Research Topics
Genomes and Genes
| Cuilin ZhangSummaryAffiliation: Harvard University Country: USA Publications
| Collaborators
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Detail Information
Publications
Molecular cloning of Porimin, a novel cell surface receptor mediating oncotic cell deathF Ma
Division of Tumor Immunology, Dana Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 98:9778-83. 2001..The Porimin gene was mapped to human chromosome 11q22.1 and is composed of four exons spanning 133 kb of genomic DNA...
A prospective study of dietary patterns, meat intake and the risk of gestational diabetes mellitusC Zhang
Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
Diabetologia 49:2604-13. 2006..The aim of this study was to prospectively examine whether dietary patterns are related to risk of gestational diabetes mellitus (GDM)...- Dietary fiber intake, dietary glycemic load, and the risk for gestational diabetes mellitusCuilin Zhang
Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
Diabetes Care 29:2223-30. 2006..We aimed to examine whether pregravid dietary fiber consumptions from cereal, fruit, and vegetable sources and dietary glycemic load were related to gestational diabetes mellitus (GDM) risk... - Variant of transcription factor 7-like 2 (TCF7L2) gene and the risk of type 2 diabetes in large cohorts of U.S. women and menCuilin Zhang
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
Diabetes 55:2645-8. 2006..48-fold increased risk (P < 10(-16)). Our findings confirm that the TCF7L2 gene represents an important locus for predicting inherited susceptibility to type 2 diabetes... - Joint effects of common genetic variants on the risk for type 2 diabetes in U.S. men and women of European ancestryMarilyn C Cornelis
Harvard School of Public Health, Channing Laboratory, Boston, MA 02115, USA
Ann Intern Med 150:541-50. 2009..Genome-wide association studies have identified novel type 2 diabetes loci, each of which has a modest impact on risk... - Obesity genotype score and cardiovascular risk in women with type 2 diabetes mellitusMeian He
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
Arterioscler Thromb Vasc Biol 30:327-32. 2010..To investigate the associations between obesity-predisposing genetic variants, cardiovascular biomarkers, and cardiovascular disease (CVD) risk in women with preexisting type 2 diabetes mellitus... - Genetic predisposition, Western dietary pattern, and the risk of type 2 diabetes in menLu Qi
Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
Am J Clin Nutr 89:1453-8. 2009..A widely held hypothesis is that interactions between genetic predisposition and Western-type lifestyle contribute to the epidemic of type 2 diabetes (T2D). No study has tested this hypothesis... - Fat mass-and obesity-associated (FTO) gene variant is associated with obesity: longitudinal analyses in two cohort studies and functional testLu Qi
Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
Diabetes 57:3145-51. 2008..To examine the longitudinal association of fat mass-and obesity-associated (FTO) variant with obesity, circulating adipokine levels, and FTO expression in various materials from human and mouse... - Interaction between dietary fat intake and the cholesterol ester transfer protein TaqIB polymorphism in relation to HDL-cholesterol concentrations among US diabetic menTricia Y Li
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
Am J Clin Nutr 86:1524-9. 2007..Cholesterol ester transfer protein (CETP) plays an important role in the regulation of HDL metabolism, and the TaqIB polymorphism of the CETP gene has been associated with elevated HDL concentrations... - Total and high-molecular-weight adiponectin and resistin in relation to the risk for type 2 diabetes in womenChristin Heidemann
Harvard School of Public Health, Massachusetts General Hospital, Brigham and Women s Hospital, and Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
Ann Intern Med 149:307-16. 2008..Adiponectin and resistin are recently discovered adipokines that may provide a molecular link between adiposity and type 2 diabetes... 
