Wei Zhou

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Dietary iron, zinc, and calcium and the risk of lung cancer
    Wei Zhou
    Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, and the Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02115, USA
    Epidemiology 16:772-9. 2005
  2. ncbi request reprint Matrix metalloproteinase polymorphisms and survival in stage I non-small cell lung cancer
    Rebecca Suk Heist
    Massachusetts General Hospital and Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Clin Cancer Res 12:5448-53. 2006
  3. doi request reprint MDM2 promoter polymorphism and pancreatic cancer risk and prognosis
    Kofi Asomaning
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Clin Cancer Res 14:4010-5. 2008
  4. ncbi request reprint Smoking cessation before diagnosis and survival in early stage non-small cell lung cancer patients
    Wei Zhou
    Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    Lung Cancer 53:375-80. 2006
  5. ncbi request reprint The SOD2 Val/Val genotype enhances the risk of nonsmall cell lung carcinoma by p53 and XRCC1 polymorphisms
    Geoffrey Liu
    Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer 101:2802-8. 2004
  6. ncbi request reprint Polymorphisms in the DNA repair genes XRCC1 and ERCC2, smoking, and lung cancer risk
    Wei Zhou
    Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 12:359-65. 2003
  7. ncbi request reprint Circulating 25-hydroxyvitamin D levels predict survival in early-stage non-small-cell lung cancer patients
    Wei Zhou
    Departments of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    J Clin Oncol 25:479-85. 2007
  8. ncbi request reprint Polymorphisms in ERCC1 and grade 3 or 4 toxicity in non-small cell lung cancer patients
    Rebecca Suk
    Massachusetts General Hospital and Harvard School of Public Health, Boston, MA 02115, USA
    Clin Cancer Res 11:1534-8. 2005
  9. ncbi request reprint Polymorphisms of vitamin D receptor and survival in early-stage non-small cell lung cancer patients
    Wei Zhou
    Departments of Environmental Health, Occupational Health Program, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 15:2239-45. 2006
  10. ncbi request reprint Counterpoint: the myeloperoxidase -463G-->a polymorphism does not decrease lung cancer susceptibility in Caucasians
    Li Lian Xu
    Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 11:1555-9. 2002

Detail Information

Publications65

  1. ncbi request reprint Dietary iron, zinc, and calcium and the risk of lung cancer
    Wei Zhou
    Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, and the Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02115, USA
    Epidemiology 16:772-9. 2005
    ..Dietary intakes of these micronutrients have been associated with altered risks of colorectal, breast, and prostate cancers...
  2. ncbi request reprint Matrix metalloproteinase polymorphisms and survival in stage I non-small cell lung cancer
    Rebecca Suk Heist
    Massachusetts General Hospital and Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Clin Cancer Res 12:5448-53. 2006
    ..We hypothesized that polymorphisms in these MMP genes may be associated with survival outcomes in early-stage non-small cell lung cancer (NSCLC)...
  3. doi request reprint MDM2 promoter polymorphism and pancreatic cancer risk and prognosis
    Kofi Asomaning
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Clin Cancer Res 14:4010-5. 2008
    ..We hypothesized that the G allele is also associated with increased risk and worse outcome in pancreatic cancer...
  4. ncbi request reprint Smoking cessation before diagnosis and survival in early stage non-small cell lung cancer patients
    Wei Zhou
    Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    Lung Cancer 53:375-80. 2006
    ..In conclusion, smoking cessation is associated with improved survival in early stage NSCLC patients. The longer the time since cessation of smoking, the better the survival outcome...
  5. ncbi request reprint The SOD2 Val/Val genotype enhances the risk of nonsmall cell lung carcinoma by p53 and XRCC1 polymorphisms
    Geoffrey Liu
    Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer 101:2802-8. 2004
    ..p53 is a tumor suppressor gene, and X-ray cross-complementing group 1 (XRCC1) is involved in the base-excision repair of ROS-induced DNA damage...
  6. ncbi request reprint Polymorphisms in the DNA repair genes XRCC1 and ERCC2, smoking, and lung cancer risk
    Wei Zhou
    Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 12:359-65. 2003
    ..In conclusion, cumulative cigarette smoking plays an important role in altering the direction and magnitude of the associations between the XRCC1 and ERCC2 polymorphisms and lung cancer risk...
