Research Topics
| Fang ZhangSummaryAffiliation: Harvard Medical School and Harvard Pilgrim Health Care Country: USA Publications
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Detail Information
Publications
Simulation-based power calculation for designing interrupted time series analyses of health policy interventionsFang Zhang
Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA 02215, USA
J Clin Epidemiol 64:1252-61. 2011..Using simulation methods, we estimated the power requirements for interrupted time series studies under various scenarios...- Comparing simulation and threshold approaches when analysing data with probabilities of categoriesFang Zhang
Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA 02215, USA
J Eval Clin Pract 16:964-7. 2010..Constructing categories based on probabilities is not unusual in defining the outcome or the exposure. We compare the threshold approach and the simulation approach in making inferences... 
Depression and cost-related medication nonadherence in Medicare beneficiariesKara Zivin Bambauer
Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA, USA
Arch Gen Psychiatry 64:602-8. 2007....
Medication adherence and racial differences in A1C controlAlyce S Adams
Ambulatory Care and Prevention, Harvard Medical School, Boston, Massachusetts, USA
Diabetes Care 31:916-21. 2008..The purpose of this study was to examine medication adherence and other self-management practices as potential determinants of higher glycemic risk among black relative to white patients...- Unintended impacts of a Medicaid prior authorization policy on access to medications for bipolar illnessChristine Y Lu
Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA
Med Care 48:4-9. 2010..The objective of this study was to examine the impact of a Maine Medicaid PA policy on initiation and switching of anticonvulsant and atypical antipsychotic treatments among patients with bipolar disorder... - Impact of two Medicaid prior-authorization policies on antihypertensive use and costs among Michigan and Indiana residents dually enrolled in Medicaid and Medicare: results of a longitudinal, population-based studyMichael R Law
Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USA
Clin Ther 32:729-41; discussion 716. 2010..However, little is known about the impact of these policies on the use of antihypertensive medicines in the United States... - Impact of prior authorization on the use and costs of lipid-lowering medications among Michigan and Indiana dual enrollees in Medicaid and Medicare: results of a longitudinal, population-based studyChristine Y Lu
Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USA
Clin Ther 33:135-44. 2011..Some Medicaid programs have adopted prior-authorization (PA) policies that require prescribers to request approval from Medicaid before prescribing drugs not included on a preferred drug list... - Effect of New York State regulatory action on benzodiazepine prescribing and hip fracture ratesAnita K Wagner
Harvard Medical School and Harvard Pilgrim Health Care, Boston, Massachusetts 02215, USA
Ann Intern Med 146:96-103. 2007..Medicare Part D excludes benzodiazepines from coverage, and numerous state government policies limit use of benzodiazepines. No data indicate that such policies have decreased the incidence of hip fracture... - Racial differences in long-term self-monitoring practice among newly drug-treated diabetes patients in an HMOConnie Mah Trinacty
Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, 133 Brookline Avenue, 6th Floor, Boston, MA 02215, USA
J Gen Intern Med 22:1506-13. 2007..However, minority patients may encounter barriers to better self-care even within settings where variations in quality of care and insurance are minimized... - Racial differences in long-term adherence to oral antidiabetic drug therapy: a longitudinal cohort studyConnie M Trinacty
Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA, USA
BMC Health Serv Res 9:24. 2009..Adherence differences may contribute to health disparities for black diabetes patients, including higher microvascular event rates, greater complication-related disability, and earlier mortality... - Cost-related medication nonadherence and spending on basic needs following implementation of Medicare Part DJeanne M Madden
Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, 133 Brookline Ave, 6th Floor, Boston, Massachusetts 02215, USA
JAMA 299:1922-8. 2008..Cost-related medication nonadherence (CRN) has been a persistent problem for individuals who are elderly and disabled in the United States. The impact of Medicare prescription drug coverage (Part D) on CRN is unknown... - Prior authorization for antidepressants in Medicaid: effects among disabled dual enrolleesAlyce S Adams
Department of Ambulatory Care and Prevention, Harvard Medical School, Harvard Pilgrim Health Care, Boston, Massachusetts, USA
