Ling Zhang

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. doi request reprint Plasticity changes of neuronal activities in central lateral nucleus by stimulation of the anterior cingulate cortex in rat
    Ling Zhang
    Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200032, China
    Brain Res Bull 81:574-8. 2010
  2. pmc TNF-α contributes to spinal cord synaptic plasticity and inflammatory pain: distinct role of TNF receptor subtypes 1 and 2
    Ling Zhang
    Department of Anesthesiology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Pain 152:419-27. 2011
  3. pmc TLR3 deficiency impairs spinal cord synaptic transmission, central sensitization, and pruritus in mice
    Tong Liu
    Sensory Plasticity Laboratory, Pain Research Center, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 122:2195-207. 2012
  4. pmc Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions
    Zhen Zhong Xu
    Department of Anesthesiology, Sensory Plasticity Laboratory, Pain Research Center, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 16:592-7, 1p following 597. 2010
  5. pmc VGLUT2-dependent glutamate release from nociceptors is required to sense pain and suppress itch
    Yang Liu
    Dana Farber Cancer Institute and Department of Neurobiology, Harvard Medical School, 1 Jimmy Fund Way, Boston, MA 02115, USA
    Neuron 68:543-56. 2010
  6. pmc JNK-induced MCP-1 production in spinal cord astrocytes contributes to central sensitization and neuropathic pain
    Yong Jing Gao
    Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Neurosci 29:4096-108. 2009
  7. pmc Spinal injection of TNF-α-activated astrocytes produces persistent pain symptom mechanical allodynia by releasing monocyte chemoattractant protein-1
    Yong Jing Gao
    Sensory Plasticity Laboratory, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Pain Research Center, Boston, Massachusetts 02115, USA
    Glia 58:1871-80. 2010
  8. pmc Cytokine mechanisms of central sensitization: distinct and overlapping role of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha in regulating synaptic and neuronal activity in the superficial spinal cord
    Yasuhiko Kawasaki
    Pain Research Center, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 28:5189-94. 2008
  9. ncbi request reprint Anterior cingulate cortex contributes to the descending facilitatory modulation of pain via dorsal reticular nucleus
    Ling Zhang
    Institute of Neurobiology, Fudan University, Shanghai 200433, P R China
    Eur J Neurosci 22:1141-8. 2005
  10. pmc Effects of renal sympathetic denervation on post-myocardial infarction cardiac remodeling in rats
    Jialu Hu
    Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, China
    PLoS ONE 7:e45986. 2012

Collaborators

Detail Information

Publications12

  1. doi request reprint Plasticity changes of neuronal activities in central lateral nucleus by stimulation of the anterior cingulate cortex in rat
    Ling Zhang
    Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200032, China
    Brain Res Bull 81:574-8. 2010
    ..Taken together, we demonstrated descending modulation to nociceptive responses of CL neurons by direct projections from the ACC, which may underlie the neuronal mechanism of negative pain emotions...
  2. pmc TNF-α contributes to spinal cord synaptic plasticity and inflammatory pain: distinct role of TNF receptor subtypes 1 and 2
    Ling Zhang
    Department of Anesthesiology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Pain 152:419-27. 2011
    ..TNF-α is shown to play a critical role in regulating spinal cord synaptic plasticity and central sensitization, and TNFR1 and TNFR2 play a distinct role in regulating different phases of inflammatory pain...
  3. pmc TLR3 deficiency impairs spinal cord synaptic transmission, central sensitization, and pruritus in mice
    Tong Liu
    Sensory Plasticity Laboratory, Pain Research Center, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 122:2195-207. 2012
    ..Our findings demonstrate a critical role of TLR3 in regulating sensory neuronal excitability, spinal cord synaptic transmission, and central sensitization. TLR3 may serve as a new target for developing anti-itch treatment...
  4. pmc Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions
    Zhen Zhong Xu
    Department of Anesthesiology, Sensory Plasticity Laboratory, Pain Research Center, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 16:592-7, 1p following 597. 2010
    ..Given the potency of resolvins and the well-known side effects of opioids and COX inhibitors, resolvins may represent new analgesics for treating inflammatory pain...
  5. pmc VGLUT2-dependent glutamate release from nociceptors is required to sense pain and suppress itch
    Yang Liu
    Dana Farber Cancer Institute and Department of Neurobiology, Harvard Medical School, 1 Jimmy Fund Way, Boston, MA 02115, USA
    Neuron 68:543-56. 2010
    ..Our studies suggest that synaptic glutamate release from a group of peripheral nociceptors is required to sense pain and suppress itch. Elimination of VGLUT2 in these nociceptors creates a mouse model of chronic neurogenic itch...
  6. pmc JNK-induced MCP-1 production in spinal cord astrocytes contributes to central sensitization and neuropathic pain
    Yong Jing Gao
    Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Neurosci 29:4096-108. 2009
    ..Inhibition of the JNK/MCP-1 pathway may provide a new therapy for neuropathic pain management...
  7. pmc Spinal injection of TNF-α-activated astrocytes produces persistent pain symptom mechanical allodynia by releasing monocyte chemoattractant protein-1
    Yong Jing Gao
    Sensory Plasticity Laboratory, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Pain Research Center, Boston, Massachusetts 02115, USA
    Glia 58:1871-80. 2010
    ..Taken together, our results suggest that activated astrocytes are sufficient to produce persistent pain symptom in naïve mice by releasing MCP-1...
  8. pmc Cytokine mechanisms of central sensitization: distinct and overlapping role of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha in regulating synaptic and neuronal activity in the superficial spinal cord
    Yasuhiko Kawasaki
    Pain Research Center, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 28:5189-94. 2008
    ..PICs may further induce long-term synaptic plasticity through CREB-mediated gene transcription. Blockade of PIC signaling could be an effective way to suppress central sensitization and alleviate chronic pain...
  9. ncbi request reprint Anterior cingulate cortex contributes to the descending facilitatory modulation of pain via dorsal reticular nucleus
    Ling Zhang
    Institute of Neurobiology, Fudan University, Shanghai 200433, P R China
    Eur J Neurosci 22:1141-8. 2005
    ....
  10. pmc Effects of renal sympathetic denervation on post-myocardial infarction cardiac remodeling in rats
    Jialu Hu
    Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, China
    PLoS ONE 7:e45986. 2012
    ..To investigate the therapeutic effects of renal denervation (RD) on post- myocardial infarction (MI) cardiac remodeling in rats, the most optimal time for intervention and the sustainability of these effects...
  11. ncbi request reprint [Metal stress-induced arrhythmia and thoracic spinal cord 1-5 nerve remodeling and myocardial electrophysiological remodeling in rats]
    Jia Lu Hu
    Department of Cardiology, Zhongshan Hospital Fudan University, Shanghai 200032, China
    Zhonghua Xin Xue Guan Bing Za Zhi 39:1094-100. 2011
    ..The study aimed to investigate the relationship between arrhythmia occurrence and nerve remodeling of thoracic spinal cord 1-5 nerves as well as myocardial electrophysiological remodeling in a metal stress rat model...
  12. doi request reprint Monocillin II inhibits human breast cancer growth partially by inhibiting MAPK pathways and CDK2 Thr160 phosphorylation
    Huanhuan Wei
    Key Laboratory of Molecular Medicine, The Ministry of Education, Shanghai Medical College, Fudan University, 138 Yixueyuan Road, Shanghai 200032, China
    Chembiochem 13:465-75. 2012
    ..These results suggest that monocillin II has potential therapeutic benefits in breast cancer prevention and intervention...