  7. ncbi request reprint Circulating 25-hydroxyvitamin D levels predict survival in early-stage non-small-cell lung cancer patients
    Wei Zhou
    Departments of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    J Clin Oncol 25:479-85. 2007
    ..We further investigated the results of circulating 25-hydroxyvitamin D (25[OH]D) levels on overall survival (OS) and recurrence-free survival (RFS) in NSCLC patients...
  8. ncbi request reprint Polymorphisms in ERCC1 and grade 3 or 4 toxicity in non-small cell lung cancer patients
    Rebecca Suk
    Massachusetts General Hospital and Harvard School of Public Health, Boston, MA 02115, USA
    Clin Cancer Res 11:1534-8. 2005
    ..Polymorphisms have been identified in the ERCC1 gene, the C8092A and codon 118 polymorphisms, which may lead to an altered capacity to regenerate damaged normal tissue and greater treatment-related toxicity...
  9. ncbi request reprint Polymorphisms of vitamin D receptor and survival in early-stage non-small cell lung cancer patients
    Wei Zhou
    Departments of Environmental Health, Occupational Health Program, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 15:2239-45. 2006
    ..71). Similar associations were found in haplotype analysis and for RFS among SCC patients. In conclusion, VDR polymorphisms may be associated with improved survival among SCC patients of early-stage NSCLC...
  10. ncbi request reprint Counterpoint: the myeloperoxidase -463G-->a polymorphism does not decrease lung cancer susceptibility in Caucasians
    Li Lian Xu
    Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 11:1555-9. 2002
    ..These findings are in contrast with earlier studies suggesting a protective effect of carrying the variant A allele...
  11. ncbi request reprint MPO and SOD2 polymorphisms, gender, and the risk of non-small cell lung carcinoma
    Geoffrey Liu
    Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Cancer Lett 214:69-79. 2004
    ..For women carrying the MPO variant genotypes, the adjusted odds ratio of the SOD2 polymorphism (Val/Val vs. Ala/Ala) was 3.26 (95% CI, 1.55-6.83). No associations were found in men or in women carrying the MPO GG wildtype genotype...
  12. ncbi request reprint Excision repair cross-complementation group 1 polymorphism predicts overall survival in advanced non-small cell lung cancer patients treated with platinum-based chemotherapy
    Wei Zhou
    Occupational Health Program, Departments of Environmental Health and Biostatistics, Harvard School of Public Health, Boston 02115, Massachusetts, USA
    Clin Cancer Res 10:4939-43. 2004
    ..9 (T/T), 16.1 (C/T), and 13.3 (C/C) months, respectively. In conclusion, the ERCC1 C8092A polymorphism may be a useful predictor of OS in advanced non-small cell lung cancer patients treated with platinum-based chemotherapy...
  13. doi request reprint VEGF polymorphisms and survival in early-stage non-small-cell lung cancer
    Rebecca Suk Heist
    Massachusetts General Hospital, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    J Clin Oncol 26:856-62. 2008
    ..Polymorphisms in the VEGF gene have been identified that are believed to have functional activity. We hypothesized that such polymorphisms may affect survival outcomes among early-stage non-small-cell lung cancer (NSCLC) patients...
  14. ncbi request reprint P53 (codon 72) and P21 (codon 31) polymorphisms alter in vivo mRNA expression of p21
    Li Su
    Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Lung Cancer 40:259-66. 2003
    ..Results were consistent in both patients with lung cancer (n=63) and in normal controls (n=21). In conclusion, the presence of a p53 Pro allele and/or p21 Arg allele is associated with lower downstream target gene expression of p21...
  15. ncbi request reprint Gene-smoking interaction associations for the ERCC1 polymorphisms in the risk of lung cancer
    Wei Zhou
    Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 14:491-6. 2005
    ..In conclusion, ERCC1 8092C > A polymorphism may modify the associations between cumulative cigarette smoking and lung cancer risk...
  16. pmc Apoptosis gene polymorphisms, age, smoking and the risk of non-small cell lung cancer
    Monica Ter-Minassian
    Department of Environmental Health, Harvard School of Public Health, Boston 02115, MA, USA
    Carcinogenesis 29:2147-52. 2008
    ..24, P(gender) = 0.17). No interactions were observed for FAS -1377 G>A and BAT3 Ser625Pro polymorphisms. Our findings indicate that age and smoking may modify the association of the FASLG -844 and IL1B + 3954 SNPs with the risk of NSCLC...
