LEONARD IRA ZON

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. Zon L. Improving the visibility of developmental biology: time for induction and specification. Development. 2019;146: pubmed publisher
    ..Here, I discuss these issues and challenges and offer potential solutions for a field that is very important to me. ..
  2. Mandelbaum J, Shestopalov I, Henderson R, Chau N, Knoechel B, Wick M, et al. Zebrafish blastomere screen identifies retinoic acid suppression of MYB in adenoid cystic carcinoma. J Exp Med. 2018;215:2673-2685 pubmed publisher
    ..Our findings establish the zebrafish pluripotent cell culture system as a method to identify modulators of tumor formation, particularly establishing retinoic acid as a potential new effective therapy for ACC. ..
  3. Fazio M, Zon L. Fishing for answers in precision cancer medicine. Proc Natl Acad Sci U S A. 2017;114:10306-10308 pubmed publisher
  4. Lahvic J, Ammerman M, Li P, Blair M, Stillman E, Fast E, et al. Specific oxylipins enhance vertebrate hematopoiesis via the receptor GPR132. Proc Natl Acad Sci U S A. 2018;115:9252-9257 pubmed publisher
    ..GPR132 responds to a select panel of oxygenated polyunsaturated fatty acids to enhance both embryonic and adult hematopoiesis. ..
  5. Blaser B, Zon L. Making HSCs in vitro: don't forget the hemogenic endothelium. Blood. 2018;: pubmed publisher
    ..Here we review the path to this discovery and discuss the future of autologous transplantation with in vitro-derived HSCs as a therapeutic modality. ..
  6. Zon L. Translational research: the path for bringing discovery to patients. Cell Stem Cell. 2014;14:146-8 pubmed publisher
    ..Here, I highlight some key insights for navigating such challenges based on recent clinical trials initiated by basic research from my lab. ..
  7. Kapp F, Perlin J, Hagedorn E, Gansner J, Schwarz D, O Connell L, et al. Protection from UV light is an evolutionarily conserved feature of the haematopoietic niche. Nature. 2018;558:445-448 pubmed publisher
  8. McConnell A, Mito J, Ablain J, Dang M, Formichella L, Fisher D, et al. Neural crest state activation in NRAS driven melanoma, but not in NRAS-driven melanocyte expansion. Dev Biol. 2019;449:107-114 pubmed publisher
    ..These early lesions are highly predisposed to reactivate a neural crest progenitor fate and form malignant melanomas. ..
  9. Dang M, Fogley R, Zon L. Identifying Novel Cancer Therapies Using Chemical Genetics and Zebrafish. Adv Exp Med Biol. 2016;916:103-24 pubmed publisher
    ..Future technological advancements in automation and high-powered imaging, as well as the development and characterization of new mutant and transgenic lines, will expand the scope of chemical genetics in zebrafish. ..

More Information

Publications24

  1. Rossmann M, Zhou Y, Zon L. Development: For cloche the Bell Tolls. Curr Biol. 2016;26:R890-R892 pubmed publisher
    ..This work poses intriguing questions as to the genetic and molecular nature of the origin of hemato-vascular lineages during early embryogenesis. ..
  2. Freeman J, Adeniyi A, Banerjee R, Dallaire S, Maguire S, Chi J, et al. Definition of the zebrafish genome using flow cytometry and cytogenetic mapping. BMC Genomics. 2007;8:195 pubmed
    ..An accurately annotated zebrafish reference genome serves as a valuable resource for investigating the molecular basis of human diseases using zebrafish mutant models. ..
  3. Fast E, ZON L. Aging Hematopoietic Stem Cells Make Their History. Dev Cell. 2016;39:390-391 pubmed publisher
    ..In a recent issue of Cell, Bernitz and colleagues (2016) determine the divisional history of hematopoietic stem cells (HSCs) to be a key player of regenerative potential in the aging mouse. ..
  4. Blaser B, Moore J, Hagedorn E, Li B, Riquelme R, Lichtig A, et al. CXCR1 remodels the vascular niche to promote hematopoietic stem and progenitor cell engraftment. J Exp Med. 2017;214:1011-1027 pubmed publisher
  5. Choudhuri A, Fast E, Zon L. Using Zebrafish to Study Pathways that Regulate Hematopoietic Stem Cell Self-Renewal and Migration. Stem Cell Reports. 2017;8:1465-1471 pubmed publisher
  6. Perlin J, Sporrij A, Zon L. Blood on the tracks: hematopoietic stem cell-endothelial cell interactions in homing and engraftment. J Mol Med (Berl). 2017;95:809-819 pubmed publisher
  7. Perlin J, Robertson A, Zon L. Efforts to enhance blood stem cell engraftment: Recent insights from zebrafish hematopoiesis. J Exp Med. 2017;214:2817-2827 pubmed publisher
    ..Manipulation of these signaling pathways and cell types may improve HSC bioengineering, which could significantly advance critical, lifesaving HSCT therapies. ..
  8. Tan J, Fogley R, Flynn R, Ablain J, Yang S, Saint André V, et al. Stress from Nucleotide Depletion Activates the Transcriptional Regulator HEXIM1 to Suppress Melanoma. Mol Cell. 2016;62:34-46 pubmed publisher
    ..Our study reveals an important role for HEXIM1 in coupling nucleotide metabolism with transcriptional regulation in melanoma. ..
  9. Kaufman C, Mosimann C, Fan Z, Yang S, Thomas A, Ablain J, et al. A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation. Science. 2016;351:aad2197 pubmed publisher
    ..Our work highlights NCP state reemergence as a key event in melanoma initiation. ..
  10. Liu X, Jia X, Yuan H, Ma K, Chen Y, Jin Y, et al. DNA methyltransferase 1 functions through C/ebpa to maintain hematopoietic stem and progenitor cells in zebrafish. J Hematol Oncol. 2015;8:15 pubmed publisher
    ..Dnmt1 is required for HSPC maintenance via cebpa regulation during definitive hematopoiesis in zebrafish. ..
  11. Jing L, Tamplin O, Chen M, Deng Q, Patterson S, Kim P, et al. Adenosine signaling promotes hematopoietic stem and progenitor cell emergence. J Exp Med. 2015;212:649-63 pubmed publisher
    ..5 aorta-gonad-mesonephros explants. Our results demonstrate that adenosine signaling plays an evolutionary conserved role in the first steps of HSPC formation in vertebrates. ..
  12. Tamplin O, Durand E, Carr L, Childs S, Hagedorn E, Li P, et al. Hematopoietic stem cell arrival triggers dynamic remodeling of the perivascular niche. Cell. 2015;160:241-52 pubmed publisher
    ..Our studies provide evidence for dynamic niche interactions upon stem cell colonization. PAPERFLICK: ..
  13. Ransom D, Bahary N, Niss K, Traver D, Burns C, Trede N, et al. The zebrafish moonshine gene encodes transcriptional intermediary factor 1gamma, an essential regulator of hematopoiesis. PLoS Biol. 2004;2:E237 pubmed
    ..Our results establish a major role for this transcriptional intermediary factor in the differentiation of hematopoietic cells in vertebrates. ..
  14. Zon L. Modeling human diseases: an education in interactions and interdisciplinary approaches. Dis Model Mech. 2016;9:597-600 pubmed publisher
  15. Ablain J, Durand E, Yang S, Zhou Y, Zon L. A CRISPR/Cas9 vector system for tissue-specific gene disruption in zebrafish. Dev Cell. 2015;32:756-64 pubmed publisher
    ..This vector system constitutes a unique tool to spatially control gene knockout and greatly broadens the scope of loss-of-function studies in zebrafish. ..