Cuilin Zhang

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Molecular cloning of Porimin, a novel cell surface receptor mediating oncotic cell death
    F Ma
    Division of Tumor Immunology, Dana Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 98:9778-83. 2001
  2. ncbi request reprint A prospective study of dietary patterns, meat intake and the risk of gestational diabetes mellitus
    C Zhang
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Diabetologia 49:2604-13. 2006
  3. ncbi request reprint Variant of transcription factor 7-like 2 (TCF7L2) gene and the risk of type 2 diabetes in large cohorts of U.S. women and men
    Cuilin Zhang
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Diabetes 55:2645-8. 2006
  4. ncbi request reprint Dietary fiber intake, dietary glycemic load, and the risk for gestational diabetes mellitus
    Cuilin Zhang
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    Diabetes Care 29:2223-30. 2006
  5. pmc Joint effects of common genetic variants on the risk for type 2 diabetes in U.S. men and women of European ancestry
    Marilyn C Cornelis
    Harvard School of Public Health, Channing Laboratory, Boston, MA 02115, USA
    Ann Intern Med 150:541-50. 2009
  6. pmc Obesity genotype score and cardiovascular risk in women with type 2 diabetes mellitus
    Meian He
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Arterioscler Thromb Vasc Biol 30:327-32. 2010
  7. pmc Genetic predisposition, Western dietary pattern, and the risk of type 2 diabetes in men
    Lu Qi
    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    Am J Clin Nutr 89:1453-8. 2009
  8. pmc Fat mass-and obesity-associated (FTO) gene variant is associated with obesity: longitudinal analyses in two cohort studies and functional test
    Lu Qi
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
    Diabetes 57:3145-51. 2008
  9. pmc FTO genotype and 2-year change in body composition and fat distribution in response to weight-loss diets: the POUNDS LOST Trial
    Xiaomin Zhang
    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    Diabetes 61:3005-11. 2012
  10. pmc Healthful dietary patterns and type 2 diabetes mellitus risk among women with a history of gestational diabetes mellitus
    Deirdre K Tobias
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Arch Intern Med 172:1566-72. 2012

Detail Information

Publications37

  1. pmc Molecular cloning of Porimin, a novel cell surface receptor mediating oncotic cell death
    F Ma
    Division of Tumor Immunology, Dana Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 98:9778-83. 2001
    ..The Porimin gene was mapped to human chromosome 11q22.1 and is composed of four exons spanning 133 kb of genomic DNA...
  2. ncbi request reprint A prospective study of dietary patterns, meat intake and the risk of gestational diabetes mellitus
    C Zhang
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Diabetologia 49:2604-13. 2006
    ..The aim of this study was to prospectively examine whether dietary patterns are related to risk of gestational diabetes mellitus (GDM)...
  3. ncbi request reprint Variant of transcription factor 7-like 2 (TCF7L2) gene and the risk of type 2 diabetes in large cohorts of U.S. women and men
    Cuilin Zhang
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Diabetes 55:2645-8. 2006
    ..48-fold increased risk (P < 10(-16)). Our findings confirm that the TCF7L2 gene represents an important locus for predicting inherited susceptibility to type 2 diabetes...
  4. ncbi request reprint Dietary fiber intake, dietary glycemic load, and the risk for gestational diabetes mellitus
    Cuilin Zhang
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    Diabetes Care 29:2223-30. 2006
    ..We aimed to examine whether pregravid dietary fiber consumptions from cereal, fruit, and vegetable sources and dietary glycemic load were related to gestational diabetes mellitus (GDM) risk...
  5. pmc Joint effects of common genetic variants on the risk for type 2 diabetes in U.S. men and women of European ancestry
    Marilyn C Cornelis
    Harvard School of Public Health, Channing Laboratory, Boston, MA 02115, USA
    Ann Intern Med 150:541-50. 2009
    ..Genome-wide association studies have identified novel type 2 diabetes loci, each of which has a modest impact on risk...
  6. pmc Obesity genotype score and cardiovascular risk in women with type 2 diabetes mellitus
    Meian He
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Arterioscler Thromb Vasc Biol 30:327-32. 2010
    ..To investigate the associations between obesity-predisposing genetic variants, cardiovascular biomarkers, and cardiovascular disease (CVD) risk in women with preexisting type 2 diabetes mellitus...
