Wnt specify hematopoietic fate by activation of the Cdx-Hox pathway
    Claudia Lengerke
    Division of Pediatric Hematology Oncology, Children s Hospital Boston and Dana Farber Cancer Institute, Boston, MA 02115, USA
    Cell Stem Cell 2:72-82. 2008
    ..Our data suggest that BMP signaling plays two distinct and sequential roles during blood formation, initially as an inducer of mesoderm, and later to specify blood via activation of Wnt signaling and the Cdx-Hox pathway...
  26. pmc Interaction of retinoic acid and scl controls primitive blood development
    Jill L O de Jong
    Stem Cell Program and Division of Hematology Oncology, Children s Hospital Boston and Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
    Blood 116:201-9. 2010
    ..Our studies establish a new connection between RA and scl during development that may participate in stem cell self-renewal and hematopoietic differentiation...
  27. pmc Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis
    Trista E North
    Stem Cell Program and Division of Hematology Oncology, Children s Hospital, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 447:1007-11. 2007
    ..The conserved role for PGE2 in the regulation of vertebrate HSC homeostasis indicates that modulation of the prostaglandin pathway may facilitate expansion of HSC number for therapeutic purposes...
  28. pmc Functional conservation of erythropoietin signaling in zebrafish
    Noelle Paffett-Lugassy
    Stem Cell Program and Division of Hematology Oncology, Children s Hospital and Dana Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Blood 110:2718-26. 2007
    ..Together, the characterization of zebrafish epo and epor demonstrates the conservation of an ancient program that ensures proper red blood cell numbers during normal homeostasis and under hypoxic conditions...
  29. ncbi request reprint Transcriptional regulation of hematopoietic stem cell development in zebrafish
    Nelson Hsia
    Stem Cell Program and Division of Hematology Oncology, Children s Hospital Boston, Howard Hughes Medical Institute, Harvard Medical School, Boston, Mass 02115, USA
    Exp Hematol 33:1007-14. 2005
    ..Future studies using new technologies in the zebrafish model will enhance our understanding of the molecular networks regulating HSC pluripotency and differentiation...
  30. pmc A chemical genetic screen in zebrafish for pathways interacting with cdx4 in primitive hematopoiesis
    Elizabeth J Paik
    Stem Cell Program and Division of Hematology Oncology, Children s Hospital Boston and Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Zebrafish 7:61-8. 2010
    ..The psoralen compounds also disrupted normal A-P patterning of embryos. These compounds modify the cdx4-mutant phenotype and will help elucidate signaling pathways that act downstream or parallel to the cdx4-hox pathway...
  31. pmc Zebrafish mutants with disrupted early T-cell and thymus development identified in early pressure screen
    Nikolaus S Trede
    Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA
    Dev Dyn 237:2575-84. 2008
    ..We discuss the advantage of this strategy and the general usefulness of the zebrafish as a model system for vertebrate lymphopoiesis and thymic organogenesis...
  32. pmc A genetic screen in zebrafish defines a hierarchical network of pathways required for hematopoietic stem cell emergence
    CAROLINE E BURNS
    Stem Cell Program and Division of Hematology Oncology, Children s Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Blood 113:5776-82. 2009
    ..Together, our results establish a hierarchy of signaling programs required and sufficient for HSC emergence in the AGM...
  33. ncbi request reprint A novel endothelial-specific heat shock protein HspA12B is required in both zebrafish development and endothelial functions in vitro
    Guang Hu
    Renal Division, Center for Study of the Tumor Microenvironment and Center for Vascular Biology Research, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Cell Sci 119:4117-26. 2006
    ....
  34. doi request reprint Zebrafish blood stem cells
    Aye T Chen
    Stem Cell Program and Division of Hematology Oncology, Children s Hospital, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Cell Biochem 108:35-42. 2009
    ..Along with the technological advancements in the field of zebrafish research, future HSC studies in zebrafish will help us illuminate the genetic network controlling the development and function of stem cells in all vertebrates...
  35. ncbi request reprint Regulation of the lmo2 promoter during hematopoietic and vascular development in zebrafish
    Hao Zhu
    Division of Hematology Oncology, Children s Hospital of Boston, Department of Pediatrics, Boston, MA 02115, USA
    Dev Biol 281:256-69. 2005
    ..Our studies elucidate the transcriptional regulation of this key transcription factor, and provide a transgenic system for the functional analysis of blood and blood vessels in zebrafish...
