J Zhao

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Expression of NPAT, a novel substrate of cyclin E-CDK2, promotes S-phase entry
    J Zhao
    Laboratory of Molecular Oncology, Massachusetts General Hospital MGH Cancer Center, Charlestown, Massachusetts 02129, USA
    Genes Dev 12:456-61. 1998
  2. pmc NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription
    J Zhao
    Massachusetts General Hospital Cancer Center, Charlestown, Massachusetts 02129, USA
    Genes Dev 14:2283-97. 2000
  3. pmc Characterization of the Aspergillus nidulans septin (asp) gene family
    M Momany
    Department of Botany, University of Georgia, Athens, Georgia 30602, USA
    Genetics 157:969-77. 2001
  4. ncbi Functional characterization of rat gp600/megalin promoter: combination of proximal Sp1 site and JCV repeat is important in rat gp600/megalin promoter activation
    J Zhao
    Department of Pediatrics, Division of Nephrology, School of Medicine, University of California, CA 95616, Davis, USA
    Gene 265:123-31. 2001
  5. ncbi Two phases of chromatin decondensation during dedifferentiation of plant cells: distinction between competence for cell fate switch and a commitment for S phase
    J Zhao
    Department of Plant Sciences, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Biol Chem 276:22772-8. 2001
  6. ncbi Focal adhesion kinase activates Stat1 in integrin-mediated cell migration and adhesion
    B Xie
    Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06520 8023, USA
    J Biol Chem 276:19512-23. 2001
  7. ncbi Gremlin negatively modulates BMP-4 induction of embryonic mouse lung branching morphogenesis
    W Shi
    Developmental Biology Program, Department of Surgery, Childrens Hospital Los Angeles Research Institute, Los Angeles, California 90027, USA
    Am J Physiol Lung Cell Mol Physiol 280:L1030-9. 2001
  8. ncbi G-protein signaling through tubby proteins
    S Santagata
    Ruttenberg Cancer Center, Structural Biology Program, Department of Physiology and Biophysics, Mount Sinai School of Medicine of New York University, 1425 Madison Avenue New York, NY 10029, USA
    Science 292:2041-50. 2001
  9. ncbi Arabidopsis thaliana tryptophan synthase alpha: gene cloning, expression, and subunit interaction
    E R Radwanski
    Boyce Thompson Institute for Plant Research, Cornell University, Ithaca, NY 14853 1801, USA
    Mol Gen Genet 248:657-67. 1995
  10. ncbi c-Abl tyrosine kinase binds and phosphorylates phospholipid scramblase 1
    J Sun
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 276:28984-90. 2001

Collaborators

  • A G Matera
  • B K Kennedy
  • Jean Y Wang
  • M Momany
  • Hong Zhang
  • J H Golbeck
  • Shiuan Chen
  • D L Crowe
  • W Yang
  • - Zhang Hong
  • A V Oleinikov
  • D Warburton
  • G Wang
  • X Li
  • W Chen
  • H Chen
  • P J Sims
  • L Qing
  • Q Q Li
  • D C Flynn
  • H Ding
  • C Cunningham
  • E Reed
  • Q Zhou
  • M M Kessler
  • H Li
  • B Xie
  • J Sun
  • S Santagata
  • W Shi
  • L Yuan
  • Y Chai
  • F Tian
  • T Wiedmer
  • P Bringas
  • Y Xia
  • J D Tefft
  • K Ling
  • R Zhou
  • H Hao
  • X M Cui
  • Y Tan
  • X J Zhao
  • Z Chen
  • J Lv
  • F Chen
  • F Huang
  • J E Coad
  • C L Moore
  • R P Rother
  • D G Myszka
  • L Shapiro
  • X Y Fu
  • W S Shan
  • J Durbin
  • M Kitagawa
  • C L Baird
  • T J Boggon
  • C A Gomez
  • K D Anderson
  • J L Guan
  • M A Schwartz
  • J A Madri
  • T Mehari
  • C Hoog
  • J G Liu
  • E R Radwanski
  • B Daneholt
  • E Brundell
  • G Pei
  • G X Wu
  • W Hu
  • S Smith
  • Z J Cheng
  • M Lee
  • A Mogharei
  • P Wang
  • M Bernfield
  • L Ma
  • C Shuler
  • Y L Wu
  • M Leinwand
  • B Xu
  • M A Berberich
  • K L Hsi
  • N Jiang
  • C F Shuler
  • X Wei
  • Y Dong
  • R A Luhm

Detail Information

Publications34

  1. pmc Expression of NPAT, a novel substrate of cyclin E-CDK2, promotes S-phase entry
    J Zhao
    Laboratory of Molecular Oncology, Massachusetts General Hospital MGH Cancer Center, Charlestown, Massachusetts 02129, USA
    Genes Dev 12:456-61. 1998
    ..Overexpression of NPAT accelerates S-phase entry, and this effect is enhanced by coexpression of cyclin E-CDK2. These results suggest that NPAT is a substrate of cyclin E-CDK2 and plays a role in S-phase entry...