  17. ncbi request reprint Matrix metalloproteinase-1 promoter polymorphism and lung cancer risk
    Li Su
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 14:567-70. 2005
    ..00-1.75; 1G/2G) and 1.23 (95% CI, 0.88-1.73; 2G/2G) in males, respectively. In conclusion, genotypes containing the 2G allele of the MMP-1 polymorphism are associated with higher risk of lung cancer in never-smokers and in males...
  18. ncbi request reprint No association between the p21 codon 31 serine-arginine polymorphism and lung cancer risk
    Li Su
    Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 12:174-5. 2003
  19. ncbi request reprint Inhibitor kappaB-alpha haplotype GTC is associated with susceptibility to acute respiratory distress syndrome in Caucasians
    Rihong Zhai
    Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    Crit Care Med 35:893-8. 2007
    ..Inhibitor kappaB-alpha (NFKBIA) inhibits NF-kappaB and controls its activities. The objective was to determine whether polymorphisms in NFKBIA gene would be associated with ARDS development...
  20. ncbi request reprint Second hand smoke exposure and survival in early-stage non-small-cell lung cancer patients
    Wei Zhou
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Clin Cancer Res 12:7187-93. 2006
    ..Second hand smoke (SHS) exposure is associated with higher risk of lung cancer. However, the role of SHS in lung cancer survival is not clear...
  21. ncbi request reprint XRCC1 and XPD polymorphisms and esophageal adenocarcinoma risk
    Geoffrey Liu
    Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Carcinogenesis 28:1254-8. 2007
    ..No relationships were found for the XPD Asp312Asn polymorphism. We conclude that combined NER and BER pathways are important to the development of EA...
  22. ncbi request reprint Genotypes and haplotypes of matrix metalloproteinase 1, 3 and 12 genes and the risk of lung cancer
    Li Su
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Carcinogenesis 27:1024-9. 2006
    ..62-8.20) when compared with the most common 1G-5A-82A-1082A haplotype. In conclusion, the combined MMP genotypes and associated haplotypes may be associated with higher risk of lung cancer, particularly among never smokers and men...
  23. ncbi request reprint MDM2 polymorphism, survival, and histology in early-stage non-small-cell lung cancer
    Rebecca Suk Heist
    Massachusetts General Hospital, Boston, MA, USA
    J Clin Oncol 25:2243-7. 2007
    ..We hypothesized that the MDM2 G/G genotype may be associated with worse survival outcomes in lung cancer, especially in squamous cell cancers where p53 abnormalities are more common...
  24. ncbi request reprint Gene-environment interaction for the ERCC2 polymorphisms and cumulative cigarette smoking exposure in lung cancer
    Wei Zhou
    Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer Res 62:1377-81. 2002
    ..A stronger gene-smoking interaction was observed for the Asp312Asn polymorphism than for the Lys751Gln polymorphism. In conclusion, cumulative cigarette smoking modifies the associations between ERCC2 polymorphisms and lung cancer risk...
  25. pmc Genotyping patients with recent blood transfusions
    Michelle Ng Gong
    Pulmonary and Critical Care Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Epidemiology 14:744-7. 2003
    ..To investigate this possibility, we assayed DNA extracted from the blood and buccal cells of ICU patients for 2 common polymorphisms in the TNF-beta gene and the surfactant protein-B (SP-B) gene...
  26. ncbi request reprint Vitamin D is associated with improved survival in early-stage non-small cell lung cancer patients
    Wei Zhou
    Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 14:2303-9. 2005
    ..In conclusion, the joint effects of surgery season and recent vitamin D intake seem to be associated with the survival of early-stage non-small cell lung cancer patients...
  27. pmc Polymorphisms in the mannose binding lectin-2 gene and acute respiratory distress syndrome
    Michelle N Gong
    Pulmonary and Critical Care Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA
    Crit Care Med 35:48-56. 2007
    ..We postulate that the variant MBL-2 genotypes are associated with increased susceptibility to and mortality in acute respiratory distress syndrome (ARDS)...