Common variations in perilipin gene, central obesity, and risk of type 2 diabetes in US womenLu Qi
Department of Nutrition, Harvard School of Public Health, and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
Obesity (Silver Spring) 16:1061-5. 2008..The variations in perilipin gene (PLIN) were previously associated with obesity and insulin sensitivity. We examined whether PLIN variability was associated with diabetes risk and obesity status modified such associations...- Prepregnancy adherence to dietary patterns and lower risk of gestational diabetes mellitusDeirdre K Tobias
Department of Nutrition, Harvard Medical School, Boston, MA, USA
Am J Clin Nutr 96:289-95. 2012.... - Common variants of the endothelial nitric oxide synthase gene and the risk of coronary heart disease among U.S. diabetic menCuilin Zhang
Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
Diabetes 55:2140-7. 2006..002), compared with noncarriers. In conclusion, our data suggested that -786T>C, Glu298Asp, and an intron 8 polymorphism of the eNOS gene are potentially involved in the atherogenic pathway among U.S. diabetic men... - A prospective study of pregravid physical activity and sedentary behaviors in relation to the risk for gestational diabetes mellitusCuilin Zhang
Department of Nutrition, Harvard School of Public Health, Boston, Massachsuetts 02115, USA
Arch Intern Med 166:543-8. 2006..Although gestational diabetes mellitus (GDM) has been associated with substantial adverse health outcomes for both mothers and offspring, few modifiable risk factors for GDM have been identified... - Interactions between the -514C->T polymorphism of the hepatic lipase gene and lifestyle factors in relation to HDL concentrations among US diabetic menCuilin Zhang
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
Am J Clin Nutr 81:1429-35. 2005..A common polymorphism (-514C-->T) of the hepatic lipase gene (LIPC), which accounts for up to 30% of the variation in hepatic lipase activity, has been associated with low hepatic lipase activity and high HDL-cholesterol concentrations... - Genetic variants, plasma lipoprotein(a) levels, and risk of cardiovascular morbidity and mortality among two prospective cohorts of type 2 diabetesQibin Qi
Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
Eur Heart J 33:325-34. 2012..To examine the relations between genetic loci, plasma lipoprotein(a) [Lp(a)] levels, and cardiovascular disease (CVD) risk among diabetic patients and compare with the observations in the general population... - Interleukin-6 genetic variability and adiposity: associations in two prospective cohorts and systematic review in 26,944 individualsLu Qi
Departments of Nutrition and Epidemiology, Harvard School of Public Health, and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
J Clin Endocrinol Metab 92:3618-25. 2007..IL-6 (IL6) is an immune-modulating cytokine associated with obesity in humans... - Trp64Arg polymorphism of the beta3-adrenergic receptor gene, pre-pregnancy obesity and risk of pre-eclampsiaCuilin Zhang
Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, WA, USA
J Matern Fetal Neonatal Med 17:19-28. 2005..We investigated the relation of the beta3-AR gene to pre-pregnancy obesity and risk of pre-eclampsia. The present study is a case-control study of 87 Caucasian pre-eclampsia cases and 214 controls... - Functional variants of the lipoprotein lipase gene and the risk of preeclampsia among non-Hispanic Caucasian womenC Zhang
Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
Clin Genet 69:33-9. 2006..6, 95% CI 1.7-25.0). Results from our study support the thesis that abnormal lipid metabolism is important in the pathogenesis of preeclampsia... - A cell surface receptor defined by a mAb mediates a unique type of cell death similar to oncosisC Zhang
Tumor Immunology, Dana Farber Cancer Institute, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 95:6290-5. 1998..The induction of cell death by anti-Porimin may represent a unique cell surface receptor-mediated pathway of cell death in the human lymphoid system... - Genetic variation in the hepatic lipase gene and the risk of coronary heart disease among US diabetic men: potential interaction with obesityC Zhang
Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA, 02115, USA
Diabetologia 49:1552-9. 2006..Moreover, data on this association among diabetic patients are limited. We investigated the association of the LIPC polymorphism with CHD risk among US diabetic men and evaluated whether this association was modified by adiposity status... - The +276 polymorphism of the APM1 gene, plasma adiponectin concentration, and cardiovascular risk in diabetic menLu Qi
Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
Diabetes 54:1607-10. 2005..0019). In conclusion, our study showed significant associations between APM1 G276T and decreased CVD risk and increased plasma adiponectin levels in diabetic men... - Increased risk of hypertension after gestational diabetes mellitus: findings from a large prospective cohort studyDeirdre K Tobias
Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
Diabetes Care 34:1582-4. 2011..Whether a history of gestational diabetes mellitus (GDM) is associated with an increased risk of hypertension after the index pregnancy is not well established... - Physical activity before and during pregnancy and risk of gestational diabetes mellitus: a meta-analysisDeirdre K Tobias
Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
Diabetes Care 34:223-9. 2011..Therefore, we aimed to systematically review and synthesize the current evidence on the relation between physical activity and the development of GDM... - Monoclonal antibodies derived from BALB/c mice immunized with apoptotic Jurkat T cells recognize known autoantigensT J Gensler
The Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA 02115, USA
J Autoimmun 16:59-69. 2001..These findings are consistent with the hypothesis that apoptosis can contribute to the development of autoimmunity... - Hepatic lipase gene polymorphism, pre-pregnancy overweight status and risk of preeclampsia among Peruvian womenDaniel A Enquobahrie
Center for Perinatal Studies, Swedish Medical Center, Seattle, WA, USA
Gynecol Endocrinol 21:211-7. 2005..In this study, we found that LIPC -514TT genotype and overweight status, when occurring together, were associated with a 3-fold increase in risk of preeclampsia among Peruvian women... - Vitamin C and the risk of preeclampsia--results from dietary questionnaire and plasma assayCuilin Zhang
Department of Epidemiology, University of Washington School of Public Health and Community Medicine, 1959 NE Pacific Avenue, Seattle, WA 98195, USA
Epidemiology 13:409-16. 2002..Oxidative stress plays an important role in the pathophysiology of preeclampsia... - Family history of hypertension and diabetes in relation to preeclampsia risk in Peruvian womenSixto E Sanchez
Dos de Mayo Hospital, Lima, Peru
Gynecol Obstet Invest 56:128-32. 2003..6; 95% CI 0.9-23.0). Our results are generally consistent with the thesis that parental history of hypertension and diabetes reflects genetic and behavioral factors whereby women may be predisposed to an increased risk of preeclampsia... - A prospective study of maternal serum C-reactive protein concentrations and risk of preeclampsiaChunfang Qiu
Center for Perinatal Studies, Swedish Medical Center, 747 Broadway, Suite 449 North, Seattle, WA 98122, USA
Am J Hypertens 17:154-60. 2004..We measured C-reactive protein (CRP), a clinical marker of systemic inflammation, in maternal serum collected at 13 weeks gestation on average, to determine whether elevations precede the clinical manifestation of preeclampsia... - Dietary fiber, potassium, magnesium and calcium in relation to the risk of preeclampsiaIhunnaya O Frederick
Center for Perinatal Studies, Swedish Medical Center, Seattle, WA 98122, USA
J Reprod Med 50:332-44. 2005..To explore the relation between preeclampsia risk and maternal intake of dietary fiber, potassium, magnesium and calcium... - Abdominal obesity and the risk of all-cause, cardiovascular, and cancer mortality: sixteen years of follow-up in US womenCuilin Zhang
Epidemiology Branch, Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, 6100 Executive Blvd, Room 7B03, MSC 7510, 9000 Rockville Pike, Bethesda, MD 20892 7510, USA
Circulation 117:1658-67. 2008..However, the association of premature death resulting from these diseases with abdominal adiposity has not been widely studied, and findings are inconsistent... - Vitamin C and the risk of gestational diabetes mellitus: a case-control studyCuilin Zhang
Department of Epidemiology, University of Washington School of Public Health and Community Medicine, Seattle, USA
J Reprod Med 49:257-66. 2004..Large, prospective, cohort studies are needed to further evaluate the potential beneficial role of vitamin C and other antioxidants in the prevention of impaired glucose tolerance in pregnancy... - Maternal plasma ascorbic Acid (vitamin C) and risk of gestational diabetes mellitusCuilin Zhang
Department of Epidemiology, University of Washington School of Public Health and Community Medicine, Seattle, Washington, USA
Epidemiology 15:597-604. 2004..Antioxidants, particularly vitamin C (ascorbic acid), have the capacity to influence glucose tolerance. Modification of diet could reduce the likelihood of developing gestational diabetes mellitus...