J D Zieske

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Activation of epidermal growth factor receptor during corneal epithelial migration
    J D Zieske
    Schepens Eye Research Institute and the Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 41:1346-55. 2000
  2. ncbi request reprint Cell cycle regulators at the ocular surface
    James D Zieske
    Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, 20 Staniford Street, Boston, MA 02114, USA
    Exp Eye Res 78:447-56. 2004
  3. ncbi request reprint Corneal development associated with eyelid opening
    James D Zieske
    Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Int J Dev Biol 48:903-11. 2004
  4. ncbi request reprint Kinetics of keratocyte proliferation in response to epithelial debridement
    J D Zieske
    Schepens Eye Research Institute, Harvard Medical School, Boston, MA, USA
    Exp Eye Res 72:33-9. 2001
  5. ncbi request reprint TGF-beta receptor types I and II are differentially expressed during corneal epithelial wound repair
    J D Zieske
    Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114 2500, USA
    Invest Ophthalmol Vis Sci 42:1465-71. 2001
  6. ncbi request reprint Extracellular matrix and wound healing
    J D Zieske
    Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
    Curr Opin Ophthalmol 12:237-41. 2001
  7. ncbi request reprint A role for MAP kinase in regulating ectodomain shedding of APLP2 in corneal epithelial cells
    K P Xu
    Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Physiol Cell Physiol 281:C603-14. 2001
  8. ncbi request reprint Expression of cyclin-dependent kinase inhibitors during corneal wound repair
    J D Zieske
    Schepens Eye Research Institute and the Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
    Prog Retin Eye Res 19:257-70. 2000
  9. ncbi request reprint Development of conjunctival goblet cells and their neuroreceptor subtype expression
    J D Rios
    Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 41:2127-37. 2000
  10. pmc Transforming growth factor-β3 regulates assembly of a non-fibrotic matrix in a 3D corneal model
    D Karamichos
    Department of Ophthalmology, Harvard Medical School, Boston, MA, USA
    J Tissue Eng Regen Med 5:e228-38. 2011