  28. ncbi request reprint Susceptibility to arsenic-induced skin lesions from polymorphisms in base excision repair genes
    Carrie V Breton
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Carcinogenesis 28:1520-5. 2007
    ..Future research on arsenic-induced skin lesions should consider the impact of genetic variation to individual susceptibility to arsenic toxicity...
  29. ncbi request reprint Molecular epidemiology of non-small cell lung cancer
    Geoffrey Liu
    Harvard Medical School, Boston, MA 02115, USA
    Semin Respir Crit Care Med 26:265-72. 2005
    ..Molecular epidemiological studies are now focused on building larger databases from existing smaller studies and developing strategies to simultaneously evaluate multiple polymorphisms and genes within the same pathway...
  30. pmc Haplotypes of estrogen receptor-beta and risk of non-small cell lung cancer in women
    Jessica K Paulus
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Lung Cancer 71:258-63. 2011
    ..Our findings indicate that ESR2 is not associated with risk of lung cancer in women...
  31. ncbi request reprint Genetic polymorphisms in N-acetyltransferase-2 and microsomal epoxide hydrolase, cumulative cigarette smoking, and lung cancer
    Wei Zhou
    Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 11:15-21. 2002
    ..The joint effects of NAT2 and mEH polymorphisms are consistent with an independent, additive effect of these two genes, modified by smoking history...
  32. ncbi request reprint Utility of the WHO neurobehavioral core test battery in Chinese workers-a meta-analysis
    Wei Zhou
    Department of Environmental Health, Harvard School of Public Health, Occupational Health Program, 665 Huntington Avenue, Boston, Massachusetts, 02115, USA
    Environ Res 88:94-102. 2002
    ..6 (7.5-13.7), respectively. For organic solvents-exposure, Digit Span, Pursuit Aiming II, and Digit Symbol were the most sensitive subtests, with effect sizes (95- CI) of 4.7 (3.3-6.1), 4.6 (3.1-6.1), and 4.1 (2.7-5.5), respectively...
  33. ncbi request reprint TLR4 Asp299Gly and Thr399Ile polymorphisms are very rare in the Chinese population
    Jingqing Hang
    Shanghai Putuo District People s Hospital, Shanghai, China
    J Endotoxin Res 10:238-40. 2004
    ..Our results suggest that the TLR4 Asp299Gly and Thr339Ile polymorphisms are very rare in the Chinese population...
  34. ncbi request reprint Microsomal epoxide hydrolase, endotoxin, and lung function decline in cotton textile workers
    Jingqing Hang
    Shanghai Putuo Districs People s Hospital, Shanghai, China
    Am J Respir Crit Care Med 171:165-70. 2005
    ..33) ml for Arg/Arg + His/Arg and His/His genotypes, respectively, for the His139Arg polymorphism. We conclude that mEH polymorphisms modify the association between occupational endotoxin exposure and longitudinal lung function decline...
  35. pmc TNF polymorphisms modify endotoxin exposure-associated longitudinal lung function decline
    Hongxi Zhang
    Shanghai Putuo District People s Hospital, Shanghai, China
    Occup Environ Med 64:409-13. 2007
    ..This study was conducted to investigate whether TNF polymorphisms modify the effect of endotoxin exposure on chronic declines in lung function...
  36. ncbi request reprint Polymorphisms in XPD (Asp312Asn and Lys751Gln) genes, sunburn and arsenic-related skin lesions
    Kathleen M McCarty
    Department of Epidemiology and Public Health, Division of Environmental Health Sciences, Yale University School of Medicine, Epidemiology and Public Health, New Haven, CT, 06520 USA
    Carcinogenesis 28:1697-702. 2007
    ....
  37. ncbi request reprint Genetic polymorphisms of MDM2, cumulative cigarette smoking and nonsmall cell lung cancer risk
    Geoffrey Liu
    Applied Molecular Oncology Department of Medicine, Ontario Cancer Institute Princess Margaret Hospital, University of Toronto, Toronto, ON, Canada
    Int J Cancer 122:915-8. 2008
    ..63 (0.4-1.1), respectively, for never, mild (<30 pack-years), moderate (30-57 pack-years) and heavy smokers (>or=58 pack-years). In conclusion, a strong gene-smoking interaction was observed between the MDM2 SNP309 and NSCLC risk...
