Research Topics
Genomes and Genes
| Wei ZhouSummaryAffiliation: Harvard University Country: USA Publications
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Detail Information
Publications
Polymorphisms of vitamin D receptor and survival in early-stage non-small cell lung cancer patientsWei Zhou
Departments of Environmental Health, Occupational Health Program, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
Cancer Epidemiol Biomarkers Prev 15:2239-45. 2006..71). Similar associations were found in haplotype analysis and for RFS among SCC patients. In conclusion, VDR polymorphisms may be associated with improved survival among SCC patients of early-stage NSCLC...- Circulating 25-hydroxyvitamin D levels predict survival in early-stage non-small-cell lung cancer patientsWei Zhou
Departments of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
J Clin Oncol 25:479-85. 2007..We further investigated the results of circulating 25-hydroxyvitamin D (25[OH]D) levels on overall survival (OS) and recurrence-free survival (RFS) in NSCLC patients... - Second hand smoke exposure and survival in early-stage non-small-cell lung cancer patientsWei Zhou
Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
Clin Cancer Res 12:7187-93. 2006..Second hand smoke (SHS) exposure is associated with higher risk of lung cancer. However, the role of SHS in lung cancer survival is not clear... - The SOD2 Val/Val genotype enhances the risk of nonsmall cell lung carcinoma by p53 and XRCC1 polymorphismsGeoffrey Liu
Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Cancer 101:2802-8. 2004..p53 is a tumor suppressor gene, and X-ray cross-complementing group 1 (XRCC1) is involved in the base-excision repair of ROS-induced DNA damage... - Polymorphisms in the DNA repair genes XRCC1 and ERCC2, smoking, and lung cancer riskWei Zhou
Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Cancer Epidemiol Biomarkers Prev 12:359-65. 2003..In conclusion, cumulative cigarette smoking plays an important role in altering the direction and magnitude of the associations between the XRCC1 and ERCC2 polymorphisms and lung cancer risk... - Counterpoint: the myeloperoxidase -463G-->a polymorphism does not decrease lung cancer susceptibility in CaucasiansLi Lian Xu
Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Cancer Epidemiol Biomarkers Prev 11:1555-9. 2002..These findings are in contrast with earlier studies suggesting a protective effect of carrying the variant A allele... - Polymorphisms in ERCC1 and grade 3 or 4 toxicity in non-small cell lung cancer patientsRebecca Suk
Massachusetts General Hospital and Harvard School of Public Health, Boston, MA 02115, USA
Clin Cancer Res 11:1534-8. 2005..Polymorphisms have been identified in the ERCC1 gene, the C8092A and codon 118 polymorphisms, which may lead to an altered capacity to regenerate damaged normal tissue and greater treatment-related toxicity... - MPO and SOD2 polymorphisms, gender, and the risk of non-small cell lung carcinomaGeoffrey Liu
Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
Cancer Lett 214:69-79. 2004..For women carrying the MPO variant genotypes, the adjusted odds ratio of the SOD2 polymorphism (Val/Val vs. Ala/Ala) was 3.26 (95% CI, 1.55-6.83). No associations were found in men or in women carrying the MPO GG wildtype genotype... 
VEGF polymorphisms and survival in early-stage non-small-cell lung cancerRebecca Suk Heist
Massachusetts General Hospital, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
J Clin Oncol 26:856-62. 2008..Polymorphisms in the VEGF gene have been identified that are believed to have functional activity. We hypothesized that such polymorphisms may affect survival outcomes among early-stage non-small-cell lung cancer (NSCLC) patients...- Gene-smoking interaction associations for the ERCC1 polymorphisms in the risk of lung cancerWei Zhou
Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
Cancer Epidemiol Biomarkers Prev 14:491-6. 2005..In conclusion, ERCC1 8092C > A polymorphism may modify the associations between cumulative cigarette smoking and lung cancer risk... - Excision repair cross-complementation group 1 polymorphism predicts overall survival in advanced non-small cell lung cancer patients treated with platinum-based chemotherapyWei Zhou
Occupational Health Program, Departments of Environmental Health and Biostatistics, Harvard School of Public Health, Boston 02115, Massachusetts, USA
Clin Cancer Res 10:4939-43. 2004..9 (T/T), 16.1 (C/T), and 13.3 (C/C) months, respectively. In conclusion, the ERCC1 C8092A polymorphism may be a useful predictor of OS in advanced non-small cell lung cancer patients treated with platinum-based chemotherapy... - P53 (codon 72) and P21 (codon 31) polymorphisms alter in vivo mRNA expression of p21Li Su
Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
Lung Cancer 40:259-66. 2003..Results were consistent in both patients with lung cancer (n=63) and in normal controls (n=21). In conclusion, the presence of a p53 Pro allele and/or p21 Arg allele is associated with lower downstream target gene expression of p21... 
