Michael Zeisberg

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi The role of epithelial-to-mesenchymal transition in renal fibrosis
    Michael Zeisberg
    Center for Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
    J Mol Med (Berl) 82:175-81. 2004
  2. ncbi Bone morphogenic protein-7 induces mesenchymal to epithelial transition in adult renal fibroblasts and facilitates regeneration of injured kidney
    Michael Zeisberg
    Center for Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 280:8094-100. 2005
  3. ncbi Renal fibroblasts and myofibroblasts in chronic kidney disease
    Frank Strutz
    Department of Nephrology and Rheumatology, Georg August University Medical Center, Goettingen, Germany
    J Am Soc Nephrol 17:2992-8. 2006
  4. ncbi Fibroblasts emerge via epithelial-mesenchymal transition in chronic kidney fibrosis
    Michael Zeisberg
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Front Biosci 13:6991-8. 2008
  5. doi Resolved: EMT produces fibroblasts in the kidney
    Michael Zeisberg
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Am Soc Nephrol 21:1247-53. 2010
  6. pmc Biomarkers for epithelial-mesenchymal transitions
    Michael Zeisberg
    Division of Matrix Biology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 119:1429-37. 2009
  7. doi Mechanisms of tubulointerstitial fibrosis
    Michael Zeisberg
    Division of Matrix Biology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Am Soc Nephrol 21:1819-34. 2010
  8. pmc Physiological levels of tumstatin, a fragment of collagen IV alpha3 chain, are generated by MMP-9 proteolysis and suppress angiogenesis via alphaV beta3 integrin
    Yuki Hamano
    Center for Matrix Biology, Department of Medicine and Gastroenterology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Cancer Cell 3:589-601. 2003
  9. pmc Type XVIII collagen is essential for survival during acute liver injury in mice
    Michael B Duncan
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Dis Model Mech 6:942-51. 2013
  10. pmc Fibroblasts in kidney fibrosis emerge via endothelial-to-mesenchymal transition
    Elisabeth M Zeisberg
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    J Am Soc Nephrol 19:2282-7. 2008