  38. doi request reprint Vascular endothelial growth factor genotypes, haplotypes, gender, and the risk of non-small cell lung cancer
    Rihong Zhai
    Department of Environmental Health, Princess Margaret Hospital Ontario Cancer Institute, University of Toronto, Toronto, Ontario, Canada
    Clin Cancer Res 14:612-7. 2008
    ..In this large case-control study, we investigated whether functional polymorphisms (-460C/T, +405C/G, +936C/T) in the VEGF gene are associated with the risk of non-small cell lung cancer (NSCLC)...
  39. ncbi request reprint XPD and XRCC1 genetic polymorphisms are prognostic factors in advanced non-small-cell lung cancer patients treated with platinum chemotherapy
    Sarada Gurubhagavatula
    Department of Medicine, Massachusetts General Hospital, Boston, MA USA
    J Clin Oncol 22:2594-601. 2004
    ..Genetic polymorphisms of DNA repair genes are associated with differential DNA repair activity and may explain interindividual differences in overall survival after therapy with platinum agents for non-small-cell lung cancer (NSCLC)...
  40. ncbi request reprint Allelic variations in gene expression
    Hai Yan
    Duke University Medical Center, Department of Pathology, Durham, North Carolina 27710, USA
    Curr Opin Oncol 16:39-43. 2004
    ..Thus, it has been hypothesized that the study of natural differential expression presenting within and among populations may enhance understanding of human phenotypic variation...
  41. doi request reprint A rapid outcomes ascertainment system improves the quality of prognostic and pharmacogenetic outcomes from observational studies
    Penelope A Bradbury
    Princess Margaret Hospital Ontario Cancer Institute, 610 University Avenue, Toronto, Ontario, Canada
    Cancer Epidemiol Biomarkers Prev 17:204-11. 2008
    ..Using clinical trial and epidemiologic methods, we assessed the quality of prognostic and outcomes data obtainable from a large case-control study of lung cancer...
  42. doi request reprint Myeloperoxidase and superoxide dismutase polymorphisms are associated with an increased risk of developing pancreatic adenocarcinoma
    Paul Wheatley-Price
    Department of Medical Oncology and Hematology, Department of Medicine, Princess Margaret Hospital, Toronto, Ontario, Canada
    Cancer 112:1037-42. 2008
    ..Myeloperoxidase (MPO) and superoxide dismutase (SOD2) are enzymes that regulate reactive oxygen species and contain recognized single nucleotide polymorphisms (SNPs) that confer altered enzyme activity...
  43. doi request reprint The tumor suppressor LKB1 regulates lung cancer cell polarity by mediating cdc42 recruitment and activity
    Shumin Zhang
    Department of Hematology and Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia 30043, USA
    Cancer Res 68:740-8. 2008
    ..Taken together, these results show that LKB1 is a critical mediator of the NSCLC polarity program in lung cancer cells through a novel LKB1-cdc42-PAK pathway...
  44. ncbi request reprint Counting alleles to predict recurrence of early-stage colorectal cancers
    Wei Zhou
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Lancet 359:219-25. 2002
    ..However, measurements of such imbalances are difficult. We used a new, quantitative approach to investigate the prognostic value of chromosome imbalances in early-stage colorectal cancers...
  45. doi request reprint Ultrasound criteria for severe in-stent restenosis following carotid artery stenting
    Wei Zhou
    Division of Vascular and Endovascular Surgery, Department of Surgery, Stanford University, 300 Pasteur Drive, Stanford, CA 94305, USA
    J Vasc Surg 47:74-80. 2008
    ..However, ultrasound criteria determining ISR are not well established. We evaluated alternative ultrasound velocity criteria for >70% ISR in our institution...
  46. ncbi request reprint Frequent inactivation of RAMP2, EFEMP1 and Dutt1 in lung cancer by promoter hypermethylation
    Wen Yue
    Department of Pharmacology, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Clin Cancer Res 13:4336-44. 2007
    ..The goal of this study is to identify novel genes frequently silenced by promoter hypermethylation in lung cancer...
