Konstantin B Zeldovich

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Understanding protein evolution: from protein physics to Darwinian selection
    Konstantin B Zeldovich
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Annu Rev Phys Chem 59:105-27. 2008
  2. pmc A first-principles model of early evolution: emergence of gene families, species, and preferred protein folds
    Konstantin B Zeldovich
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, USA
    PLoS Comput Biol 3:e139. 2007
  3. pmc Positive and negative design in stability and thermal adaptation of natural proteins
    Igor N Berezovsky
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, United States of America
    PLoS Comput Biol 3:e52. 2007
  4. pmc Protein stability imposes limits on organism complexity and speed of molecular evolution
    Konstantin B Zeldovich
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 104:16152-7. 2007
  5. ncbi request reprint Physical origins of protein superfamilies
    Konstantin B Zeldovich
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA
    J Mol Biol 357:1335-43. 2006
  6. pmc Protein and DNA sequence determinants of thermophilic adaptation
    Konstantin B Zeldovich
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, United States of America
    PLoS Comput Biol 3:e5. 2007
  7. pmc The folding mechanics of a knotted protein
    Stefan Wallin
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA
    J Mol Biol 368:884-93. 2007

Detail Information

Publications7

  1. ncbi request reprint Understanding protein evolution: from protein physics to Darwinian selection
    Konstantin B Zeldovich
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Annu Rev Phys Chem 59:105-27. 2008
    ....
  2. pmc A first-principles model of early evolution: emergence of gene families, species, and preferred protein folds
    Konstantin B Zeldovich
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, USA
    PLoS Comput Biol 3:e139. 2007
    ..Together, these results provide a microscopic first-principles picture of how first-gene families developed in the course of early evolution...
  3. pmc Positive and negative design in stability and thermal adaptation of natural proteins
    Igor N Berezovsky
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, United States of America
    PLoS Comput Biol 3:e52. 2007
    ..Such correlated mutations are indeed found in TIM barrel and other proteins...
  4. pmc Protein stability imposes limits on organism complexity and speed of molecular evolution
    Konstantin B Zeldovich
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 104:16152-7. 2007
    ....
  5. ncbi request reprint Physical origins of protein superfamilies
    Konstantin B Zeldovich
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA
    J Mol Biol 357:1335-43. 2006
    ..Convergently discovered pre-biotic initial superfamilies with wonderfold structures could have served as a seed for subsequent biological evolution involving gene duplications and divergence...
  6. pmc Protein and DNA sequence determinants of thermophilic adaptation
    Konstantin B Zeldovich
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, United States of America
    PLoS Comput Biol 3:e5. 2007
    ..Together these results provide a complete picture of how compositions of proteomes and genomes in prokaryotes adjust to the extreme conditions of the environment...
  7. pmc The folding mechanics of a knotted protein
    Stefan Wallin
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA
    J Mol Biol 368:884-93. 2007
    ..A bioinformatics analysis of the SpoU family of proteins reveals further that the critical nonnative interactions may originate from evolutionary conserved hydrophobic segments around the knotted region...