Research Topics
Genomes and Genes | Huiyan ZengSummaryAffiliation: Harvard University Country: USA Publications
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Publications
Orphan nuclear receptor TR3/Nur77 regulates VEGF-A-induced angiogenesis through its transcriptional activityHuiyan Zeng
Department of Pathology, Gastroenterology Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
J Exp Med 203:719-29. 2006..e., through transcriptional activity)...
Heterotrimeric G alpha q/G alpha 11 proteins function upstream of vascular endothelial growth factor (VEGF) receptor-2 (KDR) phosphorylation in vascular permeability factor/VEGF signalingHuiyan Zeng
Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
J Biol Chem 278:20738-45. 2003..Taken together, this study demonstrates that Gq/11 proteins mediate KDR tyrosine phosphorylation and KDR-mediated HUVEC proliferation through interaction with KDR...- Neurotensin stimulates IL-8 expression in human colonic epithelial cells through Rho GTPase-mediated NF-kappa B pathwaysDezheng Zhao
Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02468, USA
Am J Physiol Cell Physiol 284:C1397-404. 2003..Together, our findings indicate that NT-stimulated IL-8 expression is mediated via a Rho-dependent NF-kappaB-mediated pathway... - Transcription enhancer factor 3 (TEF3) mediates the expression of Down syndrome candidate region 1 isoform 1 (DSCR1-1L) in endothelial cellsXin Liu
Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
J Biol Chem 283:34159-67. 2008..Taken together, we elucidated a novel function of transcriptional factor TEF3. TEF3 was required for DSCR1-1L expression through binding to the M-CAT site in its promoter and could be an attractive target for anti-angiogenesis therapy... 
Requirement of the nuclear localization of transcription enhancer factor 3 for proliferation, migration, tube formation, and angiogenesis induced by vascular endothelial growth factorXin Liu
Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
FASEB J 25:1188-97. 2011..Our data demonstrate that TEF3, mainly its nuclear localization, is required for VEGF-A(165)-induced endothelial proliferation, migration, tube formation, and in vivo Matrigel angiogenesis...- Neurotensin stimulates expression of early growth response gene-1 and EGF receptor through MAP kinase activation in human colonic epithelial cellsDezheng Zhao
Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
Int J Cancer 120:1652-6. 2007..Together, our results suggest that NT can stimulate MAP kinase-mediated Egr-1 and EGFR gene expression in human colonocytes. Our results may be relevant to the mechanisms by which NT participates in the development of colon cancer... - Insulin-like growth factor-1 receptor transactivation modulates the inflammatory and proliferative responses of neurotensin in human colonic epithelial cellsDezheng Zhao
Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 022115, USA
J Biol Chem 286:6092-9. 2011..We propose that IGF-1R activation represents a previously unrecognized key pathway involved in the mechanisms by which NT and NTR1 modulate colonic inflammation and inflammatory bowel disease... - Requirement of protein kinase D tyrosine phosphorylation for VEGF-A165-induced angiogenesis through its interaction and regulation of phospholipase Cgamma phosphorylationLiuliang Qin
Department of Pathology and Gastroenterology Division, Beth Israel Deaconess Medical Center and Harvard Medical School, 99 Brookline Avenue, Boston, MA 02215, USA
J Biol Chem 281:32550-8. 2006..Together, we demonstrate that PKD interacts with PLCgamma and becomes tyrosine phosphorylated upon VEGF stimulation, leading to PLCgamma activation and angiogenic response of VEGF-A(165)... - Ghrelin stimulates interleukin-8 gene expression through protein kinase C-mediated NF-kappaB pathway in human colonic epithelial cellsDezheng Zhao
Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
J Cell Biochem 97:1317-27. 2006..Ghrelin may participate in the pathophysiology of colonic inflammation by inducing PKC-dependent NF-kappaB activation and IL-8 production at the colonocyte level... - Orphan nuclear transcription factor TR3/Nur77 regulates microvessel permeability by targeting endothelial nitric oxide synthase and destabilizing endothelial junctionsDezheng Zhao
Division of Gastroenterology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
Proc Natl Acad Sci U S A 108:12066-71. 2011..Both functions required TR3/Nur77 transcriptional activity. Taking these data together, TR3/Nur77 is up-regulated by several vascular permeabilizing agents and has critical roles in mediating BVP, AVH, and CVH... - Neurotensin stimulates interleukin-8 expression through modulation of I kappa B alpha phosphorylation and p65 transcriptional activity: involvement of protein kinase C alphaDezheng Zhao
Gastrointestinal Neuropeptide Center, Division of Gastroenterology, Beth Israel Deaconess Medical Center, Dana 601, 330 Brookline Avenue, Boston, MA 02215, USA