  47. ncbi request reprint Determinants of mortality and treatment outcome following surgical interventions for acute mesenteric ischemia
    Panagiotis Kougias
    Division of Vascular Surgery and Endovascular Therapy, Michael E DeBakey Department of Surgery, Baylor College of Medicine and the Michael E DeBakey VA Medical Center, Houston, TX 77030, USA
    J Vasc Surg 46:467-74. 2007
    ..The purpose of this study was to review our experience of surgical management in patients with this condition and to identify variables associated with adverse outcomes following surgical interventions...
  48. pmc SnoRNA U50 is a candidate tumor-suppressor gene at 6q14.3 with a mutation associated with clinically significant prostate cancer
    Xue Yuan Dong
    Winship Cancer Institute, Emory University School of Medicine, 1365 Clifton Road, Atlanta, GA 30322, USA
    Hum Mol Genet 17:1031-42. 2008
    ..9; 95% confidence interval 1.17-7.21). These findings establish snoRNA U50 as a reasonable candidate for the 6q tumor-suppressor gene in prostate cancer and likely in other types of cancers...
  49. pmc LKB1 is necessary for Akt-mediated phosphorylation of proapoptotic proteins
    Diansheng Zhong
    The Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Cancer Res 68:7270-7. 2008
    ..This observation may explain the lack of LKB1 somatic mutations in brain, breast, and colon cancers, where Akt is frequently activated due to mutations in phosphatidylinositol 3-kinase, PTEN, or Akt itself...
  50. ncbi request reprint Counting alleles in single lesions of prostate tumors from ethnically diverse patients
    Aki Morikawa
    Emory University School of Medicine, Winship Cancer Institute, Atlanta, Georgia 30322, USA
    Prostate 68:231-40. 2008
    ..Nevertheless, it is unclear whether such disparities are due to genetic alterations that are involved in prostate cancer initiation. Here, we evaluated chromosome 8p allelic loss in a racially diverse cohort...
  51. ncbi request reprint Abdominal aortic surgery in patients with human immunodeficiency virus infection
    Peter H Lin
    Division of Vascular Surgery and Endovascular Therapy, Michael E DeBakey Department of Surgery, Baylor College of Medicine, 2002 Holcomb Blvd 112, Houston, TX 77030, USA
    Am J Surg 188:690-7. 2004
    ..This report examined the clinical outcome of patients infected with HIV who underwent abdominal aortic reconstruction for aneurysm or occlusive disease...
  52. ncbi request reprint [Characteristics of polymorphism of 129th amino acid in PRNP among Han and Uighur Chinese]
    Xingsheng Hou
    Institute of Virology, Chinese Academy of Preventive Medicine, Beijing 100052, China
    Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 16:105-8. 2002
    ..An amino acid polymorphism for Met to Val has been identified at PrP codon 129 from different human races. In this study,the characteristics of polymorphism of PRNP 129th amino acid in Han and Uighur Chinese have been investigated...
  53. ncbi request reprint [Cloning and polymorphism analysis of prtH gene from Porphyromonas gingivalis]
    Ying Zheng
    Beijing Institute of Dental Research, Beijing Hospital for Stomatology, Capital University of Medical Sciences, Beijing 100050, China
    Zhonghua Kou Qiang Yi Xue Za Zhi 38:27-30. 2003
    ..To clone the prtH gene from Porphyromonas gingivalis (P.g) ATCC 33277 and analyze the polymorphism of prtH gene from 5 strains of P.g in order to explore the relationship between P.g and periodontitis...
  54. ncbi request reprint Two variants of the human hepatocellular carcinoma-associated HCAP1 gene and their effect on the growth of the human liver cancer cell line Hep3B
    Dafang Wan
    National Laboratory for Oncogenes and Related Genes, Cancer Institute of Shanghai Jiao Tong University, People s Republic of China
    Genes Chromosomes Cancer 39:48-58. 2004
    ..This suggests that HCAP1-M may be related to cancer susceptibility...
  55. ncbi request reprint Synthesis and antitumor activity of 10-substituted benzylidene anthrone
    Weixiao Hu
    Department of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310014, PR, China
    Bioorg Med Chem Lett 14:621-2. 2004
    ..There are six compounds which appear as strong effective inhibition for A-549 cancer cell growth. This is a kind of good leading compound which is worth researching further...
