Rihong Zhai

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Trends in nasopharyngeal carcinoma mortality in China, 1973-2005
    Tian ren Huang
    Department of Epidemiology, Guangxi Cancer Institute, Nanning, China
    Asian Pac J Cancer Prev 13:2495-502. 2012
  2. pmc Genome-wide DNA methylation profiling of cell-free serum DNA in esophageal adenocarcinoma and Barrett esophagus
    Rihong Zhai
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Neoplasia 14:29-33. 2012
  3. pmc Interactions among genetic variants in apoptosis pathway genes, reflux symptoms, body mass index, and smoking indicate two distinct etiologic patterns of esophageal adenocarcinoma
    Rihong Zhai
    Department of Environmental Health, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    J Clin Oncol 28:2445-51. 2010
  4. pmc Interactions between environmental factors and polymorphisms in angiogenesis pathway genes in esophageal adenocarcinoma risk: a case-only study
    Rihong Zhai
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer 118:804-11. 2012
  5. pmc Genetic polymorphisms of VEGF, interactions with cigarette smoking exposure and esophageal adenocarcinoma risk
    Rihong Zhai
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Carcinogenesis 29:2330-4. 2008
  6. pmc Apoptosis gene polymorphisms, age, smoking and the risk of non-small cell lung cancer
    Monica Ter-Minassian
    Department of Environmental Health, Harvard School of Public Health, Boston 02115, MA, USA
    Carcinogenesis 29:2147-52. 2008
  7. pmc Genetic polymorphisms of peptidase inhibitor 3 (elafin) are associated with acute respiratory distress syndrome
    Paula Tejera
    Department of Environmental Health, Harvard School of Public Health, 665 Huntington Avenue, Room I 1407, Boston, MA 02115, USA
    Am J Respir Cell Mol Biol 41:696-704. 2009
  8. pmc Interactions between genetic polymorphisms in the apoptotic pathway and environmental factors on esophageal adenocarcinoma risk
    I Chen Wu
    Environmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard School of Public Health, and Department of Medicine, Massachusetts General Hospital, Boston, MA 02115, USA
    Carcinogenesis 32:502-6. 2011
  9. pmc Association between polymorphisms in cancer-related genes and early onset of esophageal adenocarcinoma
    I Chen Wu
    Environmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    Neoplasia 13:386-92. 2011
  10. pmc Heme oxygenase-1 microsatellite polymorphism and haplotypes are associated with the development of acute respiratory distress syndrome
    Chau Chyun Sheu
    Department of Environmental Health, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Intensive Care Med 35:1343-51. 2009