Research Grants

Collaborators

Detail Information

Publications38

  1. ncbi The role of epithelial-to-mesenchymal transition in renal fibrosis
    Michael Zeisberg
    Center for Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
    J Mol Med (Berl) 82:175-81. 2004
    ..Such antagonism results in the repair of injured kidneys, suggesting that modulation of epithelial cell plasticity has therapeutic advantages...
  2. ncbi Bone morphogenic protein-7 induces mesenchymal to epithelial transition in adult renal fibroblasts and facilitates regeneration of injured kidney
    Michael Zeisberg
    Center for Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 280:8094-100. 2005
    ....
  3. ncbi Renal fibroblasts and myofibroblasts in chronic kidney disease
    Frank Strutz
    Department of Nephrology and Rheumatology, Georg August University Medical Center, Goettingen, Germany
    J Am Soc Nephrol 17:2992-8. 2006
  4. ncbi Fibroblasts emerge via epithelial-mesenchymal transition in chronic kidney fibrosis
    Michael Zeisberg
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Front Biosci 13:6991-8. 2008
    ..While knowledge regarding EMT was previously based on experimental rodent studies, in recent years the evolving evidence demonstrates a role for EMT in human kidney diseases with chronic fibrosis...
  5. doi Resolved: EMT produces fibroblasts in the kidney
    Michael Zeisberg
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Am Soc Nephrol 21:1247-53. 2010
    ..For 15 years, EMT has also been viewed as a principal source of fibroblasts in tissue fibrosis. Because several recent studies question its role in fibrogenesis, it seems like a good time for debate...
  6. pmc Biomarkers for epithelial-mesenchymal transitions
    Michael Zeisberg
    Division of Matrix Biology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 119:1429-37. 2009
    ....
  7. doi Mechanisms of tubulointerstitial fibrosis
    Michael Zeisberg
    Division of Matrix Biology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Am Soc Nephrol 21:1819-34. 2010
    ..How to prevent chronic kidney disease from progressing to renal failure awaits even deeper biochemical understanding...
  8. pmc Physiological levels of tumstatin, a fragment of collagen IV alpha3 chain, are generated by MMP-9 proteolysis and suppress angiogenesis via alphaV beta3 integrin
    Yuki Hamano
    Center for Matrix Biology, Department of Medicine and Gastroenterology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Cancer Cell 3:589-601. 2003
    ..These results indicate that MMP-generated fragments of basement membrane collagen can have endogenous function as integrin-mediated suppressors of pathologic angiogenesis and tumor growth...
  9. pmc Type XVIII collagen is essential for survival during acute liver injury in mice
    Michael B Duncan
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Dis Model Mech 6:942-51. 2013
    ..These findings demonstrate that type XVIII collagen is an important functional component of the liver matrix microenvironment and is crucial for hepatocyte survival during injury and stress. ..
  10. pmc Fibroblasts in kidney fibrosis emerge via endothelial-to-mesenchymal transition
    Elisabeth M Zeisberg
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    J Am Soc Nephrol 19:2282-7. 2008
    ..Collectively, our results demonstrate that EndMT contributes to the accumulation of activated fibroblasts and myofibroblasts in kidney fibrosis and suggest that targeting EndMT might have therapeutic potential...
  11. ncbi Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition
    Michael Zeisberg
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachussetts 02215, USA
    J Biol Chem 282:23337-47. 2007
    ..Furthermore, our findings suggest that EMT is a promising therapeutic target for the attenuation of liver fibrosis...
  12. pmc Stage-specific action of matrix metalloproteinases influences progressive hereditary kidney disease
    Michael Zeisberg
    Center for Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
    PLoS Med 3:e100. 2006
    ..The pathological mechanisms by which such mutations lead to eventual kidney failure are not completely understood...
  13. ncbi Animal models of renal fibrosis
    Michael Zeisberg
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Methods Mol Med 117:261-72. 2005
    ..In this chapter, the mouse models of nephrotoxic serum nephritis, COL4A3-deficiency, and unilateral urethral obstruction, which all result reliably into renal fibrosis, are described...
  14. pmc Identification of epithelial to mesenchymal transition as a novel source of fibroblasts in intestinal fibrosis
    Sarah N Flier
    Division of Matrix Biology, Dept of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Center for Life Science, 3 Blackfan Circle, Rm 11090, Boston, MA 02215, USA
    J Biol Chem 285:20202-12. 2010
    ....
  15. ncbi De-differentiation of primary human hepatocytes depends on the composition of specialized liver basement membrane
    Michael Zeisberg
    Center for Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Mol Cell Biochem 283:181-9. 2006
    ..These findings suggest that the composition of liver basement membrane is important for the maintenance of hepatocyte viability and provide anti-de-differentiation clues...
  16. ncbi Discovery of endothelial to mesenchymal transition as a source for carcinoma-associated fibroblasts
    Elisabeth M Zeisberg
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Cancer Res 67:10123-8. 2007
    ....
  17. ncbi Renal fibrosis and glomerulosclerosis in a new mouse model of diabetic nephropathy and its regression by bone morphogenic protein-7 and advanced glycation end product inhibitors
    Hikaru Sugimoto
    Harvard Medical School, Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
    Diabetes 56:1825-33. 2007
    ..Collectively, our results report a new mouse model for diabetic nephropathy with prominent interstitial inflammation and fibrosis and the selective inhibition of diabetic kidney disease by AGE inhibitors and BMP-7...
  18. ncbi Bone morphogenic protein-7 inhibits progression of chronic renal fibrosis associated with two genetic mouse models
    Michael Zeisberg
    Center for Matrix Biology, Department of Medicine, Harvard Medical School and Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
    Am J Physiol Renal Physiol 285:F1060-7. 2003
    ..Collectively, these studies provide further evidence for rhBMP-7 as an important bone-associated protein with protective function against renal pathology...
  19. pmc Methylation determines fibroblast activation and fibrogenesis in the kidney
    Wibke Bechtel
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 16:544-50. 2010
    ..These studies demonstrate that epigenetic modifications may provide a molecular basis for perpetuated fibroblast activation and fibrogenesis in the kidney...
  20. doi Activin-like kinase 3 is important for kidney regeneration and reversal of fibrosis
    Hikaru Sugimoto