  56. ncbi request reprint Surgical margin and Gleason score as predictors of postoperative recurrence in prostate cancer with or without chromosome 8p allelic imbalance
    Wei Zhou
    Department of Hematology and Oncology, Winship Cancer Institute, Emory University School of Medicine, 1365 Clifton Road NE, Atlanta, GA 30322, USA
    Prostate 61:81-91. 2004
    ..Existing pathological markers can predict disease recurrence only to a certain extent, and there is a need for more accurate predictors...
  57. ncbi request reprint [Polymorphism in intron 2 of crucian carp GH I gene]
    Sai Jun Mo
    Key Laboratory of the Ministry of Education for Developmental Biology, College of Life Science, Wuhan University, Wuhan 430072, China
    Yi Chuan Xue Bao 31:582-90. 2004
    ..Whether the length and nucleotide polymorphisms in the intron2 of crucian carp GH I gene were associated with gene expression and gene regulation remained unsolved and required further investigations...
  58. ncbi request reprint Pharmacomechanical thrombectomy for treatment of symptomatic lower extremity deep venous thrombosis: safety and feasibility study
    Ruth L Bush
    Division of Vascular Surgery and Endovascular Therapy, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA
    J Vasc Surg 40:965-70. 2004
    ..We describe a rapid and effective method of thrombus removal, with simultaneous percutaneous mechanical thrombectomy (PMT) and thrombolysis...
  59. ncbi request reprint A comparison of carotid artery stenting with neuroprotection versus carotid endarterectomy under local anesthesia
    Ruth L Bush
    Michael E DeBakey VA Medical Center, Division of Vascular Surgery and Endovascular Therapy, Houston VAMC 112, 2002 Holcomb Blvd, Baylor College of Medicine, Houston, TX 70030, USA
    Am J Surg 190:696-700. 2005
    ..In this study, we compare our results of distally protected CAS versus CEA under local anesthesia...
  60. pmc Resistance to microtubule-stabilizing drugs involves two events: beta-tubulin mutation in one allele followed by loss of the second allele
    Yuefang Wang
    Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, USA
    Cell Cycle 4:1847-53. 2005
    ..Acquired tubulin mutations in conjunction with LOH for the wt tubulin resulted in a highly resistant phenotype, revealing a new mechanism for taxane resistance...
  61. ncbi request reprint Evaluation of the ELOVL4 gene in a Chinese family with autosomal dominant STGD3-like macular dystrophy
    Zheng Lai
    Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
    J Cell Mol Med 9:961-5. 2005
    ..And IVS5-2533T-->A is never shown in the previous references. These data suggested that there exist other unknown genes responsible for the STGD3-like phenotype in the pedigree...
  62. pmc Allelic imbalances of chromosomes 8p and 18q and their roles in distant relapse of early stage, node-negative breast cancer
    Aki Morikawa
    Department of Hematology and Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA
    Breast Cancer Res 7:R1051-7. 2005
    ..Existing pathological markers can predict disease recurrence only to a certain extent, and there is a need for more accurate predictors...
  63. ncbi request reprint LKB1 mutation in large cell carcinoma of the lung
    Diansheng Zhong
    The Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 32322, USA
    Lung Cancer 53:285-94. 2006
    ..These results suggest that, in addition to adenocarcinomas, acquired loss of function mutations in LKB1 may also be frequently involved in the pathogenesis of large cell lung carcinomas...
  64. ncbi request reprint Expression analyses of 27 DNA repair genes in astrocytoma by TaqMan low-density array
    Zheng Jiang
    Laboratory of Neurosurgery, Qilu Hospital of Shandong University, Jinan 250012, China
    Neurosci Lett 409:112-7. 2006
    ..We also suggest that the down-regulation of some DNA repair genes may be associated with pathogenesis and poor prognosis of astrocytoma...
  65. ncbi request reprint Phage display particles expressing tumor-specific antigens induce preventive and therapeutic anti-tumor immunity in murine p815 model
    Yuzhang Wu
    The Institute of Immunology, The Third Medicine University, Shapingba District, Chongqing, China
    Int J Cancer 98:748-53. 2002
    ..Our results indicate that phage display particles might be a useful vaccine form for tumor-associated antigen epitopes in tumor immunotherapy...