  36. pmc Mutant-specific gene programs in the zebrafish
    Gerhard J Weber
    Children s Hospital Stem Cell Program, Department of Hematology Oncology, Howard Hughes Medical Institute, Karp 7, 1 Blackfan Circle, Boston, MA 02115, USA
    Blood 106:521-30. 2005
    ....
  37. ncbi request reprint The chianti zebrafish mutant provides a model for erythroid-specific disruption of transferrin receptor 1
    Rebecca A Wingert
    Department of Hematology Oncology, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Development 131:6225-35. 2004
    ..Taken together, these data show that zebrafish tfr1a and tfr1b share biochemical function but have restricted domains of tissue expression, and establish a genetic model to study the specific function of Tfr1 in erythroid cells...
  38. ncbi request reprint The zebrafish: a new model of T-cell and thymic development
    David M Langenau
    Stem Cell Program and Division of Hematology Oncology, Children s Hospital Boston and Dana Farber Cancer Institute, 1 Blackfan Circle, Karp Building, Seventh Floor, Boston, Massachusetts 02115 5713, USA
    Nat Rev Immunol 5:307-17. 2005
    ..Finally, we summarize the use of the zebrafish as a new model for assessing stem-cell function and for drug discovery...
  39. ncbi request reprint Deficiency of glutaredoxin 5 reveals Fe-S clusters are required for vertebrate haem synthesis
    Rebecca A Wingert
    Stem Cell Program and Division Hematology Oncology Children s Hospital and Dana Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 436:1035-39. 2005
    ..These findings uncover a connection between haem biosynthesis and Fe-S clusters, indicating that haemoglobin production in the differentiating red cell is regulated through Fe-S cluster assembly...
  40. doi request reprint APC mutant zebrafish uncover a changing temporal requirement for wnt signaling in liver development
    Wolfram Goessling
    Stem Cell Program and Hematology Oncology, Children s Hospital and Dana Farber Cancer Institute, HHMI, Harvard Medical School, Boston, MA 02115, USA
    Dev Biol 320:161-74. 2008
    ..These studies reveal an important and time-dependent role for wnt signaling during liver development and regeneration...
  41. pmc Hematopoiesis: an evolving paradigm for stem cell biology
    Stuart H Orkin
    Division of Hematology Oncology, Children s Hospital Boston and the Dana Farber Cancer Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA
    Cell 132:631-44. 2008
    ....
  42. pmc Effects of RAS on the genesis of embryonal rhabdomyosarcoma
    David M Langenau
    Stem Cell Program and Division of Hematology, Children s Hospital Boston and Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Genes Dev 21:1382-95. 2007
    ..When coupled with gene expression studies of this cell population, we propose that the zebrafish RMS cancer stem cell shares similar self-renewal programs as those found in activated satellite cells...
  43. pmc Transferrin-a modulates hepcidin expression in zebrafish embryos
    Paula G Fraenkel
    Division of Hematology Oncology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Blood 113:2843-50. 2009
    ..These data indicate that transferrin-a transports iron and that hepcidin expression is regulated by a transferrin-a-dependent pathway in the zebrafish embryo...
  44. ncbi request reprint Hematopoiesis and stem cells: plasticity versus developmental heterogeneity
    Stuart H Orkin
    Division of Hematology and Oncology, Dana Farber Cancer Institute and Children s Hospital, Department of Pediatrics, Harvard Medical School and the Howard Hughes Medical Institute, Boston, MA 02115, USA
    Nat Immunol 3:323-8. 2002
    ..In considering these findings, we draw a distinction here between the plasticity of adult stem cells and the heterogeneity of stem cell types that pre-exist within tissues...
  45. ncbi request reprint Expression and mapping of duplicate neuropilin-1 and neuropilin-2 genes in developing zebrafish
    Diane E Bovenkamp
    Vascular Biology Program, Children s Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, Boston, MA 02115, USA
    Gene Expr Patterns 4:361-70. 2004
    ..Both 125 kDa Nrp1a and 145 kDa Nrp1b bound 125I-labelled VEGFA165. In summary, two nrp1 and two nrp2 genes, with expression patterns similar to higher vertebrates, have been isolated from zebrafish...