  7. pmc Genetic predisposition, Western dietary pattern, and the risk of type 2 diabetes in men
    Lu Qi
    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    Am J Clin Nutr 89:1453-8. 2009
    ..A widely held hypothesis is that interactions between genetic predisposition and Western-type lifestyle contribute to the epidemic of type 2 diabetes (T2D). No study has tested this hypothesis...
  8. pmc Fat mass-and obesity-associated (FTO) gene variant is associated with obesity: longitudinal analyses in two cohort studies and functional test
    Lu Qi
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
    Diabetes 57:3145-51. 2008
    ..To examine the longitudinal association of fat mass-and obesity-associated (FTO) variant with obesity, circulating adipokine levels, and FTO expression in various materials from human and mouse...
  9. pmc FTO genotype and 2-year change in body composition and fat distribution in response to weight-loss diets: the POUNDS LOST Trial
    Xiaomin Zhang
    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    Diabetes 61:3005-11. 2012
    ..Our data suggest that a high-protein diet may be beneficial for weight loss and improvement of body composition and fat distribution in individuals with the risk allele of the FTO variant rs1558902...
  10. pmc Healthful dietary patterns and type 2 diabetes mellitus risk among women with a history of gestational diabetes mellitus
    Deirdre K Tobias
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Arch Intern Med 172:1566-72. 2012
    ..Adherence to healthful dietary patterns has been inversely associated with T2DM in the general population; however, whether these dietary patterns are associated with progression to T2DM among a susceptible population is unknown...
  11. pmc Total and high-molecular-weight adiponectin and resistin in relation to the risk for type 2 diabetes in women
    Christin Heidemann
    Harvard School of Public Health, Massachusetts General Hospital, Brigham and Women s Hospital, and Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Ann Intern Med 149:307-16. 2008
    ..Adiponectin and resistin are recently discovered adipokines that may provide a molecular link between adiposity and type 2 diabetes...
  12. ncbi request reprint Interaction between dietary fat intake and the cholesterol ester transfer protein TaqIB polymorphism in relation to HDL-cholesterol concentrations among US diabetic men
    Tricia Y Li
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Clin Nutr 86:1524-9. 2007
    ..Cholesterol ester transfer protein (CETP) plays an important role in the regulation of HDL metabolism, and the TaqIB polymorphism of the CETP gene has been associated with elevated HDL concentrations...
  13. doi request reprint Common variations in perilipin gene, central obesity, and risk of type 2 diabetes in US women
    Lu Qi
    Department of Nutrition, Harvard School of Public Health, and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Obesity (Silver Spring) 16:1061-5. 2008
    ..The variations in perilipin gene (PLIN) were previously associated with obesity and insulin sensitivity. We examined whether PLIN variability was associated with diabetes risk and obesity status modified such associations...
  14. pmc Prepregnancy adherence to dietary patterns and lower risk of gestational diabetes mellitus
    Deirdre K Tobias
    Department of Nutrition, Harvard Medical School, Boston, MA, USA
    Am J Clin Nutr 96:289-95. 2012
    ....
  15. ncbi request reprint Interactions between the -514C->T polymorphism of the hepatic lipase gene and lifestyle factors in relation to HDL concentrations among US diabetic men
    Cuilin Zhang
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Clin Nutr 81:1429-35. 2005
    ....
  16. ncbi request reprint A prospective study of pregravid physical activity and sedentary behaviors in relation to the risk for gestational diabetes mellitus
    Cuilin Zhang
    Department of Nutrition, Harvard School of Public Health, Boston, Massachsuetts 02115, USA
    Arch Intern Med 166:543-8. 2006
    ..Although gestational diabetes mellitus (GDM) has been associated with substantial adverse health outcomes for both mothers and offspring, few modifiable risk factors for GDM have been identified...
  17. ncbi request reprint Common variants of the endothelial nitric oxide synthase gene and the risk of coronary heart disease among U.S. diabetic men
    Cuilin Zhang
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    Diabetes 55:2140-7. 2006
    ..002), compared with noncarriers. In conclusion, our data suggested that -786T>C, Glu298Asp, and an intron 8 polymorphism of the eNOS gene are potentially involved in the atherogenic pathway among U.S. diabetic men...
