Jin Rong Zhou

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Soy and the prevention of lifestyle-related diseases
    Jin Rong Zhou
    Nutrition Metabolism Laboratory, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Clin Exp Pharmacol Physiol 31:S14-9. 2004
  2. ncbi request reprint Symposium introduction: metabolic syndrome and the onset of cancer
    Jin Rong Zhou
    Division of Nutrition, Harvard Medical School, Boston, MA, USA
    Am J Clin Nutr 86:s817-9. 2007
  3. pmc Dietary soy and tea combinations for prevention of breast and prostate cancers by targeting metabolic syndrome elements in mice
    Jin Rong Zhou
    Nutrition and Metabolism Laboratory, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Am J Clin Nutr 86:s882-8. 2007
  4. pmc Combined inhibition of estrogen-dependent human breast carcinoma by soy and tea bioactive components in mice
    Jin Rong Zhou
    Nutrition Metabolism Laboratory, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Int J Cancer 108:8-14. 2004
  5. pmc Progression to androgen-independent LNCaP human prostate tumors: cellular and molecular alterations
    Jin Rong Zhou
    Nutrition Metabolism Laboratory, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Burlington 554B, Boston, MA 02215, USA
    Int J Cancer 110:800-6. 2004
  6. pmc Inhibition of orthotopic growth and metastasis of androgen-sensitive human prostate tumors in mice by bioactive soybean components
    Jin Rong Zhou
    Nutrition Metabolism Laboratory, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Prostate 53:143-53. 2002
  7. pmc Soy phytochemicals prevent orthotopic growth and metastasis of bladder cancer in mice by alterations of cancer cell proliferation and apoptosis and tumor angiogenesis
    Ajita V Singh
    Nutrition Metabolism Laboratory, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Cancer Res 66:1851-8. 2006
  8. pmc NF-kappa B-mediated repression of growth arrest- and DNA-damage-inducible proteins 45alpha and gamma is essential for cancer cell survival
    Luiz F Zerbini
    Beth Israel Deaconess Medical Center Genomics Center and New England Baptist Bone and Joint Institute, 4 Blackfan Circle, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 101:13618-23. 2004
  9. ncbi request reprint Genistein inhibits tamoxifen effects on cell proliferation and cell cycle arrest in T47D breast cancer cells
    Julie L Jones
    Department of Surgery, University of Tennessee Medical Center, Knoxville 37920 6999, USA
    Am Surg 68:575-7; discussion 577-8. 2002
  10. pmc Soy phytochemicals and tea bioactive components synergistically inhibit androgen-sensitive human prostate tumors in mice
    Jin Rong Zhou
    Nutrition Metabolism Laboratory, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    J Nutr 133:516-21. 2003

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Soy and the prevention of lifestyle-related diseases
    Jin Rong Zhou
    Nutrition Metabolism Laboratory, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Clin Exp Pharmacol Physiol 31:S14-9. 2004
    ..4. Epidemiological investigations and intervention studies suggest that some soy products are effective for the relief of menopausal symptoms...
  2. ncbi request reprint Symposium introduction: metabolic syndrome and the onset of cancer
    Jin Rong Zhou
    Division of Nutrition, Harvard Medical School, Boston, MA, USA
    Am J Clin Nutr 86:s817-9. 2007
    ..Furthermore, it will help to guide the development of effective cancer prevention strategies via nutritional and lifestyle modifications to alleviate metabolic syndrome...
  3. pmc Dietary soy and tea combinations for prevention of breast and prostate cancers by targeting metabolic syndrome elements in mice
    Jin Rong Zhou
    Nutrition and Metabolism Laboratory, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Am J Clin Nutr 86:s882-8. 2007
    ..The combination of soy with tea was shown to have synergistic effects on preventing breast and prostate tumors, but the effects of soy and tea combinations on metabolic syndrome-related elements have not been investigated...
  4. pmc Combined inhibition of estrogen-dependent human breast carcinoma by soy and tea bioactive components in mice
    Jin Rong Zhou
    Nutrition Metabolism Laboratory, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Int J Cancer 108:8-14. 2004
    ..Our study suggests that dietary SPC plus GT may be used as a potential effective dietary regimen for inhibiting progression of estrogen-dependent breast cancer...
  5. pmc Progression to androgen-independent LNCaP human prostate tumors: cellular and molecular alterations
    Jin Rong Zhou
    Nutrition Metabolism Laboratory, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Burlington 554B, Boston, MA 02215, USA
    Int J Cancer 110:800-6. 2004
    ....
  6. pmc Inhibition of orthotopic growth and metastasis of androgen-sensitive human prostate tumors in mice by bioactive soybean components
    Jin Rong Zhou
    Nutrition Metabolism Laboratory, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Prostate 53:143-53. 2002
    ..Animal models that emulate human prostate cancer allow experimental analysis of the mechanisms of action of nutritional agents that show anti-prostate cancer activity...