  46. ncbi request reprint Modeling human hematopoietic and cardiovascular diseases in zebrafish
    Trista E North
    Division of Hematology Oncology, Department of Medicine, Children s Hospital of Boston, Enders Research Building, Boston, Massachusetts 02115, USA
    Dev Dyn 228:568-83. 2003
    ..This review aims to illustrate how the zebrafish has been used to identify unknown genes, to assign function to known genes, and to delineate genetic pathways, all contributing valuable leads toward understanding human pathophysiology...
  47. pmc TIF1gamma controls erythroid cell fate by regulating transcription elongation
    Xiaoying Bai
    Howard Hughes Medical Institute, Boston, MA 02115, USA
    Cell 142:133-43. 2010
    ..Our study establishes a mechanism for regulating tissue cell fate and differentiation through transcription elongation...
  48. ncbi request reprint Isolation and characterization of zebrafish NFE2
    Stephen J Pratt
    Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA
    Physiol Genomics 11:91-8. 2002
    ..This further establishes the block to erythroid differentiation in the sauternes mutant. Our studies demonstrate conservation of the vertebrate genetic program for the erythroid lineage...
  49. ncbi request reprint An Mll-dependent Hox program drives hematopoietic progenitor expansion
    Patricia Ernst
    Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts, USA
    Curr Biol 14:2063-9. 2004
    ..Furthermore, our results highlight a shared function of Hox proteins at this point in the development of the hematopoietic system...
  50. ncbi request reprint Use of the zebrafish system to study primitive and definitive hematopoiesis
    Jill L O de Jong
    Stem Cell Program and Division of Hematology Oncology, Children s Hospital Boston and Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Annu Rev Genet 39:481-501. 2005
    ....
  51. ncbi request reprint A critical role for calponin 2 in vascular development
    Jian Tang
    Renal Division and Center for Study of the Tumor Microenvironment, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Biol Chem 281:6664-72. 2006
    ..Collectively, these data suggest that calponin 2 plays an important role in the migration of endothelial cells both in vivo and in vitro and that its expression is critical for proper vascular development...
  52. ncbi request reprint The use of zebrafish to understand immunity
    Nikolaus S Trede
    Division of Pediatric Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115 USA
    Immunity 20:367-79. 2004
    ..Here, we discuss the advent of the zebrafish as a powerful vertebrate model organism that promises to positively impact immunologic research...
  53. doi request reprint Eya4 regulation of Na+/K+-ATPase is required for sensory system development in zebrafish
    Libin Wang
    Harvard Medical School, Department of Genetics, and Howard Hughes Medical Institute, Division of Hematology Oncology, Children s Hospital Boston, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Development 135:3425-34. 2008
    ..We conclude that eya4 regulation of Na+/K+-ATPase is crucial for the development of mechanosensory cells and the maintenance of cardiac function in zebrafish...
  54. pmc Zebrafish models of p53 functions
    Narie Y Storer
    Stem Cell Program and Division of Hematology Oncology, Children s Hospital Boston and Dana Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cold Spring Harb Perspect Biol 2:a001123. 2010
    ..This article will summarize how zebrafish models have been used to reveal numerous, important aspects of p53 function...
  55. doi request reprint Newly emerging roles for prostaglandin E2 regulation of hematopoiesis and hematopoietic stem cell engraftment
    Ellen M Durand
    Children s Hospital, Boston, Massachusetts, USA
    Curr Opin Hematol 17:308-12. 2010
    ..Recently, prostaglandin E2 (PGE2) exposure, either in vivo or ex vivo, has been shown to increase engraftment. These results establish PGE2 as a regulator of hematopoietic development...
  56. doi request reprint Small molecule screen in zebrafish and HSC expansion
    Eirini Trompouki
    Stem Cell Program and Hematology Oncology, Children s Hospital, Harvard Medical School, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Boston, MA, USA
    Methods Mol Biol 636:301-16. 2010
    ..In this protocol, we will discuss a chemical screen in zebrafish embryos to detect compounds that expand or deplete hematopoietic stem cells (HSCs) in vivo. This type of screen represents a powerful tool to study HSCs in zebrafish...