  18. pmc Blood 25-hydroxy vitamin D levels and incident type 2 diabetes: a meta-analysis of prospective studies
    Yiqing Song
    Department of Medicine, Harvard Medical School, Boston, MA, USA
    Diabetes Care 36:1422-8. 2013
    ..To quantitatively assess the strength and shape of the association between blood 25-hydroxy vitamin D [25(OH)D] levels and incident risk of type 2 diabetes...
  19. pmc Circulating 25-hydroxy-vitamin D and risk of cardiovascular disease: a meta-analysis of prospective studies
    Lu Wang
    Brigham and Women s Hospital, Boston, MA 02215, USA
    Circ Cardiovasc Qual Outcomes 5:819-29. 2012
    ..Vitamin D status has been linked to the risk of cardiovascular disease (CVD). However, the optimal 25-hydroxy-vitamin D (25[OH]-vitamin D) levels for potential cardiovascular health benefits remain unclear...
  20. pmc Genetic variants, plasma lipoprotein(a) levels, and risk of cardiovascular morbidity and mortality among two prospective cohorts of type 2 diabetes
    Qibin Qi
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    Eur Heart J 33:325-34. 2012
    ..To examine the relations between genetic loci, plasma lipoprotein(a) [Lp(a)] levels, and cardiovascular disease (CVD) risk among diabetic patients and compare with the observations in the general population...
  21. ncbi request reprint Interleukin-6 genetic variability and adiposity: associations in two prospective cohorts and systematic review in 26,944 individuals
    Lu Qi
    Departments of Nutrition and Epidemiology, Harvard School of Public Health, and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Endocrinol Metab 92:3618-25. 2007
    ..IL-6 (IL6) is an immune-modulating cytokine associated with obesity in humans...
  22. ncbi request reprint Trp64Arg polymorphism of the beta3-adrenergic receptor gene, pre-pregnancy obesity and risk of pre-eclampsia
    Cuilin Zhang
    Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, WA, USA
    J Matern Fetal Neonatal Med 17:19-28. 2005
    ..We investigated the relation of the beta3-AR gene to pre-pregnancy obesity and risk of pre-eclampsia. The present study is a case-control study of 87 Caucasian pre-eclampsia cases and 214 controls...
  23. ncbi request reprint Genetic variation in the hepatic lipase gene and the risk of coronary heart disease among US diabetic men: potential interaction with obesity
    C Zhang
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA, 02115, USA
    Diabetologia 49:1552-9. 2006
    ..Moreover, data on this association among diabetic patients are limited. We investigated the association of the LIPC polymorphism with CHD risk among US diabetic men and evaluated whether this association was modified by adiposity status...
  24. pmc A cell surface receptor defined by a mAb mediates a unique type of cell death similar to oncosis
    C Zhang
    Tumor Immunology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 95:6290-5. 1998
    ..The induction of cell death by anti-Porimin may represent a unique cell surface receptor-mediated pathway of cell death in the human lymphoid system...
  25. ncbi request reprint Functional variants of the lipoprotein lipase gene and the risk of preeclampsia among non-Hispanic Caucasian women
    C Zhang
    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    Clin Genet 69:33-9. 2006
    ..6, 95% CI 1.7-25.0). Results from our study support the thesis that abnormal lipid metabolism is important in the pathogenesis of preeclampsia...
  26. pmc Increased risk of hypertension after gestational diabetes mellitus: findings from a large prospective cohort study
    Deirdre K Tobias
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
    Diabetes Care 34:1582-4. 2011
    ..Whether a history of gestational diabetes mellitus (GDM) is associated with an increased risk of hypertension after the index pregnancy is not well established...
  27. ncbi request reprint The +276 polymorphism of the APM1 gene, plasma adiponectin concentration, and cardiovascular risk in diabetic men
    Lu Qi
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    Diabetes 54:1607-10. 2005
    ..0019). In conclusion, our study showed significant associations between APM1 G276T and decreased CVD risk and increased plasma adiponectin levels in diabetic men...
  28. pmc Physical activity before and during pregnancy and risk of gestational diabetes mellitus: a meta-analysis
    Deirdre K Tobias
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
    Diabetes Care 34:223-9. 2011
    ..Therefore, we aimed to systematically review and synthesize the current evidence on the relation between physical activity and the development of GDM...