Arch Intern Med 169:750-6. 2009.... - Relationship between patient medication adherence and subsequent clinical inertia in type 2 diabetes glycemic managementRichard Grant
General Medicine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
Diabetes Care 30:807-12. 2007..We assessed the relationship between patients' initial medication adherence and subsequent regimen intensification among patients with persistently elevated A1C levels... - Association between prior authorization for medications and health service use by Medicaid patients with bipolar disorderChristine Y Lu
Department of Population Medicine, Harvard Medical School, 133 Brookline Ave, 6th Floor, Boston, MA 02215, USA
Psychiatr Serv 62:186-93. 2011..This study examined the association between a Medicaid prior-authorization policy for second-generation antipsychotic and anticonvulsant agents and medication discontinuation and health service use by patients with bipolar disorder... - Medicare part D and changes in prescription drug use and cost burden: national estimates for the Medicare population, 2000 to 2007Becky A Briesacher
Division of Geriatric Medicine and Meyers Primary Care Institute, University of Massachusetts Medical School and Meyers Primary Care, Worcester, Boston, MA, USA
Med Care 49:834-41. 2011..The full effect of Medicare Part D, after the initial policy transition period and across the United States Medicare population, remains unclear... - Reliability of new measures of cost-related medication nonadherenceMarsha Pierre-Jacques
Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, Massachusetts 02215, USA
Med Care 46:444-8. 2008..Although several national studies have attempted to measure medication nonadherence due to cost in cross-sectional studies of the elderly and disabled, little information exists on the psychometric properties of these measures over time... - Effect of switching to a high-deductible health plan on use of chronic medicationsSheila K Reiss
Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, 133 Brookline Avenue, 6th Floor, Boston, MA 02215, USA
Health Serv Res 46:1382-401. 2011..To examine whether high-deductible health plans (HDHPs) that exempt prescription drugs from full cost sharing preserve medication use for major chronic illness, compared with traditional HMOs with similar drug cost sharing... - Factors associated with difficult electronic health record implementation in office practiceMarshall Fleurant
Boston Medical Center, Boston University School of Medicine, Section of General Internal Medicine, 801 Massachusetts Avenue, 2nd Floor, Boston, MA 02118, USA
J Am Med Inform Assoc 19:541-4. 2012..4, 95% CI 0.2 to 0.8). Physicians who own their practice may need more external support for EHR implementation than those who do not. Innovative clinical support staff may ease the EHR implementation process and contribute to its success... - Cost-related medication nonadherence and cost-saving strategies used by elderly Medicare cancer survivorsLarissa Nekhlyudov
Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA 02215, USA
J Cancer Surviv 5:395-404. 2011..This study was conducted to compare cost-related medication nonadherence among elderly Medicare enrollees with and without cancer and to describe the strategies cancer survivors used to offset the costs of medications... - Use of atypical antipsychotic drugs for schizophrenia in Maine Medicaid following a policy changeStephen B Soumerai
Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, in Boston, Massachusetts, USA
Health Aff (Millwood) 27:w185-95. 2008..AA spending was slightly lower in both states. Observed increases in treatment discontinuities without cost savings suggest that AAs should be exempt from PA for patients with severe mental illnesses... - Effect of quality improvement on racial disparities in diabetes careThomas D Sequist
Department of Health Care Policy, Harvard Medical School, Boston, MA, USA
Arch Intern Med 166:675-81. 2006..Racial disparities in care are well documented; information regarding solutions is limited. We evaluated whether generic quality improvement efforts were associated with changes in racial disparities in diabetes care... - Racial disparities in access after regulatory surveillance of benzodiazepinesSallie-Anne Pearson
Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, Massachusetts 02215, USA
Arch Intern Med 166:572-9. 2006..The policy may have resulted in an unintended decrease in nonproblematic use that disproportionately affects black populations... - Length-of-stay policies and ascertainment of postdischarge problems in newbornsJeanne M Madden
Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, Massachusetts 02215, USA
Pediatrics 113:42-9. 2004..quot;Ascertainment bias" may have confounded findings in previous reports that raised concerns about the safety of early discharge... - Provider and patient characteristics associated with antidepressant nonadherence: the impact of provider specialtyKara Zivin Bambauer
Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, Mass, USA
J Clin Psychiatry 68:867-73. 2007.... - Clinician attitudes towards prescribing and implications for interventions in a multi-specialty group practiceRobert J Fortuna
Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA 02215, USA
J Eval Clin Pract 14:969-73. 2008..Although numerous factors influence prescribing, resources to support unbiased evidence-based prescribing are not widely available... - Race differences in long-term diabetes management in an HMOAlyce S Adams
Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, 133 Brookline Ave, 6th Floor, Boston, MA 02215, USA
Diabetes Care 28:2844-9. 2005..We examined race differences in diabetes outcomes over 4-8 years in a single HMO... - High-deductible insurance: two-year emergency department and hospital useJ Frank Wharam
Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, 133 Brookline Ave, 6th Floor, Boston, MA 02114, USA
Am J Manag Care 17:e410-8. 2011..To determine the 2-year impact of high-deductible health plans (HDHPs) on high-acuity, expensive medical care... - Effects of health maintenance organization coverage of self-monitoring devices on diabetes self-care and glycemic controlStephen B Soumerai
Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA 02215, USA
Arch Intern Med 164:645-52. 2004..We evaluated whether a policy providing free blood glucose monitors increased SMBG and whether initiating SMBG was associated with increased regularity of medication use and improved glucose control (hemoglobin A(1c) [HbA(1c)] level)... - Access to care and medicines, burden of health care expenditures, and risk protection: results from the World Health SurveyAnita K Wagner
Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA
Health Policy 100:151-8. 2011..We assessed the contribution of health insurance and a functioning public sector to access to care and medicines and household economic burden... - Two-year trends in colorectal cancer screening after switch to a high-deductible health planJames Frank Wharam
Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, 133 Brookline Avenue, Boston, MA 02215
Med Care 49:865-71. 2011..Recent health reform laws might accelerate high-deductible health plan (HDHP) growth. The impact of HDHPs on long-term colorectal cancer screening rates and low socioeconomic status (SES) members is unknown... - Methods for estimating confidence intervals in interrupted time series analyses of health interventionsFang Zhang
Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA 02215, USA
J Clin Epidemiol 62:143-8. 2009..We describe and illustrate two methods for estimating confidence intervals (CIs) around absolute and relative changes in outcomes calculated from segmented regression parameter estimates... - Effects of state surveillance on new post-hospitalization benzodiazepine useAnita K Wagner
Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, 133 Brookline Avenue, 6th Floor, Boston, MA 02215, USA
Int J Qual Health Care 15:423-31. 2003..Benzodiazepines (BZD) effectively treat anxiety and insomnia accompanying major health events, including hospitalizations. Prescribing regulations to decrease BZD misuse may negatively impact therapeutic uses... - Cost-related medication nonadherence among elderly and disabled medicare beneficiaries: a national survey 1 year before the medicare drug benefitStephen B Soumerai
Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, Mass, USA
Arch Intern Med 166:1829-35. 2006..Prior to implementation of the Medicare drug benefit, we estimated the prevalence of cost-related medication nonadherence (CRN) among Medicare enrollees, including elderly and nonelderly disabled beneficiaries... - Physician alerts to increase antidepressant adherence: fax or fiction?Kara Zivin Bambauer
Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, Massachusetts 02215, USA
Arch Intern Med 166:498-504. 2006..However, the efficacy of such interventions for improving adherence among patients treated for depression is unknown... - Effects of prior authorization on medication discontinuation among Medicaid beneficiaries with bipolar disorderYuting Zhang
Drug Policy Research Group at Harvard Medical School, Boston, MA 02215, USA
Psychiatr Serv 60:520-7. 2009.... - Does antidepressant adherence have an effect on glycemic control among diabetic antidepressant users?Kara Z Bambauer
Dept of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA 02215, USA
Int J Psychiatry Med 34:291-304. 2004..To examine the relationship between adherence to antidepressant medications and HbA1c levels among patients with diabetes in a managed care setting... - Two-year trends in cancer screening among low socioeconomic status women in an HMO-based high-deductible health planJ Frank Wharam
Department of Population Medicine, Harvard Medical School, Boston, MA 02215, USA