  57. pmc Hematopoietic stem cell development is dependent on blood flow
    Trista E North
    Stem Cell Program and Hematology Oncology, Children s Hospital, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA
    Cell 137:736-48. 2009
    ..This work links blood flow to AGM hematopoiesis and identifies NO as a conserved downstream regulator of HSC development...
  58. ncbi request reprint Analysis of hematopoietic development in the zebrafish
    Noƫlle N Paffett-Lugassy
    Department of Pediatric Oncology, Children s Hospital, Boston, MA, USA
    Methods Mol Med 105:171-98. 2005
    ....
  59. ncbi request reprint AlphaA-crystallin expression prevents gamma-crystallin insolubility and cataract formation in the zebrafish cloche mutant lens
    Katsutoshi Goishi
    Vascular Biology Program Department of Surgery, Children s Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Development 133:2585-93. 2006
    ..In addition, these results show that proteomics is a valuable tool for detecting protein alterations in zebrafish...
  60. ncbi request reprint Cell-specific mitotic defect and dyserythropoiesis associated with erythroid band 3 deficiency
    Barry H Paw
    Department of Medicine, Division of Hematology Oncology, Children s Hospital, Boston, Massachusetts, USA
    Nat Genet 34:59-64. 2003
    ..1R-binding domains. Our report establishes an evolutionarily conserved role for band 3 in erythroid-specific cell division and illustrates the concept of cell-specific adaptation for mitosis...
  61. ncbi request reprint Transplantation and in vivo imaging of multilineage engraftment in zebrafish bloodless mutants
    David Traver
    Children s Hospital Boston and the Howard Hughes Medical Institute, 320 Longwood Avenue, Enders 720, Boston, Massachusetts 02115, USA
    Nat Immunol 4:1238-46. 2003
    ..Direct visualization of fluorescent donor cells in embryonic recipients allows engraftment and homing events to be imaged in real time. These results provide a cellular context in which to study the genetics of hematopoiesis...
  62. ncbi request reprint Homing sweet homing: odyssey of hematopoietic stem cells
    Caroline Erter Burns
    Stem Cell Program and Division of Hematology Oncology, Children s Hospital Boston and Dana Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Immunity 25:859-62. 2006
    ..In this issue of Immunity, Murayama et al. (2006) track the migration of nascent hematopoietic stem cells in zebrafish from their site of origin to a newly described intermediate location...
  63. ncbi request reprint Myc-induced T cell leukemia in transgenic zebrafish
    David M Langenau
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Science 299:887-90. 2003
    ..This transgenic model provides a platform for drug screens and for genetic screens aimed at identifying mutations that suppress or enhance c-myc- induced carcinogenesis...
  64. ncbi request reprint Ontogeny of hematopoiesis: examining the emergence of hematopoietic cells in the vertebrate embryo
    Jenna L Galloway
    Division of Hematology Oncology, Harvard Medical School and Howard Hughes Medical Institute, Children s Hospital, Boston, Massachusetts 02115, USA
    Curr Top Dev Biol 53:139-58. 2003
    ..This review describes both primitive and definitive hematopoiesis in mice, humans, chicks, frogs, and zebrafish and examines the current debate over the embryonic origins of HSCs...
  65. pmc The zebra fish cassiopeia mutant reveals that SIL is required for mitotic spindle organization
    Kathleen L Pfaff
    Stem Cell Program and Division of Hematology Oncology, Children s Hospital Boston, Dana Farber Cancer Research Institute, Howard Hughes Medical Institute, and Harvard Medical School, Karp Family Research Building, Boston, Massachusetts 02115, USA
    Mol Cell Biol 27:5887-97. 2007
    ..Furthermore, short hairpin RNA knockdown of SIL in human cells recapitulates the zebrafish csp mitotic spindle defects. These data, taken together, identify SIL as a novel, vertebrate-specific regulator of mitotic spindle assembly...
  66. pmc The zebrafish runzel muscular dystrophy is linked to the titin gene
    Leta S Steffen
    Department of Genetics, Harvard Medical School, and Program in Genomics, Children s Hospital, 300 Longwood Ave, Boston, MA, USA
    Dev Biol 309:180-92. 2007
    ..These studies should lead to a better understanding of titin's role in normal and diseased muscle...