Mol Pharmacol 67:2025-31. 2005..These results indicate that the conventional PKCalpha is an important mediator in the proinflammatory signaling pathway elicited by NT at the colonocyte level... - Down syndrome candidate region 1 isoform 1 mediates angiogenesis through the calcineurin-NFAT pathwayLiuliang Qin
Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, 99 Brookline Avenue RN 270A, Boston, MA 02215, USA
Mol Cancer Res 4:811-20. 2006..In sum, DSCR1-1L, unlike DSCR1-4, potently activates angiogenesis and could be an attractive target for antiangiogenesis therapy... - Metalloproteinase-dependent transforming growth factor-alpha release mediates neurotensin-stimulated MAP kinase activation in human colonic epithelial cellsDezheng Zhao
Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02468, USA
J Biol Chem 279:43547-54. 2004..Our findings indicate that matrix metalloproteinase-mediated release of TGFalpha and subsequent EGFR transactivation triggers a NT-mediated MAP kinase pathway that leads to IL-8 gene expression in human colonic epithelial cells... - Neuropilin-1-mediated vascular permeability factor/vascular endothelial growth factor-dependent endothelial cell migrationLing Wang
Department of Pathology, Beth Israel Deaconess Medical Center, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
J Biol Chem 278:48848-60. 2003..These results show for the first time that NRP-1 can independently promote cell signaling in endothelial cells and also demonstrate the importance of last three amino acids of NRP-1 for its function... - KDR stimulates endothelial cell migration through heterotrimeric G protein Gq/11-mediated activation of a small GTPase RhoAHuiyan Zeng
Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
J Biol Chem 277:46791-8. 2002..Taken together, our results indicate that KDR stimulates endothelial cell migration through a heterotrimeric G protein Gq/11 and Gbetagamma-mediated RhoA pathway... - VEGF stimulates PKD-mediated CREB-dependent orphan nuclear receptor Nurr1 expression: role in VEGF-induced angiogenesisDezheng Zhao
Division of Gastroenterolgy, Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215
Int J Cancer 128:2602-12. 2011.... - Requirement of different signaling pathways mediated by insulin-like growth factor-I receptor for proliferation, invasion, and VPF/VEGF expression in a pancreatic carcinoma cell lineHuiyan Zeng
Department of Pathology, RN270H, Beth Israel Deaconess Medical Center and Harvard Medical School, 99 Brookline Avenue, Boston, MA 02215, USA
Biochem Biophys Res Commun 302:46-55. 2003..Taken together, our data indicate the importance of IGF-IR in growth and invasiveness of the pancreatic cancer cell lines and also point out the multiple signaling pathways channeled through this receptor... - Vascular permeability, vascular hyperpermeability and angiogenesisJanice A Nagy
Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
Angiogenesis 11:109-19. 2008..Further work will be required to elucidate the signaling pathways by which each of these molecules, and others likely to be discovered, mediate the different types of vascular permeability... - Substance P-stimulated interleukin-8 expression in human colonic epithelial cells involves Rho family small GTPasesDezheng Zhao
Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, U S A
Biochem J 368:665-72. 2002..These results demonstrate that Rho family small GTPases RhoA, Rac1 and Cdc42 are novel signal transducers for SP-stimulated IL-8 expression... - Flt-1-mediated down-regulation of endothelial cell proliferation through pertussis toxin-sensitive G proteins, beta gamma subunits, small GTPase CDC42, and partly by Rac-1Huiyan Zeng
Department of Pathology, Beth Israel Deaconess Medical Center and Harvard University School of Medicine, Boston, Massachusetts 02215, USA
J Biol Chem 277:4003-9. 2002..Taken together, these results further expand our understanding of Flt-1-mediated antiproliferative activity in VPF/VEGF-stimulated endothelium... - Complexity in the vascular permeability factor/vascular endothelial growth factor (VPF/VEGF)-receptors signalingDebabrata Mukhopadhyay
Mayo Clinic Cancer Center, Department of Biochemistry and Molecular Biology, Mayo Clinic Foundation, Gugg, Rochester, MN 55905, USA
Mol Cell Biochem 264:51-61. 2004..To this end, we conclude that more research needs to be done for completely understanding the VPF/VEGF biology with relation to angiogenesis...
Research Grants
- Expression and Function of TR3/nur77 in angiogenesisHuiyan Zeng; Fiscal Year: 2006..2) Determine the function of TR3/nur77 in angiogenesis. (3) Define the molecular mechanisms regulating TR3/Nur77 expression. ..
- Orphan Nuclear Receptor TR3 in tumor angiogenesis and associated microvessel permHuiyan Zeng; Fiscal Year: 2010..PUBLIC HEALTH RELEVANCE: The mechanism of tumor growth is largely unknown. Our current proposal will identify that Nur77 is an excellent target for cancer therapy. ..