Apoptosis gene polymorphisms, age, smoking and the risk of non-small cell lung cancerMonica Ter-Minassian
Department of Environmental Health, Harvard School of Public Health, Boston 02115, MA, USA
Carcinogenesis 29:2147-52. 2008..24, P(gender) = 0.17). No interactions were observed for FAS -1377 G>A and BAT3 Ser625Pro polymorphisms. Our findings indicate that age and smoking may modify the association of the FASLG -844 and IL1B + 3954 SNPs with the risk of NSCLC...- Vitamin D is associated with improved survival in early-stage non-small cell lung cancer patientsWei Zhou
Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
Cancer Epidemiol Biomarkers Prev 14:2303-9. 2005..In conclusion, the joint effects of surgery season and recent vitamin D intake seem to be associated with the survival of early-stage non-small cell lung cancer patients... - Inhibitor kappaB-alpha haplotype GTC is associated with susceptibility to acute respiratory distress syndrome in CaucasiansRihong Zhai
Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
Crit Care Med 35:893-8. 2007..Inhibitor kappaB-alpha (NFKBIA) inhibits NF-kappaB and controls its activities. The objective was to determine whether polymorphisms in NFKBIA gene would be associated with ARDS development... - No association between the p21 codon 31 serine-arginine polymorphism and lung cancer riskLi Su
Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Cancer Epidemiol Biomarkers Prev 12:174-5. 2003 - Matrix metalloproteinase-1 promoter polymorphism and lung cancer riskLi Su
Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
Cancer Epidemiol Biomarkers Prev 14:567-70. 2005..00-1.75; 1G/2G) and 1.23 (95% CI, 0.88-1.73; 2G/2G) in males, respectively. In conclusion, genotypes containing the 2G allele of the MMP-1 polymorphism are associated with higher risk of lung cancer in never-smokers and in males... - Gene-environment interaction for the ERCC2 polymorphisms and cumulative cigarette smoking exposure in lung cancerWei Zhou
Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Cancer Res 62:1377-81. 2002..A stronger gene-smoking interaction was observed for the Asp312Asn polymorphism than for the Lys751Gln polymorphism. In conclusion, cumulative cigarette smoking modifies the associations between ERCC2 polymorphisms and lung cancer risk... - Matrix metalloproteinase polymorphisms and survival in stage I non-small cell lung cancerRebecca Suk Heist
Massachusetts General Hospital and Harvard School of Public Health, Boston, Massachusetts 02115, USA
Clin Cancer Res 12:5448-53. 2006..We hypothesized that polymorphisms in these MMP genes may be associated with survival outcomes in early-stage non-small cell lung cancer (NSCLC)... - Dietary iron, zinc, and calcium and the risk of lung cancerWei Zhou
Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, and the Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02115, USA
Epidemiology 16:772-9. 2005..CONCLUSIONS: Dietary iron, zinc, and calcium may play an important role in the development of lung cancer, especially among current smokers. These results need to be confirmed in large prospective studies... - XRCC1 and XPD polymorphisms and esophageal adenocarcinoma riskGeoffrey Liu
Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
Carcinogenesis 28:1254-8. 2007..No relationships were found for the XPD Asp312Asn polymorphism. We conclude that combined NER and BER pathways are important to the development of EA... - Smoking cessation before diagnosis and survival in early stage non-small cell lung cancer patientsWei Zhou
Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
Lung Cancer 53:375-80. 2006..In conclusion, smoking cessation is associated with improved survival in early stage NSCLC patients. The longer the time since cessation of smoking, the better the survival outcome... - Genotypes and haplotypes of matrix metalloproteinase 1, 3 and 12 genes and the risk of lung cancerLi Su
Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
Carcinogenesis 27:1024-9. 2006..62-8.20) when compared with the most common 1G-5A-82A-1082A haplotype. In conclusion, the combined MMP genotypes and associated haplotypes may be associated with higher risk of lung cancer, particularly among never smokers and men... - MDM2 polymorphism, survival, and histology in early-stage non-small-cell lung cancerRebecca Suk Heist