  67. ncbi request reprint Prostaglandin E2: making more of your marrow
    Allegra M Lord
    Stem Cell Program and Hematology Oncology, Children s Hospital and Dana Farber Cancer Institute, HHMI, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell Cycle 6:3054-7. 2007
    ..This article aims to summarize current knowledge of PGE2-mediated regulation of blood cell homeostasis as well as to discuss the proposed use of PGE2 to expand hematopoietic stem cells for transplantation in the clinical setting...
  68. pmc Topoisomerase II alpha is required for embryonic development and liver regeneration in zebrafish
    Michael Dovey
    Children s Hospital and Dana Farber Cancer Institute, Boston, MA, USA
    Mol Cell Biol 29:3746-53. 2009
    ..Regeneration analysis of other adult tissues, including fins, revealed no heterozygous phenotype. Our results confirm a conserved role for TOP2A in vertebrates as well as a dose-sensitive requirement for top2a in adults...
  69. ncbi request reprint Zebrafish slc4a2/ae2 anion exchanger: cDNA cloning, mapping, functional characterization, and localization
    Boris E Shmukler
    Molecular Medicine and Renal Units, Beth Israel Deaconess Med Ctr E RW763, 330 Brookline Ave, Boston, MA 02215, USA
    Am J Physiol Renal Physiol 289:F835-49. 2005
    ..These results will inform tests of the role of Ae2 in zebrafish kidney development and function...
  70. ncbi request reprint The pu.1 promoter drives myeloid gene expression in zebrafish
    Karl Hsu
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Blood 104:1291-7. 2004
    ..These transgenic lines will be useful to dissect the cellular and molecular control of myeloid cell differentiation, and this promoter fragment may prove useful in the development of zebrafish models of acute myeloid leukemia...
  71. ncbi request reprint Organogenesis--heart and blood formation from the zebrafish point of view
    Christine Thisse
    Institut de Biologie Moleculaire et Cellulaire, CNRS, INSERM, Universite Louis Pasteur, 1 rue Laurent Fries, BP 163, 67404 Illkirch Cedex, C U de Strasbourg, France
    Science 295:457-62. 2002
    ..This review develops the theme of modules and illustrates how zebrafish have been particularly useful for understanding heart and blood formation...
  72. ncbi request reprint Two distinct teleost hepatocyte nuclear factor 1 genes, hnf1alpha/tcf1 and hnf1beta/tcf2, abundantly expressed in liver, pancreas, gut and kidney of zebrafish
    Hong Yi Gong
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan
    Gene 338:35-46. 2004
    ..Our results indicate that distinct hnf1alpha and hnf1beta genes in teleosts had been evolved from the hnf1 ancestor gene of chordate...
  73. ncbi request reprint SUMO-1 modification represses Sp3 transcriptional activation and modulates its subnuclear localization
    Sarah Ross
    Department of Pathology, Harvard Medical School, Children s Hospital, Boston, MA 02115, USA
    Mol Cell 10:831-42. 2002
    ..These studies reveal a direct effect of SUMO-1 modification on activity of a dual function transcription factor and provide a mechanism for functional specificity within the Sp transcription factor family...
  74. ncbi request reprint Portrait of a stem cell
    Caroline Erter Burns
    Department of Hematology Oncology, Howard Hughes Medical Institute, Children s Hospital of Boston, 320 Longwood Avenue, Enders 650, Boston, MA 02115, USA
    Dev Cell 3:612-3. 2002
    ..New data sets produced by transcriptional profiling of purified stem cell populations begin to establish the nature of "stemness."..
  75. doi request reprint SnapShot: hematopoiesis
    Stuart H Orkin
    Harvard Medical School, Boston, MA 02115, USA
    Cell 132:712. 2008
  76. ncbi request reprint The complex cartography of stem cell commitment
    Koichi Akashi
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 121:160-2. 2005
    ....
  77. pmc Cdx4 dysregulates Hox gene expression and generates acute myeloid leukemia alone and in cooperation with Meis1a in a murine model
    Dimple Bansal
    Division of Hematology, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 103:16924-9. 2006
    ..Inasmuch as many human leukemias show dysregulated expression of a spectrum of HOX family members, these collective findings also suggest a central role for CDX4 expression in the genesis of acute leukemia...