  2. pmc NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription
    J Zhao
    Massachusetts General Hospital Cancer Center, Charlestown, Massachusetts 02129, USA
    Genes Dev 14:2283-97. 2000
    ..Thus, our results both show that NPAT is involved in a key S phase event and provide a link between the cell cycle machinery and activation of histone gene transcription...
  3. pmc Characterization of the Aspergillus nidulans septin (asp) gene family
    M Momany
    Department of Botany, University of Georgia, Athens, Georgia 30602, USA
    Genetics 157:969-77. 2001
    ..cerevisiae septins, Cdc3, Cdc10, Cdc11, and Cdc12. Intron-exon structure was conserved within septin classes. The results of this study suggest that most fungal septins belong to one of four orthologous classes...
  4. ncbi Functional characterization of rat gp600/megalin promoter: combination of proximal Sp1 site and JCV repeat is important in rat gp600/megalin promoter activation
    J Zhao
    Department of Pediatrics, Division of Nephrology, School of Medicine, University of California, CA 95616, Davis, USA
    Gene 265:123-31. 2001
    ..This functional characterization of the regulation of gp600/megalin gene is likely to advance the knowledge of the regulation of this gene in health and disease...
  5. ncbi Two phases of chromatin decondensation during dedifferentiation of plant cells: distinction between competence for cell fate switch and a commitment for S phase
    J Zhao
    Department of Plant Sciences, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Biol Chem 276:22772-8. 2001
    ..These findings might have implications for a wide range of dedifferentiation-driven cellular processes in higher eukaryotes...
  6. ncbi Focal adhesion kinase activates Stat1 in integrin-mediated cell migration and adhesion
    B Xie
    Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06520 8023, USA
    J Biol Chem 276:19512-23. 2001
    ..Thus, our results have demonstrated, for the first time, a critical signaling pathway from integrin/FAK to Stat1 that reduces cell adhesion and promotes cell migration...
  7. ncbi Gremlin negatively modulates BMP-4 induction of embryonic mouse lung branching morphogenesis
    W Shi
    Developmental Biology Program, Department of Surgery, Childrens Hospital Los Angeles Research Institute, Los Angeles, California 90027, USA
    Am J Physiol Lung Cell Mol Physiol 280:L1030-9. 2001
    ..Therefore, our data support the hypothesis that Gremlin is a physiologically negative regulator of BMP-4 in lung branching morphogenesis...
  8. ncbi G-protein signaling through tubby proteins
    S Santagata
    Ruttenberg Cancer Center, Structural Biology Program, Department of Physiology and Biophysics, Mount Sinai School of Medicine of New York University, 1425 Madison Avenue New York, NY 10029, USA
    Science 292:2041-50. 2001
    ....
  9. ncbi Arabidopsis thaliana tryptophan synthase alpha: gene cloning, expression, and subunit interaction
    E R Radwanski
    Boyce Thompson Institute for Plant Research, Cornell University, Ithaca, NY 14853 1801, USA
    Mol Gen Genet 248:657-67. 1995
    ..Immunoblot analysis indicated that the plant alpha and beta subunits are present throughout development...
  10. ncbi c-Abl tyrosine kinase binds and phosphorylates phospholipid scramblase 1
    J Sun
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 276:28984-90. 2001
    ..These findings indicate that c-Abl binds and phosphorylates PLSCR1, and raise the possibility that an interaction between c-Abl and plasma membrane PLSCR1 might contribute to the cellular response to genotoxic stress...
  11. ncbi Different catalytic properties and inhibitor responses of the goldfish brain and ovary aromatase isozymes
    J Zhao
    Division of Immunology, Beckman Research Institute of the City of the Hope, Duarte, California 91010, USA
    Gen Comp Endocrinol 123:180-91. 2001
    ..In addition, differences in the K(i) values of aromatase inhibitors for the two goldfish isoforms suggest structural variance in the active sites of these isozymes...