Massachusetts General Hospital, Boston, MA, USA
J Clin Oncol 25:2243-7. 2007..We hypothesized that the MDM2 G/G genotype may be associated with worse survival outcomes in lung cancer, especially in squamous cell cancers where p53 abnormalities are more common... - MDM2 promoter polymorphism and pancreatic cancer risk and prognosisKofi Asomaning
Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
Clin Cancer Res 14:4010-5. 2008..We hypothesized that the G allele is also associated with increased risk and worse outcome in pancreatic cancer... - Genotyping patients with recent blood transfusionsMichelle Ng Gong
Pulmonary and Critical Care Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
Epidemiology 14:744-7. 2003..To investigate this possibility, we assayed DNA extracted from the blood and buccal cells of ICU patients for 2 common polymorphisms in the TNF-beta gene and the surfactant protein-B (SP-B) gene... - Polymorphisms in the mannose binding lectin-2 gene and acute respiratory distress syndromeMichelle N Gong
Pulmonary and Critical Care Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA
Crit Care Med 35:48-56. 2007..We postulate that the variant MBL-2 genotypes are associated with increased susceptibility to and mortality in acute respiratory distress syndrome (ARDS)... - Genetic polymorphisms in N-acetyltransferase-2 and microsomal epoxide hydrolase, cumulative cigarette smoking, and lung cancerWei Zhou
Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
Cancer Epidemiol Biomarkers Prev 11:15-21. 2002..The joint effects of NAT2 and mEH polymorphisms are consistent with an independent, additive effect of these two genes, modified by smoking history... - Susceptibility to arsenic-induced skin lesions from polymorphisms in base excision repair genesCarrie V Breton
Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
Carcinogenesis 28:1520-5. 2007..Future research on arsenic-induced skin lesions should consider the impact of genetic variation to individual susceptibility to arsenic toxicity... - Haplotypes of estrogen receptor-beta and risk of non-small cell lung cancer in womenJessica K Paulus
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
Lung Cancer 71:258-63. 2011..Our findings indicate that ESR2 is not associated with risk of lung cancer in women... - Molecular epidemiology of non-small cell lung cancerGeoffrey Liu
Harvard Medical School, Boston, MA 02115, USA
Semin Respir Crit Care Med 26:265-72. 2005..Molecular epidemiological studies are now focused on building larger databases from existing smaller studies and developing strategies to simultaneously evaluate multiple polymorphisms and genes within the same pathway... - Utility of the WHO neurobehavioral core test battery in Chinese workers-a meta-analysisWei Zhou
Department of Environmental Health, Harvard School of Public Health, Occupational Health Program, 665 Huntington Avenue, Boston, Massachusetts, 02115, USA
Environ Res 88:94-102. 2002..6 (7.5-13.7), respectively. For organic solvents-exposure, Digit Span, Pursuit Aiming II, and Digit Symbol were the most sensitive subtests, with effect sizes (95- CI) of 4.7 (3.3-6.1), 4.6 (3.1-6.1), and 4.1 (2.7-5.5), respectively... - TLR4 Asp299Gly and Thr399Ile polymorphisms are very rare in the Chinese populationJingqing Hang
Shanghai Putuo District People s Hospital, Shanghai, China
J Endotoxin Res 10:238-40. 2004..Our results suggest that the TLR4 Asp299Gly and Thr339Ile polymorphisms are very rare in the Chinese population... - TNF polymorphisms modify endotoxin exposure-associated longitudinal lung function declineHongxi Zhang
Shanghai Putuo District People s Hospital, Shanghai, China
Occup Environ Med 64:409-13. 2007..This study was conducted to investigate whether TNF polymorphisms modify the effect of endotoxin exposure on chronic declines in lung function... - Polymorphisms in XPD (Asp312Asn and Lys751Gln) genes, sunburn and arsenic-related skin lesionsKathleen M McCarty
Department of Epidemiology and Public Health, Division of Environmental Health Sciences, Yale University School of Medicine, Epidemiology and Public Health, New Haven, CT, 06520 USA