  78. pmc Network of coregulated spliceosome components revealed by zebrafish mutant in recycling factor p110
    Nikolaus S Trede
    Institute of Biochemistry, Justus Liebig University, D 35392 Giessen, Germany
    Proc Natl Acad Sci U S A 104:6608-13. 2007
    ..Together, our data demonstrate that a mutation in a general splicing factor can lead to distinct defects in organ development and cause disease...
  79. ncbi request reprint A chemical genetic screen for cell cycle inhibitors in zebrafish embryos
    Ryan D Murphey
    Chem Biol Drug Des 68:213-9. 2006
    ..These findings demonstrate that small molecule screens in zebrafish can identify compounds with novel activity and thus may be useful tools for chemical genetics and drug discovery...
  80. ncbi request reprint BMP signaling restricts hemato-vascular development from lateral mesoderm during somitogenesis
    Sunny Gupta
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Development 133:2177-87. 2006
    ....
  81. ncbi request reprint Zebrafish KLF4 is essential for anterior mesendoderm/pre-polster differentiation and hatching
    Melissa R Gardiner
    Queensland Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia
    Dev Dyn 234:992-6. 2005
    ..These results indicate zKLF4 is expressed within the pre-polster, an early mesendodermal site, and that it plays a critical role in the differentiation of these cells into hatching gland cells...
  82. ncbi request reprint Characterization of zebrafish merlot/chablis as non-mammalian vertebrate models for severe congenital anemia due to protein 4.1 deficiency
    Ebrahim Shafizadeh
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912 USA
    Development 129:4359-70. 2002
    ..This work presents merlot/chablis as the first characterized non-mammalian vertebrate models of hereditary anemia due to a defect in protein 4.1R integrity...
  83. ncbi request reprint Effects of lethal irradiation in zebrafish and rescue by hematopoietic cell transplantation
    David Traver
    Children s Hospital Boston and the Howard Hughes Medical Institute, 1 Blackfan Circle, Rm 07211, Boston, MA 02115, USA
    Blood 104:1298-305. 2004
    ..Together, these results establish transplantation assays to test for HSC function and oncogenic transformation in zebrafish...
  84. ncbi request reprint New waves of discovery: modeling cancer in zebrafish
    Wolfram Goessling
    Stem Cell Program and Division of Hematology Oncology, Children s Hospital, and Dana Farber Cancer Institute, Harvard Medical School, Harvard Stem Cell Institute, Howard Hughes Medical Institute, Boston, MA 02115, USA
    J Clin Oncol 25:2473-9. 2007
  85. ncbi request reprint Teratoma formation assays with human embryonic stem cells: a rationale for one type of human-animal chimera
    M William Lensch
    Division of Hematology Oncology, Children s Hospital Boston and Dana Farber Cancer Institute, Boston, MA 02115, USA
    Cell Stem Cell 1:253-8. 2007
    ..We argue that this experiment raises no significant moral concerns and should be the jurisdiction of animal care and use committees and exempt from formal review by the stem cell research oversight process...

Research Grants59

  1. EMBRYONIC HEMATOPOIESIS
    LEONARD IRA ZON; Fiscal Year: 2010
    ..These studies should provide critical insight into stem cell homeostasis and may lead to potential new therapies of anemia and approaches in bone marrow transplantation. ..
  2. International Society for Stem Cell Research Meeting
    Leonard Zon; Fiscal Year: 2006
    ..abstract_text> ..
  3. Cancer Biology in the Zebrafish
    Leonard Zon; Fiscal Year: 2006
    ..These studies should provide new insight into the vertebrate cell cycle and cancer biology, and may delineate pharmaceutical targets for patients with cancer. ..
  4. Fetal Globin Silencing
    Leonard Zon; Fiscal Year: 2006
    ..These studies should improve our understanding of the basic molecular biology of globin gene regulation and could be therapeutically useful for patients with sickle anemia and thalassemia. ..
  5. A Comparative Approach to Globin Regulation/Thalassemia
    Leonard Zon; Fiscal Year: 2006
    ..Our studies should provide a better understanding of the basic biology of hemoglobin production and may have a therapeutic impact on patients with thalassemia, sickle cell anemia, and hemochromatosis. ..
  6. Red Cell Gordon Conference
    Leonard Zon; Fiscal Year: 2005
    ....
  7. Cancer Biology in the Zebrafish
    Leonard Zon; Fiscal Year: 2005
    ..These studies should provide new insight into the vertebrate cell cycle and cancer biology, and may delineate pharmaceutical targets for patients with cancer. ..