Collaborators

Detail Information

Publications31

  1. ncbi Trends in nasopharyngeal carcinoma mortality in China, 1973-2005
    Tian ren Huang
    Department of Epidemiology, Guangxi Cancer Institute, Nanning, China
    Asian Pac J Cancer Prev 13:2495-502. 2012
    ..In summary, the overall NPC mortality has consistently decreased in China over the past three decades, particularly in women and in old adults...
  2. pmc Genome-wide DNA methylation profiling of cell-free serum DNA in esophageal adenocarcinoma and Barrett esophagus
    Rihong Zhai
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Neoplasia 14:29-33. 2012
    ..Differential cfDNAm profiling may be a useful approach for the noninvasive screening of EA and EA premalignant lesions...
  3. pmc Interactions among genetic variants in apoptosis pathway genes, reflux symptoms, body mass index, and smoking indicate two distinct etiologic patterns of esophageal adenocarcinoma
    Rihong Zhai
    Department of Environmental Health, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    J Clin Oncol 28:2445-51. 2010
    ..However, how multiple factors jointly affect EA risk remains unclear...
  4. pmc Interactions between environmental factors and polymorphisms in angiogenesis pathway genes in esophageal adenocarcinoma risk: a case-only study
    Rihong Zhai
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer 118:804-11. 2012
    ..However, how angiogenic gene polymorphisms and environmental factors jointly affect esophageal adenocarcinoma development remains unclear...
  5. pmc Genetic polymorphisms of VEGF, interactions with cigarette smoking exposure and esophageal adenocarcinoma risk
    Rihong Zhai
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Carcinogenesis 29:2330-4. 2008
    ..70; 95% CI, 1.04-2.73; P = 0.034). These results suggested that cigarette smoking modifies the association between VEGF polymorphisms and EA risk among Caucasians...
  6. pmc Apoptosis gene polymorphisms, age, smoking and the risk of non-small cell lung cancer
    Monica Ter-Minassian
    Department of Environmental Health, Harvard School of Public Health, Boston 02115, MA, USA
    Carcinogenesis 29:2147-52. 2008
    ..17). No interactions were observed for FAS -1377 G>A and BAT3 Ser625Pro polymorphisms. Our findings indicate that age and smoking may modify the association of the FASLG -844 and IL1B + 3954 SNPs with the risk of NSCLC...
  7. pmc Genetic polymorphisms of peptidase inhibitor 3 (elafin) are associated with acute respiratory distress syndrome
    Paula Tejera
    Department of Environmental Health, Harvard School of Public Health, 665 Huntington Avenue, Room I 1407, Boston, MA 02115, USA
    Am J Respir Cell Mol Biol 41:696-704. 2009
    ..019) at ARDS onset as compared with those homozygous or heterozygous for the variant C allele. Our data suggest that polymorphisms in PI3 gene are significantly associated with ARDS risk and with circulating PI3 levels...
  8. pmc Interactions between genetic polymorphisms in the apoptotic pathway and environmental factors on esophageal adenocarcinoma risk
    I Chen Wu
    Environmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard School of Public Health, and Department of Medicine, Massachusetts General Hospital, Boston, MA 02115, USA
    Carcinogenesis 32:502-6. 2011
    ..15 times when ≥2 risk genotypes were present (ORi=3.15, Padj<0.0001). In conclusion, interactions among apoptotic SNPs and GERD or smoking play an important role in EA development...
  9. pmc Association between polymorphisms in cancer-related genes and early onset of esophageal adenocarcinoma
    I Chen Wu
    Environmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    Neoplasia 13:386-92. 2011
    ..In conclusion, polymorphisms in cancer-related genes, especially those in the apoptotic pathway, play an important role in the development of younger-aged EA in a dose-response manner...
  10. pmc Heme oxygenase-1 microsatellite polymorphism and haplotypes are associated with the development of acute respiratory distress syndrome
    Chau Chyun Sheu
    Department of Environmental Health, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Intensive Care Med 35:1343-51. 2009
    ..The polymorphic (GT)n repeat in the HO-1 gene (HMOX1) promoter regulates HMOX1 expression. We investigated the associations of HMOX1 polymorphisms with acute respiratory distress syndrome (ARDS) risk and plasma HO-1 levels...
  11. pmc A functional epidermal growth factor (EGF) polymorphism, EGF serum levels, and esophageal adenocarcinoma risk and outcome
    Michael Lanuti
    Division of Thoracic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Clin Cancer Res 14:3216-22. 2008
    ..We hypothesized that the EGF A61G homozygous variant genotype (GG) is (a) both a risk and poor prognostic factor for EAC and (b) associated with higher EGF serum levels in individuals with gastroesophageal reflux disease (GERD)...
  12. pmc Genetic associations with sporadic neuroendocrine tumor risk
    Monica Ter-Minassian
    Environmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Carcinogenesis 32:1216-22. 2011
    ..Our findings support further investigation of the potential role of IL12A and DAD1 in the etiology of NET...
  13. doi VEGF polymorphisms and survival in early-stage non-small-cell lung cancer
    Rebecca Suk Heist
    Massachusetts General Hospital, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    J Clin Oncol 26:856-62. 2008
    ..Polymorphisms in the VEGF gene have been identified that are believed to have functional activity. We hypothesized that such polymorphisms may affect survival outcomes among early-stage non-small-cell lung cancer (NSCLC) patients...
  14. pmc Genetic variants in the angiopoietin-2 gene are associated with increased risk of ARDS
    Li Su
    Department of Environmental Health, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Intensive Care Med 35:1024-30. 2009
    ..Genetic variants in the Ang-2 gene may lead to altered activities of Ang-2 (or ANGPT2) gene. The aim of this study was to assess if genetic variants of Ang-2 are associated with the risk of ARDS...
  15. pmc A Large-scale genetic association study of esophageal adenocarcinoma risk
    Chen Yu Liu
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Carcinogenesis 31:1259-63. 2010
    ....
  16. pmc Plasma neutrophil elastase and elafin imbalance is associated with acute respiratory distress syndrome (ARDS) development
    Zhaoxi Wang
    Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    PLoS ONE 4:e4380. 2009