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 18:396-404. 2012
    ..Our studies show that BMP signaling agonists constitute a new line of therapeutic agents with potential utility in the clinic to induce regeneration, repair and reverse established fibrosis...
  21. ncbi BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury
    Michael Zeisberg
    Center for Matrix Biology, Gastroenterology and Renal Divisions, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Nat Med 9:964-8. 2003
    ..Collectively, these results provide evidence of cross talk between BMP-7 and TGF-beta1 in the regulation of EMT in health and disease...
  22. ncbi BMP-7 functions as a novel hormone to facilitate liver regeneration
    Hikaru Sugimoto
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Ave, Boston, MA 02215, USA
    FASEB J 21:256-64. 2007
    ..Collectively, our results argue for the role of BMP-7 as a kidney- and bone-produced endogenous regulator of hepatocyte health...
  23. pmc VEGF-A and Tenascin-C produced by S100A4+ stromal cells are important for metastatic colonization
    Joyce T O'Connell
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 108:16002-7. 2011
    ..Our study demonstrates a crucial role for local S100A4(+) fibroblasts in providing the permissive "soil" for metastatic colonization, a challenging step in the metastatic cascade...
  24. pmc Transcriptional regulation of epithelial-mesenchymal transition
    Yingqi Teng
    Division of Matrix Biology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 117:304-6. 2007
    ..Collectively, their results suggest that this complex is an important regulator of the EMT transcriptome...
  25. ncbi Endothelial-to-mesenchymal transition contributes to cardiac fibrosis
    Elisabeth M Zeisberg
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Nat Med 13:952-61. 2007
    ..Our findings show that EndMT contributes to the progression of cardiac fibrosis and that rhBMP-7 can be used to inhibit EndMT and to intervene in the progression of chronic heart disease associated with fibrosis...
  26. ncbi Integrin alpha1beta1 and alpha2beta1 are the key regulators of hepatocarcinoma cell invasion across the fibrotic matrix microenvironment
    Changqing Yang
    Department of Medicine and the Liver Center, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Cancer Res 63:8312-7. 2003
    ....
  27. ncbi Chronic bile duct injury associated with fibrotic matrix microenvironment provokes cholangiocarcinoma in p53-deficient mice
    Paraskevi A Farazi
    Department of Medical Oncology and Center for Applied Cancer Science, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Cancer Res 66:6622-7. 2006
    ..Thus, p53 deficiency, chronic bile duct injury/proliferation, and the fibrotic matrix microenvironment cooperate to induce intrahepatic CCA, highlighting the key role of the ECM microenvironment in this common liver cancer...
  28. ncbi Liver fibrosis: insights into migration of hepatic stellate cells in response to extracellular matrix and growth factors
    Changqing Yang
    Program in Matrix Biology, Gastroenterology and Renal Divisions, Department of Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    Gastroenterology 124:147-59. 2003
    ..The normal basement membrane-like matrix present within the space of Disse converts to a matrix rich in fibril-forming collagens during fibrosis...
  29. doi Twist: a new link from hypoxia to fibrosis
    Wibke Bechtel
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Kidney Int 75:1255-6. 2009
    ..This study provides clues as to how hypoxia and transforming growth factor-beta can collaborate to drive renal fibrogenesis...
  30. ncbi Fibroblasts in cancer
    Raghu Kalluri
    Center for Matrix Biology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Nat Rev Cancer 6:392-401. 2006
    ..Fibroblasts are therefore a key determinant in the malignant progression of cancer and represent an important target for cancer therapies...
  31. pmc Renal fibrosis. Extracellular matrix microenvironment regulates migratory behavior of activated tubular epithelial cells
    Michael Zeisberg
    Department of Medicine and the Liver Center, Program in Matrix Biology, Renal, and Gastroenterology Divisions, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Am J Pathol 160:2001-8. 2002
    ....
  32. pmc Human tumstatin and human endostatin exhibit distinct antiangiogenic activities mediated by alpha v beta 3 and alpha 5 beta 1 integrins
    Akulapalli Sudhakar
    Program in Matrix Biology, Department of Medicine and Cancer Center, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 100:4766-71. 2003
    ..Collectively, such distinct properties of human tumstatin and human endostatin provide the first insight into their diverse antiangiogenic actions and argue for combining them for targeting tumor angiogenesis...
  33. ncbi Endogenous stimulators and inhibitors of angiogenesis in gastrointestinal cancers: basic science to clinical application
    Malin Sund
    Center for Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02125, USA
    Gastroenterology 129:2076-91. 2005
    ....
  34. ncbi Experimental strategies to reverse chronic renal disease
    Michael Zeisberg
    Center for Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Blood Purif 22:440-5. 2004
    ..This review summarizes the recent therapeutic advances using experimental models that might translate into novel human therapies to prevent, or significantly delay, requirement of renal replacement therapy...
  35. ncbi Differential expression of type IV collagen isoforms in rat glomerular endothelial and mesangial cells
    Michael Zeisberg
    Program in Matrix Biology, Renal and Gastroenterology Divisions, Department of Medicine and the Liver Center, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Biochem Biophys Res Commun 295:401-7. 2002
    ....
  36. doi Reversal of experimental renal fibrosis by BMP7 provides insights into novel therapeutic strategies for chronic kidney disease
    Michael Zeisberg
    Pediatr Nephrol 23:1395-8. 2008
    ..Here we summarize recent insights into the role of BMP7 in acute and chronic kidney injury and discuss the implications for future directions of antifibrotic therapies...
  37. ncbi Are there endogenous molecules that protect kidneys from injury? The case for bone morphogenic protein-7 (BMP-7)
    Michael Zeisberg
    Nephrol Dial Transplant 19:759-61. 2004
  38. ncbi Role of basic fibroblast growth factor-2 in epithelial-mesenchymal transformation
    Frank Strutz
    Department of Nephrology and Rheumatology, Georg August University Medical Center, Gottingen, Germany
    Kidney Int 61:1714-28. 2002
    ....

Research Grants4

  1. Re-Induction of Developmental Programs during Chronic Renal Injury
    Michael Zeisberg; Fiscal Year: 2007
    ..The study aims proposed in this application are centered around testing the potential role of fibroblasts in the repair of renal injury and they attempt to further analyze the preliminary phenotypic observation at a molecular level. ..