  8. Fetal Globin Silencing
    Leonard Zon; Fiscal Year: 2005
    ..These studies should improve our understanding of the basic molecular biology of globin gene regulation and could be therapeutically useful for patients with sickle anemia and thalassemia. ..
  9. Cancer Biology in the Zebrafish
    Leonard Zon; Fiscal Year: 2004
    ..These studies should provide new insight into the vertebrate cell cycle and cancer biology, and may delineate pharmaceutical targets for patients with cancer. ..
  10. EMBRYONIC HEMATOPOIESIS
    Leonard Zon; Fiscal Year: 2004
    ..These isolated genes may be of therapeutic value for patients with anemia or leukemia, as well as for patients undergoing marrow transplantation or gene therapy. ..
  11. A Comparative Approach to Globin Regulation/Thalassemia
    Leonard Zon; Fiscal Year: 2007
    ..Our studies should provide a better understanding of the basic biology of hemoglobin production and may have a therapeutic impact on patients with thalassemia, sickle cell anemia, and hemochromatosis. ..
  12. CHARACTERIZING THE ZEBRAFISH GENOME
    Leonard Zon; Fiscal Year: 2007
    ..These proposed studies should ensure a successful assembly of the genome based on the mapped genes and markers, and will aid investigators to rapidly isolate mutant genes and to study comparative genomics. ..
  13. Cancer Biology in the Zebrafish
    Leonard Zon; Fiscal Year: 2007
    ..These studies should provide new insight into the vertebrate cell cycle and cancer biology, and may delineate pharmaceutical targets for patients with cancer. ..
  14. A Comparative Approach to Globin Regulation/Thalassemia
    LEONARD IRA ZON; Fiscal Year: 2010
    ....
  15. EMBRYONIC HEMATOPOIESIS
    Leonard Zon; Fiscal Year: 2009
    ..These studies should provide critical insight into stem cell homeostasis and may lead to potential new therapies of anemia and approaches in bone marrow transplantation. ..
  16. Cancer Biology in the Zebrafish
    Leonard Zon; Fiscal Year: 2009
    ..By defining such pathways, new therapies can be designed to use in conjunction with conventional chemotherapy in the treatment of cancer. ..
  17. A Comparative Approach to Globin Regulation/Thalassemia
    Leonard Zon; Fiscal Year: 2009
    ....
  18. Mount Desert Island Stem Cell Symposium
    Leonard Zon; Fiscal Year: 2007
    ..Scientific sessions will include platform presentations, a poster session, and a keynote address open to the general public. ..
  19. EMBRYONIC HEMATOPOIESIS
    Leonard Zon; Fiscal Year: 2007
    ..These studies should provide critical insight into stem cell homeostasis and may lead to potential new therapies of anemia and approaches in bone marrow transplantation. ..
  20. Cancer Biology in the Zebrafish
    Leonard Zon; Fiscal Year: 2003
    ..These studies should provide new insight into the vertebrate cell cycle and cancer biology, and may delineate pharmaceutical targets for patients with cancer. ..
  21. EMBRYONIC HEMATOPOIESIS
    Leonard Zon; Fiscal Year: 2003
    ..These isolated genes may be of therapeutic value for patients with anemia or leukemia, as well as for patients undergoing marrow transplantation or gene therapy. ..
  22. Fetal Globin Silencing
    Leonard Zon; Fiscal Year: 2003
    ..These studies should improve our understanding of the basic molecular biology of globin gene regulation and could be therapeutically useful for patients with sickle anemia and thalassemia. ..
  23. COMPARATIVE APPROACH TO GLOBIN REGULATION/THALASSEMIA
    Leonard Zon; Fiscal Year: 2000
    ....
  24. CHARACTERIZING THE ZEBRAFISH GENOME
    Leonard Zon; Fiscal Year: 1999
    ....
  25. EMBRYONIC HEMATOPOIESIS
    Leonard Zon; Fiscal Year: 1999
    ..The proposed study will provide new insights into the biology of hematopoiesis in both normal and pathologic states such as anemia and hemoglobinopathies, and will be useful for bone marrow transplantation and gene therapy. ..