Research Grants

  1. CORE GRANT FOR VISION RESEARCH
    JAMES ZIESKE; Fiscal Year: 2007

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Activation of epidermal growth factor receptor during corneal epithelial migration
    J D Zieske
    Schepens Eye Research Institute and the Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 41:1346-55. 2000
    ....
  2. ncbi request reprint Cell cycle regulators at the ocular surface
    James D Zieske
    Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, 20 Staniford Street, Boston, MA 02114, USA
    Exp Eye Res 78:447-56. 2004
    ..Members of all of these families have been localized in various cells in the ocular surface. We will discuss how these proteins are involved in regulating cell proliferation both in normal homeostasis and during wound healing...
  3. ncbi request reprint Corneal development associated with eyelid opening
    James D Zieske
    Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Int J Dev Biol 48:903-11. 2004
    ..These events are the subject of this review. Readers are directed to the article by Wolosin et al., also in this volume, for an in-depth discussion of early corneal development...
  4. ncbi request reprint Kinetics of keratocyte proliferation in response to epithelial debridement
    J D Zieske
    Schepens Eye Research Institute, Harvard Medical School, Boston, MA, USA
    Exp Eye Res 72:33-9. 2001
    ..This stimulation is specific for cells immediately adjacent to the area of cell death. This activation does not involve the transformation of the stromal cells to a myofibroblast phenotype...
  5. ncbi request reprint TGF-beta receptor types I and II are differentially expressed during corneal epithelial wound repair
    J D Zieske
    Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114 2500, USA
    Invest Ophthalmol Vis Sci 42:1465-71. 2001
    ....
  6. ncbi request reprint Extracellular matrix and wound healing
    J D Zieske
    Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
    Curr Opin Ophthalmol 12:237-41. 2001
    ..The purpose of the current article is to review progress in the year 2000 toward understanding mechanisms involved in corneal wound healing and how extracellular matrix affects the healing processes...
  7. ncbi request reprint A role for MAP kinase in regulating ectodomain shedding of APLP2 in corneal epithelial cells
    K P Xu
    Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Physiol Cell Physiol 281:C603-14. 2001
    ..Our results suggest that MAPK activity accounts for basal as well as PKC- and EGF-induced APLP2 shedding. In addition, PKC-epsilon may be involved in the induction of APLP2 shedding in corneal epithelial cells...
  8. ncbi request reprint Expression of cyclin-dependent kinase inhibitors during corneal wound repair
    J D Zieske
    Schepens Eye Research Institute and the Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
    Prog Retin Eye Res 19:257-70. 2000
    ..The expression of two of these, p15 and p27. is dramatically altered during wound repair, suggesting that they may be involved in the changes in cell proliferation observed during corneal wound healing...
  9. ncbi request reprint Development of conjunctival goblet cells and their neuroreceptor subtype expression
    J D Rios
    Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 41:2127-37. 2000
    ..To investigate expression of muscarinic, cholinergic, and adrenergic receptors on developing conjunctival goblet cells...
  10. pmc Transforming growth factor-β3 regulates assembly of a non-fibrotic matrix in a 3D corneal model
    D Karamichos
    Department of Ophthalmology, Harvard Medical School, Boston, MA, USA
    J Tissue Eng Regen Med 5:e228-38. 2011
    ..HCFs stimulated by VitC and TGFβ3 appear to generate a matrix that mimics the normal adult or developing human cornea, whereas TGF-β1 and -β2 drive the constructs towards a more fibrotic path...
  11. pmc Human primary corneal fibroblasts synthesize and deposit proteoglycans in long-term 3-D cultures
    R Ren
    Departments of Biochemistry and Ophthalmology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Dev Dyn 237:2705-15. 2008
    ..The size of the Cuprolinic-positive filaments resembled those previously reported in a human corneal stroma. Under the current culture conditions, the cells mimic a development or nonfibrotic repair phenotype...
  12. ncbi request reprint Regulation of conjunctival goblet cell secretion by Ca(2+)and protein kinase C
    D A Dartt
    Schepens Eye Research Institute and Harvard Medical School, 20 Staniford St, Boston, MA 02114, USA
    Exp Eye Res 71:619-28. 2000
    ..We also conclude that activated PKC can stimulate goblet cell secretion and that seven different PKC isoforms are present in the goblet cells...
  13. doi request reprint Reversal of fibrosis by TGF-β3 in a 3D in vitro model
    D Karamichos
    Schepens Eye Research Institute Massachusetts Eye and Ear and the Department of Ophthalmology, Harvard Medical School, 20 Staniford Street, Boston, MA, USA Electronic address
    Exp Eye Res 124:31-36. 2014
    ....
  14. ncbi request reprint TAT-mediated protein transduction into human corneal epithelial cells: p15(INK4b) inhibits cell proliferation and stimulates cell migration
    Xiaoqing Guo
    Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 45:1804-11. 2004
    ..In this study, TAT-fusion protein technology was used to transduce p15(INK4b) into human corneal epithelial cells to examine the effect on cell proliferation and migration...