  12. ncbi The nonreceptor tyrosine kinase ACK2, a specific target for Cdc42 and a negative regulator of cell growth and focal adhesion complexes
    W Yang
    Department of Molecular Medicine, Cornell University, Ithaca, New York 14853, USA
    J Biol Chem 276:43987-93. 2001
    ....
  13. ncbi Antitumor effect of beta-elemene in non-small-cell lung cancer cells is mediated via induction of cell cycle arrest and apoptotic cell death
    G Wang
    The Mary Babb Randolph Cancer Center, Department of Microbiology, Immunology and Cell Biology, West Virginia University Health Sciences Center, Morgantown, West Virginia 26506, USA
    Cell Mol Life Sci 62:881-93. 2005
    ..These data indicate that the effect of beta-elemene on lung cancer cell death may be through a mitochondrial release of the cytochrome c-mediated apoptotic pathway...
  14. ncbi Antiproliferative effect of beta-elemene in chemoresistant ovarian carcinoma cells is mediated through arrest of the cell cycle at the G2-M phase
    X Li
    The Mary Babb Randolph Cancer Center, Department of Microbiology, Immunology and Cell Biology, West Virginia University Health Sciences Center, Morgantown, West Virginia 26506, USA
    Cell Mol Life Sci 62:894-904. 2005
    ....
  15. ncbi The recombinant nonstructural polyprotein NS1 of porcine parvovirus (PPV) as diagnostic antigen in ELISA to differentiate infected from vaccinated pigs
    L Qing
    Laboratory of Animal Virology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, PR China
    Vet Res Commun 30:175-90. 2006
    ..In conclusion, the PPV-NS1 ELISA can differentiate PPV-infected versus inactivated PPV-vaccinated pigs and could be applied in disease diagnosis and surveillance...
  16. ncbi NMR characterization of recombinant transmembrane protein CB2 fragment CB2(180-233)
    J Zhao
    Department of Pharmaceutical and Pharmacological Sciences, College of Pharmacy, University of Houston, TX 77204 5037, USA
    Protein Pept Lett 13:335-42. 2006
    ..These results further revealed that our established approach is a promising method to express recombinant membrane proteins for their structural studies...
  17. pmc Cytosolic adaptor protein Dab2 is an intracellular ligand of endocytic receptor gp600/megalin
    A V Oleinikov
    Department of Pediatrics, Division of Nephrology, School of Medicine, University of California, Davis, CA 95616, USA
    Biochem J 347:613-21. 2000
    ..We speculate that their interaction might involve gp600/megalin in signal transduction pathways or might mediate the intracellular trafficking of this receptor...
  18. ncbi The murine SCP3 gene is required for synaptonemal complex assembly, chromosome synapsis, and male fertility
    L Yuan
    Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden
    Mol Cell 5:73-83. 2000
    ....
  19. pmc Pta1, a component of yeast CF II, is required for both cleavage and poly(A) addition of mRNA precursor
    J Zhao
    Department of Molecular Biology, School of Medicine, Tufts University, Boston, Massachusetts, USA
    Mol Cell Biol 19:7733-40. 1999
    ..The involvement of Pta1 in both steps of mRNA 3'-end formation supports the conclusion that CF II is the functional homolog of CPSF...
  20. ncbi Modified ligands to FA and FB in photosystem I. I. Structural constraints for the formation of iron-sulfur clusters in free and rebound PsaC
    T Mehari
    Department of Chemistry, Addis Ababa University, Ethiopia
    J Biol Chem 270:28108-17. 1995
    ..Since two [4Fe-4S] clusters are found in all reconstituted PS I complexes, the presence of two cubanes in free PsaC may be a necessary precondition for binding to P700-FX cores...
  21. ncbi Characterization of C-type natriuretic peptide receptors in human mesangial cells
    J Zhao
    INSERM 64, Hopital Tenon, Paris, France
    Kidney Int 46:717-25. 1994
    ..ANPR-A, ANPR-B and ANPR-C mRNA were present in epithelial cells whereas only ANPR-B and ANPR-C mRNA were detected in mesangial cells.(ABSTRACT TRUNCATED AT 250 WORDS)..
  22. ncbi Elimination of potential sites of glycosylation fails to abrogate complement regulatory function of cell surface CD59
    R P Rother
    Alexion Pharmaceuticals Inc, New Haven, Connecticut 06511, USA
    J Biol Chem 271:23842-5. 1996
    ..These data suggest that the MAC inhibitory function of CD59 is entirely provided by residues exposed at the surface of the core polypeptide and that this core structure is not influenced by glycosylation at Asn18...