Carcinogenesis 28:1697-702. 2007.... - Genetic polymorphisms of MDM2, cumulative cigarette smoking and nonsmall cell lung cancer riskGeoffrey Liu
Applied Molecular Oncology Department of Medicine, Ontario Cancer Institute Princess Margaret Hospital, University of Toronto, Toronto, ON, Canada
Int J Cancer 122:915-8. 2008..63 (0.4-1.1), respectively, for never, mild (<30 pack-years), moderate (30-57 pack-years) and heavy smokers (>or=58 pack-years). In conclusion, a strong gene-smoking interaction was observed between the MDM2 SNP309 and NSCLC risk... - Microsomal epoxide hydrolase, endotoxin, and lung function decline in cotton textile workersJingqing Hang
Shanghai Putuo Districs People s Hospital, Shanghai, China
Am J Respir Crit Care Med 171:165-70. 2005..33) ml for Arg/Arg + His/Arg and His/His genotypes, respectively, for the His139Arg polymorphism. We conclude that mEH polymorphisms modify the association between occupational endotoxin exposure and longitudinal lung function decline... - Vascular endothelial growth factor genotypes, haplotypes, gender, and the risk of non-small cell lung cancerRihong Zhai
Department of Environmental Health, Princess Margaret Hospital Ontario Cancer Institute, University of Toronto, Toronto, Ontario, Canada
Clin Cancer Res 14:612-7. 2008..In this large case-control study, we investigated whether functional polymorphisms (-460C/T, +405C/G, +936C/T) in the VEGF gene are associated with the risk of non-small cell lung cancer (NSCLC)... - XPD and XRCC1 genetic polymorphisms are prognostic factors in advanced non-small-cell lung cancer patients treated with platinum chemotherapySarada Gurubhagavatula
Department of Medicine, Massachusetts General Hospital, Boston, MA USA
J Clin Oncol 22:2594-601. 2004..Genetic polymorphisms of DNA repair genes are associated with differential DNA repair activity and may explain interindividual differences in overall survival after therapy with platinum agents for non-small-cell lung cancer (NSCLC)... - A rapid outcomes ascertainment system improves the quality of prognostic and pharmacogenetic outcomes from observational studiesPenelope A Bradbury
Princess Margaret Hospital Ontario Cancer Institute, 610 University Avenue, Toronto, Ontario, Canada
Cancer Epidemiol Biomarkers Prev 17:204-11. 2008..Using clinical trial and epidemiologic methods, we assessed the quality of prognostic and outcomes data obtainable from a large case-control study of lung cancer... - Allelic variations in gene expressionHai Yan
Duke University Medical Center, Department of Pathology, Durham, North Carolina 27710, USA
Curr Opin Oncol 16:39-43. 2004..Thus, it has been hypothesized that the study of natural differential expression presenting within and among populations may enhance understanding of human phenotypic variation... - Counting alleles in single lesions of prostate tumors from ethnically diverse patientsAki Morikawa
Emory University School of Medicine, Winship Cancer Institute, Atlanta, Georgia 30322, USA
Prostate 68:231-40. 2008..Nevertheless, it is unclear whether such disparities are due to genetic alterations that are involved in prostate cancer initiation. Here, we evaluated chromosome 8p allelic loss in a racially diverse cohort... - The tumor suppressor LKB1 regulates lung cancer cell polarity by mediating cdc42 recruitment and activityShumin Zhang
Department of Hematology and Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia 30043, USA
Cancer Res 68:740-8. 2008..Taken together, these results show that LKB1 is a critical mediator of the NSCLC polarity program in lung cancer cells through a novel LKB1-cdc42-PAK pathway... - Counting alleles to predict recurrence of early-stage colorectal cancersWei Zhou
Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
Lancet 359:219-25. 2002..002). INTERPRETATION: In patients without metastasis, allelic imbalance is a better predictor of prognosis than histopathological stage... - SnoRNA U50 is a candidate tumor-suppressor gene at 6q14.3 with a mutation associated with clinically significant prostate cancerXue Yuan Dong
Winship Cancer Institute, Emory University School of Medicine, 1365 Clifton Road, Atlanta, GA 30322, USA