    ..In this study, we tested the hypothesis that an imbalance between neutrophil elastase (HNE) and its inhibitors in blood is related to the development of ARDS...
  17. pmc Clinical characteristics and outcomes of sepsis-related vs non-sepsis-related ARDS
    Chau Chyun Sheu
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Chest 138:559-67. 2010
    ..ARDS may occur after either septic or nonseptic injuries. Sepsis is the major cause of ARDS, but little is known about the differences between sepsis-related and non-sepsis-related ARDS...
  18. pmc An NFKB1 promoter insertion/deletion polymorphism influences risk and outcome in acute respiratory distress syndrome among Caucasians
    Ednan K Bajwa
    Pulmonary and Critical Care Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 6:e19469. 2011
    ..We hypothesized that a known functional polymorphism in the promoter of the NFKB1 gene may affect susceptibility to and outcome from ARDS...
  19. ncbi MDM2 promoter polymorphism and pancreatic cancer risk and prognosis
    Kofi Asomaning
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Clin Cancer Res 14:4010-5. 2008
    ..We hypothesized that the G allele is also associated with increased risk and worse outcome in pancreatic cancer...
  20. pmc Association test based on SNP set: logistic kernel machine based test vs. principal component analysis
    Yang Zhao
    Department of Environmental Health, Harvard School of Public Health, Harvard University, Boston, Massachusetts, United States of America
    PLoS ONE 7:e44978. 2012
    ..We also apply LKM and PCA to analyze two SNP sets extracted from an actual GWAS dataset on non-small cell lung cancer...
  21. ncbi Inhibitor kappaB-alpha haplotype GTC is associated with susceptibility to acute respiratory distress syndrome in Caucasians
    Rihong Zhai
    Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    Crit Care Med 35:893-8. 2007
    ..Inhibitor kappaB-alpha (NFKBIA) inhibits NF-kappaB and controls its activities. The objective was to determine whether polymorphisms in NFKBIA gene would be associated with ARDS development...
  22. pmc The influence of infection sites on development and mortality of ARDS
    Chau Chyun Sheu
    Department of Environmental Health, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Intensive Care Med 36:963-70. 2010
    ..However, little is known about the influence of infection sites on ARDS. This study aimed to assess the associations of infection sites with ARDS development and mortality in critically ill infected patients...
  23. pmc Smoking and smoking cessation in relation to the development of co-existing non-small cell lung cancer with chronic obstructive pulmonary disease
    Rihong Zhai
    Department of Environmental Health, Harvard School of Public Health, Boston, MA
    Int J Cancer 134:961-70. 2014
    ..Our study suggests that cigarette smoking is the major risk factor for the development of NSCLC-COPD, especially in females and among patients with squamous cell carcinoma subtype. ..
  24. pmc Distinct and replicable genetic risk factors for acute respiratory distress syndrome of pulmonary or extrapulmonary origin
    Paula Tejera
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    J Med Genet 49:671-80. 2012
    ..The aim of this study was to identify genetic variants contributing to ALI/ARDS from pulmonary or extrapulmonary causes...
  25. pmc Correction for population stratification in random forest analysis
    Yang Zhao
    Environmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard School of Public Health, Harvard University, Boston, MA, USA
    Int J Epidemiol 41:1798-806. 2012
    ..However, if PS is not appropriately corrected, RF tends to give high importance to disease-unrelated SNPs with different frequencies of allele or genotype among subpopulations, leading to inaccurate results...
  26. pmc A single-nucleotide polymorphism in the methylene tetrahydrofolate reductase (MTHFR) gene is associated with risk of radiation pneumonitis in lung cancer patients treated with thoracic radiation therapy
    Raymond H Mak
    Harvard Radiation Oncology Program, Boston, MA, USA
    Cancer 118:3654-65. 2012
    ....
  27. pmc A genome-wide expression analysis in blood identifies pre-elafin as a biomarker in ARDS
    Zhaoxi Wang
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Am J Respir Cell Mol Biol 38:724-32. 2008
    ..52, P = 0.0006). Considering that PI3 can covalently binding to extracellular matrix in lung, circulating PI3 may provide a useful clinical marker for monitoring the early development of ARDS and may have implications for ARDS treatment...
  28. pmc Variants of the adiponectin and adiponectin receptor-1 genes and posttransplantation diabetes mellitus in renal allograft recipients
    Eun Seok Kang
    Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, 330, Brookline Avenue, ST 816, Boston, Massachusetts 02215, USA
    J Clin Endocrinol Metab 97:E129-35. 2012
    ..Adiponectin (ADIPOQ) and adiponectin receptor-1 (ADIPOR1) gene polymorphisms have been associated with type 2 diabetes. However, it is unknown whether these polymorphisms are also risk factors for PTDM...
  29. pmc Surfactant protein-B polymorphisms and mortality in the acute respiratory distress syndrome
    Paul F Currier
    Pulmonary and Critical Care Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Crit Care Med 36:2511-6. 2008
    ..To determine whether polymorphisms of the surfactant protein B gene may be associated with increased mortality in patients with the acute respiratory distress syndrome...
  30. ncbi Genetic polymorphisms of MnSOD, GSTM1, GSTT1, and OGG1 in coal workers' pneumoconiosis
    Rihong Zhai
    Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    J Occup Environ Med 44:372-7. 2002
    ..Cumulative dust exposures, but not genetic polymorphisms, were associated significantly with the presence of CWP. This study illustrates the complexity of factors that may contribute to the development of CWP...
  31. ncbi Proteomic profiling in the sera of workers occupationally exposed to arsenic and lead: identification of potential biomarkers
    Rihong Zhai
    Department of Environmental Health, Occupational Health Program, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    Biometals 18:603-13. 2005
    ..These results demonstrated that proteomic technology, in conjunction with bioinformatics tools, could facilitate the discovery of new and better biomarkers of mixed metal exposure...