  15. pmc Examination of the restoration of epithelial barrier function following superficial keratectomy
    Audrey E K Hutcheon
    The Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
    Exp Eye Res 84:32-8. 2007
    ..The loss of barrier function does not extend beyond the edge of the original wound. The restoration of barrier function does not appear to correlate with reassembly of the basement membrane in this model...
  16. ncbi request reprint Effect of wound type on Smad 2 and 4 translocation
    Audrey E K Hutcheon
    Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 46:2362-8. 2005
    ..The present study was undertaken to examine whether Smads 2 and 4 translocate into the nucleus during wound repair and whether the wound type affects the extent of translocation...
  17. ncbi request reprint Transduction of functionally active TAT fusion proteins into cornea
    Xiaoqing Guo
    Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, 20 Staniford Street, Boston, MA 02114, USA
    Exp Eye Res 78:997-1005. 2004
    ..This barrier can be overcome by disrupting the epithelium. TAT-mediated protein transduction may be extremely useful in studies of corneal wound healing and homeostasis...
  18. pmc Prelude to corneal tissue engineering - gaining control of collagen organization
    Jeffrey W Ruberti
    Department of Mechanical and Industrial Engineering, Northeastern University, 360 Huntington Avenue, SN 334, Boston, MA 02115, USA
    Prog Retin Eye Res 27:549-77. 2008
    ....
  19. ncbi request reprint Extracellular matrix and matrix metalloproteinase changes in human corneas after complicated laser-assisted in situ keratomileusis (LASIK)
    Ezra Maguen
    Ophthalmology Research Laboratories, Burns and Allen Research Institute, Cedars Sinai Medical Center, UCLA Medical School, Los Angeles, California 90048, USA
    Cornea 21:95-100. 2002
    ..To characterize extracellular matrix (ECM) and nine matrix metalloproteinase (MMP) changes in two corneas that underwent a complicated laser-assisted in situ keratomileusis (LASIK) procedure...
  20. ncbi request reprint Changes in connexin43 in early ocular surface development
    J Mario Wolosin
    Department of Ophthalmology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Curr Eye Res 24:430-8. 2002
    ..Accordingly, as a means of identifying the process through which limbal cell phenotypes emerge, we investigated the expression of Cx43 in the ocular surface of embryonic rats...
  21. pmc Human diabetic corneas preserve wound healing, basement membrane, integrin and MMP-10 differences from normal corneas in organ culture
    Andrea Kabosova
    Ophthalmology Research Laboratories, Cedars Sinai Medical Center, Burns and Allen Research Institute, Los Angeles, CA 90048, USA
    Exp Eye Res 77:211-7. 2003
    ..The established corneal organ culture provides an adequate system for elucidating mechanisms of epithelial alterations in human DR corneas...
  22. ncbi request reprint In vivo and in vitro expression of connexins in the human corneal epithelium
    Daniel L Shurman
    Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Invest Ophthalmol Vis Sci 46:1957-65. 2005
    ..It also evaluates the pathologic effects of a pathogenic missense mutation in Cx26, which causes keratitis-ichthyosis-deafness syndrome (KIDS), a rare genetic disorder with corneal involvement...
  23. ncbi request reprint Effect of ectopic epithelial tissue within the stroma on keratocyte apoptosis, mitosis, and myofibroblast transformation
    Steven E Wilson
    Department of Ophthalmology, University of Washington School of Medicine, Box 356485, 1959 Pacific Street, Seattle, WA 98195 6485, USA
    Exp Eye Res 76:193-201. 2003
    ..Epithelium-derived signals also participate in the generation and/or maintenance of myofibroblasts in the corneal stroma...
  24. ncbi request reprint Molecular mechanisms controlling the fibrotic repair phenotype in cornea: implications for surgical outcomes
    Brian M Stramer
    Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, Florida 33101, USA
    Invest Ophthalmol Vis Sci 44:4237-46. 2003
    ..The purpose of this study was to investigate mechanisms that determine this differential keratocyte response...
  25. ncbi request reprint Wound healing in the cornea: a review of refractive surgery complications and new prospects for therapy
    Marcelo V Netto
    The Cole Eye Institute, The Cleveland Clinic Foundation, OH 44195, USA
    Cornea 24:509-22. 2005
    ..The purpose of this review is to provide an overview of the healing response in refractive surgery procedures...
  26. ncbi request reprint Morphologic characterization of organized extracellular matrix deposition by ascorbic acid-stimulated human corneal fibroblasts
    Xiaoqing Guo
    Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA
    Invest Ophthalmol Vis Sci 48:4050-60. 2007
    ..To characterize the structure and morphology of extracellular matrix (ECM) synthesized by untransformed, cultured human corneal fibroblasts in long-term cultures...
  27. ncbi request reprint Apoptosis, necrosis, proliferation, and myofibroblast generation in the stroma following LASIK and PRK
    Rahul R Mohan
    Department of Ophthalmology, University of Washington School of Medicine, Seattle, WA 98195 6485, USA
    Exp Eye Res 76:71-87. 2003
    ....

Research Grants1

  1. CORE GRANT FOR VISION RESEARCH
    JAMES ZIESKE; Fiscal Year: 2007
    ..Each module is under the immediate supervision of an established, experienced investigator(s). The module heads constitute the Core Grant Committee, which is responsible to the Director of Research. ..