  29. ncbi request reprint Monoclonal antibodies derived from BALB/c mice immunized with apoptotic Jurkat T cells recognize known autoantigens
    T J Gensler
    The Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA 02115, USA
    J Autoimmun 16:59-69. 2001
    ..These findings are consistent with the hypothesis that apoptosis can contribute to the development of autoimmunity...
  30. ncbi request reprint Vitamin C and the risk of preeclampsia--results from dietary questionnaire and plasma assay
    Cuilin Zhang
    Department of Epidemiology, University of Washington School of Public Health and Community Medicine, 1959 NE Pacific Avenue, Seattle, WA 98195, USA
    Epidemiology 13:409-16. 2002
    ..Oxidative stress plays an important role in the pathophysiology of preeclampsia...
  31. ncbi request reprint Hepatic lipase gene polymorphism, pre-pregnancy overweight status and risk of preeclampsia among Peruvian women
    Daniel A Enquobahrie
    Center for Perinatal Studies, Swedish Medical Center, Seattle, WA, USA
    Gynecol Endocrinol 21:211-7. 2005
    ..In this study, we found that LIPC -514TT genotype and overweight status, when occurring together, were associated with a 3-fold increase in risk of preeclampsia among Peruvian women...
  32. doi request reprint Abdominal obesity and the risk of all-cause, cardiovascular, and cancer mortality: sixteen years of follow-up in US women
    Cuilin Zhang
    Epidemiology Branch, Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, 6100 Executive Blvd, Room 7B03, MSC 7510, 9000 Rockville Pike, Bethesda, MD 20892 7510, USA
    Circulation 117:1658-67. 2008
    ..However, the association of premature death resulting from these diseases with abdominal adiposity has not been widely studied, and findings are inconsistent...
  33. ncbi request reprint Family history of hypertension and diabetes in relation to preeclampsia risk in Peruvian women
    Sixto E Sanchez
    Dos de Mayo Hospital, Lima, Peru
    Gynecol Obstet Invest 56:128-32. 2003
    ..6; 95% CI 0.9-23.0). Our results are generally consistent with the thesis that parental history of hypertension and diabetes reflects genetic and behavioral factors whereby women may be predisposed to an increased risk of preeclampsia...
  34. ncbi request reprint Dietary fiber, potassium, magnesium and calcium in relation to the risk of preeclampsia
    Ihunnaya O Frederick
    Center for Perinatal Studies, Swedish Medical Center, Seattle, WA 98122, USA
    J Reprod Med 50:332-44. 2005
    ..To explore the relation between preeclampsia risk and maternal intake of dietary fiber, potassium, magnesium and calcium...
  35. ncbi request reprint A prospective study of maternal serum C-reactive protein concentrations and risk of preeclampsia
    Chunfang Qiu
    Center for Perinatal Studies, Swedish Medical Center, 747 Broadway, Suite 449 North, Seattle, WA 98122, USA
    Am J Hypertens 17:154-60. 2004
    ..We measured C-reactive protein (CRP), a clinical marker of systemic inflammation, in maternal serum collected at 13 weeks gestation on average, to determine whether elevations precede the clinical manifestation of preeclampsia...
  36. ncbi request reprint Vitamin C and the risk of gestational diabetes mellitus: a case-control study
    Cuilin Zhang
    Department of Epidemiology, University of Washington School of Public Health and Community Medicine, Seattle, USA
    J Reprod Med 49:257-66. 2004
    ..To examine whether low maternal dietary intake of vitamin C and low maternal plasma ascorbic acid (AA) concentrations are associated with an increased risk of gestational diabetes mellitus (GDM)...
  37. ncbi request reprint Maternal plasma ascorbic Acid (vitamin C) and risk of gestational diabetes mellitus
    Cuilin Zhang
    Department of Epidemiology, University of Washington School of Public Health and Community Medicine, Seattle, Washington, USA
    Epidemiology 15:597-604. 2004
    ..Antioxidants, particularly vitamin C (ascorbic acid), have the capacity to influence glucose tolerance. Modification of diet could reduce the likelihood of developing gestational diabetes mellitus...