Affiliation: Harvard University
- Adaptive filtering for global interference cancellation and real-time recovery of evoked brain activity: a Monte Carlo simulation studyQuan Zhang
Harvard Medical School, Massachusetts General Hospital, Neural Systems Group, 13th Street, Building 149, Room 2651, Charlestown, Massachusetts 02129, USA
J Biomed Opt 12:044014. 2007..The technique can be performed in real time, an important feature required for applications such as brain activity localization, biofeedback, and potential neuroprosthetic devices...
- Study of near infrared technology for intracranial hematoma detectionQ Zhang
Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia 19104 6089, USA
J Biomed Opt 5:206-13. 2000..Model inhomogeneity tests and animal hematoma tests showed the effectiveness of the improved hematoma detector for intracranial hematoma detection...
- Development of motion resistant instrumentation for ambulatory near-infrared spectroscopyQuan Zhang
Massachusetts General Hospital, Harvard Medical School, Neural Systems Group, Charlestown, Massachusetts 02129, USA
J Biomed Opt 16:087008. 2011..To the best of our knowledge, this is the first report of multiparameter aNIRS monitoring and its application in parabolic flight...
- Adaptive filtering to reduce global interference in evoked brain activity detection: a human subject case studyQuan Zhang
Massachusetts General Hospital, Harvard Medical School, Neural Systems Group, 13th Street, Building 149, Room 2651, Charlestown, Massachusetts 02129, USA
J Biomed Opt 12:064009. 2007..In addition, the results suggested that association between the superficial layer hemodynamics and the total global interference is time-varying...
- Combined optical imaging and mammography of the healthy breast: optical contrast derived from breast structure and compressionQianqian Fang
Massachusetts General Hospital, Charlestown, MA 02148 USA
IEEE Trans Med Imaging 28:30-42. 2009..The optical images from a subset of patients show composite features from both tissue structure and pressure distribution. We present mechanical simulations which further confirm this hypothesis...
- Adaptive filtering to reduce global interference in non-invasive NIRS measures of brain activation: how well and when does it work?Quan Zhang
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
Neuroimage 45:788-94. 2009....
- Advances in the application of technology to epilepsy: the CIMIT/NIO Epilepsy Innovation SummitSteven C Schachter
Center for Integration of Medicine and Innovative Technology, Boston, MA, USA
Epilepsy Behav 16:3-46. 2009..This article summarizes the discussions and demonstrates that cross-disciplinary interactions can catalyze collaborations between physicians and engineers to address and solve many of the pressing unmet needs in epilepsy...
- Tomographic optical breast imaging guided by three-dimensional mammographyAng Li
Department of Physics, Tufts University, Medford, Massachusetts 02155, USA
Appl Opt 42:5181-90. 2003..We suggest an approach to find the optimal regularization parameters. The presented preliminary clinical result indicates the utility of the method...
- Optimal linear inverse solution with multiple priors in diffuse optical tomographyAng Li
Department of Physics Tufts University, Medford, Massachusetts 02155, USA
Appl Opt 44:1948-56. 2005..Simulations are performed to demonstrate the significant improvement in image quality afforded by combining spatial and spectral priors...
- Depth sensitivity and source-detector separations for near infrared spectroscopy based on the Colin27 brain templateGARY E STRANGMAN
Neural Systems Group, Massachusetts General Hospital Harvard Medical School, Charlestown, Massachusetts, USA
PLoS ONE 8:e66319. 2013....
- Scalp and skull influence on near infrared photon propagation in the Colin27 brain templateGARY E STRANGMAN
Neural Systems Group, Massachusetts General Hospital Harvard Medical School, Charlestown, MA, USA Electronic address
Neuroimage 85:136-49. 2014....
- Coregistered tomographic x-ray and optical breast imaging: initial resultsQuan Zhang
Harvard Medical School, Massachusetts General Hospital, The Martinos Center for Biomedical Imaging, 13th Street, Building 149, Room 2301, Charlestown, Massachusetts 02129, USA
J Biomed Opt 10:024033. 2005..This comparison will ultimately lead to a better understanding of the relationship between the functional contrast afforded by optical imaging and the structural contrast provided by x-ray imaging...
- Reconstructing chromosphere concentration images directly by continuous-wave diffuse optical tomographyAng Li
Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
Opt Lett 29:256-8. 2004..We demonstrate this improvement with simulations and a dynamic blood phantom experiment...
- Twenty-four-hour ambulatory recording of cerebral hemodynamics, systemic hemodynamics, electrocardiography, and actigraphy during people's daily activitiesQuan Zhang
Massachusetts General Hospital, Harvard Medical School Neural Systems Group, 13th Street, Building 149, Room 2651, Charlestown, Massachusetts 02129bCenter for Space Medicine, Baylor College of Medicine, Houston, Texas
J Biomed Opt 19:47003. 2014..These results also demonstrate that NINscan 4's motion artifact at 1-g head movement is smaller than physiological hemodynamic fluctuations during motionless sleep. The broader potential of this technology is also discussed...
- Migraine with aura is associated with an incomplete circle of willis: results of a prospective observational studyBrett Cucchiara
Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
PLoS ONE 8:e71007. 2013..To compare the prevalence of an incomplete circle of Willis in patients with migraine with aura, migraine without aura, and control subjects, and correlate circle of Willis variations with alterations in cerebral perfusion...
- Non-invasive and quantitative near-infrared haemoglobin spectrometry in the piglet brain during hypoxic stress, using a frequency-domain multidistance instrumentD M Hueber
University of Pennsylvania, School of Medicine in Philadelphia, USA
Phys Med Biol 46:41-62. 2001..The origin of this 'effective' background absorption may be real, an artefact caused by the application of a simplified model to a complex sample, or a combination of factors...
- Fluorescence optical diffusion tomographyAdam B Milstein
School of Electrical and Computer Engineering, Purdue University, West Lafayette, Indiana 47907 1285, USA
Appl Opt 42:3081-94. 2003..The effectiveness of the reconstruction algorithm is demonstrated by simulation and by application to experimental data from a tissue phantom containing the fluorescent agent Indocyanine Green...
- Quantitative spectroscopic diffuse optical tomography of the breast guided by imperfect a priori structural informationGregory Boverman
Department of Electrical and Computer Engineering, Northeastern University, 302 Stearns Hall, Boston, MA 02115, USA
Phys Med Biol 50:3941-56. 2005..In addition, we examine the consequences which errors in the breast segmentation have on estimating both the background and inhomogeneity chromophore concentrations...