  7. pmc Soy phytochemicals prevent orthotopic growth and metastasis of bladder cancer in mice by alterations of cancer cell proliferation and apoptosis and tumor angiogenesis
    Ajita V Singh
    Nutrition Metabolism Laboratory, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Cancer Res 66:1851-8. 2006
    ..This orthotopic human bladder tumor model also provides a clinically relevant experimental tool for assessing potential preventive activity of other dietary components against bladder tumor growth and metastasis...
  8. pmc NF-kappa B-mediated repression of growth arrest- and DNA-damage-inducible proteins 45alpha and gamma is essential for cancer cell survival
    Luiz F Zerbini
    Beth Israel Deaconess Medical Center Genomics Center and New England Baptist Bone and Joint Institute, 4 Blackfan Circle, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 101:13618-23. 2004
    ..These results establish an unambiguous role for the GADD45 family as an essential mediator of cell survival in cancer cells with implications for cancer chemotherapy and novel drug discovery...
  9. ncbi request reprint Genistein inhibits tamoxifen effects on cell proliferation and cell cycle arrest in T47D breast cancer cells
    Julie L Jones
    Department of Surgery, University of Tennessee Medical Center, Knoxville 37920 6999, USA
    Am Surg 68:575-7; discussion 577-8. 2002
    ..Genistein reversed the inhibitory effects of tamoxifen on both proliferation and G1 arrest. Thus low-dose genistein was able to inhibit the therapeutic effects of tamoxifen in this postmenopausal model of breast cancer...
  10. pmc Soy phytochemicals and tea bioactive components synergistically inhibit androgen-sensitive human prostate tumors in mice
    Jin Rong Zhou
    Nutrition Metabolism Laboratory, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    J Nutr 133:516-21. 2003
    ..This study suggests that further research is warranted to study the role of soy and tea combination as effective nutritional regimens in prostate cancer prevention...
  11. pmc Soy phytochemicals synergistically enhance the preventive effect of tamoxifen on the growth of estrogen-dependent human breast carcinoma in mice
    Zhiming Mai
    Nutrition Metabolism Laboratory, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Burlington 5, Boston, MA 02215, USA
    Carcinogenesis 28:1217-23. 2007
    ..The results from our studies suggest that further investigations may be warranted to determine if the combination of TAM and bioactive soy components may be used for prevention and/or treatment of estrogen-dependent BRCA...
  12. pmc The association between soy nut consumption and decreased menopausal symptoms
    Francine K Welty
    Division of Cardiology, Beth Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Womens Health (Larchmt) 16:361-9. 2007
    ..Epidemiological studies suggest a low incidence of hot flashes in populations that consume dietary soy. The present study examined the effect of soy nuts on hot flashes and menopausal symptoms...
  13. ncbi request reprint Genistein and daidzein downregulate prostate androgen-regulated transcript-1 (PART-1) gene expression induced by dihydrotestosterone in human prostate LNCaP cancer cells
    Lunyin Yu
    Nutrition Metabolism Laboratory, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Nutr 133:389-92. 2003
    ..Our studies suggest that use of the PART-1 gene as a biomarker for evaluating the efficacy of soy isoflavones on androgen-dependent prostate cancer warrants further investigation...
  14. ncbi request reprint Effect of soy nuts on blood pressure and lipid levels in hypertensive, prehypertensive, and normotensive postmenopausal women
    Francine K Welty
    Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Arch Intern Med 167:1060-7. 2007
    ..For people aged 40 to 70 years, each increment of 20 mm Hg in systolic blood pressure (BP) or 10 mm Hg in diastolic BP doubles the risk of cardiovascular disease for BPs of 115/75 to 185/115 mm Hg...
  15. pmc Tanshinones inhibit the growth of breast cancer cells through epigenetic modification of Aurora A expression and function
    Yi Gong
    Nutrition Metabolism Laboratory, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 7:e33656. 2012
    ..Altogether, this study warrants further investigation to develop T1 as an effective and safe agent for the therapy and prevention of breast cancer...
  16. pmc Bioactive tanshinones in Salvia miltiorrhiza inhibit the growth of prostate cancer cells in vitro and in mice
    Yi Gong
    Nutrition Metabolism Laboratory, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Int J Cancer 129:1042-52. 2011
    ..Our results support that T1 may be an efficacious and safe chemopreventive or therapeutic agent against prostate cancer progression...
  17. pmc Genistein sensitizes inhibitory effect of tamoxifen on the growth of estrogen receptor-positive and HER2-overexpressing human breast cancer cells
    Zhiming Mai
    Nutrition Metabolism Laboratory, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Mol Carcinog 46:534-42. 2007
    ....
  18. ncbi request reprint A novel pathway involving melanoma differentiation associated gene-7/interleukin-24 mediates nonsteroidal anti-inflammatory drug-induced apoptosis and growth arrest of cancer cells
    Luiz F Zerbini
    BIDMC Genomics Center, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Res 66:11922-31. 2006
    ..Our results establish MDA-7/IL-24 and GADD45alpha and GADD45gamma as critical mediators of apoptosis and growth arrest in response to NSAIDs in cancer cells...