  26. CHARACTERIZING THE ZEBRAFISH GENOME
    Leonard Zon; Fiscal Year: 1999
    ....
  27. EMBRYONIC HEMATOPOIESIS
    Leonard Zon; Fiscal Year: 1993
    ..This early hematopoietic signal will be isolated and characterized. The proposed study will provide new insights into the developmental biology of hematopoiesis in both normal and pathologic states such as anemia and hemoglobinopathies...
  28. CHARACTERIZING THE ZEBRAFISH GENOME
    Leonard Zon; Fiscal Year: 1999
    ....
  29. COMPARATIVE APPROACH TO GLOBIN REGULATION/THALASSEMIA
    Leonard Zon; Fiscal Year: 1999
    ....
  30. CHARACTERIZING THE ZEBRAFISH GENOME
    Leonard Zon; Fiscal Year: 2000
    ....
  31. EMBRYONIC HEMATOPOIESIS
    Leonard Zon; Fiscal Year: 2000
    ..The proposed study will provide new insights into the biology of hematopoiesis in both normal and pathologic states such as anemia and hemoglobinopathies, and will be useful for bone marrow transplantation and gene therapy. ..
  32. EMBRYONIC HEMATOPOIESIS
    Leonard Zon; Fiscal Year: 2001
    ..These isolated genes may be of therapeutic value for patients with anemia or leukemia, as well as for patients undergoing marrow transplantation or gene therapy. ..
  33. A Comparative Approach to Globin Regulation/Thalassemia
    Leonard Zon; Fiscal Year: 2003
    ..Our studies should provide a better understanding of the basic biology of hemoglobin production and may have a therapeutic impact on patients with thalassemia, sickle cell anemia, and hemochromatosis. ..
  34. CHARACTERIZING THE ZEBRAFISH GENOME
    Leonard Zon; Fiscal Year: 2002
    ....
  35. COMPARATIVE APPROACH TO GLOBIN REGULATION/THALASSEMIA
    Leonard Zon; Fiscal Year: 2002
    ....
  36. CHARACTERIZING THE ZEBRAFISH GENOME
    Leonard Zon; Fiscal Year: 2001
    ....
  37. COMPARATIVE APPROACH TO GLOBIN REGULATION/THALASSEMIA
    Leonard Zon; Fiscal Year: 2001
    ....
  38. EMBRYONIC HEMATOPOIESIS
    Leonard Zon; Fiscal Year: 2000
    ..The proposed study will provide new insights into the biology of hematopoiesis in both normal and pathologic states such as anemia and hemoglobinopathies, and will be useful for bone marrow transplantation and gene therapy. ..
  39. COMPARATIVE APPROACH TO GLOBIN REGULATION/THALASSEMIA
    Leonard Zon; Fiscal Year: 2000
    ....
  40. Cancer Biology in the Zebrafish
    LEONARD IRA ZON; Fiscal Year: 2010
    ..By defining such pathways, new therapies can be designed to use in conjunction with conventional chemotherapy in the treatment of cancer. ..
  41. Fetal Globin Silencing
    Leonard Zon; Fiscal Year: 2004
    ..These studies should improve our understanding of the basic molecular biology of globin gene regulation and could be therapeutically useful for patients with sickle anemia and thalassemia. ..
  42. Comparative Approach to the Hematopoietic Stem Cell
    Leonard Zon; Fiscal Year: 2004
    ..These studies should produce a better molecular characterization of hematopoietic and vasculogenic stem cells and could provide therapies for patients with anemia or leukemia. ..
  43. EMBRYONIC HEMATOPOIESIS
    Leonard Zon; Fiscal Year: 2002
    ..These isolated genes may be of therapeutic value for patients with anemia or leukemia, as well as for patients undergoing marrow transplantation or gene therapy. ..
  44. EMBRYONIC HEMATOPOIESIS
    Leonard Zon; Fiscal Year: 2005
    ..These isolated genes may be of therapeutic value for patients with anemia or leukemia, as well as for patients undergoing marrow transplantation or gene therapy. ..
  45. EMBRYONIC HEMATOPOIESIS
    Leonard Zon; Fiscal Year: 1992
    ..This early hematopoietic signal will be isolated and characterized. The proposed study will provide new insights into the developmental biology of hematopoiesis in both normal and pathologic states such as anemia and hemoglobinopathies...