Hum Mol Genet 17:1031-42. 2008..9; 95% confidence interval 1.17-7.21). These findings establish snoRNA U50 as a reasonable candidate for the 6q tumor-suppressor gene in prostate cancer and likely in other types of cancers... - Frequent inactivation of RAMP2, EFEMP1 and Dutt1 in lung cancer by promoter hypermethylationWen Yue
Department of Pharmacology, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
Clin Cancer Res 13:4336-44. 2007..The goal of this study is to identify novel genes frequently silenced by promoter hypermethylation in lung cancer... - Determinants of mortality and treatment outcome following surgical interventions for acute mesenteric ischemiaPanagiotis Kougias
Division of Vascular Surgery and Endovascular Therapy, Michael E DeBakey Department of Surgery, Baylor College of Medicine and the Michael E DeBakey VA Medical Center, Houston, TX 77030, USA
J Vasc Surg 46:467-74. 2007..The purpose of this study was to review our experience of surgical management in patients with this condition and to identify variables associated with adverse outcomes following surgical interventions... - LKB1 is necessary for Akt-mediated phosphorylation of proapoptotic proteinsDiansheng Zhong
The Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Cancer Res 68:7270-7. 2008..This observation may explain the lack of LKB1 somatic mutations in brain, breast, and colon cancers, where Akt is frequently activated due to mutations in phosphatidylinositol 3-kinase, PTEN, or Akt itself... - Ultrasound criteria for severe in-stent restenosis following carotid artery stentingWei Zhou
Division of Vascular and Endovascular Surgery, Department of Surgery, Stanford University, 300 Pasteur Drive, Stanford, CA 94305, USA
J Vasc Surg 47:74-80. 2008..However, ultrasound criteria determining ISR are not well established. We evaluated alternative ultrasound velocity criteria for >70% ISR in our institution... - Myeloperoxidase and superoxide dismutase polymorphisms are associated with an increased risk of developing pancreatic adenocarcinomaPaul Wheatley-Price
Department of Medical Oncology and Hematology, Department of Medicine, Princess Margaret Hospital, Toronto, Ontario, Canada
Cancer 112:1037-42. 2008..Myeloperoxidase (MPO) and superoxide dismutase (SOD2) are enzymes that regulate reactive oxygen species and contain recognized single nucleotide polymorphisms (SNPs) that confer altered enzyme activity... - Abdominal aortic surgery in patients with human immunodeficiency virus infectionPeter H Lin
Division of Vascular Surgery and Endovascular Therapy, Michael E DeBakey Department of Surgery, Baylor College of Medicine, 2002 Holcomb Blvd 112, Houston, TX 77030, USA
Am J Surg 188:690-7. 2004..This report examined the clinical outcome of patients infected with HIV who underwent abdominal aortic reconstruction for aneurysm or occlusive disease... - [Characteristics of polymorphism of 129th amino acid in PRNP among Han and Uighur Chinese]Xingsheng Hou
Institute of Virology, Chinese Academy of Preventive Medicine, Beijing 100052, China
Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 16:105-8. 2002..0005),but there was no difference with Japanese (P=0.5040). CONCLUSIONS: The polymorphism of 129th amino acid in PRNP of Han Chinese is similar to Japanese, but different from Uighur Chinese... - [Cloning and polymorphism analysis of prtH gene from Porphyromonas gingivalis]Ying Zheng
Beijing Institute of Dental Research, Beijing Hospital for Stomatology, Capital University of Medical Sciences, Beijing 100050, China
Zhonghua Kou Qiang Yi Xue Za Zhi 38:27-30. 2003..g strains. This polymorphism may indicate various potential virulent effects during the infection and pathogenesis. Established PCR protocol is sensitive for identification of prtH gene... - Two variants of the human hepatocellular carcinoma-associated HCAP1 gene and their effect on the growth of the human liver cancer cell line Hep3BDafang Wan
National Laboratory for Oncogenes and Related Genes, Cancer Institute of Shanghai Jiao Tong University, People s Republic of China
Genes Chromosomes Cancer 39:48-58. 2004..This suggests that HCAP1-M may be related to cancer susceptibility... - Synthesis and antitumor activity of 10-substituted benzylidene anthroneWeixiao Hu
Department of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310014, PR, China