  19. pmc Bioactive tanshinone I inhibits the growth of lung cancer in part via downregulation of Aurora A function
    Yanli Li
    Institute of Molecular and Experimental Therapeutics, East China Normal University, Shanghai, China
    Mol Carcinog 52:535-43. 2013
    ..Our results provided experimental evidence to suggest that T1 may be an efficacious and safe agent for the prevention of lung cancer progression and Aurora A may be an important molecular target for T1 action against lung cancer...
  20. doi request reprint Epigenetic and pharmacoepigenomic studies of major psychoses and potentials for therapeutics
    Hamid Mostafavi Abdolmaleky
    Laboratory of Nutrition and Metabolism at BIDMC, Harvard Medical School, Boston, MA, USA
    Pharmacogenomics 9:1809-23. 2008
    ..In fact, some therapeutics now in use target epigenetic programming. In the near future, epigenetic interventions should help stabilize affected individuals and lead to prevention strategies...
  21. pmc Effect of soy nuts on adhesion molecules and markers of inflammation in hypertensive and normotensive postmenopausal women
    Melita M Nasca
    Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Am J Cardiol 102:84-6. 2008
    ....
  22. pmc Inflammation and foveolar hyperplasia are reduced by supplemental dietary glutamine during Helicobacter pylori infection in mice
    Susan J Hagen
    Department of Surgery, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Nutr 139:912-8. 2009
    ..pylori-associated pathology in vivo that is accompanied by beneficial changes in the immune response to H. pylori early in infection. Thus, Gln supplementation may be an alternative therapy for reducing H. pylori-associated pathology...
  23. pmc Smad4 inactivation promotes malignancy and drug resistance of colon cancer
    Panagiotis Papageorgis
    Department of Medicine, Genetics and Genomics Graduate Program, Boston University School of Medicine, Boston, Massachusetts, USA
    Cancer Res 71:998-1008. 2011
    ..These findings are also consistent with targeting TGFβ-induced auxiliary pathways, such as MEK-ERK, and p38-MAPK and the glycolytic cascade, in SMAD4-deficient tumors as attractive strategies for therapeutic intervention...
  24. doi request reprint Epigenetic alterations of the dopaminergic system in major psychiatric disorders
    Hamid Mostafavi Abdolmaleky
    Laboratory of Nutrition and Metabolism at BIDMC, Harvard Medical School, Boston, Massachusetts, USA
    Methods Mol Biol 448:187-212. 2008
    ....
  25. ncbi request reprint Lignans from Dysosma versipellis with inhibitory effects on prostate cancer cell lines
    Ren Wang Jiang
    Institute of Chinese Medicine, Department of Biochemistry and Department of Biology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, People s Republic of China
    J Nat Prod 70:283-6. 2007
    ..Thus, cultivation of D. versipellis in suitable locations may serve as an alternative source for podophyllotoxin (2) production...

Research Grants20

  1. Genes Modulated by Soy in Prostate Cancer Progression
    Jin Rong Zhou; Fiscal Year: 2004
    ....
  2. Genistien and prevention of HER2-overexpressing breast *
    Jin Rong Zhou; Fiscal Year: 2004
    ..abstract_text> ..
  3. Chemoprevention of Bladder CA by soybean bioactive comp.
    Jin Rong Zhou; Fiscal Year: 2006
    ..abstract_text> ..
  4. Oldenlandia diffusa for prostate cancer treatment
    Jin Rong Zhou; Fiscal Year: 2007
    ..The cellular markers will be determined in the in vivo samples. ..
  5. Synergy between phytochemicals for prostate cancer prevention
    Jin Rong Zhou; Fiscal Year: 2007
    ..Determinations of cellular biomarkers and identification of candidate molecular markers should provide sufficient preliminary data for further mechanism elucidation in the future RO1 proposal application. ..
  6. Parental metabolic status and offspring cancer risks
    Jin Rong Zhou; Fiscal Year: 2007
    ..The results also provide essential supporting preliminary data for future RO1 grant application investigate effective dietary or nutritional regimens for cancer prevention by targeting parental MS. ..
  7. Prevention of bladder cancer progression by sulforaphane
    Jin Rong Zhou; Fiscal Year: 2004
    ..It is expected that the results will provide important information on anti-bladder cancer progression activity of sulforaphane, and provide preliminary data for R01 grant application. ..
  8. DIETARY SOYBEAN COMPONENTS AFFECT ON PROSTATE CANCER PRO
    Jin Rong Zhou; Fiscal Year: 2001
    ..It is expencted that the results from proposed project will be translated to future clinical trials on CaP prevention/intervention. ..
  9. Interactions Between Dietary Soy Components & Tamoxifen
    Jin Rong Zhou; Fiscal Year: 2003
    ....