Bin Zheng

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Oncogenic B-RAF negatively regulates the tumor suppressor LKB1 to promote melanoma cell proliferation
    Bin Zheng
    Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    Mol Cell 33:237-47. 2009
  2. ncbi request reprint In-gel stable isotope labeling for relative quantification using mass spectrometry
    John M Asara
    Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    Nat Protoc 1:46-51. 2006
  3. pmc AMPK-dependent phosphorylation of ULK1 regulates ATG9 localization
    Hildegard I D Mack
    Cancer Biology Program, Division of Hematology Oncology, Department of Medicine Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    Autophagy 8:1197-214. 2012
  4. pmc AMPK-Dependent Degradation of TXNIP upon Energy Stress Leads to Enhanced Glucose Uptake via GLUT1
    Ning Wu
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    Mol Cell 49:1167-75. 2013
  5. pmc AMP-activated protein kinase regulates neuronal polarization by interfering with PI 3-kinase localization
    Stephen Amato
    Department of Biology, Boston University, 5 Cummington Street, Boston, MA 02215, USA
    Science 332:247-51. 2011
  6. pmc GATA transcription factors directly regulate the Parkinson's disease-linked gene alpha-synuclein
    Clemens R Scherzer
    Center for Neurologic Diseases, Harvard Medical School and Brigham and Women s Hospital, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 105:10907-12. 2008
  7. pmc p70S6 kinase phosphorylates AMPK on serine 491 to mediate leptin's effect on food intake
    Yossi Dagon
    Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Cell Metab 16:104-12. 2012
  8. pmc A fluorescent reporter of AMPK activity and cellular energy stress
    Peiling Tsou
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Cell Metab 13:476-86. 2011
  9. pmc Regulation of epithelial tight junction assembly and disassembly by AMP-activated protein kinase
    Bin Zheng
    Division of Signal Transduction, Beth Israel Deaconess Medical Center, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 104:819-22. 2007
  10. pmc AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice
    Yu Li
    Department of Medicine, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02481, USA
    Cell Metab 13:376-88. 2011

Collaborators

Detail Information

Publications12

  1. pmc Oncogenic B-RAF negatively regulates the tumor suppressor LKB1 to promote melanoma cell proliferation
    Bin Zheng
    Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    Mol Cell 33:237-47. 2009
    ..Our findings provide a molecular linkage between the LKB1-AMPK and the RAF-MEK-ERK pathways and suggest that suppression of LKB1 function by B-RAF V600E plays an important role in B-RAF V600E-driven tumorigenesis...
  2. ncbi request reprint In-gel stable isotope labeling for relative quantification using mass spectrometry
    John M Asara
    Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    Nat Protoc 1:46-51. 2006
    ..This protocol should take approximately 24-26 h to complete, including the incubation time for proteolytic digestion. Additional time will be needed for data analysis and interpretation...
  3. pmc AMPK-dependent phosphorylation of ULK1 regulates ATG9 localization
    Hildegard I D Mack
    Cancer Biology Program, Division of Hematology Oncology, Department of Medicine Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    Autophagy 8:1197-214. 2012
    ..Taken together these data identify an ULK1-AMPK signaling cassette involved in regulation of the autophagy machinery...
  4. pmc AMPK-Dependent Degradation of TXNIP upon Energy Stress Leads to Enhanced Glucose Uptake via GLUT1
    Ning Wu
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    Mol Cell 49:1167-75. 2013
    ..The glucose influx through GLUT1 restores ATP-to-ADP ratios in the short run and ultimately induces TXNIP protein production to suppress glucose uptake once energy homeostasis is reestablished...
  5. pmc AMP-activated protein kinase regulates neuronal polarization by interfering with PI 3-kinase localization
    Stephen Amato
    Department of Biology, Boston University, 5 Cummington Street, Boston, MA 02215, USA
    Science 332:247-51. 2011
    ....
  6. pmc GATA transcription factors directly regulate the Parkinson's disease-linked gene alpha-synuclein
    Clemens R Scherzer
    Center for Neurologic Diseases, Harvard Medical School and Brigham and Women s Hospital, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 105:10907-12. 2008
    ..This critical link between GATA factors and SNCA may enable therapies designed to lower alpha-synuclein production...
  7. pmc p70S6 kinase phosphorylates AMPK on serine 491 to mediate leptin's effect on food intake
    Yossi Dagon
    Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Cell Metab 16:104-12. 2012
    ..This discovery has broad biologic implications since mTOR-p70S6 kinase and AMPK have multiple, fundamental and generally opposing cellular effects that regulate metabolism, cell growth, and development...
  8. pmc A fluorescent reporter of AMPK activity and cellular energy stress
    Peiling Tsou
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Cell Metab 13:476-86. 2011
    ..Finally, using this probe with U2OS cells in a microfluidic device, we observed a very high cell-to-cell variability in the amplitude and time course of AMPK activation and recovery in response to pulses of glucose deprivation...
  9. pmc Regulation of epithelial tight junction assembly and disassembly by AMP-activated protein kinase
    Bin Zheng
    Division of Signal Transduction, Beth Israel Deaconess Medical Center, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 104:819-22. 2007
    ..These results support an important role of AMPK in the regulation of epithelial tight junction assembly and disassembly and suggest an intriguing link between cellular energy status and tight junction function...
  10. pmc AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice
    Yu Li
    Department of Medicine, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02481, USA
    Cell Metab 13:376-88. 2011
    ..AMPK-dependent phosphorylation of SREBP may offer therapeutic strategies to combat insulin resistance, dyslipidemia, and atherosclerosis...
  11. ncbi request reprint In-Gel Stable-Isotope Labeling (ISIL): a strategy for mass spectrometry-based relative quantification
    John M Asara
    Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    J Proteome Res 5:155-63. 2006
    ..An advantage of ISIL is that visualization of gel differences can be used as a first quantification step followed by accurate and sensitive protein level stable-isotope labeling and mass spectrometry-based relative quantification...
  12. pmc Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease
    Marta M Lipinski
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:14164-9. 2010
    ..Finally, we provide a list of candidate drug targets that can be used to safely modulate levels of autophagy without causing cell death...