Bioorg Med Chem Lett 14:621-2. 2004..There are six compounds which appear as strong effective inhibition for A-549 cancer cell growth. This is a kind of good leading compound which is worth researching further... - Surgical margin and Gleason score as predictors of postoperative recurrence in prostate cancer with or without chromosome 8p allelic imbalanceWei Zhou
Department of Hematology and Oncology, Winship Cancer Institute, Emory University School of Medicine, 1365 Clifton Road NE, Atlanta, GA 30322, USA
Prostate 61:81-91. 2004..Existing pathological markers can predict disease recurrence only to a certain extent, and there is a need for more accurate predictors... - [Polymorphism in intron 2 of crucian carp GH I gene]Sai-Jun Mo
Key Laboratory of the Ministry of Education for Developmental Biology, College of Life Science, Wuhan University, Wuhan 430072, China
Yi Chuan Xue Bao 31:582-90. 2004..Whether the length and nucleotide polymorphisms in the intron2 of crucian carp GH I gene were associated with gene expression and gene regulation remained unsolved and required further investigations... - Pharmacomechanical thrombectomy for treatment of symptomatic lower extremity deep venous thrombosis: safety and feasibility studyRuth L Bush
Division of Vascular Surgery and Endovascular Therapy, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA
J Vasc Surg 40:965-70. 2004..We describe a rapid and effective method of thrombus removal, with simultaneous percutaneous mechanical thrombectomy (PMT) and thrombolysis... - A comparison of carotid artery stenting with neuroprotection versus carotid endarterectomy under local anesthesiaRuth L Bush
Michael E DeBakey VA Medical Center, Division of Vascular Surgery and Endovascular Therapy, Houston VAMC 112, 2002 Holcomb Blvd, Baylor College of Medicine, Houston, TX 70030, USA
Am J Surg 190:696-700. 2005..In this study, we compare our results of distally protected CAS versus CEA under local anesthesia... - Resistance to microtubule-stabilizing drugs involves two events: beta-tubulin mutation in one allele followed by loss of the second alleleYuefang Wang
Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, USA
Cell Cycle 4:1847-53. 2005..Acquired tubulin mutations in conjunction with LOH for the wt tubulin resulted in a highly resistant phenotype, revealing a new mechanism for taxane resistance... - Evaluation of the ELOVL4 gene in a Chinese family with autosomal dominant STGD3-like macular dystrophyZheng Lai
Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
J Cell Mol Med 9:961-5. 2005..And IVS5-2533T-->A is never shown in the previous references. These data suggested that there exist other unknown genes responsible for the STGD3-like phenotype in the pedigree... - Allelic imbalances of chromosomes 8p and 18q and their roles in distant relapse of early stage, node-negative breast cancerAki Morikawa
Department of Hematology and Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA
Breast Cancer Res 7:R1051-7. 2005..Existing pathological markers can predict disease recurrence only to a certain extent, and there is a need for more accurate predictors... - LKB1 mutation in large cell carcinoma of the lungDiansheng Zhong
The Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 32322, USA
Lung Cancer 53:285-94. 2006..These results suggest that, in addition to adenocarcinomas, acquired loss of function mutations in LKB1 may also be frequently involved in the pathogenesis of large cell lung carcinomas... - Expression analyses of 27 DNA repair genes in astrocytoma by TaqMan low-density arrayZheng Jiang
Laboratory of Neurosurgery, Qilu Hospital of Shandong University, Jinan 250012, China
Neurosci Lett 409:112-7. 2006..We also suggest that the down-regulation of some DNA repair genes may be associated with pathogenesis and poor prognosis of astrocytoma... - Phage display particles expressing tumor-specific antigens induce preventive and therapeutic anti-tumor immunity in murine p815 modelYuzhang Wu
The Institute of Immunology, The Third Medicine University, Shapingba District, Chongqing, China
Int J Cancer 98:748-53. 2002..Our results indicate that phage display particles might be a useful vaccine form for tumor-associated antigen epitopes in tumor immunotherapy...