  23. ncbi Purification of the Saccharomyces cerevisiae cleavage/polyadenylation factor I. Separation into two components that are required for both cleavage and polyadenylation of mRNA 3' ends
    M M Kessler
    Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts 02111 1800, USA
    J Biol Chem 271:27167-75. 1996
    ..RNA15 is the only subunit of CF I that can be cross-linked to pre-mRNA...
  24. ncbi Abrogation of transforming growth factor-beta type II receptor stimulates embryonic mouse lung branching morphogenesis in culture
    J Zhao
    Department of Surgery, Pediatrics, and Cardiothoracic Surgery, Childrens Hospital, Los Angeles Research Institute, California, USA
    Dev Biol 180:242-57. 1996
    ....
  25. ncbi Molecular cloning of human plasma membrane phospholipid scramblase. A protein mediating transbilayer movement of plasma membrane phospholipids
    Q Zhou
    Blood Research Institute, The Blood Center of Southeastern Wisconsin, Milwaukee, Wisconsin 53201 2178, USA
    J Biol Chem 272:18240-4. 1997
    ..PL scramblase mRNA was found in a variety of hematologic and nonhematologic cells and tissues, suggesting that this protein functions in all cells...
  26. pmc Hrp1, a sequence-specific RNA-binding protein that shuttles between the nucleus and the cytoplasm, is required for mRNA 3'-end formation in yeast
    M M Kessler
    Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Genes Dev 11:2545-56. 1997
    ..Like Npl3p, Hrp1p shuttles between the nucleus and cytoplasm, providing a potential link between 3'-end processing and mRNA export from the nucleus...
  27. ncbi Identity of the residues responsible for the species-restricted complement inhibitory function of human CD59
    X J Zhao
    Blood Research Institute, The Blood Center, Milwaukee, Wisconsin 53201 2178, USA
    J Biol Chem 273:10665-71. 1998
    ....
  28. pmc Evidence that HetR protein is an unusual serine-type protease
    R Zhou
    College of Life Sciences, Peking University, Beijing, 100871, China
    Proc Natl Acad Sci U S A 95:4959-63. 1998
    ..DnsF-labeled rHetR was digested with trypsin, and the labeled peptide was isolated and sequenced. The labeled peptide matches a sequence from HetR. These results show that HetR is a protease...
  29. ncbi Immunohistochemical localization of TGF-beta type II receptor and TGF-beta3 during palatogenesis in vivo and in vitro
    X M Cui
    The University of Southern California, School of Dentistry, Center for Craniofacial Molecular Biology, Los Angeles 90033, USA
    Int J Dev Biol 42:817-20. 1998
    ....
  30. ncbi Conserved function of mSpry-2, a murine homolog of Drosophila sprouty, which negatively modulates respiratory organogenesis
    J D Tefft
    Center for Craniofacial Molecular Biology Departments of Surgery and Pediatrics The Childrens Hospital Los Angeles Research Institute University of Southern California Schools of Dentistry and Medicine Los Angeles California 90033, USA
    Curr Biol 9:219-22. 1999
    ..These results support a striking conservation of function between the Drosophila and mammalian sprouty gene families to negatively modulate respiratory organogenesis...
  31. ncbi Molecular embryology of the lung: then, now, and in the future
    D Warburton
    Developmental Biology Program and Department of Surgery, Childrens Hospital Los Angeles Research Institute, Los Angeles, California 90027, USA
    Am J Physiol 276:L697-704. 1999
    ..A scientific rationale for developing new therapeutic approaches to urgent questions of human pulmonary health such as bronchopulmonary dysplasia is beginning to emerge from work in this field...
  32. pmc Five-transmembrane domains appear sufficient for a G protein-coupled receptor: functional five-transmembrane domain chemokine receptors
    K Ling
    Shanghai Institute of Cell Biology, Chinese Academy of Sciences, Shanghai, 200031, People s Republic of China
    Proc Natl Acad Sci U S A 96:7922-7. 1999
    ....
  33. ncbi Inhibition of transforming growth factor-beta type II receptor signaling accelerates tooth formation in mouse first branchial arch explants
    Y Chai
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033, USA
    Mech Dev 86:63-74. 1999
    ....
  34. doi Production, purification, and characterization of a potential thermostable galactosidase for milk lactose hydrolysis from Bacillus stearothermophilus
    W Chen
    State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi 214122, China
    J Dairy Sci 91:1751-8. 2008
    ..The results suggest that this recombinant thermostable enzyme may be suitable for both the hydrolysis of lactose and the production of galactooligosaccharides in milk processing...