J Gen Intern Med 27:1112-9. 2012..Cancer screening is often fully covered under high-deductible health plans (HDHP), but low socioeconomic status (SES) women still might forego testing... - Measuring adherence to antiretroviral treatment in resource-poor settings: the clinical validity of key indicatorsDennis Ross-Degnan
Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston MA, USA
BMC Health Serv Res 10:42. 2010..Access to antiretroviral therapy has dramatically expanded in Africa in recent years, but there are no validated approaches to measure treatment adherence in these settings... - Effect of pay for performance on the management and outcomes of hypertension in the United Kingdom: interrupted time series studyBrian Serumaga
Department of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, Boston, MA 02215, USA
BMJ 342:d108. 2011..To assess the impact of a pay for performance incentive on quality of care and outcomes among UK patients with hypertension in primary care... - Barriers to self-monitoring of blood glucose among adults with diabetes in an HMO: a cross sectional studyAlyce S Adams
Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA, USA
BMC Health Serv Res 3:6. 2003..The purpose of the current study was to examine the relationship between patient characteristics and self-monitoring in a large health maintenance organization (HMO) using test strips as objective measures of self-monitoring practice... - Failure of automated telephone outreach with speech recognition to improve colorectal cancer screening: a randomized controlled trialSteven R Simon
Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA 02215, USA
Arch Intern Med 170:264-70. 2010..Automated telephone outreach with speech recognition (ATO-SR) is used extensively by health plans. Whether ATO-SR can increase rates of colorectal cancer (CRC) screening is unknown... - Benzodiazepine use and hip fractures in the elderly: who is at greatest risk?Anita K Wagner
Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA 02215, USA
Arch Intern Med 164:1567-72. 2004..It remains unclear whether benzodiazepine use increases hip fracture incidence. We studied this relationship in a large cohort, controlling for multiple potential confounders... - Massachusetts e-Health Project increased physicians' ability to use registries, and signals progress toward better careMarshall Fleurant
Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, and Brigham and Women s Hospital, Boston, MA, USA
Health Aff (Millwood) 30:1256-64. 2011..This statewide project may be a viable model for regional efforts to expand health information technology and improve the quality of care... - A distributed research network model for post-marketing safety studies: the Meningococcal Vaccine StudyPriscilla Velentgas
Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA 02215, USA
Pharmacoepidemiol Drug Saf 17:1226-34. 2008..Implementation has addressed several issues relevant to creation of a large scale post-marketing drug safety surveillance system envisioned by the FDA's Sentinel Initiative... - Risk of Guillain-Barré syndrome after meningococcal conjugate vaccinationPriscilla Velentgas
Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA
Pharmacoepidemiol Drug Saf 21:1350-8. 2012..We conducted a study to assess the risk of GBS after MCV4 vaccination using health plan administrative and claims data together with the review of primary medical records of potential cases... - Intended and unintended consequences of the gabapentin off-label marketing lawsuit among patients with bipolar disorderMeredith J Chace
Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care, 133 Brookline Ave, 6th Floor, Boston, MA 02215, USA
J Clin Psychiatry 73:1388-94. 2012.... - Reducing the prescribing of heavily marketed medications: a randomized controlled trialRobert J Fortuna
Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA, USA
J Gen Intern Med 24:897-903. 2009..Prescription drug costs are a major component of health care expenditures, yet resources to support evidence-based prescribing are not widely available... - Effects on breastfeeding of changes in maternity length-of-stay policy in a large health maintenance organizationJeanne M Madden
Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, Massachusetts 02215, USA
Pediatrics 111:519-24. 2003..CONCLUSIONS: Early postpartum discharge with outpatient breastfeeding support and a home visitor program has no adverse effects on initiation or continuation of breastfeeding... - Effects of a law against early postpartum discharge on newborn follow-up, adverse events, and HMO expendituresJeanne M Madden
Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA 02215, USA
N Engl J Med 347:2031-8. 2002..After the mandate, newborns were less likely to be examined as recommended on day 3 or 4. Because of changes in hospital prices, the two policies had minimal effects on HMO expenditures for hospital and home-based services...